Therapeutic effect of genetically modified human neural stem cells encoding cytosine deaminase on experimental glioma

Biochemical and Biophysical Research Communications

Volumn 417, Issue 1, 2012, Pages 534-540

  Kim, Jae Ho ^a   Kim, Jin Young ^b   Kim, Seung U ^c,d   Cho, Kyung Gi ^e  

^a Korea Basic Science Institute (KBSI)   (South Korea)

^b Chingelhan Neurosurgery Clinic   (South Korea)

^c Chung Ang University College of Medicine   (South Korea)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e CHA University   (South Korea)

Author keywords

Cytosine deaminase; Gene therapy; Glioma; Neural stem cells; Suicide gene

Indexed keywords

CYTOSINE DEAMINASE; FLUCYTOSINE; FLUOROURACIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; FEMALE; GENE THERAPY; GENETIC TRANSDUCTION; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; NEURAL STEM CELL; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR VOLUME;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; CYTOSINE DEAMINASE; FEMALE; FLUOROURACIL; GENE THERAPY; GLIOMA; HUMANS; MAGNETIC RESONANCE IMAGING; NEOPLASMS, EXPERIMENTAL; NEURAL STEM CELLS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RATTUS;

EID: 84855819198     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.11.155     Document Type: Article

References (25)

1. Vogel T.W., Zhuang Z., Li J., Okamoto H., Furuta M., Lee Y.S., Zeng W., Oldfield E.H., Vortmeyer A.O., Weil R.J. Proteins and protein pattern differences between glioma cell lines and glioma multiforme. Clin. Cancer Res. 2005, 11(10):3624-3632.
2. Forsyth P.A., Cairncross J.G. Treatment of malignant glioma in adults. Curr. Opin. Neurol. 1995, 8(6):414-418.
3. Imperato J.P., Paleologos N.A., Vick N.A. Effects of treatment on long-term survivors with malignant astrocytomas. Ann. Neurol. 1990, 28(6):818-822.
4. Glass R., Synowitz M., Kronenberg G., Walzlein J.H., Markovic D.S., Wang L.P., Gast D., Kiwit J., Kempermann G., Kettenmann H. Glioma-induced attraction of endogenous neural precursor cells is associated with improved survival. J. Neurosci. 2005, 25(10):2637-2646.
5. Lee H.J., Kim K.S., Kim E.J., Lee K.H., Choi H.B., Park I.H., Ko Y., Jeong S.W., Kim S.U. Brain transplantation of human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model. Stem Cells 2007, 25(1):211-224.
6. Kim S.U., de Vellis J. Stem cell-based cell therapy in neurological diseases: A review. J. Neurosci. Res. 2009, 88(10):2183-2200.
7. A. Giese, I.M. Westpha, Glioma invasion in the central nervous system. Neurosurgery, 39 (2) (1996) 235-250 (discussion, pp. 50-52).
8. Aboody K.S., Brown A., Rainov N.G., Bower K.A., Liu S., Yang W., Small J.E., Herrlinger U., Ourednik V., Black P.M., Breakefield X.O., Snyder E.Y. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc. Natl. Acad. Sci. USA 2000, 97(23):12846-12851.
9. Ahmed A.U., Alexiades N.G., Lesniak M.S. The use of neural stem cells in cancer gene therapy: predicting the path to the clinic. Curr. Opin. Mol. Ther. 2010, 12(5):546-552.
10. Kim S.U. Neural stem cell-based gene therapy for brain tumors. Stem Cell Rev. Rep. 2011, 7(1):130-140.
11. Kim S.K., Kim S.U., Park I.H., Bang J.H., Aboody K.S., Wang K.C., Cho B.K., Kim M., Menon L.G., Black P.M., Carroll R.S. Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression. Clin. Cancer Res. 2006, 12(18):5550-5556.
12. Shimato S., Natsume A., Takeuchi H., Wakabayashi T., Fujii M., Ito M., Ito S., Park I.H., Bang J.H., Kim S.U., Yoshida J. Human neural stem cells target and deliver therapeutic gene to experimental leptomeningeal medulloblastoma. Gene Ther. 2007, 14(15):1132-1142.
13. Kendall S.E., Najbauer J., Johnston H.F., Metz M.Z., Li S., Bowers M., Garcia E., Kim S.U., Barish M.E., Aboody K.S., Glackin C.A. Neural stem cell targeting of glioma is dependent on phosphoinositide 3-kinase signaling. Stem Cells 2008, 26(6):1575-1586.
14. Zhao D., Najbauer J., Garcia E., Metz M.Z., Gutova M., Glackin C.A., Kim S.U., Aboody K.S. Neural stem cell tropism to glioma: critical role of tumor hypoxia. Mol. Cancer Res. 2008, 6(12):1819-1829.
15. Lee D.H., Ahn Y., Kim S.U., Wang K.C., Cho B.K., Phi J.H., Park I.H., Black P.M., Carroll R.S., Lee J., Kim S.K. Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells. Clin. Cancer Res. 2009, 15(10):4925-4934.
16. Thu M.S., Najbauer J., Kendall S.E., Harutyunyan I., Sangalang N., Gutova M., Metz M.Z., Garcia E., Frank R.T., Kim S.U., Moats R.A., Aboody K.S. Iron labeling and pre-clinical MRI visualization of therapeutic human neural stem cells in a murine glioma model. PLoS One 2009, 4:e7218.
17. Kim J.H., Lee J.E., Kim S.U., Cho K.G. Stereological analysis on migration of human neural stem cells in the brain of rats bearing glioma. Neurosurgery 2010, 66(2):333-342.
18. Lee S.J., Kim Y., Jo M.Y., Kim H.S., Jin Y., Kim S.U., Jin J., Joo K.M., Nam D.H. Combined treatment of tumor-tropic human neural stem cells containing the CD suicide gene effectively targets brain tumors provoking a mild immune response. Oncol. Rep. 2011, 25(1):63-68.
19. Aboody K.S., Najbauer J., Schmidt N.O., Yang W., Wu J.K., Zhuge Y., Przylecki W., Carroll R., Black P.M., Perides G. Targeting of melanoma brain metastases using engineered neural stem/progenitor cells. Neuro-Oncology 2006, 8(2):119-126.
20. K. Kurozumi, T. Tamiya, Y. Ono, S. Otsuka, H. Kambara, Y. Adachi, T. Ichikawa, H. Hamada, T. Ohmoto, Apoptosis induction with 5-fluorocytosine/cytosine deaminase gene therapy for human malignant glioma cells mediated by adenovirus, J. Neuro-Oncol. 66 (1-2) (2004) 117-127.
21. Joo K.M., Park I.H., Shin J.Y., Jin J., Kang B.G., Kim M.H., Lee S.J., Jo M.Y., Kim S.U., Nam D.H. Human neural stem cells can target and deliver therapeutic genes to breast cancer brain metastases. Mol. Ther. 2009, 17(3):570-575.
22. Barresi V., Belluardo N., Sipione S., Mudo G., Cattaneo E., Condorelli D.F. Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy. Cancer Gene Ther. 2003, 10(5):396-402.
23. Chen J.K., Hu L.J., Wang D., Lamborn K.R., Deen D.F. Cytosine deaminase/5-fluorocytosine exposure induces bystander and radiosensitization effects in hypoxic glioma cells in vitro. Int. J. Radiat. Oncol. 2007, 67(5):1538-1547.
24. Miyagi T., Koshida K., Hori O., Konaka H., Katoh H., Kitagawa Y., Mizokami A.A., Egawa M., Ogawa S., Hamada H., Namiki M. Gene therapy for prostate cancer using the cytosine deaminase/uracil phosphoribosyltransferase suicide system. J. Gene Med. 2003, 5(1):30-37.
25. Ramnaraine M., Pan W., Goblirsch M., Lynch C., Lewis V., Orchard P., Mantyh P., Clohisy D.R. Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene. Cancer Res. 2003, 63(20):6847-6854.