Real-time prompt gamma monitoring in spot-scanning proton therapy using imaging through a knife-edge-shaped slit

Physics in Medicine and Biology

Volumn 57, Issue 2, 2012, Pages 297-308

  Bom, Victor ^a   Joulaeizadeh, Leila ^a   Beekman, Freek ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DEPTH PROFILE; GAMMA DETECTORS; GAMMA-RAY EMISSION; HIGH ENERGY; HIGH POTENTIAL; HIGH SENSITIVITY; MONTE CARLO SIMULATION; NUCLEAR REACTIONS; PARTICLE THERAPY; POSITION SENSITIVE; PROMPT GAMMA-RAYS; PROTON THERAPY; REAL TIME MONITORING; SLIT CAMERAS; SOFTWARE PHANTOM; SPATIAL CORRELATIONS;

COMPUTER SIMULATION; MONITORING; MONTE CARLO METHODS; SOFTWARE TESTING;

GAMMA RAYS;

PROTON;

ARTICLE; FEASIBILITY STUDY; GAMMA RADIATION; HEAD; HUMAN; IMAGE QUALITY; METHODOLOGY; MONTE CARLO METHOD; RADIATION MONITORING; SCINTISCANNING; TIME; UNCERTAINTY;

FEASIBILITY STUDIES; GAMMA RAYS; HEAD; HUMANS; MONTE CARLO METHOD; PHANTOMS, IMAGING; PROTONS; RADIATION MONITORING; RADIONUCLIDE IMAGING; TIME FACTORS; UNCERTAINTY;

EID: 84855615112     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/57/2/297     Document Type: Article

References (45)

1. Agostinelli S et al 2003 GEANT4: a simulation toolkit Nucl. Instrum. Methods A 506 250303 http://geant4.web.cern.ch/geant4/ http://geant4.web.cern. ch/geant4/
2. Allison J et al 2006 GEANT4: developments and applications IEEE Trans. Nucl. Sci. 53 2708
3. Attanasi F, Belcari N, Guerra A D, Enghardt W, Moehrs S, Parodi K, Rasso V and Vecchio S 2008 Comparison of two dedicated in beam PET systems via simultaneous imaging of C-induced (+)-activity Phys. Med. Biol. 54 N2935
4. Beekman F J and Have F v d 2007 The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging Eur. J. Nucl. Med. Mol. Imag. 34 15161
5. Bohlen T T, Cerutti F, Dosanjh M, Ferrari A, Gudowska I, Mairani A and Quesada J M 2010 Benchmarking nuclear models of FLUKA and GEANT4 for carbon ion therapy Phys. Med. Biol. 55 583347
6. Chera B S, Rodriguez C, Morris C G, Louis D, Yeung D, Li Z and Mendenhall N P 2009 Dosimetric comparison of three different involved nodal irradiation techniques for stage II Hodgkins lymphoma patients: conventional radiotherapy, intensity-modulated radiotherapy, and three-dimensional proton radiotherapy Int. J. Radiat. Oncol. Biol. Phys. 75 117380
7. Cirrone G 2009 Hadrontherapy. TWiki Geant4 site
8. Combs S E, Nikoghosyan A, Jaekel O, Karger C P, Haberer T, Muenter M W, Huber P E, Debus J and Schulz-Ertner D 2009 Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull base Cancer 115 134855
9. Durante M and Loeffler J S 2010 Charged particles in radiation oncology Nat. Rev. Clin. Oncol. 7 3743
10. ENVISION 2010 European Novel Imaging Systems for ION Therapy (funded under 7th FWP) (Seventh Framework Programme) http://www.envision-project.org
11. Fielder F, Shakirin G, Skowron J, Braess H, Crespo P, Kunath D, Pawelke J, Ponisch F and Enghardt W 2010 On line effectiveness of ion range determination from in-beam PET data Phys. Med. Biol. 55 198998
12. Foulher F L et al 2010 Monte Carlo simulations of prompt-gamma emission during carbon ion irradiation IEEE Trans. Nucl. Sci. 57 276872
13. Fourkal E, Fan J and Veltchev I 2009 Absolute dose reconstruction in proton therapy using PET imaging modality: feasibility study Phys. Med. Biol 54 N21728
14. Frandes M, Zoglauer A, Maxim V and Prost R 2010 A tracking Compton-scattering imaging system for hadron therapy monitoring IEEE Trans. Nucl. Sci. 57 14450
15. Gillin M T et al 2010 Commissioning of the discrete spot scanning proton beam delivery system at the University of Texas MD Anderson Cancer Center, Proton Therapy Center, Houston Med. Phys. 37 15463
16. Grevillot L, Frisson T, Zahra N, Bertrand D, Stichelbaut F, Freud N and Sarrut D 2010 Optimization of GEANT4 settings for proton pencil beam scanning simulations using GATE Nucl. Instrum. Methods B 268 3295305
17. Hausser O, Lone M A, Alexander T K, Kushneriuk S A and Gascon J 1983 The prompt response of bismuth-germanate and NaI(Tl) scintillation detectors to fast-neutrons Nucl. Instrum. Methods A 213 3019 (Pubitemid 13606343)
18. Hug E B 2004 Protons versus photons: a status assessment at the beginning of the 21st Century Radiother. Oncol. 73 (Suppl. 2) 3542
19. Kang B H and Kim J W 2009 Monte carlo design study of a gamma detector system to locate distal dose falloff in proton therapy IEEE Trans. Nucl. Sci. 56 4650
20. Kim D, Yim H and Kim J 2009 Pinhole camera measurements of prompt gamma-rays for detection of beam range variation in proton therapy J. Korean Phys. Soc. 55 16736
21. Kuhn A, Surti S, Karp J, Muehllehner G, Newcomer F and VanBerg R 2006 Performance assessment of pixelated LaBr3 detector modules for time-of-flight PET IEEE Trans. Nucl. Sci. 53 10905 (Pubitemid 44109399)
22. Matsuzaki Y, Date H, Sutherland K and Kiyanagi Y 2010 Nuclear collision processes around the Bragg peak in proton therapy Radiol. Phys. Technol. 3 8492
23. Min C, Kim C H, Youn M and Kim J 2006 Prompt gamma measurements for locating the dose falloff region in the proton therapy Appl. Phys. Lett. 89 183517
24. Min C H, Kim J W, Youn M Y and Kim C H 2007 Determination of distal dose edge location by measuring right-angled prompt-gamma rays from a 38 MeV proton beam Proc. 10th Int. Symp. on Radiation PhysicsISRP 10, Nucl. Instrum. Methods A 580 5625 (Pubitemid 47331938)
25. Moteabbed M, na S E and Paganetti H 2011 Monte carlo patient study on the comparison of prompt gamma and PET imaging for range verification in proton therapy Phys. Med. Biol. 56 1063
26. Park M, Lee W and Kim J 2010 Estimation of proton distribution by means of three-dimensional reconstruction of prompt gamma rays Appl. Phys. Lett. 97 153705
27. Parodi K, Ponisch F and Enghardt W 2005 Experimental study on the feasibility of in-beam PET for accurate monitoring of proton therapy IEEE Trans. Nucl. Sci. 52 77886 (Pubitemid 41178521)
28. Pedroni E et al 1995 The 200 MeV proton therapy project at the Paul Scherrer Instituteconceptual design and practical realization Med. Phys. 22 3753
29. Pedroni E et al 2004 The PSI Gantry 2: a second generation proton scanning gantry Z. Med. Phys. 14 2534 (Pubitemid 38435678)
30. Peters A, Cee R, Haberer T, Hoffmann T, Reiter A, Schwickert M and Winkelman T 2008 Spill structure measurements at HIT Proc. EPAC08 (Genoa, Italy,) pp 1824-1826
31. Peterson S W, Robertson D and Polf J 2010 Optimizing a three-stage Compton camera for measuring prompt gamma rays emitted during proton radiotherapy Phys. Med. Biol. 55 6841
32. Polf J C, Peterson S, Ciangaru G, Gillin M and Beddar S 2009a Prompt gamma-ray emission from biological tissues during proton irradiation: a preliminary study Phys. Med. Biol. 54 731
33. Polf J C, Peterson S, McCleskey M, Roeder B T, Spiridon A, Beddar S and Trache L 2009b Measurement and calculation of characteristic prompt gamma ray spectra emitted during proton irradiation Phys. Med. Biol. 54 N519
34. PSI 2009 http://mpss.iop.org/Summer-School/2009/Programme2009/Loma xProtontherapy.pdf
35. Richard M H et al 2011 Design guidelines for a double scattering Compton camera for prompt- imaging during ion beam therapy: a Monte Carlo simulation study IEEE Trans. Nucl. Sci. 58 8794
36. Savitzky A and Golay M J E 1964 Smoothing and differentiation of data by simplified least-squares procedures Anal. Chem. 36 162739
37. Smith A R 2009 Vision 20/20: proton therapy Med. Phys. 36 55668
38. Smith A et al 2009 The M. D. Anderson proton therapy system Med. Phys. 36 406883
39. Smith D J 2008 Tissue substitutes in radiation dosimetry and measurement http://www.icru.org/index.php?option=com-content&task=vi ew&id=80
40. Sommerer F, Cerutti F, Oarodi K, Ferrari A, Enghardt W and Aiginger H 2009 In-beam PET monitoring of mono-energetic O and C beam: experiments and FLUKA simulations for homogeneous targets Phys. Med. Biol. 54 397996
41. Talcott J A, Rossi C, Shipley W U, Clark J A, Slater J D, Niemierko A and Zietman A L 2010 Patient-reported long-term outcomes after conventional and high-dose combined proton and photon radiation for early prostate cancer J. Am. Med. Assoc. 303 104653
42. Testa E, Bajard M, Chevallier M, Dauvergne D, Foulher F L, Freud N, Letang J M, Poizat J C, Ray C and Testa M 2008 Monitoring the Bragg peak location of 73 MeV/u carbon ions by means of prompt gamma-ray measurements Appl. Phys. Lett. 93 093506
43. Testa M et al 2010 Real-time monitoring of the Bragg-peak position in ion therapy by means of single photon detection Radiat. Environ. Biophys. 49 33743
44. Vacchio S, Attanasi F, Belcari N, Camarda M, Cirrone G A P and Cuttone G 2007 A PET prototype for in-beam monitoring of proton therapy IEEE Nucl. Sci. Symp. Conf. Record N24-362 pp 160711
45. Vincke H, Gschwendtner E, Fabjan C W and Otto T 2002 Response of a BGO detector to photon and neutron sources: simulations and measurements Nucl. Instrum. Methods A 484 10210 (Pubitemid 34545740)