Modulation of 11 β-hydroxysteroid dehydrogenase isozymes by growth hormone and insulin-like growth factor: In vivo and in vitro studies

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 11, 1999, Pages 4172-4177

  Moore, J S ^a   Monson, J P ^b   Kaltsas, G ^b   Putignano, P ^b   Wood, P J ^c   Sheppard, M C ^a   Besser, G M ^b   Taylor, N F ^d   Stewart, P M ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTISONE; HYDROCORTISONE; ISOENZYME; OCTREOTIDE; RECOMBINANT GROWTH HORMONE; RECOMBINANT SOMATOMEDIN C; TETRAHYDROCORTISOL; TETRAHYDROCORTISONE; HUMAN GROWTH HORMONE; HYDROXYSTEROID DEHYDROGENASE; SOMATOMEDIN C;

ACROMEGALY; ADIPOCYTE; ADULT; ARTICLE; CATALYSIS; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENETIC TRANSFECTION; GLUCOSE HOMEOSTASIS; GROWTH HORMONE DEFICIENCY; HORMONAL REGULATION; HORMONE DETERMINATION; HORMONE SUBSTITUTION; HUMAN; HUMAN CELL; HYPOPITUITARISM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; OBESITY; PRIORITY JOURNAL; TRANSSPHENOIDAL SURGERY; ADENOHYPOPHYSIS; ADIPOSE TISSUE; AGED; CELL LINE; ENZYMOLOGY; KIDNEY; METABOLISM; MIDDLE AGED; STROMA CELL;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ACROMEGALY; ADIPOSE TISSUE; ADULT; AGED; CELL DIFFERENTIATION; CELL LINE; FEMALE; HUMAN GROWTH HORMONE; HUMANS; HYDROXYSTEROID DEHYDROGENASES; INSULIN-LIKE GROWTH FACTOR I; ISOENZYMES; KIDNEY; MALE; MIDDLE AGED; OCTREOTIDE; PITUITARY GLAND, ANTERIOR; STROMAL CELLS; TETRAHYDROCORTISOL; TETRAHYDROCORTISONE;

EID: 0033237712     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.84.11.6108     Document Type: Article

References (35)

1. 11β-Hydoxysteroid dehydrogenase: Implications for clinical medicine
2. 11β-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess
3. The human gene for 11β-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization
4. Immunohistochemical localization of type 1 11β-hydroxysteroid dehydrogenase in human tissues
5. Carbenoxolone increases hepatic insulin sensitivity in man: A novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation
6. 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycaemia on obesity or stress
7. Does central obesity reflect 'Cushing's disease of the omentum?'
8. Differentiation of omental adipose stromal cells: Role of glucocorticoids and 11β-hydroxysteroid dehydrogenase
9. Localisation of 11β-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor
10. Mineralocorticoid action: Target tissue specificity is enzyme, not receptor, mediated
11. Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme
12. Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11β-hydroxysteroid dehydrogenase type 2 gene
13. Mineralocorticoid activity of liquorice: 11β-hydroxysteroid dehydrogenase deficiency comes of age
14. Mass spectrometry in the diagnosis of steroid-related disorders and hypertension research
15. Urinary free cortisone and the assessment of 11β-hydroxysteroid dehydrogenase activity in man
16. Body composition in acromegaly
17. Growth hormone and the heart
18. Clinical aspects of growth hormone deficiency in adults
19. The effect of growth hormone replacement on cortisol metabolism and glucocorticoid sensitivity in hypopituitary adults
20. The effect of growth hormone replacement therapy on cortisol-cortisone interconversion in hypopituitary adults: Evidence for growth hormone modulation of extrarenal 11β-hydroxysteroid dehydrogenase activity
21. Growth hormone replacement inhibits renal and hepatic 11β-hydroxysteroid dehydrogenases in ACTH deficient patients
22. Sexual dimorphism in 11β hydroxysteroid dehydrogenase activity and its relation to fat distribution and insulin sensitivity; a study in hypopituitary subjects
23. Localization of the growth hormone receptor, identified by immunocytochemistry, in second trimester human fetal tissues and in placenta throughout gestation
24. Localization and characterization of IGF-1 receptors in fetal and adult human kidneys
25. Human 11β-hydroxysteroid dehydrogenases studies on the stably transfected isoforms and localization of the type 2 isozyme within renal tissue
26. +-dependent enzyme and differs from the cloned 'type I' isoform
27. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principal of protein dye binding
28. A monoclonal antibody to human insulin-like growth factor-I: Characterisation, use in radioimmunoassay and effect on the biological activities of the growth factor
29. Depot long-acting somatosatin analog (Sandostatin-LAR) is an effective treatment for acromegaly
30. Clinical and biochemical response following withdrawal of a long-acting, depot injection form of octreotide (Sandostatin LAR)
31. Syndrome of apparent mineralocorticoid excess: A defect in the cortisol-cortisone shuttle
32. Apparent cortisone reductase deficiency: A unique form of hypercortisolism
33. Sexual dimorphism of hepatic 11β-hydroxysteroid dehydrogenase in the rat: The role of growth hormone patterns
34. Effect of growth hormone, insulin and dexamethasone on 11β-hydroxysteroid dehydrogenase activity on a primary culture of rat hepatocytes
35. 11β-hydroxysteroid dehydrogenase is an exclusive 11β-reductase in primary cultures of rat hepatocytes: Effect of physicochemical and hormonal manipulations