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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 958-962

Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent

(14) Huang, Huang a Lu, Weiqiang a Li, Xi a Cong, Xiaoli b Ma, Hongmei a Liu, Xiaofeng a Zhang, Yu a Che, Peng a Ma, Ruoqun a Li, Honglin a Shen, Xu a,b,c Jiang, Hualiang a,b,c Huang, Jin a Zhu, Jin a

a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)

b Minsheng Pharma Binjiang Branch (China)

c SHANGHAI INSTITUTE OF MATERIA MEDICA (China)

Author keywords

Antimalarial drug; Dihydrofolate reductase; Dual inhibitor; Falcipain 2; Molecular docking; SAR

Indexed keywords

ANTIMALARIAL AGENT; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FALCIPAIN 2; FALCIPAIN 2 INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SURVIVAL RATE;

ANIMALS; ANTIMALARIALS; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MALARIA; MICE; MICE, INBRED STRAINS; MODELS, MOLECULAR; MOLECULAR WEIGHT; PLASMODIUM BERGHEI; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84855660458 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.12.011 Document Type: Article

Times cited : (43)

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