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Volumn 32, Issue 2, 2012, Pages 279-286

Growth hormone, dehydroepiandrosterone and adiponectin levels in non-alcoholic steatohepatitis: An endocrine signature for advanced fibrosis in obese patients

Author keywords

Adiponectin; Fibrosis; Growth hormone; NASH

Indexed keywords

ADIPONECTIN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C PEPTIDE; C REACTIVE PROTEIN; CYTOKERATIN 18; GROWTH HORMONE; INTERLEUKIN 6; LEPTIN; PRASTERONE; RESISTIN; SOMATOMEDIN C; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

EID: 84855554342     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2011.02637.x     Document Type: Article
Times cited : (52)

References (46)
  • 1
    • 33747517955 scopus 로고    scopus 로고
    • The epidemiology of nonalcoholic fatty liver disease in adults
    • Clark JM. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol 2006; 40: S5-10.
    • (2006) J Clin Gastroenterol , vol.40
    • Clark, J.M.1
  • 2
    • 11144264156 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a review of current understanding and future impact
    • Charlton M. Nonalcoholic fatty liver disease: a review of current understanding and future impact. Clin Gastroenterol Hepatol 2004; 2: 1048-58.
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 1048-1058
    • Charlton, M.1
  • 3
    • 0345491544 scopus 로고    scopus 로고
    • Metabolic effects of growth hormone therapy in an Alstrom syndrome patient
    • Tai TS, Lin SY, Sheu WH. Metabolic effects of growth hormone therapy in an Alstrom syndrome patient. Horm Res 2003; 60: 297-301.
    • (2003) Horm Res , vol.60 , pp. 297-301
    • Tai, T.S.1    Lin, S.Y.2    Sheu, W.H.3
  • 4
    • 1842480297 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction
    • Adams LA, Feldstein A, Lindor KD, Angulo P. Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction. Hepatology 2004; 39: 909-14.
    • (2004) Hepatology , vol.39 , pp. 909-914
    • Adams, L.A.1    Feldstein, A.2    Lindor, K.D.3    Angulo, P.4
  • 5
    • 0028953083 scopus 로고
    • Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects
    • Rasmussen MH, Hvidberg A, Juul A, et al. Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects. J Clin Endocrinol Metab 1995; 80: 1407-15.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1407-1415
    • Rasmussen, M.H.1    Hvidberg, A.2    Juul, A.3
  • 6
    • 0037162116 scopus 로고    scopus 로고
    • Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery
    • Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002; 346: 1623-30.
    • (2002) N Engl J Med , vol.346 , pp. 1623-1630
    • Cummings, D.E.1    Weigle, D.S.2    Frayo, R.S.3
  • 7
    • 25444485682 scopus 로고    scopus 로고
    • Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression
    • Beyea JA, Olson DM, Harvey S. Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression. Dev Dyn 2005; 234: 404-12.
    • (2005) Dev Dyn , vol.234 , pp. 404-412
    • Beyea, J.A.1    Olson, D.M.2    Harvey, S.3
  • 8
    • 33646815305 scopus 로고    scopus 로고
    • Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function
    • Luque RM, Kineman RD. Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology 2006; 147: 2754-63.
    • (2006) Endocrinology , vol.147 , pp. 2754-2763
    • Luque, R.M.1    Kineman, R.D.2
  • 9
    • 0034456568 scopus 로고    scopus 로고
    • Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans
    • Katz A, Nambi SS, Mather K, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000; 85: 2402-10.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2402-2410
    • Katz, A.1    Nambi, S.S.2    Mather, K.3
  • 11
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference
    • Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003; 37: 1202-19.
    • (2003) Hepatology , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 12
    • 0038460302 scopus 로고    scopus 로고
    • The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report
    • Chobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289: 2560-72.
    • (2003) JAMA , vol.289 , pp. 2560-2572
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3
  • 13
    • 0842277242 scopus 로고    scopus 로고
    • Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition
    • Grundy SM, Brewer HB, Jr., Cleeman JI, Smith SC, Jr., Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004; 109: 433-8.
    • (2004) Circulation , vol.109 , pp. 433-438
    • Grundy, S.M.1    Brewer Jr., H.B.2    Cleeman, J.I.3    Smith Jr., S.C.4    Lenfant, C.5
  • 14
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: a population-based cohort study
    • Adams LA, Lymp JF, St Sauver J, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005; 129: 113-21.
    • (2005) Gastroenterology , vol.129 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St Sauver, J.3
  • 15
    • 33644636469 scopus 로고    scopus 로고
    • Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis
    • Musso G, Gambino R, Biroli G, et al. Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2005; 100: 2438-46.
    • (2005) Am J Gastroenterol , vol.100 , pp. 2438-2446
    • Musso, G.1    Gambino, R.2    Biroli, G.3
  • 16
    • 20944450486 scopus 로고    scopus 로고
    • Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms
    • Bugianesi E, Gastaldelli A, Vanni E, et al. Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia 2005; 48: 634-42.
    • (2005) Diabetologia , vol.48 , pp. 634-642
    • Bugianesi, E.1    Gastaldelli, A.2    Vanni, E.3
  • 17
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006; 44: 27-33.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3    Lopez, A.R.4    McCullough, A.J.5    Feldstein, A.E.6
  • 18
    • 55149102644 scopus 로고    scopus 로고
    • Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients
    • Diab DL, Yerian L, Schauer P, et al. Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients. Clin Gastroenterol Hepatol 2008; 6: 1249-54.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1249-1254
    • Diab, D.L.1    Yerian, L.2    Schauer, P.3
  • 19
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two "hits"? [editorial].
    • Day CP, James OF. Steatohepatitis: a tale of two "hits"? [editorial]. Gastroenterology 1998; 114: 842-5.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 20
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt M, Franzen LE, Mathiesen UL, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006; 44: 865-73.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3
  • 21
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • erratum appears in Hepatology 2003 Aug;38:536
    • Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome [erratum appears in Hepatology 2003 Aug;38(2):536]. Hepatology 2003; 37: 917-23.
    • (2003) Hepatology , vol.37 , Issue.2 , pp. 917-923
    • Marchesini, G.1    Bugianesi, E.2    Forlani, G.3
  • 22
    • 39549088317 scopus 로고    scopus 로고
    • Low circulating levels of dehydroepiandrosterone in histologically advanced nonalcoholic fatty liver disease
    • Charlton M, Angulo P, Chalasani N, et al. Low circulating levels of dehydroepiandrosterone in histologically advanced nonalcoholic fatty liver disease. Hepatology 2008; 47: 484-92.
    • (2008) Hepatology , vol.47 , pp. 484-492
    • Charlton, M.1    Angulo, P.2    Chalasani, N.3
  • 23
    • 0034060289 scopus 로고    scopus 로고
    • Influence of dehydroepiandrosterone on platelet aggregation, superoxide dismutase activity and serum lipid peroxide concentrations in rabbits with induced hypercholesterolemia
    • Bednarek-Tupikowska G, Gosk I, Szuba A, et al. Influence of dehydroepiandrosterone on platelet aggregation, superoxide dismutase activity and serum lipid peroxide concentrations in rabbits with induced hypercholesterolemia. Med Sci Monit 2000; 6: 40-5.
    • (2000) Med Sci Monit , vol.6 , pp. 40-45
    • Bednarek-Tupikowska, G.1    Gosk, I.2    Szuba, A.3
  • 24
    • 0034811158 scopus 로고    scopus 로고
    • Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women
    • Lasco A, Frisina N, Morabito N, et al. Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women. Eur J Endocrinol 2001; 145: 457-61.
    • (2001) Eur J Endocrinol , vol.145 , pp. 457-461
    • Lasco, A.1    Frisina, N.2    Morabito, N.3
  • 25
    • 14644401716 scopus 로고    scopus 로고
    • Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women
    • Dhatariya K, Bigelow ML, Nair KS. Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. Diabetes 2005; 54: 765-9.
    • (2005) Diabetes , vol.54 , pp. 765-769
    • Dhatariya, K.1    Bigelow, M.L.2    Nair, K.S.3
  • 26
    • 0032484123 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging
    • Poynter ME, Daynes RA. Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem 1998; 273: 32833-41.
    • (1998) J Biol Chem , vol.273 , pp. 32833-32841
    • Poynter, M.E.1    Daynes, R.A.2
  • 27
    • 0027507813 scopus 로고
    • Insulin sensitivity and insulin resistance in growth-hormone-deficient adults
    • Salomon F, Cuneo R, Sonksen PH. Insulin sensitivity and insulin resistance in growth-hormone-deficient adults. Horm Res 1993; 40: 34-6.
    • (1993) Horm Res , vol.40 , pp. 34-36
    • Salomon, F.1    Cuneo, R.2    Sonksen, P.H.3
  • 28
    • 0028060110 scopus 로고
    • Interactions of body fat and muscle mass with substrate concentrations and fasting insulin levels in adults with growth hormone deficiency
    • Salomon F, Cuneo RC, Umpleby AM, Sonksen PH. Interactions of body fat and muscle mass with substrate concentrations and fasting insulin levels in adults with growth hormone deficiency. Clin Sci 1994; 87: 201-6.
    • (1994) Clin Sci , vol.87 , pp. 201-206
    • Salomon, F.1    Cuneo, R.C.2    Umpleby, A.M.3    Sonksen, P.H.4
  • 29
    • 0033237712 scopus 로고    scopus 로고
    • Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by growth hormone and insulin-like growth factor: in vivo and in vitro studies
    • Moore JS, Monson JP, Kaltsas G, et al. Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by growth hormone and insulin-like growth factor: in vivo and in vitro studies. J Clin Endocrinol Metab 1999; 84: 4172-7.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 4172-4177
    • Moore, J.S.1    Monson, J.P.2    Kaltsas, G.3
  • 30
    • 34250173079 scopus 로고    scopus 로고
    • Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes
    • Hennebert O, Chalbot S, Alran S, Morfin R. Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes. J Steroid Biochem Mol Biol 2007; 104: 326-33.
    • (2007) J Steroid Biochem Mol Biol , vol.104 , pp. 326-333
    • Hennebert, O.1    Chalbot, S.2    Alran, S.3    Morfin, R.4
  • 31
    • 38449112478 scopus 로고    scopus 로고
    • Randomized trial of steroid-free induction versus corticosteroid maintenance among orthotopic liver transplant recipients with hepatitis C virus: impact on hepatic fibrosis progression at one year
    • Kato T, Gaynor JJ, Yoshida H, et al. Randomized trial of steroid-free induction versus corticosteroid maintenance among orthotopic liver transplant recipients with hepatitis C virus: impact on hepatic fibrosis progression at one year. Transplantation 2007; 84: 829-35.
    • (2007) Transplantation , vol.84 , pp. 829-835
    • Kato, T.1    Gaynor, J.J.2    Yoshida, H.3
  • 32
    • 0030841660 scopus 로고    scopus 로고
    • Effect of growth hormone on fatty liver in panhypopituitarism
    • Takano S, Kanzaki S, Sato M, Kubo T, Seino Y. Effect of growth hormone on fatty liver in panhypopituitarism. Arch Dis Child 1997; 76: 537-8.
    • (1997) Arch Dis Child , vol.76 , pp. 537-538
    • Takano, S.1    Kanzaki, S.2    Sato, M.3    Kubo, T.4    Seino, Y.5
  • 33
    • 0027143634 scopus 로고
    • Marked effects of sustained low growth hormone (GH) levels on day-to-day fuel metabolism: studies in GH-deficient patients and healthy untreated subjects
    • Jorgensen JO, Moller J, Alberti KG, et al. Marked effects of sustained low growth hormone (GH) levels on day-to-day fuel metabolism: studies in GH-deficient patients and healthy untreated subjects. J Clin Endocrinol Metab 1993; 77: 1589-96.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 1589-1596
    • Jorgensen, J.O.1    Moller, J.2    Alberti, K.G.3
  • 34
    • 0028206903 scopus 로고
    • Acute growth hormone effects on amino acid and lipid metabolism
    • Copeland KC, Nair KS. Acute growth hormone effects on amino acid and lipid metabolism. J Clinical Endocrinol Metabol 1994; 78: 1040-7.
    • (1994) J Clinical Endocrinol Metabol , vol.78 , pp. 1040-1047
    • Copeland, K.C.1    Nair, K.S.2
  • 37
    • 77954978462 scopus 로고    scopus 로고
    • Role of growth hormone, insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in development of non-alcoholic fatty liver disease
    • Ichikawa T, Nakao K, Hamasaki K, et al. Role of growth hormone, insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in development of non-alcoholic fatty liver disease. Hepatol Int 2007; 1: 287-94.
    • (2007) Hepatol Int , vol.1 , pp. 287-294
    • Ichikawa, T.1    Nakao, K.2    Hamasaki, K.3
  • 38
    • 67650733195 scopus 로고    scopus 로고
    • Adiponectin regulate growth hormone secretion via adiponectin receptor mediated Ca2+ signalling in rat somatotrophs in vitro
    • Steyn FJ, Boehme F, Vargas E, Wang K, Chen C. Adiponectin regulate growth hormone secretion via adiponectin receptor mediated Ca2+ signalling in rat somatotrophs in vitro. J Neuroendocrinol 2009; 21: 698-704.
    • (2009) J Neuroendocrinol , vol.21 , pp. 698-704
    • Steyn, F.J.1    Boehme, F.2    Vargas, E.3    Wang, K.4    Chen, C.5
  • 40
    • 21044455602 scopus 로고    scopus 로고
    • Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue
    • Nilsson L, Binart N, Bohlooly YM, et al. Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue. Biochem Biophys Res Commun 2005; 331: 1120-6.
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 1120-1126
    • Nilsson, L.1    Binart, N.2    Bohlooly, Y.M.3
  • 42
    • 36448973807 scopus 로고    scopus 로고
    • Type 2 diabetes and metabolic syndrome are associated with increased expression of 11[beta]-hydroxysteroid dehydrogenase 1 in obese subjects
    • Alberti L, Girola A, Gilardini L, et al. Type 2 diabetes and metabolic syndrome are associated with increased expression of 11[beta]-hydroxysteroid dehydrogenase 1 in obese subjects. Int J Obes 2007; 31: 1826-31.
    • (2007) Int J Obes , vol.31 , pp. 1826-1831
    • Alberti, L.1    Girola, A.2    Gilardini, L.3
  • 43
    • 33846888049 scopus 로고    scopus 로고
    • 11[beta]-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients[ast]
    • Desbriere R, Vuaroqueaux V, Achard V, et al. 11[beta]-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients[ast]. Obesity 2006; 14: 794-8.
    • (2006) Obesity , vol.14 , pp. 794-798
    • Desbriere, R.1    Vuaroqueaux, V.2    Achard, V.3
  • 44
    • 0032412523 scopus 로고    scopus 로고
    • AST/ALT ratio predicts cirrhosis in patients with chronic hepatitis C virus infection
    • Sheth SG, Flamm SL, Gordon FD, Chopra S. AST/ALT ratio predicts cirrhosis in patients with chronic hepatitis C virus infection. Am J Gastroenterol 1998; 93: 44-8.
    • (1998) Am J Gastroenterol , vol.93 , pp. 44-48
    • Sheth, S.G.1    Flamm, S.L.2    Gordon, F.D.3    Chopra, S.4
  • 45
    • 0031696864 scopus 로고    scopus 로고
    • AST/ALT ratio > or = 1 is not diagnostic of cirrhosis in patients with chronic hepatitis C
    • Reedy DW, Loo AT, Levine RA. AST/ALT ratio > or = 1 is not diagnostic of cirrhosis in patients with chronic hepatitis C. Dig Dis Sci 1998; 43: 2156-9.
    • (1998) Dig Dis Sci , vol.43 , pp. 2156-2159
    • Reedy, D.W.1    Loo, A.T.2    Levine, R.A.3
  • 46
    • 0034099413 scopus 로고    scopus 로고
    • Aspartate aminotransferase: alanine aminotransferase ratio in chronic hepatitis C infection: is it a useful predictor of cirrhosis?
    • Park GJ, Lin BP, Ngu MC, Jones DB, Katelaris PH. Aspartate aminotransferase: alanine aminotransferase ratio in chronic hepatitis C infection: is it a useful predictor of cirrhosis? J Gastroenterol Hepatol 2000; 15: 386-90.
    • (2000) J Gastroenterol Hepatol , vol.15 , pp. 386-390
    • Park, G.J.1    Lin, B.P.2    Ngu, M.C.3    Jones, D.B.4    Katelaris, P.H.5


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