Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA 2

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 868-871

  Lin, Emme C K ^a   Hu, Yi ^a   Amantea, Christopher M ^a   Pham, Lan M ^a   Cajica, Julia ^a   Okerberg, Eric ^a   Brown, Heidi E ^a   Fraser, Allister ^a   Du, Lingling ^a   Kohno, Yasushi ^b   Ishiyama, Junichi ^b   Kozarich, John W ^a   Shreder, Kevin R ^a  

^a ACTIVX BIOSCIENCES INC   (United States)

^b KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

AX10185; Lp PLA 2; Xanthurenic acid; Zn 2+ dependent inhibitor

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; AMIDE; AX 10185; EDETIC ACID; ESTERASE INHIBITOR; PHENYL GROUP; UNCLASSIFIED DRUG; XANTHURENIC ACID; ZINC;

ARTICLE; DRUG STRUCTURE; ENZYME ACTIVITY; IC 50; STRUCTURE ACTIVITY RELATION;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; AMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHURENATES; ZINC;

EID: 84855661420     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.045     Document Type: Article

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