Explanting is an ex vivo model of renal epithelial-mesenchymal transition

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Winbanks, Catherine E ^a,b   Darby, Ian A ^b   Kelynack, Kristen J ^a   Pouniotis, Dodie ^b   Becker, Gavin J ^a,c   Hewitson, Tim D ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b RMIT UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CYTOKERATIN; DESMIN; GELATIN; LECTIN; RECA PROTEIN; VIMENTIN; BIOLOGICAL MARKER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL STRUCTURE; EPITHELIAL MESENCHYMAL TRANSITION; EX VIVO STUDY; EXPLANT; IMMUNOCYTOCHEMISTRY; KIDNEY CELL; KIDNEY FUNCTION; KIDNEY PARENCHYMA; KIDNEY PROXIMAL TUBULE; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; RAT; VALIDATION STUDY; ANIMAL; CELL DIFFERENTIATION; CELL PROLIFERATION; CULTURE TECHNIQUE; CYTOLOGY; ENDOTHELIUM CELL; EPITHELIUM CELL; IMMUNOCHEMISTRY; KIDNEY; MESENCHYMAL STEM CELL; METABOLISM; METHODOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; STAINING;

RATTUS;

ANIMALS; BIOLOGICAL MARKERS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; ENDOTHELIAL CELLS; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; IMMUNOCHEMISTRY; KIDNEY; KIDNEY TUBULES, PROXIMAL; MESENCHYMAL STEM CELLS; MYOFIBROBLASTS; PHENOTYPE; RATS; RATS, SPRAGUE-DAWLEY; STAINING AND LABELING;

EID: 84855523893     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/212819     Document Type: Article

References (32)

1. Eddy A. A., Progression in chronic kidney disease Advances in Chronic Kidney Disease 2005 12 4 353 365 (Pubitemid 41376493)
2. Hewitson T. D., Renal tubulointerstitial fibrosis: common but never simple American Journal of Physiology 2009 296 6 F1239 F1244
3. Darby I., Skalli O., Gabbiani G., -Smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing Laboratory Investigation 1990 63 1 21 29 (Pubitemid 20234670)
4. Hewitson T. D., Becker G. J., Interstitial myofibroblasts in IgA glomerulonephritis American Journal of Nephrology 1995 15 2 111 117
5. Iwano M., Fischer A., Okada H., Plieth D., Xue C., Danoff T. M., Neilson E. G., Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts Molecular Therapy 2001 3 2 149 159 (Pubitemid 32509817)
6. Liu Y., New insights into epithelial-mesenchymal transition in kidney fibrosis Journal of the American Society of Nephrology 2010 21 2 212 222
7. Iwano M., Plieth D., Danoff T. M., Xue C., Okada H., Neilson E. G., Evidence that fibroblasts derive from epithelium during tissue fibrosis Journal of Clinical Investigation 2002 110 3 341 350 (Pubitemid 34847966)
8. Jinde K., Nikolic-Paterson D. J., Huang X. R., Sakai H., Kurokawa K., Atkins R. C., Lan H. Y., Tubular phenotypic change in progressive tubulointerstitial fibrosis in human glomerulonephritis American Journal of Kidney Diseases 2001 38 4 761 769
9. Ng Y. Y., Huang T. P., Yang W. C., Chen Z. P., Yang A. H., Mu W., Nikolic- Paterson D. J., Atkins R. C., Lan H. Y., Tubular epithelial- myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats Kidney International 1998 54 3 864 876 (Pubitemid 28397404)
10. Quaggin S. E., Kapus A., Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition Kidney International 2011 80 1 41 50
11. Zeisberg M., Duffield J. S., Resolved: EMT produces fibroblasts in the kidney Journal of the American Society of Nephrology 2010 21 8 1247 1253
12. Humphreys B. D., Lin S. L., Kobayashi A., Hudson T. E., Nowlin B. T., Bonventre J. V., Valerius M. T., McMahon A. P., Duffield J. S., Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis American Journal of Pathology 2010 176 1 85 97
13. Thiery J. P., Sleeman J. P., Complex networks orchestrate epithelial-mesenchymal transitions Nature Reviews Molecular Cell Biology 2006 7 2 131 142 (Pubitemid 43278296)
14. Prindull G., Zipori D., Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm Blood 2004 103 8 2892 2899 (Pubitemid 38451657)
15. Hewitson T. D., Tait M. G., Kelynack K. J., Martic M., Becker G. J., Dipyridamole inhibits in vitro renal fibroblast proliferation and collagen synthesis Journal of Laboratory and Clinical Medicine 2002 140 3 199 208
16. Hewitson T. D., Kelynack K. J., Tait M. G., Martic M., Jones C. L., Margolin S. B., Becker G. J., Pirfenidone reduces in vitro rat renal fibroblast activation and mitogenesis Journal of Nephrology 2001 14 6 453 460 (Pubitemid 34168279)
17. Silva F. G., Nadasdy T., Laszik Z., Immunohistochemical and lectin dissection of the human nephron in health and disease Archives of Pathology and Laboratory Medicine 1993 117 12 1233 1239 (Pubitemid 24005835)
18. Truong L. D., Phung V. T., Yoshikawa Y., Mattioli C. A., Glycoconjugates in normal human kidney. A histochemical study using 13 biotinylated lectins Histochemistry 1988 90 1 51 60
19. Wong S. E., Winbanks C. E., Samuel C. S., Hewitson T. D., Lectin histochemistry for light and electron microscopy Methods in Molecular Biology 2010 611 103 114
20. Lee J. M., Dedhar S., Kalluri R., Thompson E. W., The epithelial-mesenchymal transition: new insights in signaling, development, and disease Journal of Cell Biology 2006 172 7 973 981
21. Khew-Goodall Y., Wadham C., A perspective on regulation of cell-cell adhesion and epithelial- mesenchymal transition: known and novel Cells Tissues Organs 2005 179 1-2 81 86 (Pubitemid 40976292)
22. Gupta I. R., Lapointe M., Yu O. H., Morphogenesis during mouse embryonic kidney explant culture Kidney International 2003 63 1 365 376 (Pubitemid 35463943)
23. Boyer B., Tucker G. C., Valles A. M., Franke W. W., Thiery J. P., Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells Journal of Cell Biology 1989 109 4 1495 1509 (Pubitemid 19251206)
24. Hinz B., Phan S. H., Thannickal V. J., Galli A., Bochaton-Piallat M. L., Gabbiani G., The myofibroblast: one function, multiple origins American Journal of Pathology 2007 170 6 1807 1816 (Pubitemid 47339255)
25. Yang J., Liu Y., Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis American Journal of Pathology 2001 159 4 1465 1475 (Pubitemid 32947976)
26. Dwivedi D. J., Pino G., Banh A., Nathu Z., Howchin D., Margetts P., Sivak J. G., West-Mays J. A., Matrix metalloproteinase inhibitors suppress transforming growth factor- -induced subcapsular cataract formation American Journal of Pathology 2006 168 1 69 79 (Pubitemid 43062560)
27. Masszi A., Fan L., Rosivall L., McCulloch C. A., Rotstein O. D., Mucsi I., Kapus A., Integrity of cell-cell contacts is a critical regulator of TGF- 1-induced epithelial-to-myofibroblast transition: role for -catenin American Journal of Pathology 2004 165 6 1955 1967 (Pubitemid 39578374)
28. Masszi A., Speight P., Charbonney E., Lodyga M., Nakano H., Szszi K., Kapus A., Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3 Journal of Cell Biology 2010 188 3 383 399
29. Baer P. C., Tunn U. W., Nunez G., Scherberich J. E., Geiger H., Transdifferentiation of distal but not proximal tubular epithelial cells from human kidney in culture Experimental Nephrology 1999 7 4 306 313 (Pubitemid 29361670)
30. Oldfield M. D., Bach L. A., Forbes J. M., Nikolic-Paterson D., McRobert A., Thallas V., Atkins R. C., Osicka T., Jerums G., Cooper M. E., Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE) Journal of Clinical Investigation 2001 108 12 1853 1863 (Pubitemid 34015131)
31. Copeland J. W. G. V., Beaumont B. W., Merrilees M. J., Pilmore H. L., Epithelial-to-mesenchymal transition of human proximal tubular epithelial cells: effects of rapamycin, mycophenolate, cyclosporin, azathioprine, and methylprednisolone Transplantation 2007 83 6 809 814 (Pubitemid 46569201)
32. Butt M. J., Tarantal A. F., Jimenez D. F., Matsell D. G., Collecting duct epithelial-mesenchymal transition in fetal urinary tract obstruction Kidney International 2007 72 8 936 944 (Pubitemid 47530573)