EUS or percutaneously guided intratumoral TNFerade biologic with 5-fluorouracil and radiotherapy for first-line treatment of locally advanced pancreatic cancer: A phase I/II study

Gastrointestinal Endoscopy

Volumn 75, Issue 2, 2012, Pages 332-338

  Hecht, J Randolph ^a   Farrell, James J ^a   Senzer, Neil ^b   Nemunaitis, John ^b   Rosemurgy, Alexander ^c   Chung, Theodore ^d   Hanna, Nader ^e   Chang, Kenneth J ^f   Javle, Milind ^g   Posner, Mitchell ^h   Waxman, Irving ^h   Reid, Anthony ⁱ   Erickson, Richard ^j   Canto, Marcia ^k   Chak, Amitabh ^l   Blatner, Gretta ^m   Kovacevic, Milan ^m   Thornton, Mark ^m  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Mary Crowley Medical Research Center   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^h UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

ⁱ UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^j SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^k JOHNS HOPKINS HOSPITAL   (United States)

^l UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^m GENVEC INC   (United States)

more..

Author keywords

5 fluorouracil; 5 FU; absolute neutrophil count; ANC; chemoradiation therapy; CRT; deep vein thrombosis; DLT; dose limiting toxicity; DVT; EUS FNI; EUS guided fine needle viral injection; fine needle viral injection; FNI; LAPC; locally advanced pancreatic cancerv; maximal tolerated dose; MTD; particle units; PU; TNF ; tumor necrosis factor

Indexed keywords

FLUOROURACIL; GOLNERMINOGENE PRADENOVEC;

ABDOMINAL PAIN; ADULT; ADVANCED CANCER; AGED; ALOPECIA; ANEMIA; ANOREXIA; ARTICLE; BILE DUCT OBSTRUCTION; BLOOD CLOTTING DISORDER; BRADYCARDIA; CANCER COMBINATION CHEMOTHERAPY; CANCER LOCALIZATION; CANCER PATIENT; CARDIOPULMONARY ARREST; CEREBROVASCULAR ACCIDENT; CHEMORADIOTHERAPY; CHEMOTHERAPY INDUCED EMESIS; CHOLANGITIS; CHOLECYSTITIS; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; CONTINUOUS INFUSION; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DIARRHEA; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ELECTROLYTE DISTURBANCE; ENDOSCOPIC ECHOGRAPHY; EXTERNAL BEAM RADIOTHERAPY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMAN; HYPERAMYLASEMIA; HYPERLIPASEMIA; HYPOKALEMIA; HYPOTENSION; INJECTION; INTESTINE ISCHEMIA; LOCALLY ADVANCED PANCREAS CANCER; LUNG EMBOLISM; MALE; MAXIMUM TOLERATED DOSE; MENTAL HEALTH; MULTICENTER STUDY; NAUSEA; NEUTROPENIA; OVERALL SURVIVAL; PANCREAS CANCER; PANCREATICODUODENECTOMY; PANCREATITIS; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RADIATION DOSE; RESPONSE EVALUATION CRITERIA IN SOLID TUMOR; SIDE EFFECT; STAPHYLOCOCCUS INFECTION; SUPRAVENTRICULAR TACHYCARDIA; THROMBOCYTOPENIA; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; WORLD HEALTH ORGANIZATION;

ADENOVIRUSES, HUMAN; ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; CARCINOMA; CHEMORADIOTHERAPY; CHOLANGITIS; DISEASE-FREE SURVIVAL; DNA; DOSE FRACTIONATION; FEMALE; FLUOROURACIL; GENETIC VECTORS; HUMANS; INJECTIONS, INTRALESIONAL; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; PANCREATIC NEOPLASMS; PANCREATITIS; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84855826028     PISSN: 00165107     EISSN: 10976779     Source Type: Journal    
DOI: 10.1016/j.gie.2011.10.007     Document Type: Article

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