Mutated in colorectal cancer protein modulates the NFκB pathway

Anticancer Research

Volumn 32, Issue 1, 2012, Pages 73-79

  Sigglekow, Nicholas D ^a   Pangon, Laurent ^a   Brummer, Tilman ^a,b   Molloy, Mark ^c   Hawkins, Nicholas J ^d   Ward, Robyn L ^d   Musgrove, Elizabeth A ^a,e   Kohonen Corish, Maija R J ^a,e  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF FREIBURG   (Germany)

^c MACQUARIE UNIVERSITY   (Australia)

^d University of New South Wales   (Australia)

^e ST VINCENT'S CLINIC   (Australia)

Author keywords

Colorectal cancer; Inflammatory bowel disease; NF B pathway; TNFa

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LUCIFERASE; MYOSIN; TUMOR NECROSIS FACTOR ALPHA; VALOSIN CONTAINING PROTEIN;

ADULT; AGED; ARTICLE; CANCER CELL; CLINICAL ARTICLE; COLORECTAL CANCER; ENTERITIS; ENZYME ASSAY; FEMALE; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; IN VITRO STUDY; MALE; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN METHYLATION; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; TISSUE SECTION;

ADENOSINE TRIPHOSPHATASES; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CASPASE 8; CELL CYCLE PROTEINS; COLORECTAL NEOPLASMS; DNA METHYLATION; ENZYME ACTIVATION; FEMALE; HUMANS; I-KAPPA B PROTEINS; INFLAMMATORY BOWEL DISEASES; LIPOPOLYSACCHARIDES; LUCIFERASES; MALE; MIDDLE AGED; MYOSINS; NF-KAPPA B; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEINS;

EID: 84855709768     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A, Carlson M, Joslyn G, Groden J, White R, Miki Y, Miyoshi Y, Nishisho I and Nakamura Y: Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 251: 1366-1370, 1991. (Pubitemid 21916922)
2. Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S and Hedge P: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 253: 665-669, 1991. (Pubitemid 21917200)
3. Kohonen-Corish MRJ, Sigglekow ND, Susanto J, Chapuis PH, Bokey EL, Dent OF, Chan C, Lin BPC, Seng TJ, Laird PW, Young J, Leggett BA, Jass JR and Sutherland RL: Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer. Oncogene 26: 4435-4441, 2007. (Pubitemid 47014456)
4. Fukuyama R, Niculaita R, Ng KP, Obusez E, Sanchez J, Kalady M, Aung PP, Casey G and Sizemore N: Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses β-catenin-dependent transcription. Oncogene 27: 6044-6055, 2008.
5. Starr TK, Allaei R, Silverstein KAT, Staggs RA, Sarver AL, Bergemann TL, Gupta M, O'Sullivan MG, Matise I, Dupuy AJ, Collier LS, Powers S, Oberg AL, Asmann YW, Thibodeau SN, Tessarollo L, Copeland NG, Jenkins NA, Cormier RT and Largaespada DA: A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science 323: 1747-1750, 2009.
6. 1 to S phase. J Biol Chem 271: 10341-10346, 1996.
7. Pangon L, Sigglekow ND, Larance M, Al-Sohaily S, Mladenova D, Selinger C, Musgrove EA and Kohonen-Corish MRJ: 'Mutated in colorectal cancer' (MCC) is a novel target of the UV-induced DNA damage response. Genes Cancer 1: 917-926, 2010.
8. Bouwmeester T, Bauch A, Ruffner H, Angrand P-O, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangrano R, Michon A-M, Schirle M, Schlegl J, SChwab M, Stein M, Bauer A, Casari G, Drewes G, Gavin A-C, Jackson D, Joberty G, Neubauer G, Rick J, Kuster B and Superti-Furga G: A physical and functional map of the human TNFα/ NFκB signal transduction pathway. Nature Cell Biol 6: 97-105, 2004.
9. Wang S, Liu Z, Wang L and Zhang X: NFκB signalling pathway, inflammation and colorectal cancer. Cell Mol Immunol 6: 327-324, 2009.
10. Lind DS, Hochwald SN, Malaty J, Rekkas S, Hebig P, Mishra G, Moldawer LL, Copeland EM and MacKay S: Nuclear factor-κB is up-regulated in colorectal cancer. Surgery 130: 363-369, 2001. (Pubitemid 32721692)
11. Yu H-G, Yu L-L, Yang Y, Luo H-S, Yu J-P, Meier JJ, Schrader H, Bastian A, Schmidt WE and Schmitz F: Increased expression of RelA/NFκB protein correlates with colorectal tumourigenesis. Oncology 65: 37-45, 2003. (Pubitemid 36829089)
12. Seril DN, Liao J, Yang G-Y and Yang CS: Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models. Carcinogenesis 24: 353-362, 2003. (Pubitemid 36432628)
13. Greten FR, Eckmann L, Greten TF, Park JM, Li Z-W, Egan LJ, Kagnoff MF and Karin M: IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118: 285-296, 2004. (Pubitemid 39061110)
14. Karin M and Greten FR: NFκB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5: 749-759, 2005. (Pubitemid 41400849)
15. Chen G and Goeddel DV: TNF-R1 signaling: A beautiful pathway. Science 296: 1634-1635, 2002. (Pubitemid 34579145)
16. Hayden MS and Ghosh S: Signaling to NFκB. Genes Dev 18: 2195-2224, 2004.
17. Seng TJ, Currey N, Cooper WA, Lee CS, Chan C, Horvath L, Sutherland RL, Kennedy C, McCaughan B and Kohonen-Corish MRJ: DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma. Br J Cancer 99: 375-82, 2008.
18. Minguet S, Huber M, Rosenkranz L, Schamel W, Reth M and Brummer T: Adenosine and cAMP are potent inhibitors of the NFκB pathway downstream of immunoreceptors. Eur J Immunol 35: 31-41, 2005. (Pubitemid 40123849)
19. Hoffmann A, Levchenko A, Scott ML and Baltimore D: The IκB-NFκB signaling module: temporal control and selective gene activation. Science 298: 1241-1245, 2002. (Pubitemid 35285493)
20. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert J-P, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams S-L, Moran MF, Morin GB, Topaloglou T and Figeys D: Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Systems Biol 3: 1-17, 2007.
21. Wadgaonkar R, Linz-McGillem L, Zaiman AL and Garcia JG: Endothelial cell myosin light chain kinase (MLCK) regulates TNFα-induced NFκB activity. J Cell Biochem 94: 351-64, 2005. (Pubitemid 41420313)
22. Dai R-M, Chen E, Longo DL, Gorbea CM and Li C-CH: Involvement of valosin-containing protein, an ATPase co-purified with IκBα and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IκBα. J Biol Chem 273: 3562-3573, 1998. (Pubitemid 28109780)
23. Asai T, Tomita Y, Nakatsuka S, Hoshida Y, Myoui A, Yoshikawa H and Aozasa K: VCP (p97) regulates NFκB signaling pathway, which is important for metastasis of osteosarcoma cell line. Jpn J Cancer Res 93: 296-304, 2002. (Pubitemid 34464366)
24. Yamamoto S, Tomita Y, Hoshida Y, Sakon M, Kameyama M, Imaoka S, Sekimoto M, Nakamori S, Monden M and Aozasa K: Expression of valosin-containing protein in colorectal carcinomas as a predictor for disease recurrence and prognosis. Clin Cancer Res 10: 651-657, 2004. (Pubitemid 38174005)