Effect of leptin treatment on neonatal hypoxic-ischemic brain injury

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 25, Issue 2, 2012, Pages 141-146

  Kumral, Abdullah ^a   Yesilirmak, Didem Cemile ^a   Sozmen, Sule ^a   Ergur, Bekir Ugur ^a   Tugyan, Kazim ^a   Ozbal, Seda ^a   Guclu, Serkan ^a   Duman, Nuray ^a   Ozkan, Hasan ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

Hypoxic ischemic brain damage; Leptin; Neonate

Indexed keywords

LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CONTROLLED STUDY; DENTATE GYRUS; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA2 REGION; HIPPOCAMPAL CA3 REGION; HYPOXIC ISCHEMIC ENCEPHALOPATHY; LEFT HEMISPHERE; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; RIGHT HEMISPHERE; SINGLE DRUG DOSE; TREATMENT DURATION;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; DRUG EVALUATION, PRECLINICAL; FEMALE; HIPPOCAMPUS; HYPOXIA-ISCHEMIA, BRAIN; LEPTIN; NEUROPROTECTIVE AGENTS; PREGNANCY; RATS; RATS, WISTAR;

EID: 84855691866     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2011.565834     Document Type: Article

References (22)

1. Liu J, Cao YH, Meng HF, Rong PX. The role and mechanisms of IL-6, IL-8 and TNF-a for regulating cerebral hemodynamics in term infants with hypoxic-ischemic encephalopathy. J Turk German Gynecol Assoc 2007; 8: 63-66. (Pubitemid 46649788)
2. Bonfold E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: two distinct events, induced respectively by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 1995; 92: 7162-7166.
3. Edwards AD, Mehmet H. Apoptosis in perinatal hypoxicischemic cerebral damage. Neuropathol Appl Neurobiol 1996; 22: 494-498. (Pubitemid 27023360)
4. Grow J, Barks DE. Pathogenesis of hypoxic-ischemic cerebral injury in the term infant: current concepts. Clin Perinatol 2002; 29: 585-602. (Pubitemid 36076373)
5. Volpe JJ. Hypoxic-ischemic encephalopathy. In: Volpe JJ, editor. Neurology of the Newborn. Philadelphia, PA: WB Saunders; 2001. Chapter 9, p 331-394.
6. Hull J, Dodd KL. Falling incidence of hypoxic-ischaemic encephalopathy in term infants. Br J Obstet Gynaecol 1992; 99: 386-391.
7. Schubring C, Kiess W, Englaro P, Rascher W, Dö tsch J, Hanitsch S, Attanasio A, Blum WF. Levels of leptin in maternal serum amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. J Clin Endocrinol Metab 1997; 82: 1480-1483. (Pubitemid 27200422)
8. Boston BA, Blaydon K M, Varnerin J, Cone RD. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 1997; 278: 1641-1644. (Pubitemid 27516287)
9. Vannucci RC, Vannucci SJ. Perinatal hypoxic-ischemic brain damage: evolution of an animal model. Dev Neurosci 2005; 572: 81-86. (Pubitemid 41096212)
10. Balasubramaniyan V, Nalini N. Leptin alters brain adenosine triphosphatase activity in ethanol-mediated neurotoxicity in mice. Singapore Med J 2006; 47: 864-868. (Pubitemid 44519179)
11. Paxinos G, Watson C. The rat brain in stereotaxic coordinates 4th ed. New York, USA: Academic Press; 2002.
12. Heijmans-Antonissen C, Wesseldijk F, Munnikes RJ, Huygen FJ, van der Meijden P, Hop WC, Hooijkaas H, Zijlstra FJ. Multiplex bead array assay for detection of 25 soluble cytokines in blister fluid of patients with complex regional pain syndrome type 1. Mediators Inflamm 2006; 2006: 1-8.
13. Mikhail AA, Beck EX, Shafer A, Barut B, Gbur JS, Zupancic TJ, Schweitzer AC, Cioffi JA, Lacaud G, Ouyang B, Keller G, Snodgrass HR. Leptin stimulates fetal and adult erythroid and myeloid development. Blood 1997; 89: 1507-1512. (Pubitemid 27097441)
14. Sierra-Honigmann MR, Nath AK, Murakami C, García-Cardeñ a G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR. Biological action of leptin as an angiogenic factor. Science 1998; 281: 1683-1686.
15. Bornstein SR, Licinio J, Tauchnitz R, Engelmann L, Negrão AB, Gold P, et al. Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm in cortisol and leptin secretion. J Clin Endocrinol Metab 1998; 83: 280-283. (Pubitemid 28498351)
16. Russo VC, Metaxas S, Kobayashi K, Harris M, Werther GA. Antiapoptotic effects of leptin in human neuroblastoma cells. Endocrinology 2004; 145: 4103-4112. (Pubitemid 39120558)
17. Signore AP, Zhang F, Weng Z, Gao Y, Chen J. Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials. J Neurochem 2008; 106: 1977-1990.
18. Shn EJ, Schram K, Zheng XL, Sweeney G. Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. J Cell Physiol 2009; 221: 490-497.
19. Dicou E, Attoub S, Gressens P. Neuroprotective effects of leptin in vivo and in vitro. Neuroreport 2001; 12: 3947-3951. (Pubitemid 33152431)
20. Zhang F, Wang SP, Signore AP, Chen J. Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia. Stroke 2007; 38: 2329-2336. (Pubitemid 47457577)
21. Shanley LJ, Irving AJ, Harvey J. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. J. Neurosci 2001; 21: 86-191.
22. Li XL, Aou S, Oomura Y, Hori N, Fukunaga K, Hori T. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience 2002; 113: 607-615. (Pubitemid 34874684)