SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonist

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 854-858

  Huang, Xianhai ^a   Su, Jing ^a   Rao, Ashwin U ^a   Tang, Haiqun ^a   Zhou, Wei ^a   Zhu, Xiaohong ^a   Chen, Xiao ^a   Liu, Zhidan ^a   Huang, Ying ^a   Degrado, Sylvia ^a   Xiao, Dong ^a   Qin, Jun ^a   Aslanian, Robert ^a   McKittrick, Brian A ^a   Greenfeder, Scott ^a   Heek, Margaret Van ^a   Chintala, Madhu ^a   Palani, Anandan ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Agonist; Dyslipidemia; FFA; Flushing; HDI; HM74A; Nicotinic acid; TG

Indexed keywords

2H PYRANO[2,3 D]PYRIMIDINE 2,4,7(1H,3H) TRIONE DERIVATIVE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ETHER; NICOTINIC ACID; PROPARGYLETHER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ETHERS; HUMANS; LACTONES; MOLECULAR STRUCTURE; PYRIMIDINES; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84855680267     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.041     Document Type: Article

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