Transdifferentiation of distal but not proximal tubular epithelial cells from human kidney in culture

Experimental Nephrology

Volumn 7, Issue 4, 1999, Pages 306-313

  Baer, Patrick C ^a   Tunn, Ulf W ^b   Nunez, German ^b   Scherberich, Jürgen E ^c   Geiger, Helmut ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Academic Hospital   (Germany)

^c Hospital Mu nchen Harlaching   (Germany)

Author keywords

Dedifferentiation; Distal tubular cells; Human kidney; Phenotypic alterations; Proximal tubular cells; Transdifferentiation

Indexed keywords

CYTOKERATIN; VIMENTIN;

ANTIGEN EXPRESSION; ANTIGENICITY; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL POPULATION; ENZYME ACTIVITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; KIDNEY TUBULE EPITHELIUM; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0032779204     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: 10.1159/000020618     Document Type: Article

References (32)

1. Nath KA: Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 1992;20:1-17.
2. Frank J, Engler-Blum G, Rodemann HP, Müller GA: Human renal tubular cells as a cytokine source: PDGF-β, GM-CSF and IL-6 mRNA expression in vitro. Exp Nephrol 1993;1:26-35.
3. Boswell RN, Yard BA, Schrama E, van Es LA, Daha MR, van der Woude FJ: Interleukin 6 production by human proximal tubular epithelial cells in vitro: Analysis of effects of interleukin 1α and other cytokines. Nephrol Dial Transplant 1994;9:599-606.
4. Wuthrich RP, Glimcher LH, Yui MA, Jevnikar AM, Dumas SE, Kelley YE: Generation of highly differentiated murine renal tubular epithelial cell lines: MHC II regulation, antigen presentation and tumor necrosis factor production. Kidney Int 1994;37:783-792.
5. Baer PC, Nockher WA, Haase W, Scherberich JE: Isolation of proximal and distal tubule cells from human kidney by immunomagnetic separation. Kidney Int 1997;52:1321-1331.
6. Scherberich JE, Wolf G: Disintegration and recovery of kidney membrane proteins: Consequence of acute and chronic renal failure. Kidney Int 1994;46(suppl 47):52-57.
7. Wilson PD, Dillingham MA, Breckon R, Anderson RJ: Defined human renal tubular epithelia in culture: Growth, characterization, and hormonal response. Am J Physiol 1985;248: F436-F443.
8. Sikri KL, Foster CL, Machugh C, Marshall RD: Localization of Tamm-Horsfall glycoprotein in the human kidney using immunofluorescence and immuno-electron microscopical techniques. J Anat 1982;132:597-605.
9. Fischer P, Scherberich JE, Schoeppe W: Comparative biochemical and immunological studies on gamma-glutamyltransferases from human kidney and renal cell carcinoma applying monoclonal antibodies. Clin Chim Acta 1990; 191:185-200.
10. Miltenyi S, Müller W, Weichel W, Radbruch A: High gradient magnetic cell separation with MACS. Cytometry 1989;11:231-238.
11. Helbert M, De Meester I, Scherberich JE, Nouwen E, De Broe M: Adenosine deaminase complcxing protein (ADCP) is expressed on both human proximal and distal tubular epithelial cells in vitro (abstract). Nephrol Dial Transplant 1996;11:29.
12. Morimoto C, Schlossmann SF: CD26: A key costimulatory molecule on CD4 memory T cells. Immunologist 1994;2:4-7.
13. Van Det N, Van Den Born J, Tamsma J, Verhagen N, Berden J, Daha M, Van Der Woude F: Effects of high glucose on the production of heparan sulfate proteoglycan by mesangial and epithelial cells. Kidney Int 1991;49:1079-1089.
14. Ziyadeh FN, Snipes ER, Watanabe M, Alvarez RJ, Goldfarb S, Haverty TP: High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule. Am J Physiol 1990;259:F704-F714.
15. Eguchi G, Kodama R: Transdifferentiation. Curr Opin Cell Biol 1993;5:1023-1028.
16. Strutz F: The fibroblast - a (trans-)differentiated cell? Nephrol Dial Transplant 1995;10: 1504-1506.
17. Lipton BH, Bensch KG, Karasek MA: Microvascular endothelial cell transdifferentiation: Phenotypic alterations. Differentiation 1991; 46:117-133.
18. Lipton BH, Bensch KG, Karasek MA: Histamine-modulated transdifferentiation of dermal microvascular endothelial cells. Exp Cell Res 1992;199:279-291.
19. Watt F: Cell culture models of differentiation. FASEB J 1991;5:287-294.
20. Minuth WW, Steiner P, Strehl R, Kloth S, Taue M: Electrolyte environment modulates differentiation in embryonic renal collecting duct epithelia. Exp Nephrol 1997;5:414-422.
21. Handler JS: Studies of kidney cells in culture. Kidney Int 1986;30:208-215.
22. Koechlin N, Pisam M, Poujeol P, Tauc M, Rambourg A: Conversion of a rabbit proximal convoluted tubule (PCT) into a cell monolayer: Ultrastructural study of cell dedifferentiation and redifferentiation. Eur J Cell Biol 1991;54: 224-236.
23. Hay ED: Extracellular matrix alters epithelial differentiation. Curr Opin Cell Biol 1993;5: 1029-1035.
24. Triffilis A, Del Valle P, Lipsky M, Cui X, Kane A: Cultured rabbit renal proximal straight tubular cells are more susceptible to mercuric chloride than convoluted tubular cells (abstract). FASEB J 1997;11:460.
25. Lash LH, Tokarz JJ: Oxidative stress in isolated rat renal proximal and distal tubular cells. Am J Physiol 1990;259:F338-F347.
26. Bacallao R: The role of the cytoskcleton in renal development. Semin Nephrol 1995;15: 285-290.
27. Wallin A, Zhang G, Jones TW, Jaken S, Stevens JL: Mechanisms of the nephrogenic repair response. Lab Invest 1992;66:474-484.
28. Zhu MQ, De Broc ME, Nouwen EJ: Vimentin expression and distal tubular damage in the rat kidney. Exp Nephrol 1996;4:172-183.
29. Gröne HJ, Weber K, Gröne E, Helmchen U, Osborn M: Coexprcssion of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney. Am J Pathol 1987;129: 1-8.
30. Nouwen EJ, Versteppen WA, Buyssens N, Zhu MQ, De Broc ME: Hyperplasia, hypertrophy, and phenotypic alterations in the distal nephron after acute proximal injury in the rat. Lab Invest 1994;70:479-493.
31. Bacallao R, Fine LG: Molecular events in the organisation of renal tubular epithelium: From nephrogenesis to regeneration. Am J Physiol 1989;257:F913-F924.
32. Wolf G, Scherberich JE, Schoeppe W: Peptidase-associated antigens as a marker of differentiation in human kidney and renal cell carcinoma. Cell Mol Biol 1988;34:311-321.