Gene polymorphisms: The keys for marker assisted selection and unraveling core regulatory pathways for mastitis resistance

Journal of Mammary Gland Biology and Neoplasia

Volumn 16, Issue 4, 2011, Pages 421-432

  Pighetti, Gina M ^a   Elliott, A A ^b  

^a UNIVERSITY OF TENNESSEE   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

Dairy; Immunity; Mastitis; QTL; SNP

Indexed keywords

CHEMOKINE RECEPTOR CXCR1; CXCL2 CHEMOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; HIGH MOBILITY GROUP B1 PROTEIN; LEPTIN; OSTEOPONTIN; TOLL LIKE RECEPTOR 4;

ADAPTIVE IMMUNITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL MIGRATION; CELL SURVIVAL; CYTOKINE PRODUCTION; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HERITABILITY; HUMAN; INNATE IMMUNITY; LACTATION; MASTITIS; MICROSATELLITE MARKER; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC CELL;

ANIMALS; BACTERIAL INFECTIONS; CATTLE; DISEASE RESISTANCE; FEMALE; GENES; GENETIC MARKERS; MASTITIS, BOVINE; POLYMORPHISM, GENETIC; SIGNAL TRANSDUCTION;

EID: 84855667152     PISSN: 10833021     EISSN: 15737039     Source Type: Journal    
DOI: 10.1007/s10911-011-9238-9     Document Type: Article

References (125)

1. NMC. Laboratory handbook on bovine mastitis. 2nd ed. Madison: National Mastitis Council; 1999.
2. USDA. Dairy 2007, part III: Reference of dairy cattle health and management practices in the Unites States, 2007. In: USDAAPHIS- VS-CEAH, editor. Fort Collins, CO2008.
3. WHO. Mastitis: Causes and management. In: Development DoCaAHa, editor. Geneva: World Health Organization; 2000.
4. Bannerman DD. Pathogen-dependent induction of cytokines and other soluble inflammatory mediators during intramammary infection of dairy cows. J Anim Sci. 2009;87(13 SUPPL.):10-25. doi:10.2527/jas.2008-1187.
5. Bannerman DD, Paape MJ, Lee JW, Zhao X, Hope JC, Rainard P. Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection. Clin Diagn Lab Immunol. 2004;11(3):463-72. doi:10.1128/ CDLI.11.3.463-472.2004. (Pubitemid 38661412)
6. Hogan JS, Smith KL, Hoblet KH, Schoenberger PS, Todhunter DA, Hueston WD, et al. Field survey of clinical mastitis in low somatic cell count herds. J Dairy Sci. 1989;72(6):1547-56.
7. Hogan JS,WeissWP, Smith KL. Role of vitamin E and selenium in host defense against mastitis. J Dairy Sci. 1993;76(9):2795-803.
8. Burvenich C, Van Merris V, Mehrzad J, Diez-Fraile A, Duchateau L. Severity of E. coli mastitis is mainly determined by cow factors. Vet Res. 2003;34(5):521-64. doi:10.1051/ vetres:2003023. (Pubitemid 37419855)
9. Rupp R, Boichard D. Genetics of resistance to mastitis in dairy cattle. Vet Res. 2003;34(5):671-88. (Pubitemid 37407276)
10. Nash DL, Rogers GW, Cooper JB, Hargrove GL, Keown JF. Heritability of intramammary infections at first parturition and relationships with sire transmitting abilities for somatic cell score, udder type traits, productive life, and protein yield. J Dairy Sci. 2003;86(8):2684-95. (Pubitemid 39067042)
11. Heringstad B, Rekaya R, Gianola D, Klemetsdal G, Weigel KA. Genetic change for clinical mastitis in Norwegian cattle: A threshold model analysis. J Dairy Sci. 2003;86(1):369-75. (Pubitemid 39067190)
12. Zwald NR, Weigel KA, Chang YM, Welper RD, Clay JS. Genetic analysis of clinical mastitis data from on-farm management software using threshold models. J Dairy Sci. 2006;89 (1):330-6. (Pubitemid 43105938)
13. Wiggans GR, VanRaden PM, Cooper TA. The genomic evaluation system in the United States: Past, present, future. J Dairy Sci. 2011;94(6):3202-11. doi:10.3168/jds.2010-3866.
14. Cole JB, VanRaden PM, O'Connell JR, Van Tassell CP, Sonstegard TS, Schnabel RD, et al. Distribution and location of genetic effects for dairy traits. J Dairy Sci. 2009;92(6):2931-46. doi:10.3168/jds.2008-1762.
15. Hayes BJ, Pryce J, Chamberlain AJ, Bowman PJ, Goddard ME. Genetic architecture of complex traits and accuracy of genomic prediction: Coat colour, milk-fat percentage, and type in holstein cattle as contrasting model traits. Plos Genet. 2010;6(9). doi:10.1371/journal.pgen.1001139.
16. Heringstad B, Klemetsdal G, Steine T. Selection responses for disease resistance in two selection experiments with Norwegian red cows. J Dairy Sci. 2007;90(5):2419-26. (Pubitemid 350045366)
17. Heringstad B, Gianola D, Chang YM, Odegard J, Klemetsdal G. Genetic associations between clinical mastitis and somatic cell score in early first-lactation cows. J Dairy Sci. 2006;89(6):2236-44. (Pubitemid 44365814)
18. Heringstad B, Klemetsdal G, Ruane J. Selection for mastitis resistance in dairy cattle: A review with focus on the situation in the Nordic countries. Livest Prod Sci. 2000;64:95-106. (Pubitemid 30319471)
19. Shook GE. Genetic improvement of mastitis through selection on somatic cell count. Vet Clin North Am Food Anim Prac. 1993;9:563-81.
20. de Haas Y, Ouweltjes W, ten Napel J, Windig JJ, de Jong G. Alternative somatic cell count traits as mastitis indicators for genetic selection. J Dairy Sci. 2008;91(6):2501-11. doi:10.3168/ jds.2007-0459. (Pubitemid 351807995)
21. Windig JJ, Ouweltjes W, ten Napel J, de Jong G, Veerkamp RF, De Haas Y. Combining somatic cell count traits for optimal selection against mastitis. J Dairy Sci. 2010;93(4):1690-701. doi:10.3168/jds.2009-2052.
22. Tal-Stein R, Fontanesi L, Dolezal M, Scotti E, Bagnato A, Russo V, et al. A genome scan for quantitative trait loci affecting milk somatic cell score in Israeli and Italian Holstein cows by means of selective DNA pooling with single- and multiple-marker mapping. J Dairy Sci. 2010;93(10):4913-27. doi:10.3168/ jds.2010-3254.
23. Schulman NF, Moisio SM, Koning DJd, Elo K, Maki-Tanila A, Vilkki J, et al. QTL for health traits in Finnish Ayrshire cattle. Proceedings of the 7th World Congress on Genetics Applied to Livestock Production, Montpellier, France, August, 2002. Session 9. 2002.
24. Schulman NF, Sahana G, Iso-Touru T, Lund MS, Andersson- Eklund L, Viitala SM, et al. Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11. Anim Genet. 2009;40(4):509-15. doi:10.1111/j.1365-2052. 2009.01872.x.
25. Schulman NF, Viitala SM, de Koning DJ, Virta J, Maki-Tanila A, Vilkki JH. Quantitative trait loci for health traits in Finnish Ayrshire cattle. J Dairy Sci. 2004;87:443-9. (Pubitemid 44145415)
26. Rodriguez-Zas SL, Southey BR, Heyen DW, Lewin HA. Detection of quantitative trait loci influencing dairy traits using a model for longitudinal data. J Dairy Sci. 2002;85(10):2681-91. doi:10.3168/jds.S0022-0302(02)74354-3. (Pubitemid 38571468)
27. Klungland H, Sabry A, Heringstad B, Gro Olsen H, Gomez- Raya L, Inge Vage D, et al. Quantitative trait loci affecting clinical mastitis and somatic cell count in dairy cattle. Mamm Genome. 2001;12:837-42. (Pubitemid 33022282)
28. Schrooten C, Bink MCAM, Bovenhuis H. Whole genome scan to detect chromosomal regions affecting multiple traits in dairy cattle. J Dairy Sci. 2004;87:3550-60. (Pubitemid 39408491)
29. Longeri M, Polli M, Strillacci MG, Samore AB, Zanotti M. Short communication: Quantitative trait loci affecting the somatic cell score on chromosomes 4 and 26 in Italian Holstein cattle. J Dairy Sci. 2006;89(8):3175-7. (Pubitemid 44197234)
30. Heyen DW, Weller JI, Ron M, Band M, Beever JE, Feldmesser E, et al. A genome scan for QTL influencing milk production and health traits in dairy cattle. Physiol Genomics. 1999;1:165-75. (Pubitemid 129622463)
31. Sorensen LP, Guldbrandtsen B, Thomasen JR, Lund MS. Pathogen-specific effects of quantitative trait loci affecting clinical mastitis and somatic cell count in Danish Holstein cattle. J Dairy Sci. 2008;91(6):2493-500. doi:10.3168/jds.2007-0583. (Pubitemid 351807994)
32. Lund MS, Guldbrandtsen B, Buitenhuis AJ, Thomsen B, Bendixen C. Detection of quantitative trait loci in Danish Holstein cattle affecting clinical mastitis, somatic cell score, udder conformation traits, and assessment of associated effects on milk yield. J Dairy Sci. 2008;91(10):4028-36. doi:10.3168/ jds.2007-0290.
33. Lund MS, Sahana G, Andersson-Eklund L, Hastings N, Fernandez A, Schulman N, et al. Joint analysis of quantitative trait loci for clinical mastitis and somatic cell score on five chromosomes in three Nordic dairy cattle breeds. J Dairy Sci. 2007;90(11):5282-90. doi:10.3168/jds.2007-0177. (Pubitemid 351455417)
34. Holmberg M, Andersson-Eklund L. Quantitative trait loci affecting health traits in Swedish dairy cattle. J Dairy Sci. 2004;87:2653-9. (Pubitemid 39103993)
35. Ashwell MS, Heyen DW, Sonstegard TS, Van Tassell CP, Da Y, VanRaden PM, et al. Detection of quantitative trait loci affecting milk production, health, and reproductive traits in Holstein cattle. J Dairy Sci. 2004;87:468-75. (Pubitemid 44145418)
36. Ashwell MS, Van Tassell CP. Detection of putative loci affecting milk, health, and type traits in a US Holstein population using 70 microsatellite markers in a genome scan. J Dairy Sci. 1999;82:2497-502. (Pubitemid 129558967)
37. Ron M, Feldmesser E, Golik M, Tager-Cohen I, Kliger D, Reiss V, et al. A complete genome scan of the Israeli Holstein population for quantitative trait loci by a daughter design. J Dairy Sci. 2004;87(2):476-90. (Pubitemid 44145419)
38. Weller JI. Power of daughter and granddaughter designs for determining linkage between marker loci and quantitative loci in dairy cattle. J Dairy Sci. 1990;73(9):2525-37.
39. Sahana G, Lund MS, Andersson-Eklund L, Hastings N, Fernandez A, Iso-Touru T, et al. Fine-mapping QTL for mastitis resistance onBTA9 in three Nordic red cattle breeds. Anim Genet. 2008;39 (4):354-62. doi:10.1111/j.1365-2052.2008. 01729.x. (Pubitemid 351994113)
40. Kuhn C, Bennewitz J, Reinsch N, Xu N, Thomsen H, Looft C, et al. Quantitative trait loci mapping of functional traits in the German Holstein cattle population. J Dairy Sci. 2003;86:360-8. (Pubitemid 39067189)
41. Baes C, Mayer M, Tetens J, Liu Z, Reinhardt F, Thaller G, et al. Refined mapping of a QTL for somatic cell score on BTA27 in the German Holstein using combined linkage and linkage disequilibrium analysis. Can J Anim Sci. 2010;90(2):169-78.
42. Hu Z-L, Park CA, Fritz ER, Reecy JM. QTLdb: A comprehensive database tool building bridges between genotypes and phenotypes. The 9th World Congress on Genetics Applied to Livestock Production; August 1-6, 2010; Leipzig, Germany 2010.
43. Khatkar MS, Thomson PC, Tammen I, Raadsma HW. Combined QTL map of dairy cattle traits. University of Sydney. 2005. http://www.vetsci.usyd.edu.au/ reprogen/QTL-Map/?QTL=Yes. Accessed June 8, 2005.
44. Khatkar MS, Thomson PC, Tammen I, Raadsma HW. Quantitative trait loci mapping in dairy cattle: Review and metaanalysis. Genet Sel Evol. 2004;36:163-90. (Pubitemid 38272284)
45. Ogorevc J, Kunej T, Razpet A, Dovc P. Database of cattle candidate genes and genetic markers for milk production and mastitis. Anim Genet. 2009;40(6):832-51. doi:10.1111/j.1365- 2052.2009.01921.x.
46. Sodeland M, Kent MP, Olsen HG, Opsal MA, Svendsen M, Sehested E, et al. Quantitative trait loci for clinical mastitis on chromosomes 2, 6, 14, and 20 in Norwegian Red cattle. Animal Gen. 2011. doi:10.1111/j.1365-2052.2010.02165.x.
47. Grob PM, David E, Warren TC, DeLeon RP, Farina PR, Homon CA. Characterization of a receptor for human monocyte-derived neutrophil chemotactic factor/interleukin-8. J Biol Chem. 1990;265(14):8311-6.
48. Takata H, Tomiyama H, Fujiwara M, Kobayashi N, Takiguchi M. Cutting edge: Expression of chemokine receptor CXCR1 on human effector CD8+ T cells. J Immunol. 2004;173:2231-5.
49. Zlotnik A, Yoshie O. Chemokines: A new classification system and their role in immunity. Immunity. 2000;12(2):121-7. (Pubitemid 30398626)
50. Nilsen H, Olsen HG, Hayes B, Nome T, Sehested E, Svendsen M, et al. Characterization of a QTL region affecting clinical mastitis and protein yield on BTA6. Anim Genet. 2009;40 (5):701-12. doi:10.1111/j.1365-2052.2009.01908.x.
51. Koshland ME. The coming of age of the immunoglobulin JChain. Annu Rev Immunol. 1985;3:425-53.
52. Nickerson SC. Immune mechanisms of the bovine udder: An overview. J Am Vet Med Assoc. 1985;187(1):41-5. (Pubitemid 15062342)
53. Youngerman SM, Saxton AM, Oliver SP, Pighetti GM. Association of CXCR2 polymorphisms with subclinical and clinical mastitis in dairy cattle. J Dairy Sci. 2004;87:2442-8. (Pubitemid 39103969)
54. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors. Nat Immunol. 2010;11(5):373-84. doi:10.1038/ni.1863.
55. IpWK, Takahashi K, Ezekowitz RA, Stuart LM. Mannose-binding lectin and innate immunity. Immunol Rev. 2009;230(1):9-21.
56. Ingham A, Menzies M. Identification and expression of Toll-like receptors 1-10 in selected bovine and ovine tissues. Vet Immunol Immunopathol. 2006;109(1-2):23-30. doi:10.1016/j. vetimm.2005.06.014. (Pubitemid 41739672)
57. Smith KL, Todhunter DA, Schoenberger PS. Environmentalmastitis: Cause, prevalence, prevention. J Dairy Sci. 1985;68(6):1531-53.
58. Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med. 2007;13(9):1050-9. (Pubitemid 47517504)
59. White SN, Taylor KH, Abbey CA, Gill CA, Womack JE. Haplotype variation in bovine Toll-like receptor 4 and computational prediction of a positively selected ligand-binding domain. Proc Natl Acad Sci USA. 2003;100(18):10364-9. doi:10.1073/pnas.1333957100. (Pubitemid 37071884)
60. Sharma BS, Leyva I, Schenkel F, Karrow NA. Association of toll-like receptor 4 polymorphisms with somatic cell score and lactation persistency in Holstein bulls. J Dairy Sci. 2006;89 (9):3626-35. (Pubitemid 44306008)
61. Opsal MA, Hayes B, Berget I, Lien S, Vage DI. Genomic organization and transcript profiling of the bovine toll-like receptor gene cluster TLR6-TLR1-TLR10. Gene. 2006;384:45-50. doi:10.1016/j.gene.2006.06.027. (Pubitemid 44738328)
62. Wang X, Xu S, Xue G, Ren H, Chen J. Genetic polymorphism of TLR4 gene and correlation with mastitis in cattle. J Genet Genomics. 2007;34(5):406-12. (Pubitemid 46874282)
63. Beecher C, Daly M, Childs S, Berry DP, Magee DA, McCarthy TV, et al. Polymorphisms in bovine immune genes and their associations with somatic cell count and milk production in dairy cattle. BMC Genet. 2010;11. doi:10.1186/1471-2156-11-99.
64. Sharma BS, Mount J, Karrow NA. Functional characterization of a single gene nucleotide polymorphism in the 5' UTR region of the bovine toll-like receptor 4 gene. Dev Biol. 2008;132:331-6.
65. Kutikhin AG. Impact of Toll-like receptor 4 polymorphisms on risk of cancer. Hum Immunol. 2011;72:193-206.
66. Franchi L, Park JH, Shaw MH, Marina-Garcia N, Chen G, Kim YG, et al. Intracellular NOD-like receptors in innate immunity, infection and disease. Cell Microbiol. 2008;10(1):1-8. doi:10.1111/j.1462-5822.2007.01059.x. (Pubitemid 350239051)
67. Pant SD, Schenkel FS, Leyva-Baca I, Sharma BS, Karrow NA. Identification of single nucleotide polymorphisms in bovine CARD15 and their associations with health and production traits in Canadian Holsteins. Bmc Genomics. 2007;8. doi:10.1186/ 1471-2164-8-421.
68. Tanabe T, Chamaillard M, Ogura Y, Zhu L, Qiu S, Masumoto J, et al. Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J. 2004;23(7):1587-97. doi:10.1038/sj.emboj.7600175. (Pubitemid 38579519)
69. Wang C, Liu M, Li Q, Ju Z, Huang J, Li J. Three novel singlenucleotide polymorphisms of MBL1 gene in Chinese native cattle and their associations with milk performance traits. Vet Immunol Immunopathol. 2011;139:229-36.
70. Bernig T, Breunis W, Brouwer N, Hutchinson A, Welch R, Roos D, et al. An analysis of genetic variation across the MBL2 locus in Dutch Caucasians indicates that 3' haplotypes could modify circulating levels of mannose-binding lectin. Hum Genet. 2005;118:404-15. (Pubitemid 43091211)
71. Bernig T, Boersma BJ, Howe TM, Welch R, Yadavalli S, Staats B, et al. The mannose-binding lectin (MBL2) haplotype and breast cancer: An association study in African-American and Caucasian women. Carcinogenesis. 2007;28(4):828-36. (Pubitemid 46523340)
72. Hill AW. Factors influencing the outcome of Escherichia coli mastitis in dairy cows. Res Vet Sci. 1981;31:107-12. (Pubitemid 11063276)
73. Desbaillets I, Diserens AC, Tribolet N, Hamou MF, Van Meir EG. Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis. J Exp Med. 1997;186(8):1201-12. (Pubitemid 27469015)
74. Bobrovnikova-Marjon EV, Marjon PL, Barbash O, Vander Jagt DL, Abcouwer SF. Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: Role of nuclear factor-kappaB and activating protein-1. Cancer Res. 2004;64 (14):4858-69. (Pubitemid 38924530)
75. DeForge LE, Preston AM, Takeuchi E, Kenney J, Boxer LA, Remick DG. Regulation of interleukin 8 gene expression by oxidant stress. J Biol Chem. 1993;268(34):25568-76. (Pubitemid 23358166)
76. Bannerman DD, Paape MJ, Goff JP, Kimura K, Lippolis JD, Hope JC. Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis. Vet Res. 2004;35(6):681-700. doi:10.1051/vetres:2004040. (Pubitemid 39585506)
77. Rambeaud M, Almeida RA, Pighetti GM, Oliver SP. Dynamics of leukocytes and cytokines during experimentally induced Streptococcus uberis mastitis. Vet Immunol Immunopathol. 2003;96:193-205. (Pubitemid 37330000)
78. 5a and inflammatory cytokines in neutrophil recruitment during intramammary infection with Escherichia coli. Infect Immun. 1997;65(8):3286-92. (Pubitemid 27342412)
79. Kettritz R, Gaido ML, Haller H, Luft FC, Jennette CJ, Falk RJ. Interleukin-8 delays spontaneous and tumor necrosis factoralpha- mediated apoptosis of human neutrophils. Kidney Int. 1998;53:84-91. (Pubitemid 28066906)
80. Mitchell GB, Albright BN, Casewell JL. Effect of interleukin- 8 and granulocyte colony stimulating factor on priming and activation of bovine neutrophils. Infect Immun. 2003;71 (4):1643-9. (Pubitemid 36368692)
81. Lahouassa H, Rainard P, Caraty A, Riollet C. Identification and characterization of a new interleukin-8 receptor in bovine species. Mol Immunol. 2008;45(4):1153-64. (Pubitemid 350027717)
82. Gabellini C, Trisciuoglio D, DesideriM, Candiloro A, Ragazzoni Y, Orlandi A, et al. Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression. Eur J Cancer. 2009;45(14):2618-27. doi:10.1016/j.ejca.2009.07.007.
83. Shamaladevi N, Lyn DA, Escudero DO, Lokeshwar BL. CXC receptor-1 silencing inhibits androgen-independent prostate cancer. Cancer Res. 2009;69(21):8265-74. doi:10.1158/0008- 5472.CAN-09-0374.
84. Charafe-Jauffret E, Ginestier C, Iovino F, Wicinski J, Cervera N, Finetti P, et al. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res. 2009;69(4):1302-13. doi:10.1158/0008- 5472.can-08-2741.
85. Gasser O, Schmid TA, Zenhaeusern G, Hess C. Cyclooxygenase regulates cell surface expression of CXCR3/1-storing granules in human CD4+ T cells. J Immunol. 2006;177(12):8806-12. (Pubitemid 44893847)
86. Murdoch C, Monk PN, Finn A. CXC chemokine receptor expression on human endothelial cells. Cytokine. 1999;11 (9):704-12. doi:10.1006/cyto.1998.0465. (Pubitemid 29428004)
87. Sallusto F, Schaerli P, Loetscher P, Schaniel C, Lenig D, Mackay CR, et al. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol. 1998;28(9):2760-9. doi:10.1002/(SICI)1521-4141(199809) 28:093.0.CO;2-N. (Pubitemid 28425234)
88. Berahovich RD, Lai NL, Wei Z, Lanier LL, Schall TJ. Evidence for NK cell subsets based on chemokine receptor expression. J Immunol. 2006;177(11):7833-40. (Pubitemid 44846299)
89. Youngerman SM, Saxton AM, Pighetti GM. Novel single nucleotide polymorphisms and haplotypes within the bovine CXCR2 gene. Immunogenetics. 2004;56:355-9. (Pubitemid 39222767)
90. Pighetti GM, Rambeaud M. Genome conservation between the bovine and human interleukin-8 receptor complex: Improper annotation of bovine interleukin-8 receptor b identified. Immunogenetics. 2006;114:335-40. (Pubitemid 44634732)
91. Pighetti GM, Kojima CJ, Wojakiewicz L, Rambeaud M. The bovine CXCR1 gene is highly polymorphic. Vet Immunol Immunopathol. 2011. doi:10.1016/j.vetimm. 2011.09.012.
92. Leyva-Baca I, Schenkel F, Martin J, Karrow NA. Polymorphisms in the 5' upstream region of the CXCR1 chemokine receptor gene, and their association with somatic cell score in Holstein cattle in Canada. J Dairy Sci. 2008;91 (1):407-17. (Pubitemid 351455858)
93. Leyva-Baca I, Schenkel F, Sharma BS, Jansen GB, Karrow NA. Identification of single nucleotide polymorphisms in the bovine CCL2, IL8, CCR2 and IL8RA genes and their association with health and production in Canadian Holsteins. Anim Genet. 2007;38(3):198-202. doi:10.1111/j.1365-2052.2007.01588.x. (Pubitemid 46848868)
94. Goertz I, Baes C, Weimann C, Reinsch N, Erhardt G. Association between single nucleotide polymorphisms in the CXCR1 gene and somatic cell score in Holstein dairy cattle. J Dairy Sci. 2009;92:4018-22.
95. Rambeaud M, Clift R, Pighetti GM. Association of a bovine CXCR2 gene polymorphism with neutrophil survival and killing ability. Vet Immunol Immunopathol. 2006;111:231-8.
96. Rambeaud M, Pollock A, Clift R, Pighetti GM, editors. Differential intracellular calcium release in neutrophils of cattle with different CXCR2 genotypes upon interleukin- 8 activation. Conference Research Workers in Animal Disease; 2005.
97. Rambeaud M, Pighetti GM. Differential calcium signaling in dairy cows with specific CXCR1 genotypes potentially related to interleukin-8 receptor functionality. Immunogenetics. 2007;59 (1):53-8. doi:10.1007/s00251-006-0170-x. (Pubitemid 46011192)
98. Burton JL, Madsen SA, Chang LC, Weber PS, Buckham KR, van Dorp R, et al. Gene expression signatures in neutrophils exposed to glucocorticoids: A new paradigm to help explain "neutrophil dysfunction" in parturient dairy cows. Vet Immunol Immunopathol. 2005;105(3-4):197-219. (Pubitemid 40460946)
99. Feng J, Li Y, Hashad M, Schur E, Gros P, Adams LG, et al. Bovine natural resistance associated macrophage protein 1 (Nramp1) gene. Genome Res. 1996;6:956-64. (Pubitemid 26388087)
100. Wessling-Resnick M. Iron homeostasis and the inflammatory response. Annu Rev Nutr. 2010;30:105-22. doi:10.1146/ annurev.nutr.012809.104804.
101. Martinez R, Dunner S, Barrera G, Canon J. Novel variants within the coding regions of the Slc11A1 gene identifed in Bos taurus and Bos indicus breeds. J Anim Breed Genet. 2008;125 (1):57-62. (Pubitemid 351185321)
102. Zhang C, Wang Y, Chen H, Gu C, Fang X. SLC11A1 gene polymorphisms are not associated to somatic cell score and milk yield in Chinese Holstein. Vet Immunol Immunopathol. 2009;127:389-92.
103. Kelm SC, Detilleux JC, Freeman AE, Kehrli Jr ME, Dietz AB, Fox LK, et al. Genetic association between parameters of innate immunity and measures of mastitis in periparturient Holstein cattle. J Dairy Sci. 1997;80(8):1767-75. (Pubitemid 127446898)
104. Starkenburg RJ, Hansen LB, Kehrli MEJ, Chester-Jones H. Frequencies and effects of alternative DRB3.2 alleles of bovine lymphocyte antigen for Holsteins in milk selection and control lines. J Dairy Sci. 1997;80:3411-9. (Pubitemid 127447075)
105. Rupp R, Hernandez A, Mallard BA. Association of bovine leukocyte antigen (BoLA) DRB3.2 with immune response, mastitis, and production and type traits in Canadian Holsteins. J Dairy Sci. 2007;90(2):1029-38. (Pubitemid 350049751)
106. Sharif SB, Mallard BA, Wilkie BN, Sargeant JM, Scott HM, Dekkers JCM, et al. Associations of the bovine major histocompatibility complex DRB3 (BoLA-DRB3) alleles with occurrence of disease and milk somatic cell score in Canadian dairy cattle. Anim Genet. 1998;29:185-93. (Pubitemid 28371571)
107. Taub DD, Murphy WJ, Longo DL. Rejuvenation of the aging thymus: Growth hormone-mediated and ghrelin-mediated signaling pathways. Curr Opin Pharmacol. 2010;10(4):408-24.
108. Shuster DE, Kehrli Jr ME, Baumrucker CR. Relationship of inflammatory cytokines, growth hormone, and insulin-like growth factor-I to reduced performance during infectious disease. Proc Soc Exp Biol Med. 1995;210(2):140-9.
109. Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, et al. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Anim Genet. 2010;42:39-49.
110. Banos G, Woolliams JA, Woodward BW, Forbes AB, Coffey MP. Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows. J Dairy Sci. 2008;91:3190-200.
111. Magee DA, Sikora KM, Berkowicz EW, Berry DP, Howard DJ, Mullen MP, et al. DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle. BMC Genet. 2010;11:93.
112. Drake NM, Park YJ, Shirali AS, Cleland TA, Soloway PD. Imprint switch mutations at Rasgrf1 support conflict hypothesis of imprinting and define a growth control mechanism upstream of IGF1. Mamm Genome. 2009;20(9-10):654-63. doi:10.1007/ s00335-009-9192-7.
113. Chebel RC, Susca F, Santos JEP. Leptin genotype is associated with lactation performance and health of Holstein cows. J Dairy Sci. 2008;91(7):2893-900. doi:10.3168/jds.2007-0891. (Pubitemid 351976611)
114. Buchanan FC, Van Kessel AG, Waldner C, Christensen DA, Laarveld B, Schmutz SM. Hot topic: An association between a leptin single nucleotide polymorphism and milk and protein yield. J Dairy Sci. 2003;86:3164-6. (Pubitemid 38995020)
115. Fernandez-Riejos P, Najib S, Santos-Alvarez J, Martin-Romero C, Perez-Perez A, Gonzalez-Yanes C, et al. Role of leptin in the activation of immune cells. Mediators Inflamm. 2010;2010:568343.
116. Giblin L, Butler ST, Kearney B, Waters SM, Callanan MJ, Berry DP. Association of bovine leptin polymorphisms with energy output and energy storage traits in progeny tested Holstein- Friesian dairy cattle sires. BMC Genet. 2010;11:73.
117. Liefers SC, Veerkamp RF, te Pas MFW, Delavaud C, Chilliard Y, Platje M, et al. Leptin promoter mutations affect leptin levels and performance traits in dairy cows. Anim Genet. 2005;36:111-8. (Pubitemid 40518693)
118. Alain K, Karrow NA, Thibault C, St-Pierre J, Lessard M, Bissonnette N. Osteopontin: An early innate immune marker of Escherichia coli mastitis harbors genetic polymorphisms with possible links with resistance to mastitis. BMC Genomics. 2009;10. doi:10.1186/1471-2164-10-444.
119. Quirion MR, Gregory GD, Umetsu SE, Winandy S, Brown MA. Cutting edge: Ikaros is a regulator of Th2 cell differentiation. J Immunol. 2009;182(2):741-5.
120. Morimoto J, Kon S, Matsui Y, Uede T. Osteopontin; as a target molecule for the treatment of inflammatory diseases. Curr Drug Targets. 2010;11(4):494-505.
121. Lutzow YC, Donaldson L, Gray CP, Vuocolo T, Pearson RD, Reverter A, et al. Identification of immune genes and proteins involved in the response of bovine mammary tissue to Staphylococcus aureus infection. BMC Vet Res. 2008;4:18.
122. Zhu J, Paul WE. CD4 T cells: Fates, functions, and faults. Blood. 2008;112(5):1557-69. doi:10.1182/blood-2008-05-078154.
123. Skelding A, Schenkel FS, Sharma BS, Verschoor C, Pant S, Biggar G, et al. Identification of single nucleotide polymorphisms in the bovine interleukin-12 and interleukin-23 receptor genes and their associations with health and production traits in Holstein cows. J Dairy Sci. 2010;93(10):4860-71. doi:10.3168/ jds.2009-2392.
124. Verschoor CP, Pant SD, Biggar GA, Schenkel FS, Sharma BS, Karrow NA. Identification of SNPs in interferon gamma, interleukin-22, and their receptors and associations with health and production-related traits in Canadian Holstein bulls. Anim Biotechnol. 2011;22(1):7-15. doi:10.1080/10495398.2011.536078.
125. Verschoor CP, Pant SD, Schenkel FS, Sharma BS, Karrow NA. SNPs in the bovine IL-10 receptor are associated with somatic cell score in Canadian dairy bulls. Mamm Genome. 2009;20 (7):447-54. doi:10.1007/s00335-009-9198-1.