The anti-inflammatory role of vitamin e in prevention of osteoporosis

Advances in Pharmacological Sciences

Volumn 2012, Issue , 2012, Pages

  Nazrun, A S ^a   Norazlina, M ^a   Norliza, M ^a   Nirwana, S Ima ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; COLONY STIMULATING FACTOR 1; CYCLOOXYGENASE 2; FREE RADICAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR BINDING PROTEIN;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; DRUG EFFICACY; ENZYME INHIBITION; HUMAN; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPOROSIS; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

EID: 84855582945     PISSN: 16876334     EISSN: 16876342     Source Type: Journal    
DOI: 10.1155/2012/142702     Document Type: Review

References (95)

1. Delmas P. D., Treatment of postmenopausal osteoporosis Lancet 2002 359 9322 2018 2026 (Pubitemid 34663722)
2. Yun A. J., Lee P. Y., Maldaptation of the link between inflammation and bone turnover may be a key determinant of osteoporosis Medical Hypotheses 2004 63 3 532 537 (Pubitemid 38993626)
3. Mitra D., Elvins D. M., Speden D. J., Collins A. J., The prevalence of vertebral fractures in mild ankylosing spondylitis and their relationship to bone mineral density Rheumatology 2000 39 1 85 89 (Pubitemid 30095412)
4. Hougeberg G., Lodder M. C., Lems W. F., Uhlig T., rstavik R. E., Dijkmans B. A.C., Kvien T. K., Woolf A. D., Hand cortical bone mass and its associations with radiographic joint damage and fractures in 5070 year old female patients with rheumatoid arthritis: cross sectional Oslo-Truro-Amsterdam (OSTRA) collaborative study Annals of the Rheumatic Diseases 2004 63 10 1331 1334 (Pubitemid 39273517)
5. Bultink I. E. M., Lems W. F., Kostense P. J., Dijkmans B. A. C., Voskuyl A. E., Prevalence of and risk factors for low bone mineral density and vertebral fractures in patients with systemic lupus erythematosus Arthritis and Rheumatism 2005 52 7 2044 2050 (Pubitemid 40994328)
6. Mikuls T. R., Saag K. G., Curtis J., Bridges S. L., Alarcon G. S., Westfall A. O., Lim S. S., Smith E. A., Jonas B. L., Moreland L. W., Prevalence of osteoporosis and osteopenia among African Americans with early rheumatoid arthritis: the impact of ethnic-specific normative data Journal of the National Medical Association 2005 97 8 1155 1160 (Pubitemid 41098543)
7. Franceschi C., Bonaf M., Valensin S., Olivieri F., De Luca M., Ottaviani E., De Benedictis G., Inflamm-aging. An evolutionary perspective on immunosenescence Annals of the New York Academy of Sciences 2000 908 244 254 (Pubitemid 30462008)
8. Kiecolt-Glaser J. K., Preacher K. J., MacCallum R. C., Atkinson C., Malarkey W. B., Glaser R., Chronic stress and age-related increases in the proinflammatory cytokine IL-6 Proceedings of the National Academy of Sciences of the United States of America 2003 100 15 9090 9095 (Pubitemid 36899228)
9. Ishihara K., Hirano T., IL-6 in autoimmune disease and chronic inflammatory proliferative disease Cytokine and Growth Factor Reviews 2002 13 4-5 357 368
10. Moschen A. R., Kaser A., Enrich B., Ludwiczek O., Gabriel M., Obrist P., Wolf A. M., Tilg H., The RANKL/OPG system is activated in inflammatory bowel diseases and relates to the state or bone loss Gut 2005 54 4 479 487 (Pubitemid 40395499)
11. Saidenberg-Kermanac'h N., Cohen-Solal M., Bessis N., De Vernejoul M. C., Boissier M. C., Role for osteoprotegerin in rheumatoid inflammation Joint Bone Spine 2004 71 1 9 13 (Pubitemid 38183280)
12. Ganesan K., Teklehaimanot S., Tran T. H., Asuncion M., Norris K., Relationship of C-reactive protein and bone mineral density in community-dwelling elderly females Journal of the National Medical Association 2005 97 3 329 333 (Pubitemid 40315936)
13. Arron J. R., Choi Y., Bone versus immune system Nature 2000 408 6812 535 536
14. Lorenzo J., Interactions between immune and bone cells: new insights with many remaining questions Journal of Clinical Investigation 2000 106 6 749 752
15. Teitelbaum S. L., Bone resorption by osteoclasts Science 2000 289 5484 1504 1508
16. Lacey D. L., Timms E., Tan H. L., Kelley M. J., Dunstan C. R., Burgess T., Elliott R., Colombero A., Elliott G., Scully S., Hsu H., Sullivan J., Hawkins N., Davy E., Capparelli C., Eli A., Qian Y. X., Kaufman S., Sarosi I., Shalhoub V., Senaldi G., Guo J., Delaney J., Boyle W. J., Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation Cell 1998 93 2 165 176 (Pubitemid 28180851)
17. Stern A., Laughlin G. A., Bergstrom J., Barrett-Connor E., The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor B legend with bone mineral density in older adults: the Rancho Bernardo study European Journal of Endocrinology 2007 156 5 555 562 (Pubitemid 46796522)
18. Lloyd S. A. J., Yuan Y. Y., Kostenuik P. J., Ominsky M. S., Lau A. G., Morony S., Stolina M., Asuncion F. J., Bateman T. A., Soluble RANKL induces high bone turnover and decreases bone volume, density, and strength in mice Calcified Tissue International 2008 82 5 361 372
19. Boyle W. J., Simonet W. S., Lacey D. L., Osteoclast differentiation and activation Nature 2003 423 6937 337 342 (Pubitemid 40852708)
20. Pacifici R., Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis Journal of Bone and Mineral Research 1996 11 8 1043 1051 (Pubitemid 26321353)
21. Manolagas S. C., Jilka R. L., Mechanisms of disease: bone marrow, cytokines, and bone remodeling-Emerging insights into the pathophysiology of osteoporosis New England Journal of Medicine 1995 332 5 305 311
22. Fuller K., Wong B., Fox S., Choi Y., Chambers T. J., TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts Journal of Experimental Medicine 1998 188 5 997 1001 (Pubitemid 28433427)
23. Pacifici R., Cytokines and osteoclast activity Calcified Tissue International 1995 56 1 S27 S28
24. Jilka R. L., Cytokines, bone remodeling, and estrogen deficiency: a 1998 update Bone 1998 23 2, supplement 1 75 81 (Pubitemid 28379866)
25. Matsuzaki K., Udagawa N., Takahashi N., Yamaguchi K., Yasuda H., Shima N., Morinaga T., Toyama Y., Yabe Y., Higashio K., Suda T., Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures Biochemical and Biophysical Research Communications 1998 246 1 199 204 (Pubitemid 28413951)
26. Cohen-Solal M. E., Boitte F., Bernard-Poenaru O., Denne M. A., Graulet A. M., Brazier M., De Vernejoul M. C., Increased bone resorbing activity of peripheral monocyte culture supernatants in elderly women Journal of Clinical Endocrinology and Metabolism 1998 83 5 1687 1690 (Pubitemid 28501043)
27. Pfeilschifter J., Chenu C., Bird A., Mundy G. R., Roodman G. D., Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclastlike cells in vitro Journal of Bone and Mineral Research 1989 4 1 113 118 (Pubitemid 19079131)
28. Kanatani M., Sugimoto T., Fukase M., Chihara K., Role of interleukin-6 and prostaglandins in the effect of monocyte- conditioned medium on osteoclast formation American Journal of Physiology 1994 267 6 E868 E876
29. Pacifici R., Cytokines and osteoclast activity Calcified Tissue International 1995 56 1, supplement 1 S27 S28
30. Suda T., Udagawa N., Nakamura I., Miyaura C., Takahashi N., Modulation of osteoclast differentiation by local factors Bone 1995 17 2 S87 S91
31. Kitazawa R., Kimble R. B., Vannice J. L., Kung V. T., Pacifici R., Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice Journal of Clinical Investigation 1994 94 6 2397 2406 (Pubitemid 24379614)
32. Kasama T., Kobayashi K., Fukushima T., Tabata M., Ohno I., Negishi M., Ide H., Takahashi T., Niwa Y., Production of interleukin 1-like factor from human peripheral blood monocytes and polymorphonuclear leukocytes by superoxide anion: the role of interleukin 1 and reactive oxygen species in inflamed sites Clinical Immunology and Immunopathology 1989 53 3 439 448 (Pubitemid 19284837)
33. Devaraj S., Li D., Jialal I., The effects of alpha tocopherol supplementation on monocyte function: decreased lipid oxidation, interleukin 1 secretion, and monocyte adhesion to endothelium Journal of Clinical Investigation 1996 98 3 756 763 (Pubitemid 26349181)
34. Ahmad N. S., Khalid B. A. K., Luke D. A., Nirwana S. I., Tocotrienol offers better protection than tocopherol from free radical-induced damage of rat bone Clinical and Experimental Pharmacology and Physiology 2005 32 9 761 770 (Pubitemid 41603156)
35. Serbinova E., Kagan V., Han D., Packer L., Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol Free Radical Biology and Medicine 1991 10 5 263 275 (Pubitemid 121003898)
36. Jiang Q., Ames B. N., -tocopherol, but not -tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats FASEB Journal 2003 17 8 816 822 (Pubitemid 36538656)
37. Patel A., Liebner F., Netscher T., Mereiter K., Rosenau T., Vitamin E chemistry. Nitration of non- -tocopherols: products and mechanistic considerations Journal of Organic Chemistry 2007 72 17 6504 6512 (Pubitemid 47267574)
38. Traber M. G., Sies H., Vitamin E in humans: demand and delivery Annual Review of Nutrition 1996 16 321 347 (Pubitemid 26286857)
39. Brigelius-Flohé R., Vitamin E and drug metabolism Biochemical and Biophysical Research Communications 2003 305 3 737 740 (Pubitemid 36579290)
40. Singh U., Devaraj S., Vitamin E: inflammation and atherosclerosis Vitamins and Hormones 2007 76 519 549
41. Devaraj S., Tang R., Adams-Huet B., Harris A., Seenivasan T., De Lemos J. A., Jialal I., Effect of high-dose -tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease American Journal of Clinical Nutrition 2007 86 5 1392 1398 (Pubitemid 350126243)
42. Jiang Q., Yin X., Lil M. A., Danielson M. L., Freiser H., Huang J., Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases Proceedings of the National Academy of Sciences of the United States of America 2008 105 51 20464 20469
43. Yang C. S., Lu G., Ju J., Li G. X., Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols Annals of the New York Academy of Sciences 2010 1203 29 34
44. Clinton S. K., Libby P., Cytokines and growth factors in atherogenesis Archives of Pathology and Laboratory Medicine 1992 116 12 1292 1300
45. Pacifici R., Rifas L., Teitelbaum S., Spontaneous release of interleukin 1 from human blood monocytes reflects bone formation in idiopathic osteoporosis Proceedings of the National Academy of Sciences of the United States of America 1987 84 13 4616 4620 (Pubitemid 17097860)
46. Ralston S. H., Analysis of gene expression in human bone biopsies by polymerase chain reaction: evidence for enhanced cytokine expression in postmenopausal osteoporosis Journal of Bone and Mineral Research 1994 9 6 883 890 (Pubitemid 24178071)
47. Kawano M., Yamamoto I., Iwato K., Tanaka H., Asaoku H., Tanabe O., Ishikawa H., Nobuyoshi M., Ohmoto Y., Hirai Y., Kuramoto A., Interleukin-1 beta rather than lymphotoxin as the major bone resorbing activity in human multiple myeloma Blood 1989 73 6 1646 1649 (Pubitemid 19131912)
48. Hopkins S. J., Humphreys M., Jayson M. I. V., Cytokines in synovial fluid. I. The presence of biologically active and immunoreactive IL-1 Clinical and Experimental Immunology 1988 72 3 422 427
49. Al Saffar N., Revell P. A., Interleukin-1 production by activated macrophages surrounding loosened orthopaedic implants: a potential role in osteolysis British Journal of Rheumatology 1994 33 4 309 316 (Pubitemid 24110576)
50. Boyce B. F., Aufdemorte T. B., Garrett I. R., Yates A. J. P., Mundy G. R., Effects of interleukin-1 on bone turnover in normal mice Endocrinology 1989 125 3 1142 1150 (Pubitemid 19223955)
51. Gowen M., Wood D. D., Ihrie E. J., An interleukin 1 like factor stimulates bone resorption in vitro Nature 1983 306 5941 378 380 (Pubitemid 14242749)
52. Suda T., Takahashi N., Martin T. J., Modulation of osteoclast differentiation Endocrine Reviews 1992 13 1 66 80
53. Thomson B. M., Saklatvala J., Chambers T. J., Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts Journal of Experimental Medicine 1986 164 1 104 112 (Pubitemid 16069225)
54. Xu L. X., Kukita T., Nakano Y., Yu H., Hotokebuchi T., Kuratani T., Iijima T., Koga T., Osteoclasts in normal and adjuvant arthritis bone tissues express the mRNA for both type I and II interleukin-1 receptors Laboratory Investigation 1996 75 5 677 687 (Pubitemid 26392798)
55. Yu H., Ferrier J., Interleukin-1 alpha induces a sustained increase in cytosolic free calcium in cultured rabbit osteoclasts Biochemical and Biophysical Research Communications 1993 191 2 343 350 (Pubitemid 23222641)
56. Jimi E., Ikebe T., Takahashi N., Hirata M., Suda T., Koga T., Interleukin-1 activates an NF- B-like factor in osteoclast-like cells Journal of Biological Chemistry 1996 271 9 4605 4608
57. Jimi E., Nakamura I., Ikebe T., Akiyama S., Takahashi N., Suda T., Activation of NF- B is involved in the survival of osteoclasts promoted by interleukin-1 Journal of Biological Chemistry 1998 273 15 8799 8805 (Pubitemid 28176159)
58. Pacifici R., Brown C., Puscheck E., Friedrich E., Slatopolsky E., Maggio D., McCracken R., Avioli L. V., Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells Proceedings of the National Academy of Sciences of the United States of America 1991 88 12 5134 5138 (Pubitemid 21914698)
59. Sato F., Ouchi Y., Masuyama A., Nakamura T., Hosoi T., Okamoto Y., Sasaki N., Shiraki M., Orimo H., Effects of estrogen replacement on insulin-like growth factor I concentrations in serum and bone tissue and on interleukin 1 secretion from spleen macrophages in oophorectomized rats Calcified Tissue International 1993 53 2 111 116 (Pubitemid 23215385)
60. Pacifici R., Rifas L., McCracken R., Vered I., McMurtry C., Avioli L. V., Peck W. A., Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release Proceedings of the National Academy of Sciences of the United States of America 1989 86 7 2398 2402 (Pubitemid 19102516)
61. Kimble R. B., Vannice J. L., Bloedow D. C., Thompson R. C., Hopfer W., Kung V. T., Brownfield C., Pacifici R., Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats Journal of Clinical Investigation 1994 93 5 1959 1967 (Pubitemid 24143073)
62. Devaraj S., Jialal I., The effects of alpha-tocopherol on critical cells in atherogenesis Current Opinion in Lipidology 1998 9 1 11 15 (Pubitemid 28052533)
63. Manolagas S. C., Role of cytokines in bone resorption Bone 1995 17 2 635 675
64. Girasole G., Jilka R. L., Passeri G., Boswell S., Boder G., Williams D. C., Manolagas S. C., 17 -Estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens Journal of Clinical Investigation 1992 89 3 883 891
65. McSheehy P. M. J., Chambers T. J., Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoclastic bone resorption Endocrinology 1986 119 4 1654 1659 (Pubitemid 17170533)
66. Kurihara N., Bertolini D., Suda T., Akiyama Y., Roodman G. D., IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release Journal of Immunology 1990 144 11 4226 4230 (Pubitemid 20187761)
67. Papanicolaou D. A., Vgontzas A. N., Interleukin-6: the endocrine cytokine Journal of Clinical Endocrinology and Metabolism 2000 85 3 1331 1333
68. Straub R. H., Hense H. W., Andus T., Schlmerich J., Riegger G. A. J., Schunkert H., Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: a population-based study Journal of Clinical Endocrinology and Metabolism 2000 85 3 1340 1344 (Pubitemid 32269398)
69. Baldwin A. S., Control of oncogenesis and cancer therapy resistance by the transcription factor NF- B Journal of Clinical Investigation 2001 107 3 241 246 (Pubitemid 32157954)
70. Maggio D., Barabani M., Pierandrei M., Polidori M. C., Catani M., Mecocci P., Senin U., Pacifici R., Cherubini A., Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study Journal of Clinical Endocrinology and Metabolism 2003 88 4 1523 1527 (Pubitemid 36623364)
71. Norazlina M., Nik-Farideh Y. M. K., Arizi A., Faisal A., Ima-Nirwana S., Effects of nicotine on bone resorbing cytokines in male rats International Medical Journal 2004 3 2 1 9
72. Awai M., Narasaki M., Yamanoi Y., Seno S., Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate A model of experimental hemochromatosis American Journal of Pathology 1976 95 3 663 673 (Pubitemid 9201266)
73. Kawabata T., Awai M., Kohno M., Generation of active oxygen species by iron nitrilotriacetate (Fe-NTA) Acta Medica Okayama 1986 40 3 163 173 (Pubitemid 16004562)
74. Carballo M., Conde M., El Bekay R., Martn-Nieto J., Camacho M. J., Monteseirn J., Conde J., Bedoya F. J., Sobrino F., Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes Journal of Biological Chemistry 1999 274 25 17580 17586
75. Visseren F. L. J., Verkerk M. S. A., Van Der Bruggen T., Marx J. J. M., Van Asbeck B. S., Diepersloot R. J. A., Iron chelation and hydroxyl radical scavenging reduce the inflammatory response of endothelial cells after infection with Chlamydia pneumoniae or influenza A European Journal of Clinical Investigation 2002 32 1 84 90
76. Hermizi H., Faizah O., Nirwana S. I., Nazrun S. A., Luke D. A., Norazlina M., Nicotine impaired bone histomorphometric parameters and bone remodeling biomarkers in SpragueDawley male rats Annals of Microscopy 2007 7 10 24
77. Ill P. O., Alexandre C., Tobacco as risk factor of osteoporosis, myth or reality? Revue du Rhumatisme 1993 60 4 280 286
78. Hoffmann D., Hoffmann I., El-Bayoumy K., The less harmful cigarette: a controversial issue. A tribute to Ernst L. Wynder Chemical Research in Toxicology 2001 14 7 767 790 (Pubitemid 32663874)
79. Broulik P. D., Rosenkrancov J., Rika P., Sedlek R., Kurcov I., The effect of chronic nicotine administration on bone mineral content and bone strength in normal and castrated male rats Hormone and Metabolic Research 2007 39 1 20 24 (Pubitemid 46535152)
80. Riesenfeld A., Growth-depressing effects of alcohol and nicotine in two strains of rats Acta Anatomica 1985 122 1 18 24 (Pubitemid 15076557)
81. Broulik P. D., Jarab J., The effect of chronic nicotine administration on bone mineral content in mice Hormone and Metabolic Research 1993 25 4 219 221 (Pubitemid 23138684)
82. Yee J. A., Yan L., Cullen D. M., Akhter M. P., Recker R. R., Nicotine inhibits osteoblast differentiation in cultures of neonatal rat calvarial cells Journal of Bone and Mineral Research 1999 14 supplement 1 S23 S29
83. Henemyre C. L., Scales D. K., Hokett S. D., Cuenin M. F., Peacock M. E., Parker M. H., Brewer P. D., Chuang A. H., Nicotine stimulates osteoclast resorption in a porcine marrow cell model Journal of Periodontology 2003 74 10 1440 1446 (Pubitemid 37461456)
84. Kamer A. R., El-Ghorab N., Marzec N., Margarone J. E., Dziak R., Nicotine induced proliferation and cytokine release in osteoblastic cells International Journal of Molecular Medicine 2006 17 1 121 127
85. Zheng L.W., Ma L. K., Cheung L. K., Effects of nicotine on mandibular distraction osteogenesis: a radiological and immunohistochemical study European Cellular Material 2007 13 supplement 2 54
86. Fang M. A., Frost P. J., Iida-Klein A., Hahn T. J., Effects of nicotine on cellular function in UMR 106-01 osteoblast-like cells Bone 1991 12 4 283 286
87. Ramp W. K., Lenz L. G., Galvin R. J. S., Nicotine inhibits collagen synthesis and alkaline phosphatase activity, but stimulates DNA synthesis in osteoblast-like cells Proceedings of the Society for Experimental Biology and Medicine 1991 197 1 36 43
88. Wetscher G. J., Bagchi M., Bagchi D., Perdikis G., Hinder P. R., Glaser K., Hinder R. A., Free radical production in nicotine treated pancreatic tissue Free Radical Biology and Medicine 1995 18 5 877 882
89. Kalpana C., Menon V. P., Protective effect of curcumin on circulatory lipid peroxidation and antioxidant status during nicotine-induced toxicity Toxicology Mechanisms and Methods 2004 14 6 339 343 (Pubitemid 39391849)
90. Crowley-Weber C. L., Dvorakova K., Crowley C., Bernstein H., Bernstein C., Garewal H., Payne C. M., Nicotine increases oxidative stress, activates NF- B and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis Chemico-Biological Interactions 2003 145 1 53 66 (Pubitemid 36246610)
91. Jimi E., Ghosh S., Role of nuclear factor- B in the immune system and bone Immunological Reviews 2005 208 80 87 (Pubitemid 41746386)
92. Maniam S., Mohamed N., Shuid A. N., Soelaiman I. N., Palm tocotrienol exerted better antioxidant activities in bone than -tocopherol Basic and Clinical Pharmacology and Toxicology 2008 103 1 55 60 (Pubitemid 351874536)
93. Yam M. L., Abdul Hafid S. R., Cheng H. M., Nesaretnam K., Tocotrienols suppress proinflammatory markers and cyclooxygenase-2 expression in RAW264.7 macrophages Lipids 2009 44 9 787 797
94. Yamamoto Y., Gaynor R. B., Therapeutic potential of inhibition of the NF- B pathway in the treatment of inflammation and cancer Journal of Clinical Investigation 2001 107 2 135 142 (Pubitemid 32096826)
95. Suarna C., Hood R. L., Dean R. T., Stocker R., Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins Biochimica et Biophysica Acta 1993 1166 2-3 163 170 (Pubitemid 23060889)