메뉴 건너뛰기




Volumn 14, Issue 4, 2011, Pages 339-352

A small interfering RNA targeting the KLF6 splice variant, KLF6-SV1, as gene therapy for gastric cancer

Author keywords

Apoptosis; Gastric cancer; KLF6 SV1; RNA interference; Tumor gene therapy

Indexed keywords

GELATINASE B; KI 67 ANTIGEN; PHOSPHATIDYLINOSITOL KINASE; POLYETHYLENEIMINE; PROTEIN BCL 2; PROTEIN KINASE B; SMALL INTERFERING RNA; UVOMORULIN; VASCULOTROPIN;

EID: 84855641952     PISSN: 14363291     EISSN: 14363305     Source Type: Journal    
DOI: 10.1007/s10120-011-0049-x     Document Type: Article
Times cited : (24)

References (48)
  • 2
    • 0034254165 scopus 로고    scopus 로고
    • Current status and future perspectives in gastric cancer management
    • DOI 10.1053/ctrv.2000.0164
    • Roukos DH. Current status and future perspectives in gastric cancer management. Cancer Treat Rev. 2000;26:243-55. (Pubitemid 30604036)
    • (2000) Cancer Treatment Reviews , vol.26 , Issue.4 , pp. 243-255
    • Roukos, D.H.1
  • 3
    • 1442310498 scopus 로고    scopus 로고
    • Focus on gastric cancer
    • DOI 10.1016/S1535-6108(04)00033-9, PII S1535610804000339
    • Ushijima T, Sasako M. Focus on gastric cancer. Cancer Cell. 2004;5:121-5. (Pubitemid 38283798)
    • (2004) Cancer Cell , vol.5 , Issue.2 , pp. 121-125
    • Ushijima, T.1    Sasako, M.2
  • 4
    • 0034929708 scopus 로고    scopus 로고
    • Sp1 and Krüppel-like factor family of transcription factors in cell growth regulation and cancer
    • DOI 10.1002/jcp.1111
    • Black AR, Black JD, Azizkhan-Clifford J. Sp1 and Kruppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol. 2001;188:143-60. (Pubitemid 32622905)
    • (2001) Journal of Cellular Physiology , vol.188 , Issue.2 , pp. 143-160
    • Black, A.R.1    Black, J.D.2    Azizkhan-Clifford, J.3
  • 7
    • 11144357280 scopus 로고    scopus 로고
    • Kruppel-like factor 6 (KLF6) is a tumour suppressor gene frequently inactivated in colorectal cancer
    • Reeves HL, Narla G, Ogunbiyi O, Haq AI, Katz A, Benzeno S, et al. Kruppel-like factor 6 (KLF6) is a tumour suppressor gene frequently inactivated in colorectal cancer. Gastroenterology. 2004;126:1090-3.
    • (2004) Gastroenterology , vol.126 , pp. 1090-3
    • Reeves, H.L.1    Narla, G.2    Ogunbiyi, O.3    Haq, A.I.4    Katz, A.5    Benzeno, S.6
  • 8
    • 33745713651 scopus 로고    scopus 로고
    • Genetic alterations of the KLF6 gene in colorectal cancers
    • Cho YG, Choi BJ, Kim CJ, Song JW, Kim SY, Nam SW, et al. Genetic alterations of the KLF6 gene in colorectal cancers. APMIS. 2006;114:458-64.
    • (2006) APMIS , vol.114 , pp. 458-64
    • Cho, Y.G.1    Choi, B.J.2    Kim, C.J.3    Song, J.W.4    Kim, S.Y.5    Nam, S.W.6
  • 10
    • 39449090999 scopus 로고    scopus 로고
    • A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response
    • DOI 10.1158/0008-5472.CAN-07-2604
    • DiFeo A, Feld L, Rodriguez E, Wang C, Beer DG, Martignetti JA, et al. A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response. Cancer Res. 2008;68:965-70. (Pubitemid 351272212)
    • (2008) Cancer Research , vol.68 , Issue.4 , pp. 965-970
    • DiFeo, A.1    Feld, L.2    Rodriguez, E.3    Wang, C.4    Beer, D.G.5    Martignetti, J.A.6    Narla, G.7
  • 12
    • 0038174752 scopus 로고    scopus 로고
    • KLF6, a putative tumour suppressor gene, is mutated in astrocytic gliomas
    • Jeng YM, Hsu HC. KLF6, a putative tumour suppressor gene, is mutated in astrocytic gliomas. Int J Cancer. 2003;105:625-9.
    • (2003) Int J Cancer , vol.105 , pp. 625-9
    • Jeng, Y.M.1    Hsu, H.C.2
  • 14
    • 0036824877 scopus 로고    scopus 로고
    • Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas
    • Chen HK, Liu XQ, Lin J, Chen TY, Feng QS, Zeng YX. Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas. Ai Zheng. 2002;21:1047-50.
    • (2002) Ai Zheng , vol.21 , pp. 1047-50
    • Chen, H.K.1    Liu, X.Q.2    Lin, J.3    Chen, T.Y.4    Feng, Q.S.5    Zeng, Y.X.6
  • 16
    • 34347337761 scopus 로고    scopus 로고
    • Inactivation of the tumour suppressor Kruppel-like factor 6 (KLF6) by mutation or decreased expression in hepatocellular carcinomas
    • Pan XC, Chen Z, Chen F, Chen XH, Jin HY, Xu XY. Inactivation of the tumour suppressor Kruppel-like factor 6 (KLF6) by mutation or decreased expression in hepatocellular carcinomas. J Zhejiang Univ Sci B. 2006;7:830-6.
    • (2006) J Zhejiang Univ Sci B , vol.7 , pp. 830-6
    • Pan, X.C.1    Chen, Z.2    Chen, F.3    Chen, X.H.4    Jin, H.Y.5    Xu, X.Y.6
  • 19
    • 49549098364 scopus 로고    scopus 로고
    • Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer
    • Hartela M, Narla G, Wente MN, Giese NA, Martignoni ME, Martignetti JA, et al. Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer. Eur J Cancer. 2008;44:1895-903.
    • (2008) Eur J Cancer , vol.44 , pp. 1895-903
    • Hartela, M.1    Narla, G.2    Wente, M.N.3    Giese, N.A.4    Martignoni, M.E.5    Martignetti, J.A.6
  • 24
    • 48749088691 scopus 로고    scopus 로고
    • KLF-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis
    • Narla G, DiFeo A, Fernandez Y, Dhanasekaran S, Huang F, Sangodkar J, et al. KLF-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis. J Clin Invest. 2008;118:2711-21.
    • (2008) J Clin Invest , vol.118 , pp. 2711-21
    • Narla, G.1    DiFeo, A.2    Fernandez, Y.3    Dhanasekaran, S.4    Huang, F.5    Sangodkar, J.6
  • 26
    • 66349114312 scopus 로고    scopus 로고
    • KLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model
    • Difeo A, Huang F, Sangodkar J, Terzo EA, Leake D, Narla G, et al. KLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model. Cancer Res. 2009;69:4733-41.
    • (2009) Cancer Res , vol.69 , pp. 4733-41
    • Difeo, A.1    Huang, F.2    Sangodkar, J.3    Terzo, E.A.4    Leake, D.5    Narla, G.6
  • 27
    • 47249145601 scopus 로고    scopus 로고
    • Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells
    • DOI 10.1002/art.23490
    • Fan KX, Dai JX, Wang H, Wei HF, Cao ZG, Hou S, et al. Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells. Arthritis Rheum. 2008;58: 2041-52. (Pubitemid 351988096)
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.7 , pp. 2041-2052
    • Fan, K.1    Dai, J.2    Wang, H.3    Wei, H.4    Cao, Z.5    Hou, S.6    Qian, W.7    Wang, H.8    Li, B.9    Zhao, J.10    Xu, H.11    Yang, C.12    Guo, Y.13
  • 28
    • 33745684527 scopus 로고    scopus 로고
    • Metastasis: A question of life or death
    • Mehlen P, Puisieux A. Metastasis: A question of life or death. Nat Rev Cancer. 2006;6:449-58.
    • (2006) Nat Rev Cancer , vol.6 , pp. 449-58
    • Mehlen, P.1    Puisieux, A.2
  • 29
    • 0036547417 scopus 로고    scopus 로고
    • Death and anti-death: Tumour resistance to apoptosis
    • Igney FH, Krammer PH. Death and anti-death: Tumour resistance to apoptosis. Nat Rev Cancer. 2002;2:277-88. (Pubitemid 37328781)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.4 , pp. 277-288
    • Igney, F.H.1    Krammer, P.H.2
  • 30
    • 62949123360 scopus 로고    scopus 로고
    • The role of KLF6 and its splice variants in cancer therapy
    • DiFeo A, Martignetti JA, Narla G. The role of KLF6 and its splice variants in cancer therapy. Drug Resist Updat. 2009;12:1-7.
    • (2009) Drug Resist Updat , vol.12 , pp. 1-7
    • DiFeo, A.1    Martignetti, J.A.2    Narla, G.3
  • 31
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 1999;13: 1899-911. (Pubitemid 29407357)
    • (1999) Genes and Development , vol.13 , Issue.15 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 32
    • 0033288336 scopus 로고    scopus 로고
    • Mitochondrial control of apoptosis: An overview
    • Kroemer G. Mitochondrial control of apoptosis: An overview. Biochem Soc Symp. 1999;66:1-15. (Pubitemid 129639017)
    • (1999) Biochemical Society Symposium , vol.66 , pp. 1-15
    • Kroemer, G.1
  • 33
    • 0030584088 scopus 로고    scopus 로고
    • Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
    • DOI 10.1016/S0092-8674(00)81382-3
    • Zha J, Harada H, Osipov K, Jockel J, Waksman G, Korsmeyer SJ. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not Bcl-xl. Cell. 1996;87:619-28. (Pubitemid 26386936)
    • (1996) Cell , vol.87 , Issue.4 , pp. 619-628
    • Zha, J.1    Harada, H.2    Yang, E.3    Jockel, J.4    Korsmeyer, S.J.5
  • 34
    • 44849127680 scopus 로고    scopus 로고
    • Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells
    • Wang J, Yang J, Kuropatwinski K, Wang W, Liu XQ, Hauser J, et al. Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells. Cancer Res. 2008;68:3152-60.
    • (2008) Cancer Res , vol.68 , pp. 3152-60
    • Wang, J.1    Yang, J.2    Kuropatwinski, K.3    Wang, W.4    Liu, X.Q.5    Hauser, J.6
  • 35
    • 0036196165 scopus 로고    scopus 로고
    • Eradication of osteosarcoma lung metastases following intranasal interleukin-12 gene therapy using a nonviral polyethylenimine vector
    • DOI 10.1038/sj/cgt/7700432
    • Jia SF, Worth LL, Densmore CL, Xu B, Zhou Z, Kleinerman ES. Eradication of osteosarcoma lung metastases following intranasal interleukin-12 gene therapy using a nonviral polyethylenimine vector. Cancer Gene Ther. 2002;9:260-6. (Pubitemid 34205500)
    • (2002) Cancer Gene Therapy , vol.9 , Issue.3 , pp. 260-266
    • Jia, S.-F.1    Worth, L.L.2    Densmore, C.L.3    Xu, B.4    Zhou, Z.5    Kleinerman, E.S.6
  • 37
    • 8844286089 scopus 로고    scopus 로고
    • A new role for the Krüppel-like transcription factor KLF6 as an inhibitor of c-Jun proto-oncoprotein function
    • DOI 10.1038/sj.onc.1208020
    • Slavin DA, Koritschoner NP, Prieto CC, Lopez-Diaz FJ, Chatton B, Bocco JL. A new role for the Kruppel-like transcription factor KLF6 as an inhibitor of c-jun proto-oncoprotein function. Oncogene. 2004;23:8196-205. (Pubitemid 39531831)
    • (2004) Oncogene , vol.23 , Issue.50 , pp. 8196-8205
    • Slavin, D.A.1    Koritschoner, N.P.2    Prieto, C.C.3    Lopez-Diaz, F.J.4    Chatton, B.5    Bocco, J.L.6
  • 38
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi A, Dixit VM. Death receptors: Signaling and modulation. Science. 1998;281:1305-8. (Pubitemid 28406815)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 39
    • 0035253051 scopus 로고    scopus 로고
    • P53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells
    • DOI 10.1038/sj.onc.1204124
    • Bartke T, Siegmond D, Peters N, Reichwein M, Henkler F, Scheurich P, et al. p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. Oncogene. 2001;20:571-80. (Pubitemid 32156181)
    • (2001) Oncogene , vol.20 , Issue.5 , pp. 571-580
    • Bartke, T.1    Siegmund, D.2    Peters, N.3    Reichwein, M.4    Henkler, F.5    Scheurich, P.6    Wajant, H.7
  • 41
    • 38549130324 scopus 로고    scopus 로고
    • BH3 mimetics to improve cancer therapy; mechanisms and examples
    • DOI 10.1016/j.drup.2007.08.002, PII S1368764607000593
    • Zhang L, Ming L, Yu J. BH3mimetics to improve cancer therapy: Mechanisms and examples. Drug Resist Updat. 2007;10:207-17. (Pubitemid 351163146)
    • (2007) Drug Resistance Updates , vol.10 , Issue.6 , pp. 207-217
    • Zhang, L.1    Ming, L.2    Yu, J.3
  • 42
    • 27144477415 scopus 로고    scopus 로고
    • Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells
    • DOI 10.1038/sj.onc.1208825, PII 1208825
    • Jeong SJ, Pise-Masison CA, Radonovich MF, Park HU, Brady JN. Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells. Oncogene. 2005;24:6719-28. (Pubitemid 41486802)
    • (2005) Oncogene , vol.24 , Issue.44 , pp. 6719-6728
    • Jeong, S.-J.1    Pise-Masison, C.A.2    Radonovich, M.F.3    Park, H.U.4    Brady, J.N.5
  • 43
    • 0039425278 scopus 로고    scopus 로고
    • Negative regulation of the forkhead transcription factor FKHR by Akt
    • Tang ED, Nuñez G, Barr FG, Guan KL. Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem. 1999;274:16741-6.
    • (1999) J Biol Chem , vol.274 , pp. 16741-6
    • Tang, E.D.1    Nunez, G.2    Barr, F.G.3    Guan, K.L.4
  • 44
    • 13444262170 scopus 로고    scopus 로고
    • Inhibition of respiratory viruses by nasally administered siRNA
    • DOI 10.1038/nm1164
    • Bitko V, Musiyenko A, Shulyayeva O, Barik S. Inhibition of respiratory viruses by nasally administered siRNA. Nat Med. 2005;11:50-5. (Pubitemid 40215837)
    • (2005) Nature Medicine , vol.11 , Issue.1 , pp. 50-55
    • Bitko, V.1    Musiyenko, A.2    Shulyayeva, O.3    Barik, S.4
  • 45
    • 50149101511 scopus 로고    scopus 로고
    • Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
    • Frank-Kamenetsky M, Grefhorst A, Anderson NN, Racie TS, Bramlage B, Akinc A, et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci USA. 2008;105: 11915-20.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11915-20
    • Frank-Kamenetsky, M.1    Grefhorst, A.2    Anderson, N.N.3    Racie, T.S.4    Bramlage, B.5    Akinc, A.6
  • 48
    • 0029160083 scopus 로고
    • A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine
    • Boussif O, Lezoualc'h F, Zanta A, Mergny MD, Scherman D, Demeneix B, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine. Proc Natl Acad Sci USA. 1995;92:7297-301.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7297-301
    • Boussif, O.1    Lezoualc'h, F.2    Zanta, A.3    Mergny, M.D.4    Scherman, D.5    Demeneix, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.