Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis

Arthritis Research and Therapy

Volumn 13, Issue 6, 2011, Pages

  Zhang, Zhongying ^a   Kakutani, Kenichiro ^a   Maeno, Koichiro ^a   Takada, Toru ^a   Yurube, Takashi ^a   Doita, Minoru ^a   Kurosaka, Masahiro ^a   Nishida, Kotaro ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; COLLAGEN TYPE 2; MESSENGER RNA; PROTEIN P53; SIRTUIN 1; TRANSCRIPTION FACTOR SOX9; SIRT1 PROTEIN, HUMAN; SOX9 PROTEIN, HUMAN;

ACETYLATION; ADOLESCENT; ADULT; AGED; ARTICLE; CARTILAGE CELL; CELL COUNT; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; DEACETYLATION; EXTRACELLULAR MATRIX; FEMALE; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IDIOPATHIC SCOLIOSIS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISC CELL; INTERVERTEBRAL DISK; LUMBAR DISK HERNIA; MALE; MONOLAYER CULTURE; NUCLEOTIDE SEQUENCE; NUCLEUS PULPOSUS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; VERTEBRAL CANAL STENOSIS; WESTERN BLOTTING; CELL CULTURE; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; INTERVERTEBRAL DISK HERNIA; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; SCOLIOSIS;

ADOLESCENT; ADULT; AGED; AGGRECANS; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN TYPE II; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; HOMEOSTASIS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DISPLACEMENT; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCOLIOSIS; SIRTUIN 1; SOX9 TRANSCRIPTION FACTOR; SPINAL STENOSIS; TRANSFECTION; YOUNG ADULT;

EID: 84855577865     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3533     Document Type: Article

References (42)

1. Andersson GB. Epidemiological features of chronic low-back pain. Lancet 1999, 354:581-585. 10.1016/S0140-6736(99)01312-4, 10470716.
2. Luoma K, Riihimaki H, Luukkonen R, Raininko R, Viikari-Juntura E, Lamminen A. Low back pain in relation to lumbar disc degeneration. Spine (Phila Pa 1976) 2000, 25:487-492.
3. Holm S, Maroudas A, Urban JP, Selstam G, Nachemson A. Nutrition of the intervertebral disc: solute transport and metabolism. Connect Tissue Res 1981, 8:101-119. 10.3109/03008208109152130, 6453689.
4. Diamant B, Karlsson J, Nachemson A. Correlation between lactate levels and pH in discs of patients with lumbar rhizopathies. Experientia 1968, 24:1195-1196. 10.1007/BF02146615, 5703005.
5. Nachemson A. Intradiscal measurements of pH in patients with lumbar rhizopathies. Acta Orthop Scand 1969, 40:23-42. 10.3109/17453676908989482, 4312806.
6. Zhao CQ, Wang LM, Jiang LS, Dai LY. The cell biology of intervertebral disc aging and degeneration. Ageing Res Rev 2007, 6:247-261. 10.1016/j.arr.2007.08.001, 17870673.
7. Osada R, Ohshima H, Ishihara H, Yudoh K, Sakai K, Matsui H, Tsuji H. Autocrine/paracrine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs. J Orthop Res 1996, 14:690-699. 10.1002/jor.1100140503, 8893760.
8. Thompson JP, Oegema TJ, Bradford DS. Stimulation of mature canine intervertebral disc by growth factors. Spine 1991, 16:253-260. 10.1097/00007632-199103000-00001, 2028297.
9. Le Maitre CL, Hoyland JA, Freemont AJ. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile. Arthritis Res Ther 2007, 9:R77. 10.1186/ar2275, 2206382, 17688691.
10. Burke JG, Watson RW, Conhyea D, McCormack D, Dowling FE, Walsh MG, Fitzpatrick JM. Human nucleus pulposus can respond to a pro-inflammatory stimulus. Spine 2003, 28:2685-2693. 10.1097/01.BRS.0000103341.45133.F3, 14673370.
11. Ishii T, Tsuji H, Sano A, Katoh Y, Matsui H, Terahata N. Histochemical and ultrastructural observations on brown degeneration of human intervertebral disc. J Orthop Res 1991, 9:78-90. 10.1002/jor.1100090111, 1984052.
12. Thompson JP, Pearce RH, Schechter MT, Adams ME, Tsang IK, Bishop PB. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine (Phila Pa 1976) 1990, 15:411-415.
13. Urban JP, Smith S, Fairbank JC. Nutrition of the intervertebral disc. Spine (Phila Pa 1976) 2004, 29:2700-2709.
14. Roberts S, Urban JP, Evans H, Eisenstein SM. Transport properties of the human cartilage endplate in relation to its composition and calcification. Spine (Phila Pa 1976) 1996, 21:415-420.
15. Urban MR, Fairbank JC, Etherington PJ, Loh FL, Winlove CP, Urban JP. Electrochemical measurement of transport into scoliotic intervertebral discs in vivo using nitrous oxide as a tracer. Spine (Phila Pa 1976) 2001, 26:984-990.
16. Kauppila LI. Prevalence of stenotic changes in arteries supplying the lumbar spine. A postmortem angiographic study on 140 subjects. Ann Rheum Dis 1997, 56:591-595. 10.1136/ard.56.10.591, 1752265, 9389219.
17. Zeng L, Chen R, Liang F, Tsuchiya H, Murai H, Nakahashi T, Iwai K, Takahashi T, Kanda T, Morimoto S. Silent information regulator, Sirtuin 1, and age-related diseases. Geriatr Gerontol Int 2009, 9:7-15. 10.1111/j.1447-0594.2008.00504.x, 19260974.
18. Dali-Youcef N, Lagouge M, Froelich S, Koehl C, Schoonjans K, Auwerx J. Sirtuins: the 'magnificent seven', function, metabolism and longevity. Ann Med 2007, 39:335-345. 10.1080/07853890701408194, 17701476.
19. Kim EJ, Um SJ. SIRT1: roles in aging and cancer. BMB Rep 2008, 41:751-756. 10.5483/BMBRep.2008.41.11.751, 19017485.
20. Takayama K, Ishida K, Matsushita T, Fujita N, Hayashi S, Sasaki K, Tei K, Kubo S, Matsumoto T, Fujioka H, Kurosaka M, Kuroda R. SIRT1 regulation of apoptosis of human chondrocytes. Arthritis Rheum 2009, 60:2731-2740. 10.1002/art.24864, 19714620.
21. Gagarina V, Gabay O, Dvir-Ginzberg M, Lee EJ, Brady JK, Quon MJ, Hall DJ. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. Arthritis Rheum 2010, 62:1383-1392. 2923474, 20131294.
22. Dvir-Ginzberg M, Gagarina V, Lee EJ, Hall DJ. Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. J Biol Chem 2008, 283:36300-36310. 10.1074/jbc.M803196200, 2605985, 18957417.
23. Kwon HS, Ott M. The ups and downs of SIRT1. Trends Biochem Sci 2008, 33:517-525. 10.1016/j.tibs.2008.08.001, 18805010.
24. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976) 2001, 26:1873-1878.
25. Sakai D, Nakai T, Mochida J, Alini M, Grad S. Differential phenotype of intervertebral disc cells: microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus. Spine (Phila Pa 1976) 2009, 34:1448-1456.
26. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262, 11846609.
27. ImageJ. , http://rsbweb.nih.gov/ij/
28. Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF, Sadoshima J. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 2007, 100:1512-1521. 10.1161/01.RES.0000267723.65696.4a, 17446436.
29. Li J, Wang E, Rinaldo F, Datta K. Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway. Oncogene 2005, 24:5510-5520. 10.1038/sj.onc.1208693, 15897888.
30. Chong ZZ, Lin SH, Li F, Maiese K. The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated 'anti-apoptotic' pathways. Curr Neurovasc Res 2005, 2:271-285. 10.2174/156720205774322584, 1986682, 16181120.
31. Li Y, Xu W, McBurney MW, Longo VD. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab 2008, 8:38-48. 10.1016/j.cmet.2008.05.004, 2822839, 18590691.
32. Fujita N, Matsushita T, Ishida K, Kubo S, Matsumoto T, Takayama K, Kurosaka M, Kuroda R. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. J Orthop Res 2011, 29:511-515. 10.1002/jor.21284, 21337390.
33. Lee RB, Urban JP. Evidence for a negative Pasteur effect in articular cartilage. Biochem J 1997, 321:95-102. 1218041, 9003406.
34. Ishihara H, Urban JP. Effects of low oxygen concentrations and metabolic inhibitors on proteoglycan and protein synthesis rates in the intervertebral disc. J Orthop Res 1999, 17:829-835. 10.1002/jor.1100170607, 10632449.
35. Urban JP. The role of the physicochemical environment in determining disc cell behaviour. Biochem Soc Trans 2002, 30(Pt 6):858-864.
36. Miller JA, Schmatz C, Schultz AB. Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens. Spine (Phila Pa 1976) 1988, 13:173-178.
37. Sowa G, Vadala G, Studer R, Kompel J, Iucu C, Georgescu H, Gilbertson L, Kang J. Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression. Spine (Phila Pa 1976) 2008, 33:1821-1828.
38. Kauppila LI. Ingrowth of blood vessels in disc degeneration. Angiographic and histological studies of cadaveric spines. J Bone Joint Surg Am 1995, 77:26-31.
39. Masuda K, Oegema TR, An HS. Growth factors and treatment of intervertebral disc degeneration. Spine (Phila Pa 1976) 2004, 29:2757-2769.
40. Sakai D, Mochida J, Yamamoto Y, Nomura T, Okuma M, Nishimura K, Nakai T, Ando K, Hotta T. Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration. Biomaterials 2003, 24:3531-3541. 10.1016/S0142-9612(03)00222-9, 12809782.
41. Boos N, Weissbach S, Rohrbach H, Weiler C, Spratt KF, Nerlich AG. Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine (Phila Pa 1976) 2002, 27:2631-2644.
42. Sudo H, Minami A. Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration in rabbits. Arthritis Rheum 2011, 63:1648-1657. 10.1002/art.30251, 21305515.