Expressions of bax, bcl-2 and Ki-67 in odontogenic keratocysts (Keratocystic odontogenic tumor) in comparison with ameloblastomas and radicular cysts;Odontojen keratokistlerin (keratokistik odontojen tümör) bax, bcl-2 ve ki-67 ekspresyonlarının ameloblastom ve radiküler kistlerle karşılaştırılması

Turk Patoloji Dergisi/Turkish Journal of Pathology

Volumn 28, Issue 1, 2012, Pages 49-55

  Soluk Tekkeşin, Merva ^a   Mutlu, Sevcihan ^b   Olgaç, Vakur ^a  

^a Department of tumor Pathology ^*  (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Bax protein; Bcl 2 genes; Ki 67 antigen; Odontogenic cysts; Squamous odontogenic tumor

Indexed keywords

KI 67 ANTIGEN; PROTEIN BAX; PROTEIN BCL 2;

ADULT; AMELOBLASTOMA; APOPTOSIS; ARTICLE; CELL PROLIFERATION; COMPARATIVE STUDY; CONNECTIVE TISSUE CELL; EPITHELIUM CELL; EPITHELIUM TUMOR; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MANDIBLE; MANDIBULAR NERVE; MAXILLA; ODONTOGENIC CYST; ODONTOGENIC KERATOCYST; PREMOLAR TOOTH; PROTEIN EXPRESSION;

EID: 84855754213     PISSN: 10185615     EISSN: 13095730     Source Type: Journal    
DOI: 10.5146/tjpath.2012.01097     Document Type: Article

References (22)

1. Regezzi JA, Sciubba JJ, Jordan RCK: Oral Pathology: Clinical Pathologic Correlations. 5th ed., Philadelphia, Elsevier Saunders, 2008, 245
2. Li TJ: Te odontogenic keratocyst: a cyst, or a cystic neoplasm? J Dent Res 2011, 90:133-142
3. Philipsen HP: Keratocystic odontogenic tumor. In Barnes L, Eveson JW, Reichart P, Sinransky D. (Eds.): Head and Neck Tumors, WHO classifcation of Tumors. 5th ed., Lyon, IARC Press, 2005, 306-307
4. Billen LP, Kokoski CL, Lovell JF, Leber B, Andrews DW: Bcl-XL inhibits membrane permeabilization by competing with Bax. PLoS Biol 2008, 6:e147
5. Baliga BC, Kumar S: Role of bcl-2 family of proteins in malignancy. Hematol Oncol 2002, 20:63-74
6. Krajewski S, Hugger A, Krajewska M, Reed JC, Mai JK: Development expression patterns of bcl-2, bcl-X, bax and bak in teeth. Cell Death Difer 1998, 5:408-415
7. Shear M: Te aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 2. Proliferation and genetic studies. Oral Oncol 2002, 38:323-331
8. Ayoub MS, Baghdadi HM, El-Kholy M: Immunohistochemical detection of laminin-1 and Ki-67 in radicular cysts and keratocystic odontogenic tumors. BMC Clin Pathol 2011, 11:4
9. Kichi E, Enokiya Y, Muramatsu T, Hashimoto S, Inoue T, Abiko Y, Shimono M: Cell proliferation, apoptosis and apoptosis-related factors in odontogenic keratocysts and in dentigerous cysts. J Oral Pathol Med 2005, 34:280-286
10. Kuroyanagi N, Sakuma H, Miyabe S, Machida J, Kaetsu A, Yokoi M, Maeda H, Warnakulasuriya S, Nagao T, Shimozato K: Prognostic factors for keratocystic odontogenic tumor (odontogenic keratocyst): analysis of clinico-pathologic and immunohistochemical fndings in cysts treated by enucleation. J Oral Pathol Med 2009, 38:386-392
11. Saraçoǧlu U, Kurt B, Günhan O, Güven O: MIB-1 expression in odontogenic epithelial rests, epithelium of healthy oral mucosa and epithelium of selected odontogenic cysts. An immunohistochemical study. Int J Oral Maxillofac Surg 2005, 34:432-435
12. Brunelle JK, Letai A: Control of mitochondrial apoptosis by the Bcl-2 family. J Cell Sci 2009, 122:437-441
13. Leber B, Lin J, Andrews DW: Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes. Apoptosis 2007, 12:897-911
14. Fletcher JI, Meusburger S, Hawkins CJ, Riglar DT, Lee EF, Fairlie WD, Huang DC, Adams JM: Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. Proc Natl Acad Sci U S A 2008, 105:18081-18087
15. Piattelli A, Fioroni M, Rubini C: Diferentiation of odontogenic keratocysts from other odontogenic cysts by the expression of bcl-2 immunoreactivity. Oral Oncol 1998, 34:404-407
16. Suzuki T, Kumamoto H, Kunimori K, Ooya K: Immunohisto-chemical analysis of apoptosis-related factors in lining epithelium of radicular cysts. J Oral Pathol Med 2005, 34:46-52
17. Loyola AM, Cardoso SV, Lisa GS, Oliveira LJ, Mesquita RA, Carmo MA, Aguiar MC: Apoptosis in epithelial cells of apical radicular cysts. Int Endod J 2005, 38:465-469
18. Mitsuyasu T, Harada H, Higuchi Y, Kimura K, Nakamura N, Katsuki T, Kubota E, Toyoshima K, Ohishi M: Immuno-histochemical demonstration of bcl-2 protein in ameloblastoma. J Oral Pathol Med 1997, 26:345-348
19. Sandra F, Nakamura N, Mitsuyasu T, Shiratsuchi Y, Ohishi M: Two relatively distinct patterns of ameloblastoma: an anti-apoptotic proliferating site in the outer layer (periphery) and a pro-apoptotic diferentiating site in the inner layer (centre). Histopathology 2001, 39:93-98
20. Kolár Z, Geierová M, Bouchal J, Pazdera J, Zboril V, Tvrdý P: Immunohistochemical analysis of the biological potential of odontogenic keratocysts. J Oral Pathol Med 2006, 35:75-80
21. Safronova MM, Arantes M, Lima I, Domingues S, Almeida M, Moniz P: Gorlin-Goltz syndrome: review of the neuroradiological and maxillofacial features illustrated with two clinical cases. Acta Med Port 2010, 23:1119-1126
22. Vered M, Peleg O, Taicher S, Buchner A: Te immunoprofle of odontogenic keratocyst (keratocystic odontogenic tumor) that includes expression of PTCH, SMO, GLI-1 and bcl-2 is similar to ameloblastoma but diferent from odontogenic cysts. J Oral Pathol Med 2009, 38:597-604