Peripheral nerve regeneration

Neuroscience Research

Volumn 25, Issue 2, 1996, Pages 101-121

  Ide, Chizuka ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Adhesion molecule; Basal lamina; Growth cone; Growth factor; Peripheral nerve regeneration; Protein kinase C; Schwann cell; Synaptic vesicle associated protein; Tyrosine kinase

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CADHERIN; CILIARY NEUROTROPHIC FACTOR; INTEGRIN; NERVE CELL ADHESION MOLECULE; NERVE GROWTH FACTOR; NEUROMODULIN; NEUROTROPHIC FACTOR; PROTEIN; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; SYNAPSIN I; SYNAPTOPHYSIN; SYNAPTOTAGMIN;

BASEMENT MEMBRANE; CELL ADHESION; EXOCYTOSIS; GROWTH CONE; MORPHOLOGY; NERVE FIBER; NERVE FIBER MEMBRANE; NERVE REGENERATION; PERIPHERAL NERVE; PRIORITY JOURNAL; RANVIER NODE; REINNERVATION; REVIEW; SCHWANN CELL; SIGNAL TRANSDUCTION; SYNAPSE VESICLE;

EID: 0030176406     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(96)01042-5     Document Type: Review

References (246)

1. Adler, R., Landa, K.B., Manthorpe, M. and Varon, S. (1979) Cholinergic neurotrophic factors: Intraocular distribution of soluble trophic activity for ciliary neurons. Science, 204: 1434-1436.
2. Aigner, L. and Caroni, R. (1995) Absence of persistent spreading, branching and adhesion in Gap-43-depleted growth cones. J. Cell Biol., 128: 647-660.
3. Akagi, S., Mizoguchi, A., Sobue, K., Nakamura, H. and Ide, C. (1996) Localization of synapsin I in normal fibers and regenerating axonal sprouts of the rat sciatic nerve. Histochem. Cell Biol., (in press).
4. Alexander, K.A., Wakim, B.T., Doyle, G.S., Walsh, K.A. and Storm, D.R. (1988) Identification and characterization of the calmodulin-binding domain of neuromodulin, neurospecific calmodulin-binding protein. J. Biol. Chem., 263: 7544-7549.
5. Ann, E.S., Mizoguchi, A., Okajima, S. and Ide, C. (1994) Motor axon terminal regeneration studied by protein gene product 9.5 immunohistochemistry on the rat. Arch. Histol. Cytol., 57: 317-330.
6. Apel, E.D., Byford, M.F., Au, D., Walsh, K.A. and Storm, D.R. (1990) Identification of the protein kinase C phosphorylation site in neuromodulin. Biochemistry, 29: 2330-2335.
7. Arakawa, M., Mizoguchi, A., Masutani, M., Tomatsuri, M., Okajima, S. and Ide, C. (1993) Ultrastructural localization of protein kinase C β subtype in the axon terminal of rat neuromuscular junction. Neurosci. Res., 16: 125-130.
8. Arakawa, Y., Sendthner, M. and Thoenen, H. (1990) Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines. J. Neurosci., 10: 3507-3515.
9. Atashi, J.R., Klinz, S.G., Ingraham, C.A., Matten, W.T., Schachner, M. and Maness, P.F. (1992) Neural cell adhesion molecules modulate tyrosine phosphorylation of tubulin in nerve growth cone membranes. Neuron, 8: 831-842.
10. s-scr(-) in the developing chick spinal cord as revealed with anti-hexapeptide antibody. J. Neurocytol., 22: 244-258.
11. Baetge, E.E. and Hammang, J.P. (1991) Neurite outgrowth in PC12 cells deficient in GAP-43. Neuron, 6: 21-30.
12. Bähler, M. and Greengard, P. (1987) Synapsin 1 bundles F-actin in a phosphorylation-dependent manner. Nature, 326: 704-707.
13. Barbacid, M. (1994) The Trk family of neurotrophin receptors. J. Neurobiol., 25: 1386-1403.
14. Barde, Y.-A. (1989) Trophic factors and neuronal survival. Neuron, 2: 1525-1534.
15. Basi, G.S., Jacobson, R.D., Virag, I., Schilling, J. and Skene, J.H.P. (1987) Primary structure and transcriptional regulation of GAP-43, a protein associated with nerve growth. Cell, 49: 785-791.
16. Beggs, H.E., Soriano, P. and Maness, P.F. (1994) N-CAM-dependent neurite outgrowth is inhibited in neurons frog fyn-minus mice. J. Cell Biol., 127: 825-833.
17. Benowitz, L.I. and Routenberg, A. (1987) A membrane phosphorylation associated with neuronal development, axonal regulation, phospholipid metabolism and synaptic plasticity. Trends Neurosci., 10: 527-531.
18. Bixby, J.L. (1989) Protein kinase C is involved in laminin stimulation of neurite outgrowth. Neuron, 3: 287-297.
19. Bixby, J.L., Lilien, J. and Reichardt, L.F. (1988) Identification of the major proteins that promote neuronal process outgrowth on Schwann cells in vitro. J. Cell Biol., 107: 353-361.
20. Bixby, J.L. and Jhabvala, P. (1990) Extracellular matrix molecules and cell adhesion molecules induce neurites through different mechanisms. J. Cell. Biol., 111: 2725-2732.
21. Bixby, J.L. and Zhang, R. (1990) Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth. J. Cell Biol., 110: 1253-1260.
22. Bixby, J.L. and Harris, W.A. (1991) Molecular mechanisms of axon growth and guidance. Ann. Rev. Cell Biol., 7: 117-159.
23. Borghini, I., Ania-Lahuerta, A. Regazzi, R. Ferrari, G., Gjinovci, A., Wollheim, C.B. and Pralong, W.-F. (1994) α, βI, βII, δ and ε protein kinase C isoforms and compound activity in the sciatic nerve of normal and diabetic rats. J. Neurochem., 62: 686-696.
24. Bray, D. (1970) Surface movements during the growth of single explanted neurons. Proc. Natl. Acad. Sci. USA. 65: 905-910.
25. Bridgman, P.C. and Dailey, M.E. (1989) The organization of myosin and actin in rapid frozen growth cones. J. Cell Biol., 108: 95-109.
26. Brose, N., Petrenko, A.G., Südhof, T.C. and Jahn, R. (1992) Synaptotagmin: A calcium sensor on the synaptic vesicle surface. Science, 256: 1021-1025.
27. Brown, M.C., Perry, V.H., Lunn, E.R., Gordon, S. and Heumann, R. (1991) Macrophage dependence of peripheral sensory nerve regeneration: possible involvement of nerve growth factor. Neuron, 6: 359-370.
28. c-scr. Nature, 316: 554-557.
29. Bunge, M.B. (1973) Fine structure of nerve fibers and growth cones of isolated sympathetic neurons in culture. J. Cell Biol., 56: 713-735.
30. Bunge, R.P. (1993) Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration. Curr. Opin. Neurobiol., 3: 805-809.
31. Bunge, M.B., Bunge, R.P., Kleitman, N. and Dean, A.C. (1989) Role of peripheral nerve extracellular matrix in Schwann cell function and in neurite regeneration. Dev. Neurosci., 11: 348-360.
32. Büngner, O.V. (1891) Über die Degenerations-und Regenerationsvorgange am Nerven nach Verletzungen. Beitr. Pathol. Anat., 10: 321-387.
33. fak accompanies cell adhesion to extracellular matrix: a role of cytoskeletal assembly. J. Cell Biol., 119: 893-903.
34. Cajal, S.R.y. (1928) Degeneration and Regeneration of the Nervous System. Hafner, London (Facsimile of the 1928 edition).
35. Chang, H.Y., Takei, K. Sydor, A.M., Born, T., Rusnak, F and Jay, D.G. (1995) Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin. Nature, 376: 688-699.
36. Craig, A.M., Wyborski, R.J. and Banker, G. (1995) Preferential addition of newly synthesized membrane proteins at axonal growth cones. Nature, 375: 592-594.
37. Daston, M.M. and Ratner, N. (1991) Expression of P30. a protein with adhesive properties, in Schwann cells and neurons of the developing and regenerating peripheral nerve. J. Cell Biol., 112: 1229-1239.
38. David, S. and Aguayo, A.J. (1981) Axonal elongation in peripheral nervous system "bridges" after central nervous system injury in adult rats. Science, 214: 931-933.
39. De Camilli, P., Cameron, R. and Greengard, P. (1983) Synapsin I (protein I), a new terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections. J. Cell Biol., 96: 1337-1354.
40. Dezawa, M. and Nagano, T. (1993) Contacts between regenerating axons and the Schwann cells of sciatic nerve segments grafted at the optic nerve of adult rats. J. Neurocytol., 22: 1103-1112.
41. Doherty, P. and Walsh, F.S. (1994) Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules. Curr. Opin. Neurobiol., 4: 49-55.
42. Edbladh, M., Fex-Svenningsen, Å., Ekström, P.A.R. and Endström, A. (1994) Insulin and IGF-II, but not IGF-I, stimulate the in vitro regeneration of adult frog sciatic sensory axons. Brain Res., 641: 76-82.
43. Edger, D. (1989) Neuronal laminin receptors. Trends Neurosci., 12: 248-251.
44. Fan, J., Mansfield, S.G., Redmond, T., Gordon-Weeks, P.R. and Raper, J.A. (1993) The organization of F-actin and microtubules in growth cones exposed to a brain-derived collapsing factors. J. Cell Biol., 121: 867-878.
45. Fannon, A.M., Sherman, D.L., Ilyina-Gragerova, G., Brophy, P.J., Friedrich, V.L., Jr. and Colman, D.R. (1995) Novel E-cadherin-mediated adhesion in peripheral nerve: Schwann cell architecture is stabilized by autotypic ahdherens junctions. J. Cell Biol. 129: 189-202.
46. Feany, M.B. and Buckley, K.M. (1993) The synaptic vesicle protein synaptotagmin promotes formation of filopodia in fibroblasts. Nature, 364: 537-540.
47. Feldman, E.L. Axelrod, M., Schwartz, M., Heacock, A.M. and Agranof, B.W. (1981) Studies on the localization of newly added membrane in growing neurites. J. Neurobiol., 12: 591-598.
48. Felsenfeld, D.P. Hynes, A., Skoler, K.M., Furley, A.J. and Jessell, T.M. (1994) TAG-I can mediate homophilic binding, but neurite outgrowth on TAG-I requires an L1-like molecule and β1 integrins. Neuron, 12: 675-690.
49. Friedman, B., Shever, S.S., Rudge, J.S., Helgren, M., Morrisey, D., McClain, J., Wang, D. Wiegand, S.J., Furth, M.E., Lindsay, R.M. and Ip, N.T. (1992) Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo. Neuron, 9: 295-305.
50. Fujimoto, E., Miki, A. and Ide, C. (1992) Regenerating axons in basal lamina tubes of non-neural tissues. Biomed. Res., 13: 59-68.
51. Fujimoto, E., Mizoguchi, A., Hanada, K., Yajima, M. and Ide, C. (1996) Basic fibroblast growth factor promotes extension of regenerating axons of the peripheral nerve in vivo. J. Neurocytol. (submitted).
52. Fukuda, J., Yamaguchi, K., Akimoto, S. and Tada, Y. (1985) NGF-dependent and -independent growth of neurite from sympathetic ganglion cells of the aged human in a serum-free culture. Neurosci. Res., 2: 460-471.
53. Fukuda, Y., Sasaki, H., Adachi, E., Inoue, T. and Morigiwa, K. (1990) Optic nerve regeneration by peripheral nerve transplant. Neurosci. Res., (Suppl.) 13: S24-S30.
54. Gispen, W.H., Boonstra, J., De Graan, P.N.E., Jennekens, F. G.I., Oestreicher, A.B., Schotman, P., Schrama, L.H., Verhaagen, J. and Margolis, F.L. (1990) B-50/GAP-43 in neuronal development and repair. Restorat. Neurol. Neurosci., 1: 237-244.
55. Glazner, G.W., Lupien, S., Miller, J.A. and Ishii, D.N. (1993) Insulin-like growth factor II increases the rate of sciatic nerve regeneration in rats. Neuroscience, 54: 791-797.
56. 2+ in formation of veils in growth cones. J. Neurosci., 8: 2596-2605.
57. Goldberg, D.J. and Wu, D.-Y. (1994) Regulation of events within the growth cone by extracellular cues: tyrosine phosphorylation. Prog. Brain Res., 103: 75-83.
58. Gomez, T.M., Snow, D.M. and Letourneau, P.C. (1995) Characterization of spontaneous calcium transients in nerve growth cones and their effects on growth cone migration. Neuron, 14: 1233-1246.
59. Goshima, Y., Nakamura, F., Strittmatter, P. and Strittmatter, S. (1995) Collapsin-induced growth cone collapse mediated by an intracellular protein related to Unc 33. Nature, 376: 509-514.
60. Goslin, K.G. and Banker, G. (1990) Rapid changes in the distribution of GAP-43 correlate with the expression of neuronal polarity during normal development and under experimental conditions. J. Cell Biol., 110: 1319-1331.
61. Gospodarowicz, D., Ferrara, N., Schweigerer, L., and Newfeld, G. (1987) Structural characterization and biolgical functions of fibroblast growth factor. Endocrin. Rev., 8: 95-114.
62. Griffin, J.W., Price, D.L., Drachman, D.B. and Morris, J. (1981) Incorporation of axonally transported glycoproteins into axolemma during nerve regeneration. J. Cell Biol., 88: 205-214.
63. Guénard, V., Dinarello, C.A., Weston, P.J. and Aebisher, P. (1991) Peripheral nerve regeneration is impeded by interleukin-1 receptor antagonist released from polymeric guidance channel. J. Neurosci. Res., 29: 396-400.
64. Gulati, A.K. and Cole, G.P. (1994) Immunogenicity and regenerative potential of acellular nerve allografts to repair peripheral nerve in rats and rabbits. Acta Neurochir. -Wien, 126: 158-164.
65. Haas, T.A. and Plow, E.P. (1994) Integrin-ligand interactions: a year in review. Curr. Opin. Cell Biol., 6: 656-662.
66. Hagg, T., Gulati, A.K., Behzadian, M.A., Vahlsing, H. Varon, S. and Manthorpe, M. (1991) Nerve growth factor promotes CNS cholinergic axonal regeneraton into acellular peripheral nerve graft. Exp. Neurol., 112: 79-88
67. Hall, D.E., Reichardt, L.F., Crowley, E., Holley, B., Moezzi, H., Sommenberg, A. and Damsky, C.H. (1990) The α1β1 and α6β1 integrin heterodimers mediate cell attachment to distinct sites on laminin. J. Cell Biol. 110: 2175-2184.
68. Hatta, K. and Takeichi, M. (1986) Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development. Nature, 320: 447-449.
69. Haynes, L.W. (1988) Fibroblast (heparin-binding) growing factors in neuronal development and repair. Mol. Neurobiol., 2: 263-289.
70. Helmke, S. and Pfenninger, K.H. (1995) Growth cone enrichment and cytoskeletal association of non-receptor tyrosine kinases. Cell Motil. Cytoskel., 30: 194-207.
71. Heumann, R., Korshing, S., Bandtlow, C. and Thoenen, H. (1987) Changes of nerve growth factor synthesis in non-neuronal cells in response to sciatic nerve transection. J. Cell Biol., 104: 1623-1631.
72. Hidaka, H., Tanaka, T., Onodera, K., Hagiwara, M., Watanabe, M., Ohta, H., Ito, Y., Tsurudome, M. and Yoshida, T. (1988) Cell type-specific expression of protein kinase C isozymes in the rabbit cerebellum. J. Biol. Chem., 263: 4523-4526.
73. Hietanen, M., Koistinaho, J., Rechardt, L., Roivainen, R. and Pelto-Huikko, M. (1990) Immunohistochemical evidence for the presence of protein kinase C β-subtype in the rat motoneurons and myoneural junction. Neurosci. Lett., 115: 126-130.
74. Hietanen-Peltola, M., Rechardt, L. and Pelto-Huikko, M. (1991) Protein kinase C β-subtype-immunoreactive motor and sensory nerves in rat muscle spindle. Neurosci. Lett., 132: 65-68.
75. Hirokawa, N., Sobue, K., Kanda, K., Harada, A. and Yorifuji, H. (1989) The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin I. J. Cell Biol., 108: 111-126.
76. Hökfelt, T., Wiesenfeld-Hallin, Z., Villar, M. and Melander, T. (1987) Increase of galanin-like immunoreactivity in rat dorsal root ganglion cells after peripheral nerve axotomy. Neurosci. Lett., 83: 217-220.
77. Hopkins, W.G., and Slack, J.R. (1981) The sequential development of nodal sprouts in mouse muscles in response to nerve degeneration. J. Neurocytol., 10: 537-556.
78. Horie, H., Fukuda, N. and Bando, Y. (1991) Hepatocytes enhance neurite regeneration and survival from transected nerve terminals. Neuroreport, 2: 521-524.
79. Hsu, L., Jeng, A. and Chen, K. (1989) Induction of neurite outgrowth from chick embryo ganglia explants by activators of protein kinase C. Neurosci. Lett., 99: 257-262.
80. Hunter, D.D., Shah, V., Merlie, J.P. and Sanes, J.R. (1989) A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction. Nature, 338: 229-234.
81. Hynes, R.O. (1987) Integrins: a family of cell surface receptors. Cell, 48: 549-554.
82. Hynes, R.O. (1992) Integrins: versatility, modulation and signaling in cell adhesion. Cell, 69: 11-25.
83. Hynes, R.O. and Lander, A.D. (1992) Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell, 68: 303-322.
84. Ide, C. (1982a) Degeneration of mouse digital corpuscles. Am. J. Anat., 163: 59-72.
85. Ide, C. (1982b) Regeneration of mouse digital corpuscles. Am. J. Amat., 163: 73-85.
86. Ide, C. (1983) Nerve regeneration and Schwann cell basal lamina: Observations of the long-term regeneration. Arch. Histol. Jpn., 46: 243-257.
87. Ide, C. (1984) Nerve regeneration through the basal lamina scaffold of the skeletal muscle. Neurosci. Res., 1: 379-391.
88. Ide, C., Tohyama, K., Yokota, R., Nitatori, T. and Onodera, S. (1983) Schwann cell basal lamina and nerve regeneration. Brain Res., 288: 61-75.
89. Ide, C. and Kato, S. (1990) Peripheral nerve regeneration. Neurosci. Res. (Suppl.) 13: S157-S164.
90. Ide, C., Osawa, T. and Tohyama, K. (1990) Nerve regeneration through allogeneic nerve grafts, with special reference to the role of the Schwann cell basal lamina. Prog. Neurobiol., 34: 1-38.
91. Igarashi, M., Saito, S. and Komiya, Y. (1990) Vinculin is one of the major endogenous substrates for intrinsic tyrosine kinases in neuronal growth cones isolated from fetal rat brain. Eur. J. Biochem., 193: 551-558.
92. Igarashi, M. and Komiya, Y. (1991) Subtypes of protein kinase C in isolated nerve growth cones: only type II is associated with the membrane skeleton from growth cones. Biochem. Biophy. Res. Comm., 178: 751-757.
93. Igarashi, M., Strittmatter, S.M., Vartanian, T. and Fishman, M. C. (1993) Mediation by G proteins of signals that cause collapse of growth cones. Science, 259: 77-79.
94. Igarashi, M., Tagaya, M. and Komiya, Y. (1996) Accumulation of the presynaptic proteins in growth cones: maturation of the axon terminal in molecular aspects. J. Neurosci. (submitted).
95. Ignatius, M.J., Large, T.H., Houle, M., Tawil, J.W., Barton, A., Esch, F., Carbonetto, S. and Reichardt, L.F. (1990) Molecular cloning of the rat integrin α1-subunit: a receptor for laminin and collagen. J. Cell Biol., 111: 709-720.
96. c-scr induced by peripheral nerve injury. J. Comp. Neurol., 315: 171-177.
97. Ignelzi, M.A., Miller, D.R., Soriano, P. and Maness, P.F. (1994) Impaired neurite outgrowth of src-minus cerebellar neurons on the cell adhesion molecule L1. Neuron, 12: 873-884.
98. Ito, A., Saito, N., Hirata, M., Kose, A., Tsujino, T., Yoshihara, C., Ogita, K., Kishimoto, A., Nishizuka, Y. and Tanaka, C. (1990) Immunocytochemical localization of the a subspecies of protein kinase C in rat brain. Proc. Natl. Acad. Sci. USA, 89: 3195-3199.
99. Iwashita, Y., Kawaguchi, S. and Murata, M. (1994) Restoration of function by replacement of spinal cord segments in the rat. Nature, 367: 167-170.
100. Jaakkola, S., Savunen, O., Halme, T., Utto, J. and Peltonen, J. (1993) Basement membranes during development of human nerve: Schwann cells and perineurial cells display marked changes in their expression profiles for laminin subunits and β1 and β4 integrins. J. Neurocytol., 22: 215-230.
101. Jahn, R., Schiebler, W., Ouiment, C. and Greengard, P. (1985) A 38000 dalton membrane protein (p38) present in synaptic vesicles. Proc. Natl. Acad. Sci. USA, 82: 4137-4141.
102. Kaechi, K., Ikegamin, R., Nakamura, N., Nakajima, M., Furukawa, Y. and Furukawa, S. (1995) 4-Methylcatechol, as inducer of NGF synthesis, enhances peripheral nerve regeneration across nerve gaps. J. Pharmacol. Exp. Ther., 272: 1300-1304.
103. Kaplan, D.R., and Stephens, R.M. (1994) Neurotrophin signal transduction by the Trk receptor. J. Neurobiol., 25: 1404.
104. Kashiba, H., Noguchi, K., Ueda, Y. and Senba, E. (1994) Neuropeptide Y and galanin are co-expressed after peripheral transection. Peptide, 15: 411-416.
105. Kato, S. and Ide, C. (1994) Axonal sprouting at the node of Ranvier of the peripheral nerve disconnected with the cell body. Restorat. Neurol. Neurosci., 6: 181-187.
106. 2+ -independent protein kinase C (δ, ε, ζ subtypes) in normal nerve fibers and regenerating growth cones of the rat peripheral nervous system. Neuroscience (submitted).
107. Keynes, R.J., Hopkins, W.G. and Huang, L.H. (1984) Regeneration of mouse peripheral nerves in degenerating skeletal muscle: guidance by residual muscle fiber basement membrane. Brain Res., 295: 275-281.
108. Kiryu, S., Morita, N., Ohno, K., Maeno, H. and Kiyama, H. (1995) Regulation of mRNA expression involved in Ras and PKA signal pathways during rat hypoglossal nerve regeneration. Mol. Brain Res., 29: 147-156.
109. Kitano, T., Hashimoto, T., Kikkawa, U., Ase, K., Saito, N., Tanaka, C, Ichimori, Y., Tsukamoto, K. and Nishizuka, Y. (1987) Monoclonal antibodies against rat brain protein kinase C and their application to immunocytochemistry in nervous tissues. J. Neurosci., 7: 1520-1525.
110. Klinz, S.G., Schachner, M. and Maness, P.F. (1995) L1 and N-CAM antibodies trigger protein phosphatase activity in growth cone-enriched membranes. J. Neurochem., 65: 84-95.
111. Kobayashi, N., Kiyama, H. and Tohyama, M. (1994) GAP-43 (B50/ F1) gene regulation by axonal injury of the hypoglossal nerve in the adult rat. Mol. Brain Res., 21: 9-18.
112. Kordeli, E., Davis, J., Trapp, B. and Bennett, V. (1990) An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves. J. Cell Biol., 110: 1341-1352.
113. Kuffler, D.P. (1986) Isolated satellite cells of a peripheral nerve direct the growth of regenerating frog axons. J. Comp. Neurol., 249: 57-64.
114. Kühn, T.B., Schmidt, M.F. and Kater, S.B. (1995) Laminin and fibronectin guideposts signal sustained but opposite effects to passing growth cones. Neuron, 14: 275-285.
115. Kumagai, K., Ushiki, T., Tohyama, K. and Ide, C. (1990) Regenerating axons and their growth cones observed by scanning electron microscopy. J. Electron Microsc., 39: 109-115.
116. Landis, S.C. (1983) Neuronal growth cones. Ann. Rev. Physiol., 45: 567-580.
117. Laquerriere, A., Peulve, P., Jin, O., Tiollier, J., Tardy, M., Vandry, H., Hemet, J. and Tadie, M. (1994) Effect of basic fibroblast growth factor and α-melanocyte stimulating hormone on nerve regeneration through a collagen channel. Microsurgery, 15: 203-210.
118. Le Beau, J.M., Tedeshi, B. and Walter, G. (1991) Increased expression of pp60c-src protein-tyrosine kinase during peripheral nerve regeneration. J. Neurosci. Res., 28: 299-309.
119. Lefcort, F., Venstrom, K., McDonald, J.A. and Reichardt, L.F. (1992) Regulation of expression of fibronectin and its receptor, α5β1, during development and regeneration of peripheral nerve. Development, 116: 767-782.
120. Leivo, I. and Engvall, E. (1988) Merosin, a protein specific for basement membranes of Schwann cells, striated muscle, and trophoblast, is expressed late in nerve and muscle development. Proc. Natl. Acad. Sci. USA, 85: 1544-1548.
121. Letourneau, P.C. (1975) Cell to substratum adhesion and guidance of axonal elongation. Dev. Biol., 44: 92-101.
122. Letourneau, P.C., Shattuck, T.A., Roche, F.K., Takeichi, M. and Lemmon, V. (1990) Nerve growth cone migration onto Schwann cells involves the calcium-dependent adhesion molecule, N-cadherin. Dev. Biol., 138: 430-442.
123. Letourneau, P.C., Condic, M.L. and Snow, D.M. (1994) Interactions of developing neurons with the extracellular matrix. J. Neurosci., 14: 915-928.
124. 2+/phospholipid-binding protein, depends on rab3A/3C. Neuron. 13: 885-898.
125. Lieberman, A.R. (1972) The axon reaction: A review of the principal features of perikaryal response to axon injury. Int. Rev. Neurobiol., 14: 49-124.
126. Lindholm, D., Heumann, R., Meyer, M. and Thoenen, H. (1987) Interleukin-1 regulates synthesis of the nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature, 330: 658-659.
127. Maness, P.F., Aubry, M., Shores, C.G., Frame, L. and Pfenninger, K.H. (1988) c-src gene product in developing rat brain is enriched in nerve growth cone membranes. Proc Natl. Acad. Sci. USA, 85: 5001-5005.
128. Martini, R. (1994) Expression and functional roles of neural cell surface molecules and extracellular matrix components during development and regeneration of peripheral nerves. J. Neurocytol., 23: 1-28.
129. Martini, R. and Schachner, M. (1986) Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protrein in developing sciatic nerve. J. Cell Biol., 103: 2439-2448
130. Martini, R. and Schachner, M. (1988) Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM and myelin-associated glycoprotein) in regenerating adult mouse sciatic nerve. J. Cell Biol., 106: 1735-1746.
131. Martini, R., Xin, Y., Schmitz, B. and Schachner, M. (1992) The L2/HNK-1 carbohydrate epitope is involved in the preferential outgrowth of motor neurons in ventral roots and motor nerves. Eur. J. Neuroscl., 4: 628-639.
132. Masutani, M., Mizoguchi, A., Arii, T., Iwasaki, T. and Ide, C. (1994) Localization of protein kinase C α, β, γ-subtypes in sensory axon terminals of the rat muscle spindle. J. Neurocytol., 23: 811-819.
133. c-src in nerve growth cone membranes. J. Cell Biol., 111: 1959-1970.
134. McKerracher, L. David, S., Jackson, D.L., Kottis, V., Dunn, R.J. and Braun, P. E. (1994) Identification of myetin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron, 13: 805-811.
135. McQuarrie, G.I. (1985) Effect of a conditioning lesion on axonal sprout formation of nodes of Ranvier. J. Comp. Neurol., 231: 239-249.
136. Meiri, K.F., Bickerstaff, L.E. and Schwob, J.E. (1991) Monoclonal antibodies show that kinase C phosphorylation of GAP-43 during axonogenesis is both spatially and temporally restricted in vivo. J. Cell Biol., 112: 991-1005.
137. Meyer, M., Matsuoka, I., Wetmore, C., Olson, L. and Thoenen, H. (1992) Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J. Cell Biol., 119: 45-54.
138. Miller, D.R., Lee, G.M. and Maness, P.F. (1993) Increased neurite outgrowth induced by inhibition of protein tyrosine kinase activity in PC12 pheochromocytoma cells. J. Neurochem., 60: 2134-2144.
139. Mirsky, R., Jessen, K.R., Schachner, M. and Cordis, C. (1986) Distribution of the adhesion molecules N-CAM and L1 on peripheral neurons and glia in adult rats. J. Neurocytol., 15: 799-815.
140. Miyamoto, S., Teramoto, H., Coso, O.A., Gutkind, J.S., Burbelo, P.D., Akiyama, S.K. and Yamada, K.M. (1995) Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J. Cell Biol., 131: 791-805.
141. Mizoguchi, A. (1994) Rab3A-rabGDI-rabphilin-3A system regulating membrane fusion machinery in the synapse and the growth cone. Acta Histochem. Cytochem., 27: 117-126.
142. Mizoguchi, A., Arakawa, M., Masutani, M., Tamegane, A., Yamaguchi, H., Minami, N., Takai, Y. and Ide, C. (1992) Localization of smg25A/rab3A, a small GTP-binding protein, at the active zone of the rat neuromuscular junction. Biochem. Biophy. Res. Commun., 186: 1345-1352.
143. Mizoguchi, A., Yano, Y., Hamaguchi, H., Yanagida, H., Ide, C., Zahraoui, A., Sirataki, H., Sasaki, T. and Takai, Y. (1994) Localization of rabphilin-3A on the synaptic vesicle. Biochem. Biophy. Res. Comm., 202: 1235-1243.
144. Nakai, J. (1956) Dissociated dorsal root ganglia in tissue culture. Am. J. Anat., 99: 81-129.
145. Nakai, J. and Kawasaki, Y. (1959) Studies on the mechanism determining the course of nerve fibers in tissue culture. I. The reaction of the growth cone to various obstructions. Z. Zellforsh., 51: 108-122.
146. Needham, L.K. and Schnaar, R.L. (1993) Carbohydrate recognition in the peripheral nervous system: A calcium-dependent membrane binding site for HNK-1 reactive glycopeptide potentially involved in Schwann cell adhesion. J. Cell Biol., 121: 397-408.
147. Neugebauer, K.M., Tomaselli, K.J. and Reichardt, L.F. (1988) N-cadherin, N-CAM and integrin promote retinal neurite outgrowth on astrocytes in vitro. J. Cell Biol., 107: 1177-1189.
148. Nishizuka, Y. (1988) The molecular heterogeneity of protein kinase C and its implication for cellular regulation. Nature, 334: 661-665.
149. Nishizuka, Y. (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science, 258: 607-614.
150. Noguchi, K., Dubner, R., De Leon, M., Senba, E. and Ruda, M.A. (1994) Axotomy induces preprotachykinin gene expression in a subpopulation of dorsal root ganglion neurons. J. Neurosci. Res., 37: 596-603.
151. Nolte, C., Schachner, M. and Martini, R. (1989) Immunocytochemical localization of the neural cell adhesion molecules L1, N-CAM and J1 in developing, adult and adult denervated and reinnervated Pacinian corpuscles. J. Neurocytol., 18: 795-808.
152. Okajima, S., Mizoguchi, A., Masutani, M., Tomatsuri, M. Tamai. K., Hirasawa, Y. and Ide, C. (1993) Synaptophysin immunocytochemistry in the regenerating sprouts from the nodes of Ranvier in injured rat sciatic nerve. Brain Res., 631: 133-136.
153. Okajima, S., Mizoguchi, A., Hirasawa, Y. and Ide, C. (1995) Distribution of protein kinase C (α, β, γ subtypes) in normal nerve fibers and regenerating growth cones of the rat peripheral nervous system. Neuroscience, 66: 645-654.
154. Oppenheim, R.W., Houenor, L.J., Johnson, J.E., Lin, L.-F.H., Li, L., Lo, A.C., Newsome, A.L., Prevette, D.M. and Wang, S. (1995) Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature, 373: 344-346.
155. Osawa, T., Tohyama, K. and Ide, C. (1987) Nerve regeneration through cryo-treated xenogeneic nerve grafts. Arch. Histol. Jpn., 50: 193-208.
156. Osawa, T., Tohyama, K. and Ide, C. (1990) Allogeneic nerve grafts in the rat, with special reference to the role of Schwann cell basal laminae in nerve regeneration. J. Neurocytol., 19: 833-849.
157. Otey, C.A., Pavalko, F.M. and Burridge, K. (1990) An interaction between α-actinin and β1-integrin subunit in vitro. J, Cell Biol., 111: 721-729.
158. Ozawa, M., Baribault, H. and Kemler, R. (1989) The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J., 8: 1711-1717.
159. Patterson, P.H. (1988) On the importance of being inhibited, or saying no to growth cones. Neuron, 1: 263-267.
160. Pfenninger, K.H. and Maylié-Pfenninger, M.-F. (1981) Lectin labeling of sprouting neurons. II. Relative movement and appearance of glycoconjugates during plasmalemmal expansion. J. Cell Biol., 89: 547-559.
161. Pholan, P. and Gordon-Weeks, P.R. (1992) Widespread distribution of synaptophysin, a synaptic vesicle glycoprotein, in growing neurites and growth cone. Eur. J. Neurosci., 4: 1160-1190
162. Plantinga, L.C. Verhaaren, J., Edwards, P.M., Hol, E.M., Bär, P.R. and Gispen, W.H. (1993) The expression of B50/GAP-43 in Schwann cells is upregulated in regenerating peripheral nerve stumps following nerve injury. Brain Res., 602: 69-76.
163. Popov, S., Brown, A. and Poo, M.M. (1993) Forward plasma membrane flow in growing nerve processes. Science, 259: 244-246.
164. Raivich, G., Hellweg, R. and Kreutzberg, G.W. (1991) NGF receptor-mediated reduction in axonal NGF uptake and retrograde transport following sciatic nerve injury and during regeneration. Neuron, 7: 151-164.
165. Ranscht, R. (1994) Cadherins and catenins: interactions and functions in embryonic development. Curr. Opin. Cell Biol., 6: 740-746.
166. Rathjen, F.G. (1988) A neurite outgrowth-promoting molecule in developing fiber tracts. Trends Neurosci., 11: 183-184.
167. Rehder, V. and Kater, S.B. (1992) Regulation of neuronal growth cone filopodia by intracellular calcium. J. Neurosci., 12: 3175-3186.
168. Reichardt, L.F. and Tomaselli, K.J. (1991) Extracellular matrix molecules and their receptors: Functions in neural development. Ann. Rev. Neurosci., 14: 531-570.
169. Rende, N., Muir, D., Ruoslahti, E., Hagg, T., Varon, S. and Manthorpe, M. (1992) Immunolocalization of ciliary neurono-trophic factor in adult rat sciatic nerve. Glia, 5: 25-32.
170. Roivainen, R., Koistinaho, J. and Hervonen, A. (1990) Localization of protein kinase C-β-like immunoreactivity in the rat dorsal root ganglion. Neurosci. Res., 7: 381-384.
171. Roivainen, R., Iadarola, M., Hervonen, A and Koistinaho, J. (1991) The localization of β-subtype of protein kinase C (PKC-β) in rat sympathetic neurons. Histochemistry, 95: 247-253.
172. Rotshenker, S., Aamar, S. and Barak, V. (1992) Interleukin-1 activity in lesioned peripheral nerve. J. Neuroimmunol., 39: 75-80.
173. Rutishauser, U. (1985) Influence of the neural cell adhesion molecule on axon growth and guidance. J. Neurosci. Res., 13: 123-131.
174. Rutishauser, U., Acheson, A., Hall, A.K., Mann, D.M. and Sunshine, J. (1988) The neural cell adhesion molecule (NCAM) as a regulator of cell-cell interactions. Science, 240: 53-59.
175. II subspecies of protein kinase C in rat brain. Proc. Natl. Acad. Sci. USA, 86: 3409-3413.
176. Salzer, J.L. and Bunge, R.P. (1980) Studies of Schwann cell proliferation. I. An analysis in tissue culture of proliferation during development, Wallerian degeneration, and direct injury. J. Cell Biol., 84: 739-752.
177. Salzer, J.L., Bunge, R.P. and Glaser, L. (1980) Studies of Schwann cell proliferation. III. Evidence for the surface localization of the neurite mitogen. J. Cell Biol., 84: 767-778.
178. Sanes, J.R., Engvall, E., Butkowski, R. and Hunter, D.D. (1990) Molecular heterogeneity of basal laminae: Isoforms of laminin and collagen IV at the neuromuscular junction and elsewhere. J. Cell Biol., 111: 1685-1699.
179. Sano, K., Tanihara, H., Haimark, R.L., Obata, S., Davidson, M., St. John, T., Taketani, S. and Suzuki, S. (1993) Protocadherins: a large family of cadherin-related molecules in the central nervous system. EMBO J., 12: 2249-2256.
180. Schachner, M. (1995) Neural recognition molecules in development and regeneration. Abstract of the 4th IBRO World Congress of Neuroscience, p. 39.
181. Scheldt, P. and Friede, R.L. (1987) Myelin phagocytosis in Wallerian degeneration. Properties of millipore diffusion chambers and immunohistochemical identification of cell populations. Acta Neuropathol., 75: 77-84.
182. Schneides-Schaulies, J., Von Brunn, A. and Schachner, M. (1990) Recombinant peripheral myelin protein Po confers both adhesion and neurite outgrowth-promoting properties. J. Neurosci. Res., 27: 286-297.
183. Schnell, L. and Schwab, M. (1990) Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated with neurite-growth inhibitors. Nature, 343: 269-272.
184. Schwab, M. and Caroni, P. (1988) Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro. J. Neurosci., 8: 2381-2393.
185. Seeds, N.W., Hafke, S.P., Hawkins, R.L., Krystosek, A., McQuire, P.G. and Verrall, S. (1992) Neuronal growth cones: battering rams or lasers? In: P.C. Letourneau, S.B. Kater and E.R. Macagno (Eds.), The Nerve Growth Cone, Raven Press, New York, pp. 219-229.
186. Seilheimer, B. and Schachner, M. (1988) Studies of adhesion molecules mediating interactions between cells of peripheral nervous systems indicate a major role for L1 in mediating sensory neuron growth on Schwann cells in culture. J. Cell Biol., 107: 341-351.
187. Sendtner, M., Holtmann, B., Kolbeck, R., Thoenen, H. and Barde, Y.-A. (1992a) Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve transection. Nature. 360: 757-759.
188. Sendtner, M., Stöckli, K.A. and Thoenen, H. (1992b) Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration. J. Cell Biol., 118: 139-148.
189. Shehab, S.A.S. and Atkinson, M.E. (1986) Vasoactive intestinal peptide (VIP) increases in the spinal cord after peripheral axotomy of the sciatic nerve originate from primary afferent neurons. Brain Res., 372: 37-44.
190. Sheu, F.-S., Marais, R.M., Parker, P.J., Bazan, N.G. and Routenberg, A. (1990) Neuron-specific protein F1 GAP-43 shows substrate specificity for the β subtype of protein kinase C. Biochem. Biophys. Res. Commun., 171: 1236-1243.
191. Shibuya, Y., Mizoguchi, A., Takeichi, M., Shimada, K. and Ide, C. (1995) Localization of N-cadherin in the normal and regenerating nerve fibers of the chicken peripheral nervous system. Neuroscience, 67: 253-261.
192. Shimamura, K., Takahashi, T. and Takeichi, M. (1992) E-cadherin expression in a particular subset of sensory neurons. Dev. Biol., 152: 242-254.
193. Shirasaki, R., Tamada, A., Katsumata, R. and Murakami, F. (1995) Guidance of cerebellofugal axons in the rat embryo: directed growth toward the floor plate and subsequent elongation along the longitudinal axis. Neuron, 14: 961-972.
194. Shirataki, H., Kaibuchi, K., Yamaguchi, T., Wada, K., Horiuchi, H. and Takai, Y. (1992) A positive target protein for smg-25A/rab3A small GTP-binding protein. J. Biol. Chem., 267: 10946-10949.
195. Skene, J.H.P. (1989) Axonal growth-associated proteins. Ann, Rev. Neurosci., 12: 127-156.
196. Skene, J.H.P. and Willard, M. (1981a) Characteristics of growth-associated polypeptides in regenerating toad retinal ganglion 'cell axons. J. Neurosci., 1: 419-426.
197. Skene, J.H.P. and Willard, M. (1981b) Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous system. J. Cell Biol., 89: 96-103.
198. Smith, G.M., Rabinovsky, E.D., McManaman, J.L. and Shine, H.D. (1993) Temporal and spatial expression of ciliary neurotrophic factor after peripheral nerve injury. Exp. Neurol., 121: 239-247.
199. So, K.-F. and Aguayo, A.J. (1985) Lengthy regrowth of cut axons from ganglion cells after peripheral nerve transplantation into the retina of adult rats. Brain Res., 328: 349-354.
200. Sobue, K. (1993) Actin-based cytoskeleton in growth cone activity. Neurosci. Res., 18: 91-102.
201. c-scr in growth cone of PC12 cell. Biochem. Biophys. Res. Comm., 157; 1383-1389.
202. Sonneberg, A., Linders, C.J.T., Modderman, P.W., Damsky, C.H., Aumailley, M and Timpl, R. (1990) Integrin recognition of different cell-binding fragments of laminin (PI, E3, E8) and evidence that α6β1 but not α6β4 functions as a major receptor for fragment E8. J. Cell Biol., 110: 2145-2156.
203. Srinivasan, Y., Elmer, L., Davis, J., Bennett, V. and Angelides, K. (1988) Ankyrin and spectrin associate with voltage-dependent sodium channel in brain. Nature, 333: 177-180.
204. Stoll, G., Griffin, J.W., Li, C.Y. and Trapp, B.D. (1989) Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin degeneration. J. Neurocytol. 18: 671-683.
205. Strittmatter, S.M., Igarashi, M. and Fishman, M.C. (1994) GAP-43 amino terminal peptides modulate growth cone morphology and neurite outgrowth. J. Neurosci., 14: 5503-5513.
206. Südhof, T.C. (1995) Synaptic vesicle cycle: a cascade of protein-protein interactions. Nature, 357: 645-653.
207. Südhof, T.C. and Jahn, R. (1991) Proteins of synaptic vesicles involved in exocytosis and membrane recycling. Neuron, 6: 665-677.
208. Taira, E., Takeda, N. and Miki, N. (1993) Extracellular matrix protein with neurite promoting activity and their receptors. Neurosci. Res., 17: 1-8.
209. Tajima, K., Tohyama, K., Ide, C. and Abe, M. (1991) Regeneration through nerve allografts in the cynomolgus monkey (Macaca fascicularis). J. Bone Joint Surg., 73-A: 172-185.
210. Takeichi, M. (1990) Cadherin: a molecular family important in selective cell-cell adhesion. Ann. Rev. Biochem., 59: 237-252.
211. Takeichi, M. (1991) Cadherin cell adhesion receptors as a morphogeneic regulator. Science, 251: 1451-1455.
212. Tamkun, J.W., DeSimone, D.W., Fonda, D., Patel, R.S., Buck, C., Horwitz, A.F. and Hynes, R.O. (1986) Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell, 46: 271-282.
213. Tanaka, H. and Obata, K. (1984) Developmental changes in unique cell surface antigens of chick embryo spinal motoneurons and ganglion cells. Dev. Biol., 106: 26-37.
214. Tang, J., Rutishauser, U. and Landmesser, L. (1994) Polysialic acid regulates growth cone behavior during sorting of motor axons in the plexus region. Neuron, 13: 405-414.
215. Taniuchi, M., Clark, H.B., Schweitzer, J.B. and Johnson, E.M. (1988) Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: ultrastructural location, suppression by axonal contact, and binding properties. J. Neurosci., 8: 664-681.
216. Tennyson, V.M. (1970) The fine structure of the axon and growth cone of the dorsal root neuroblast of the rabbit embryo. J. Cell Biol., 44: 62-79.
217. Tohyama, K., Ide, C. and Osawa, T. (1990) Nerve regeneration through the cryo-injured allogenetc nerve graft in the rabbit. Acta Neuropathol., 80: 138-144.
218. Tomaselli, K.J., Damsky, C.H. and Reichardt, L.F. (1987) Interactions of neural cell line (PC12) with laminin, collagen IV, and fibronectin: identification of integrin-related glycoproteins involved in attachment and process outgrowth. J. Cell Biol., 105: 2347-2358.
219. Tomaselli, K.J., Neugebauer, K.M., Bixby J.L., Lilien, J. and Reichardt, L.F. (1988) N-cadherin and integrin: Two receptor systems that mediate neuronal process outgrowth on astrocyte surface. Neuron, 1: 33-43.
220. Tomaselli, K.J., Hall, D.E., Flier, L.A. Gehlsen, K.R., Turner, D.C., Carbonetto, S. and Reichardt, L.F. (1990) A neuronal cell line (PC12) expresses two β1-class integrins-α1β1 and α3β1-that recognize different neurite outgrowth-promoting domains in laminin. Neuron, 5: 651-662.
221. Tomaselli, K.J., Doherty, P., Emmett, C.J., Damsky, C.H., Walsh, F.S. and Reichardt, L.F. (1993) Expression of β1 integrins in sensory neurons of the dorsal root ganglion and their functions in neurite outgrowth on two laminin isoforms. J. Neurosci., 13: 4880-4888.
222. Tomatsuri, M., Okajima, S. and Ide, C. (1993) Sprout formation at nodes of Ranvier of crush-injured peripheral nerves. Restor. Neurol. Neurosci., 5: 275-282.
223. Tsujihara, T., Kawano, S., Okajima, S., Hirasawa, Y., Mizoguchi, A. and Ide, C. (1995) Localization of protein kinase C (α, β, γ, δ, ε and ζ) in growth cones in vivo and in vitro. Abstracts of the 4th IBRO World Congress of Neuroscience, p. 216.
224. Tsukita, S., Onishi, K., Akiyama, T., Yamanashi, Y., Yamamoto, T. and Tsukita, S. (1991) Specific proto-oncogene tyrosine kinase of src family are enriched in cell-to-cell adhesion junctions where the level of tyrosine phosphorylation is elevated. J. Cell Biol., 113: 867-879.
225. Uchiyama, N., Hasegawa, M., Yamashita, T., Yamashita, J., Shimamura, K. and Takeichi, M. (1994) Immunoelectron microscopic localization of E-cadherin in dorsal root ganglion, dorsal root and dorsal horn of postnatal mice. J. Neurocytol., 23: 460-468.
226. Uehara, K., Mizoguchi, A., Takahashi, M., Mizuno, K. and Ide, C. (1995) Localization of synaptotagmin in the regenerating sprouts emanating from the nodes of Ranvier. Acta Histochem. Cytochem., 28: 401-407.
227. Usuda, N., Kong, Y., Hagiwara, M., Uchida, C., Terasawa, M., Nagata, T. and Hidaka, H. (1991) Differential localization of protein kinase C isoforms in retinal neurons. J. Cell Biol., 112: 1241-1247.
228. Van Lookeren Campagne, M., Oestreicher, A.B., Van Bergen En Henegouwen, P.M.P. and Gispen, W.H. (1989) Ultrastructural immunocytochemical localization of B50/GAP-43, a protein kinase C substrate, in isolated presynaptic terminals and neuronal growth cones. J. Neurocytol., 18: 479-489.
229. Verhaagen, J., Van Hooff, C.O.M., Edwards, P.M., DeGraan, P.N.E., Oestreicher, A.B., Schotman, P., Jennekins, F.G.I, and Gispen, W.H. (1986) The kinase C substrate protein B-50 and axonal regeneration. Brain Res. Bull., 17: 737-741.
230. 2+-dependent exocytosis in PC12 cells. Biochem. Biophy. Res. Commun., 198: 158-165.
231. Walicke, P.A. and Baird, A. (1988) Trophic effects of fibroblast growth factor on neuronal tissue. Prog. Brain Res., 78: 333-338.
232. Waller, A. (1850) Experiments on the section of the glossopharyngeal and hypoglossal nerves of the frog, and observations of the alterations produced thereby in the structure of their primitive fibers. Philos. Trans. R. Soc. London (Biol.), 140: 423-429.
233. Wetsel, W.C., Khan, W.A., Merchenthaler, I., Rivera, H., Halpern, A.E., Phung, H.M., Negro-Vilar, A. and Hannun, Y. A. (1992) Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J. Cell Biol., 117: 121-133.
234. Wiedermann, B. and Franke, W.W. (1985) Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38000 characteristic of presynaptic vesicles. Cell, 41: 1017-1028.
235. Williams, P.L. and Hall, S.M. (1971) Chronic Wallerian degeneration. An in vivo and ultrastructural study. J. Anat., 109: 487-503.
236. Williams, E.J., Mittal, B., Walsh, F.S. and Doherty, P. (1995) FGF inhibits neurite outgrowth over monolayers of astrocytes and fibroblasts expressing transfected cell adhesion molecules. J. Cell Sci., 108: 3523-3530.
237. Woolf, C.J., Reynolds, M.L., Chang, M.S., Emson, P., Irwin, N. and Benowitz, L.I. (1992) Denervation of the motor endoplate results in the rapid expression by terminal Schwann cells of the growth-associated protein GAP-43. J. Neurosci., 12: 3999-4010.
238. Xu, X.M., Guénard, V., Kleitman, N. and Bunge, M.B. (1994) Axonal regeneration into Schwann cell-seeded guidance channels grafted into transected adult rat spinal cord. J. Comp. Neurol., 351: 145-160.
239. Yamada, K.M., Spooner, B.S. and Wessels, N.K. (1971) Ultrastructure and function of growth cones and axons of cultured nerve cells. J. Cell Biol., 40: 614-635.
240. Yan, Q., Matheson, C. and Lopez, O.T. (1995) In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature, 373: 341-344.
241. Yanagida, H., Mizoguchi, A., Tanaka, J., Maruo, S. and Ide, C. (1995) Localization of integrin α5 in growth cones, the distal end of regenerating axons. Abstracts of the 4th IBRO World Congress of Neuroscience, p. 245.
242. Yazaki, T., Miura, M., Asou, H., Toya, S. and Uyemura, K. (1994) Peripheral myelin Po protein mediates neurite outgrowth of cortical neurons in vitro and axonal regeneraton in vivo. Neurosci. Lett., 176: 13-16.
243. Yoshihara, Y., Kawasaki, M., Tani, A., Tamada, A., Nagata, S., Kagamiyama, H. and Mori, K. (1994) Big-I: A new TAG-1/F3-related member of the immunoglobulin superfamily with neurite outgrowth-promoting activity. Neuron, 13: 415-426.
244. Yurchenco, P.D. and O'Rear, J.J. (1994) Basal lamina assembly. Curr. Opin. Cell Biol., 6: 674-681.
245. Zelená, J. (1994) Nerves and Mechanoreceptors. The Role of Innervation in the Development and Maintenance of Mammalian Mechanoreceptors, Chapman and Hall, London.
246. Zuber, M.X., Strittmatter, S.M. and Fishman, M.C. (1989) A membrane-targeting signal in the amino terminus of the neuronal protein GAP-43. Nature, 341: 345-348.