Intron 4 polymorphism of the endothelial nitric oxide synthase (eNOS) gene is associated with decreased NO production in a mercury-exposed population

Science of the Total Environment

Volumn 414, Issue , 2012, Pages 708-712

  de Marco, Katia Cristina ^a   Antunes, Lusania Maria Greggi ^a   Tanus Santos, Jose Eduardo ^a   Barbosa, Fernando ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cardiovascular diseases; Genetic polymorphisms; Mercury exposure; Nitric oxide

Indexed keywords

ARTERIAL BLOOD PRESSURE; BODY MASS INDEX; CARDIAC FREQUENCY; CARDIO-VASCULAR DISEASE; ENDOTHELIAL NITRIC-OXIDE SYNTHASE (ENOS); FISH CONSUMPTION; GENETIC POLYMORPHISMS; HEART RATES; HG CONCENTRATIONS; INTRON 4; MERCURY EXPOSURE; METHYLMERCURY; NITRITE REDUCTION; NO RELEASE; PLASMA CONCENTRATION; TANDEM REPEATS;

BLOOD; BLOOD PRESSURE; DISEASES; GENE EXPRESSION; HEALTH; MERCURY (METAL); MERCURY COMPOUNDS;

NITRIC OXIDE;

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GENOMIC DNA; METHYLMERCURY; NITRIC OXIDE;

BODY MASS; CARDIOVASCULAR DISEASE; GENE EXPRESSION; HEALTH IMPACT; MERCURY (ELEMENT); NITRIC OXIDE; POLLUTION EXPOSURE; POLYMORPHISM; PUBLIC HEALTH;

ADULT; AGED; ARTERIAL PRESSURE; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE PREDISPOSITION; FEMALE; GENE CONTROL; GENETIC POLYMORPHISM; GENETIC REGULATION; GENOTYPE; HEART RATE; HUMAN; INTRON; MALE; MERCURIALISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT TANDEM REPEAT; SYSTOLIC BLOOD PRESSURE;

AGE FACTORS; ANIMALS; BLOOD PRESSURE; BODY MASS INDEX; CARDIOVASCULAR DISEASES; FEMALE; FISHES; GENETIC PREDISPOSITION TO DISEASE; HEART RATE; HEMOGLOBINS; HUMANS; INTRONS; MALE; METHYLMERCURY COMPOUNDS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; POLYMORPHISM, GENETIC; SEAFOOD; TANDEM REPEAT SEQUENCES;

EID: 84855542284     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2011.11.010     Document Type: Article

References (47)

1. Barbosa F., Sandrim V.C., Uzuelli J.A., Gerlach R.F., Tanus-Santos J.E. eNOS genotype-dependent correlation between whole blood lead and plasma nitric oxide products concentrations. Nitric Oxide 2006, 14:58-64.
2. Barbosa F., Sertorio J., Gerlach R.F., Tanus-Santos J.E. Clinical evidence for lead-induced inhibition of nitric oxide formation. Arch Toxicol 2006, 80(12):811-816.
3. Bridges C.C., Zalups K.R. Transport of inorganic mercury and methylmercury in target tissues and organs. J Toxicol Environ Health B 2010, 13(5):385-410.
4. Casas J.P., Bautista L.E., Humphries S.E., Hingorani A.D. Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Circulation 2004, 109:1359-1365.
5. Casas J.P., Cavalleri G.L., Bautista L.E., Smeeth L., Humphries S.E., Hingorani A.D. Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review. Am J Epidemiol 2006, 164:921-935.
6. Choi A.L., Weihe P., Budtz-Jorgensen E., Jorgensen P.J., Salonen J.T., Tuomainen T.P., et al. Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men. Environ Health Perspect 2009, 17(3):367-372.
7. Dosenko V.E., Zagoriy V.Y., Haytovich N.V., Gordok O.A., Moibenko A.A. Allelic polymorphism of endothelial NO synthase gene and its functional manifestations. Acta Biochim Pol 2006, 53:299-302.
8. Ghilardi G., Biondi M.L., DeMonti M., Bernini M., Turri O., Massaro F., et al. Independent risk factor for moderate to severe internal carotid artery stenosis: T786C mutation of the endothelial nitric oxide synthase gene. Clin Chem 2002, 48:989-993.
9. Grotto D., Castro M.M., Barcelos G.R.M., Garcia S.C., Barbosa F. Low level and sub-chronic exposure to methylmercury induces hypertension in rats: nitric oxide depletion and oxidative damage as possible mechanisms. Arch Toxicol 2009, 83:653-662.
10. Guallar E., Sanz-Gallardo M.I., Van't Veer P., Bode P., Aro A., Gómez-Aracena J., et al. Mercury, fish oils, and the risk of myocardial infarction. N Engl J Med 2002, 347:1747-1754.
11. Hibi K., Ishigami T., Tamura K., Mizushima S., Nyui N., Fujita T., et al. Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction. Hypertension 1998, 32:521-526.
12. Hingorani A.D., Liang C.F., Fatibene J., Lyon A., Monteith S., Parsons A., et al. A common variant of the endothelial nitric oxide synthase (Glu298Asp) is a major risk factor for coronary artery disease in the UK. Circulation 1999, 100:1515-1520.
13. Hou L., Osei-Hyiaman D., Yu H., Ren Z., Zhang Z., Wang B., et al. Association of a 27bp repeat polymorphism in eNOS gene with ischemic stroke in Chinese population. Neurology 2001, 56(4):490-496.
14. Ichihara S., Yamada Y., Fujimura T., Nakashima N., Yokota M. Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial infarction in the Japanese population. Am J Cardiol 1998, 81:83-86.
15. Jemaa R., Kallel A., Bem A.S., Omar S., Chabrak S., Elasmi M., et al. Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with myocardial infarction in Tunisian patients. Clin Chem Lab Med 2007, 45:1476-1480.
16. Jemaa R., Bem A.S., Kallel A., Feki M., Elasmi M., Taieb S.H., et al. Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with hypertension in a Tunisian population. Clin Biochem 2009, 42:852-856.
17. Kishimoto T., Oguri T., Tada M. Effect of methylmercury (CH3HgCl) injury on nitric oxide synthase (NOS) activity in cultured human umbilical vascular endothelial cells. Toxicology 1995, 103:1-7.
18. Kleinbongard P., Dejam A., Lauer T., Rassaf T., Schindler A., Picker O., et al. Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med 2003, 35:790-796.
19. Kleinbongard P., Dejam A., Lauer T., Jax T., Kerber S., Gharini P., et al. Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Free Radic Biol Med 2006, 40:295-302.
20. Kuo T.C., Huang C.I., Lin-Shiau S.Y. Methylmercury inhibits nitric oxide production mediated by Ca(2+) overload and protein kinase A activation. Toxicology 2002, 176:113-122.
21. Marco K.C., Passos C.J.S., Sertorio J., Tanus-Santos J.E., Barbosa F. Environmental exposure to methylmercury is associated with a decrease in nitric oxide production. Basic Clin Pharmacol Toxicol 2009, 106:411-415.
22. Matyar S., Attila G., Acartqrk E., Akpinar O., Inal T. eNOS gene intron 4a/b VNTR polymorphism is a risk factor for coronary artery disease in Southern Turkey. Clin Chim Acta 2005, 354:153-158.
23. Moncada S., Palmer R.M., Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991, 43:109-142.
24. Mozaffarian D. Fish, mercury, selenium and cardiovascular risk: current evidence and unanswered questions. Int J Environ Res Public Health 2009, 6(6):1894-1916.
25. Ogawa H., Motoyama T., Saito Y., Ogawa Y., Miyamoto Y., Nakao K. T-786→C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 1999, 99:2864-2870.
26. Ou H., Shen Y.H., Utama B., Wang J., Wang X., Coselli J., et al. Effect of nuclear actin on endothelial nitric oxide synthase expression. Arterioscler Thromb Vasc Biol 2005, 25:2509-2514.
27. Palmer C.D., Lewis M.E., Geraghtya C.M., Barbosa F., Parsons P.J. Determination of lead, cadmium and mercury in blood for assessment of environmental exposure: a comparison between inductively coupled plasma-mass spectrometry and atomic absorption spectrometry. Spectrochim Acta B 2006, 61:980-990.
28. Patkar S., Charita B.H., Ramesh C., Padma T. High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene. Indian J Hum Genet 2009, 15(2):49-53.
29. Salonen J.T., Seppänen K., Nyyssönen K., Korpela H., Kauhanen J., Kantola M., et al. Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men. Circulation 1995, 91(3):645-655.
30. Salonen J.T., Seppanen K., Lakka T.A., Salonen R., Kaplan G.A. Mercury accumulation and accelerated progression of carotid atherosclerosis: a population based prospective 4-year follow-up study in men in eastern Finland. Atherosclerosis 2000, 148(2):265-273.
31. Senthil D., Raveendran M., Shen Y.H., Utama B., Dudley D., Wang J., et al. Genotype-dependent expression of endothelial nitric oxide synthase (eNOS) and its regulatory proteins in cultured endothelial cells. DNA Cell Biol 2005, 24:218-224.
32. Sing C.F., Stengard J.H., Kardia S.L. Genes, environment, and cardiovascular disease. Arterioscler Thromb Vasc Biol 2003, 23(7):1190-1196.
33. Stern A.H. A review of the studies of the cardiovascular health effects of methylmercury with consideration of their suitability for risk assessment. Environ Res 2005, 98:133-142.
34. Tanus-Santos J.E., Desai M., Flockhart D.A. Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants. Pharmacogenetics 2001, 11:719-725.
35. Tsukada T., Yokoyama K., Arai T., Takemoto F., Hara S., Yamada A., et al. Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Biochem Biophys Res Commun 1998, 245:190-193.
36. Uwabo J., Soma M., Nakayama T., Kanmatsuse K. Association of a variable number of tandem repeats in the endothelial constitutive nitric oxide synthase gene with essential hypertension in Japanese. Am J Hypertens 1998, 11:125-128.
37. Virtanen J.K., Voutilainen S., Rissanen T.H., Mursu J., Tuomainen T.P., Korhonen M.J., et al. Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland. Arterioscler Thromb Vasc Biol 2005, 25:228-233.
38. Wang Y., Marsden P.A. Nitric oxide synthase: biochemical and molecular regulation. Curr Opin Nephrol Hypertens 1995, 4:12-22.
39. Wang X.L., Sim A.S., Badenhop R.F., McCredie R.M., Wilcken D.E. A smoking dependant risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat Med 1996, 2:41-45.
40. Wang X.L., Sim A.S., Wang M.X., Murrell G.A., Trudinger B., Wang J. Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity. FEBS Lett 2000, 471(1):45-50.
41. Wang J., Dudley D., Wang X.L. Haplotype specifc effects on endothelial nitric oxide synthase promoter efficiency: modifiable by cigarette smoking. Arterioscler Thromb Vasc Biol 2002, 22:1-4.
42. Yao S.K., Ober J.C., Krishnaswami A., Ferguson J.J., Anderson V., Golino P., et al. Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium injured arteries. Circulation 1992, 86:1302-1309.
43. Yoshimura M., Yasue H., Nakayama M., Shimasaki Y., Sumida H., Sugiyama S., et al. A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. Hum Genet 1998, 103:65-69.
44. Yoshimura M., Yasue H., Nakayama M., Shimasaki Y., Ogawa H., Kugiyama K., et al. Genetic risk factors for coronary artery spasm; significance of endothelial nitric oxide synthase gene T-786→C and missense Glu298Asp variants. J Invest Med 2000, 48:367-374.
45. Zhang M.X., Ou H., Shen Y.H., Wang J., Coselli J., Wang X.L. Regulation of endothelial nitric oxide synthase by small RNA. Proc Natl Acad Sci USA 2005, 102:16967-16972.
46. Zhang M.X., Zhang C., Shen Y.H., Wang J., Li X.N., Chen L., et al. Effect of 27nt small RNA on endothelial nitric-oxide synthase expression. Mol Biol Cell 2007, 19:3997-4005.
47. Zhang M.X., Zhang C., Shen Y.H., Wang J., Li X.N., Zhang Y., et al. Biogenesis of short intronic repeat 27-nucleotide small RNA from endothelial nitric-oxide synthase gene. J Biol Chem 2008, 283(21):14685-14693.