GPR109a agonists. Part 2: Pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4472-4474

  Imbriglio, Jason E ^a   Chang, Sookhee ^a   Liang, Rui ^a   Raghavan, Subharekha ^a   Schmidt, Darby ^a   Smenton, Abby ^a   Tria, Scott ^a   Schrader, Thomas O ^b   Jung, Jae Kyu ^b   Esser, Craig ^a   Holt, Tom G ^a   Wolff, Michael S ^a   Taggart, Andrew K P ^a   Cheng, Kang ^a   Carballo Jane, Ester ^a   Waters, M Gerard ^a   Tata, James R ^a   Colletti, Steven L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ARENA PHARMACEUTICALS   (United States)

Author keywords

Agonists; GPR109a; Niacin

Indexed keywords

G PROTEIN COUPLED RECEPTOR; NICOTINIC ACID; PYRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL REACTION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG STRUCTURE; MOUSE; NONHUMAN;

ANIMALS; FATTY ACIDS; HUMANS; MICE; NIACIN; PYRAZOLES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC;

EID: 77955413624     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.041     Document Type: Article

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