Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2797-2800

  Boatman, P Douglas ^a   Schrader, Thomas O ^a   Kasem, Michelle ^a   Johnson, Benjamin R ^a   Skinner, Philip J ^a   Jung, Jae Kyu ^a   Xu, Jerry ^a   Cherrier, Martin C ^a   Webb, Peter J ^a   Semple, Graeme ^a   Sage, Carleton R ^a   Knudsen, Jens ^a   Chen, Ruoping ^a   Taggart, Andrew K ^b   Carballo Jane, Ester ^b   Richman, Jeremy G ^a  

^a ARENA PHARMACEUTICALS   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Atherosclerosis; Free fatty acids; Niacin receptor; Vasodilation

Indexed keywords

FATTY ACID; GPR 109A; MK 0354; NICOTINIC ACID; NICOTINIC ACID RECEPTOR; NICOTINIC RECEPTOR; TRICYCLIC PYRAZOLE AGONIST; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CYCLOADDITION; DRUG HALF LIFE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN;

ANIMALS; DOGS; HAPLORHINI; HUMANS; MICE; PYRAZOLES; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC; TETRAZOLES; VASODILATOR AGENTS;

EID: 77950865449     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.062     Document Type: Article

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