Expression of Th17 Cells in Breast Cancer Tissue and Its Association with Clinical Parameters

Cell Biochemistry and Biophysics

Volumn 62, Issue 1, 2012, Pages 153-159

  Yang, LiJuan ^a   Qi, YiXin ^a   Hu, Jie ^a   Tang, Longmei ^a   Zhao, Sha ^a   Shan, BaoEn ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Blood vessel invasion; Breast carcinoma; Flow cytometry; Metastasis; Th17 cells

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6;

ARTICLE; BREAST TUMOR; CANCER STAGING; FEMALE; GENE EXPRESSION REGULATION; HUMAN; IMMUNOLOGY; LYMPH NODE METASTASIS; METABOLISM; PATHOLOGY; REGRESSION ANALYSIS; REGULATORY T LYMPHOCYTE; TH17 CELL;

BREAST NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-17; INTERLEUKIN-1BETA; INTERLEUKIN-6; LYMPHATIC METASTASIS; NEOPLASM STAGING; REGRESSION ANALYSIS; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84855587806     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-011-9276-3     Document Type: Article

References (27)

1. Weaver, C. T., & Murphy, K. M. (2007). T-cell subsets: The more the merrier. Current Biology, 17, R61-R63.
2. Bettelli, E., & Kuchroo, V. K. (2005). IL-12- and IL-23-induced T helper cell subsets: Birds of the same feather flock together. Journal of Experimental Medicine, 201, 169-171.
3. Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y. H., et al. (2005). A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nature Immunology, 6, 1133-1141.
4. Afzali, B., Lombardi, G., Lechler, R. I., & Lord, G. M. (2007). The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clinical and Experimental Immunology, 148, 32-46.
5. Schmidt-Weber, C. B., Akdis, M., & Akdis, C. A. (2007). TH17 cells in the big picture of immunology. Journal of Allergy and Clinical Immunology, 120, 247-254.
6. Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., & Murphy, K. M. (2006). Th17: An effector CD4 T cell lineage with regulatory T cell ties. Immunity, 24, 677-688.
7. Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., et al. (2008). T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity, 28, 29-39.
8. Lubberts, E. (2008). IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis? Cytokine, 41, 84-91.
9. Dong, C. (2008). TH17 cells in development: An updated view of their molecular identity and genetic programming. Nature Reviews Immunology, 8, 337-348.
10. Langowski, J. L., Zhang, X., Wu, L., Mattson, J. D., Chen, T., Smith, K., et al. (2006). IL-23 promotes tumour incidence and growth. Nature, 442, 461-465.
11. Kryczek, I., Wei, S., Zou, L., Altuwaijri, S., Szeliga, W., Kolls, J., et al. (2007). Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. Journal of Immunology, 178, 6730-6733.
12. Bettelli, E., Oukka, M., & Kuchroo, V. K. (2007). T(H)-17 cells in the circle of immunity and autoimmunity. Nature Immunology, 8, 345-350.
13. Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009). IL-17 and Th17 cells. Annual Review of Immunology, 27, 485-517.
14. Williams, L. M., & Rudensky, A. Y. (2007). Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nature Immunology, 8, 277-284.
15. Wan, Y. Y., & Flavell, R. A. (2007). Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature, 445, 766-770.
16. Prabhala, R. H., Pelluru, D., Fulciniti, M., Prabhala, H. K., Nanjappa, P., Song, W., et al. (2010). Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma. Blood, 115, 5385-5392.
17. Zhang, B., Rong, G., Wei, H., Zhang, M., Bi, J., Ma, L., et al. (2008). The prevalence of Th17 cells in patients with gastric cancer. Biochemical and Biophysical Research Communications, 374, 533-537.
18. Steiner, G. E., Newman, M. E., Paikl, D., Stix, U., Memaran-Dagda, N., Lee, C., et al. (2003). Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate. Prostate, 56, 171-182.
19. Miyahara, Y., Odunsi, K., Chen, W., Peng, G., Matsuzaki, J., & Wang, R. F. (2008). Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Proceedings of the National Academy of Sciences of USA, 105, 15505-15510.
20. Kryczek, I., Banerjee, M., Cheng, P., Vatan, L., Szeliga, W., Wei, S., et al. (2009). Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood, 114, 1141-1149.
21. Sfanos, K. S., Bruno, T. C., Maris, C. H., Xu, L., Thoburn, C. J., DeMarzo, A. M., et al. (2008). Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clinical Cancer Research, 14, 3254-3261.
22. + regulatory T cells in small cell lung cancer reflects disease stage. Clinical Cancer Research, 14, 6770-6779.
23. Boni, A., Muranski, P., Cassard, L., Wrzesinski, C., Paulos, C. M., Palmer, D. C., et al. (2008). Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers. Blood, 112, 4746-4754.
24. Muranski, P., Boni, A., Antony, P. A., Cassard, L., Irvine, K. R., Kaiser, A., et al. (2008). Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood, 112, 362-373.
25. Kottke, T., Sanchez-Perez, L., Diaz, R. M., Thompson, J., Chong, H., Harrington, K., et al. (2007). Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer. Cancer Research, 67, 11970-11979.
26. Shime, H., Yabu, M., Akazawa, T., Kodama, K., Matsumoto, M., Seya, T., et al. (2008). Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway. Journal of Immunology, 180, 7175-7183.
27. Schreiber, T. H., Deyev, V. V., Rosenblatt, J. D., & Podack, E. R. (2009). Tumor-induced suppression of CTL expansion and subjugation by gp96-Ig vaccination. Cancer Research, 69, 2026-2033.