Prognostic factors for keratocystic odontogenic tumor (odontogenic keratocyst): Analysis of clinico-pathologic and immunohistochemical findings in cysts treated by enucleation

Journal of Oral Pathology and Medicine

Volumn 38, Issue 4, 2009, Pages 386-392

  Kuroyanagi, Norio ^a   Sakuma, Hidenori ^a,b   Miyabe, Satoru ^a,b   Machida, Junichiro ^a   Kaetsu, Atsuo ^a   Yokoi, Motoo ^b   Maeda, Hatsuhiko ^a   Warnakulasuriya, Saman ^c   Nagao, Toru ^a,c,d   Shimozato, Kazuo ^a  

^a AICHI GAKUIN UNIVERSITY   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c ST THOMAS HOSPITAL   (United Kingdom)

^d Okazaki City Hospital   (Japan)

Author keywords

Keratocystic odontogenic tumor; Ki 67; Odontogenic keratocyst; p53; Prognostic markers

Indexed keywords

BIOLOGICAL MARKER; KI 67 ANTIGEN; PROTEIN P53;

ADOLESCENT; AGED; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; ODONTOGENIC KERATOCYST; ORAL SURGERY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RADIODIAGNOSIS; RECURRENT DISEASE; TREATMENT OUTCOME; TUMOR LOCALIZATION;

ADOLESCENT; ADULT; AGED; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; KI-67 ANTIGEN; MALE; MIDDLE AGED; ODONTOGENIC CYSTS; PROGNOSIS; RECURRENCE; TUMOR SUPPRESSOR PROTEIN P53; YOUNG ADULT;

EID: 62949158234     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2008.00729.x     Document Type: Article

References (18)

1. Brannon RB. The odontogenic keratocysts. A clinocopathologic study of 312 cases. Part I. Clinical features. Oral Surg Oral Med Oral Pathol 1976 42 : 54 72.
2. Ahlfors E, Larsson A, Sjögren S. The odontogenic keratocyst: a benign cystic tumor? J Oral Maxillofac Surg 1984 42 : 10 9.
3. Philipsen HP. Keratocystic odontogenic tumour. In : Barnes L, Eveson JW, Reichart P, Sidransky D, eds. World Health Organization classification of tumours: pathology and genetic of head and neck tumours. Lyon : IARC Press, 2005 306 7.
4. Jing W, Xuan M, Lin Y, et al. Odontogenic tumours: a retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg 2007 36 : 20 5.
5. Jones AV, Craig GT, Franklin CD. Range and demographics of odontogenic cysts diagnosed in a UK population over a 30-year period. J Oral Pathol Med 2006 35 : 500 7.
6. Partridge M, Towers JF. The primordial cyst (odontogenic keratocyst): its tumour-like characteristics and behaviour. Br J Oral Maxillofac Surg 1987 25 : 271 9.
7. Shear M. The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 1. Clinical and early experimental evidence of aggressive behaviour. Oral Oncol 2002 38 : 219 26.
8. Blanas N, Freund B, Schwartz M, Furst IM. Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol 2000 90 : 553 8.
9. Shear M. The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 2. Proliferation and genetic studies. Oral Oncol 2002 38 : 323 31.
10. Kolář Z, Geierová M, Bouchal J, Pazdera J, Zboril V, Tvrdý P. Immunohistochemical analysis of the biological potential of odontogenic keratocyst. J Oral Pathol Med 2006 35 : 75 80.
11. Kaplan I, Hirshberg A. The correlation between epithelial cell proliferation and inflammation in odontogenic keratocyst. Oral Oncol 2004 40 : 985 91.
12. Myoung H, Hong SP, Hong SD, et al. Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathological parameters. Oral Surg Oral Med Oral Pathol 2001 91 : 328 33.
13. Murtadi A, Grehan D, Toner M, McCartan BE. Proliferating cell nuclear antigen staining in syndrome and nonsyndrome odontogenic keratocysts. Oral Surg Oral Med Oral Pathol 1996 81 : 217 20.
14. Li TJ, Browne RM, Matthews JB. Epithelial cell proliferation in odontogenic keratocyst: a comparative immunohistochemical study of Ki-67 in simple, recurrent and basal cell naevus syndrome (BCNS)-associated lesions. J Oral Pathol Med 1995 24 : 221 6.
15. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984 133 : 1710 5.
16. Talve LA, Collan YU, Ekfors TO. Nuclear morphometry, immunohistochemical staining with Ki-67 antibody and mitotic index in the assessment of proliferative activity and prognosis of primary malignant melanomas of the skin. J Cutan Pathol 1996 23 : 335 43.
17. Forssel K, Forssel H, Kahnberg KE. Recurrence of keratocysts. A long-term follow-up study. Int J Oral Maxillofac Surg 1988 17 : 25 8.
18. Agaram NP, Collins BM, Barnes L, et al. Molecular analysis to demonstrate that odontogenic keratocysts are neoplastic. Arch Pathol Lab Med 2004 128 : 313 7.