Monte Carlo patient study on the comparison of prompt gamma and PET imaging for range verification in proton therapy

Physics in Medicine and Biology

Volumn 56, Issue 4, 2011, Pages 1063-1082

  Moteabbed, M ^a   Espana S ^a   Paganetti, H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUISITION TIME; BEAM DIRECTION; BEAM WIDTHS; COMPUTED TOMOGRAPHY; DATA ANALYSIS; DETECTION EFFICIENCY; DETECTION SENSITIVITY; DETECTION TECHNOLOGY; DOSE DISTRIBUTIONS; ELEMENTAL COMPOSITIONS; FIELD SIZE; GAMMA SIGNALS; HALF LIVES; HEAD AND NECK; HETEROGENEOUS TISSUES; MONTE CARLO; MONTE CARLO CODES; NON-INVASIVE; ON-LINE MEASUREMENT; PATIENT ANATOMY; PATIENT GEOMETRIES; PENCIL BEAM; PET IMAGES; PET IMAGING; PRODUCTION RATES; PROTON THERAPY; SCATTERED FIELD; SITE-SPECIFIC; SMALL TUMORS; TISSUE DENSITY; TISSUE HETEROGENEITY; TREATMENT SITES; TREATMENT VALIDATION; TUMOR LOCATION;

DETECTORS; ISOTOPES; MONTE CARLO METHODS; POSITRON EMISSION TOMOGRAPHY; PROTON BEAMS; PROTONS; SIGNAL DETECTION; TUMORS;

COMPUTERIZED TOMOGRAPHY;

DIAGNOSTIC AGENT; PROTON;

ARTICLE; COMPARATIVE STUDY; COMPUTER ASSISTED RADIOTHERAPY; COMPUTER PROGRAM; FEASIBILITY STUDY; GAMMA RADIATION; HUMAN; MALE; METHODOLOGY; MONTE CARLO METHOD; NEOPLASM; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING;

FEASIBILITY STUDIES; GAMMA RAYS; HUMANS; MALE; MONTE CARLO METHOD; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; PROTONS; RADIOTHERAPY, COMPUTER-ASSISTED; SOFTWARE;

EID: 79551706093     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/56/4/012     Document Type: Article

References (29)

1. Agostinelli S et al 2003 GEANT4-a simulation toolkit Nucl. Instrum. Methods Phys. Res. A 506 250-303
2. Attanasi F et al 2008 Experimental validation of the filtering approach for dose monitoring in proton therapy at low energy Phys. Med. 24 102-6
3. Enghardt W, Crespo P, Fiedler F, Hinz R, Parodi K, Pawelke J and Ponisch F 2004 Charged hadron tumour therapy monitoring by means of PET Nucl. Instrum. Methods Phys. Res. A 525 284-88
4. España S and Paganetti H 2010 The impact of uncertainties in the CT conversion algorithm when predicting proton beam ranges in patients from dose and PET-activity distributions Phys. Med. Biol. 55 7557-71
5. España S, Zhu X, Daartz J, Liebsch N, El Fakhri G, Bortfeld T and Paganetti H 2010 Feasibility of in-room PET imaging for in vivo proton beam range verification Med. Phys. 37 3180
6. Frandes M, Zoglauer A, Maxim V and Prost R 2010 A tracking Compton-scattering imaging system for hadron therapy monitoring IEEE Trans. Nucl. Sci. 57 144-50
7. Kang B H and Kim J W 2009 Monte Carlo design study of a gamma detector system to locate distal dose falloff in proton therapy IEEE Trans. Nucl. Sci. 56 46-50
8. Kim D, Yim H and Kim J W 2009 Pinhole camera measurements of prompt gamma-ray for detection of beam range variation in proton therapy J. Korean Phys. Soc. 55 1673-6
9. Knopf A, Parodi K, Bortfeld T, Shih H A and Paganetti H 2009 Systematic analysis of biological and physical limitations of proton beam range verification with offline PET/CT scans Phys. Med. Biol. 54 4477-95
10. Kooy H M et al 2010 A case study in proton pencil-beam scanning delivery Int. J. Rad. Onc. Biol. Phys. 76 624-30
11. Lu H M 2008 A point dose method for in vivo range verification in proton therapy Phys. Med. Biol. 53 N415-22
12. Min C H, Kim C H, Youn M Y and Kim J W 2006 Prompt gamma measurements for locating the dose falloff region in the proton therapy Appl. Phys. Lett. 89 183517
13. (Pubitemid 37020977)
14. Nishio T, Ogino T, Nomura K and Uchida H 2006 Dose-volume delivery guided proton therapy using beam on-line PET system Med. Phys. 33 4190-7 (Pubitemid 44673109)
15. Oelfke U, Lam G K Y and Atkins M S 1995 Proton dose monitoring with PET: quantitative studies in Lucite Phys. Med. Biol. 41 177-196 (Pubitemid 26034231)
16. Paans A M J and Schippers J M 1993 Proton therapy in combination with PET as monitor: a feasibility study IEEE Trans. Nucl. Sci. 40 1041-44
17. Paganetti H, Jiang H, Lee S Y and Kooy H M 2004 Accurate Monte Carlo simulations for nozzle design, commissioning and quality assurance for a proton radiation therapy facility Med. Phys. 31 2107-18 (Pubitemid 38924832)
18. Paganetti H, Jiang H, Parodi K, Slopsema R and Engelsman M 2008 Clinical implementation of full Monte Carlo dose calculation in proton beam therapy Phys. Med. Biol. 53 4825-53
19. Parodi K, Bortfeld T and Haberer T 2008 Comparison between in-beam and offline positron emission tomography imaging of proton and carbon ion therapeutic irradiation at synchrotron-and cyclotron-based facilities Int. J. Radiat. Oncol. Biol. Phys. 71 945-56 (Pubitemid 351749526)
20. Parodi K, Paganetti H, Cascio E, Flanz J, Bonab A A, Alpert N M, Lohmann K and Bortfeld T 2007a PET/CT imaging for treatment verification after proton therapy: a study with plastic phantoms and metallic implants Med. Phys. 34 419-35 (Pubitemid 46185120)
21. Parodi K et al 2007b Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy Int. J. Radiat. Oncol. Biol. Phys. 68 920-34 (Pubitemid 46818759)
22. Parodi K, Ponisch F and Enghardt W 2005 Experimental study on the feasibility of in-beam PET for accurate monitoring of proton therapy IEEE Trans. Nucl. Sci. 52 778-86 (Pubitemid 41178521)
23. Peterson S W, Robertson D and Polf J 2010 Optimizing a three-stage Compton camera for measuring prompt gamma rays emitted during proton radiotherapy Phys. Med. Biol. 55 6841-56
24. Polf J C, Peterson S, Ciangaru G, Gillin M and Beddar S 2009a Prompt gamma-ray emission from biological tissues during proton irradiation: a preliminary study Phys. Med. Biol. 54 731-43
25. Polf J C, Peterson S, McCleskey M, Roeder B T, Spiridon A, Beddar S and Trache L 2009b Measurement and calculation of characteristic prompt gamma ray spectra emitted during proton irradiation Phys. Med. Biol. 54 N519-27
26. Richard M H et al 2010 Design guidelines for a double scattering Compton camera for prompt-γ imaging during ion beam therapy: a monte-carlo simulation study IEEE Trans. Nucl. Sci. at press DOI: 10.1109/TNS.2010.2076303
27. Testa M et al 2010 Real-time monitoring of the Bragg-peak position in ion therapy by means of single photon detection Radiat. Environ. Biophys. 49 337-43
28. Schneider W, Bortfeld T and Schlegel W 2000 Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions Phys. Med. Biol. 45 459-78 (Pubitemid 30096775)
29. Vynckier S, Derreumaux S, Richard F, Bol A, Michel C and Wambersie A 1993 Is it possible to verify directly a proton-treatment plan using positron emission tomography Radiother. Oncol. 26 275-7