Mouse digit tip regeneration is mediated by fate-restricted progenitor cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 51, 2011, Pages 20609-20614

  Lehoczky, Jessica A ^a   Robert, Benoît ^b   Tabin, Clifford J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CNRS   (France)

Author keywords

Epimorphic regeneration; Fibrin clot; Lineage analysis; Mitogenic signal; Transdifferentiation

Indexed keywords

BETA GALACTOSIDASE; TRANSCRIPTION FACTOR MSX1;

AMPUTATION; ANIMAL EXPERIMENT; ARTICLE; BLASTEMA; CELL LINEAGE; CONTROLLED STUDY; DIGIT TIP REGENERATION; ECTODERM; FATE RESTRICTED PROGENITOR CELL; LIMB REGENERATION; MESENCHYME CELL; MESODERM; MOUSE; NAIL BED; NONHUMAN; OSTEOBLAST; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; ECTODERM; EXTREMITIES; FEMALE; FIBRIN; INTEGRASES; KERATINOCYTES; MALE; MESODERM; MICE; MSX1 TRANSCRIPTION FACTOR; OSTEOBLASTS; PLURIPOTENT STEM CELLS; REGENERATION; SIGNAL TRANSDUCTION; STEM CELLS;

INVERTEBRATA; MAMMALIA; MUS; VERTEBRATA;

EID: 84855507663     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1118017108     Document Type: Article

References (35)

1. Thornton CS (1957) The effect of apical cap removal on limb regeneration in Amblystoma larvae. J Exp Zool 134:357-381.
2. Mescher AL (1976) Effects on adult newt limb regeneration of partial and complete skin flaps over the amputation surface. J Exp Zool 195:117-128.
3. Repesh LA, Oberpriller JC (1978) Scanning electron microscopy of epidermal cell migration in wound healing during limb regeneration in the adult newt, Notophthalmus viridescens. Am J Anat 151:539-555. (Pubitemid 8345748)
4. Hay ED, Fischman DA (1961) Origin of the blastema in regenerating limbs of the newt Triturus viridescens. An autoradiographic study using tritiated thymidine to follow cell proliferation and migration. Dev Biol 3:26-59.
5. Butler EG, O'Brien JP (1942) Effects of localized x-radiation on regeneration of the urodele limb. Anat Rec 84:407-413.
6. Echeverri K, Tanaka EM (2002) Ectoderm to mesoderm lineage switching during axolotl tail regeneration. Science 298:1993-1996. (Pubitemid 35425255)
7. Namenwirth M (1974) The inheritance of cell differentiation during limb regeneration in the axolotl. Dev Biol 41:42-56.
8. Thornton CS (1938) The histogenesis of the regenerating for limb of larval Ambystoma after exarticulation of the humerus. J Morphol 62:219-241.
9. Kragl M, et al. (2009) Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature 460:60-65.
10. Tu S, Johnson SL (2011) Fate restriction in the growing and regenerating zebrafish fin. Dev Cell 20:725-732.
11. Sousa S, et al. (2011) Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration. Development 138:3897-3905.
12. Illingworth CM (1974) Trapped fingers and amputated finger tips in children. J Pediatr Surg 9:853-858.
13. Borgens RB (1982) Mice regrow the tips of their foretoes. Science 217:747-750.
14. Reginelli AD, Wang YQ, Sassoon D, Muneoka K (1995) Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice. Development 121:1065-1076.
15. Allan CH, et al. (2006) Tissue response and Msx1 expression after human fetal digit tip amputation in vitro. Wound Repair Regen 14:398-404. (Pubitemid 44266595)
16. Crews L, et al. (1995) Expression and activity of the newt Msx-1 gene in relation to limb regeneration. Proc Biol Sci 259:161-171.
17. Simon HG, et al. (1995) Differential expression of myogenic regulatory genes and Msx-1 during dedifferentiation and redifferentiation of regenerating amphibian limbs. Dev Dyn 202:1-12.
18. Odelberg SJ, Kollhoff A, Keating MT (2000) Dedifferentiation of mammalian myotubes induced by msx1. Cell 103:1099-1109. (Pubitemid 32037396)
19. Han M, Yang X, Farrington JE, Muneoka K (2003) Digit regeneration is regulated by Msx1 and BMP4 in fetal mice. Development 130:5123-5132. (Pubitemid 37369672)
20. Han M, Yang X, Lee J, Allan CH, Muneoka K (2008) Development and regeneration of the neonatal digit tip in mice. Dev Biol 315:125-135.
21. Fernando WA, et al. (2011) Wound healing and blastema formation in regenerating digit tips of adult mice. Dev Biol 350:301-310.
22. Vasioukhin V, Degenstein L, Wise B, Fuchs E (1999) The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci USA 96:8551-8556. (Pubitemid 29354829)
23. Soriano P (1999) Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71.
24. Madisen L, et al. (2010) A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13:133-140.
25. Casanova JC, Sanz-Ezquerro JJ (2007) Digit morphogenesis: is the tip different? Dev Growth Differ 49:479-491. (Pubitemid 47174212)
26. Nakamura E, Nguyen MT, Mackem S (2006) Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton. Dev Dyn 235:2603-2612. (Pubitemid 44325273)
27. Rodda SJ, McMahon AP (2006) Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 133:3231-3244. (Pubitemid 44404346)
28. Houzelstein D, Cohen A, Buckingham ME, Robert B (1997) Insertional mutation of the mouse Msx1 homeobox gene by an nlacZ reporter gene. Mech Dev 65:123-133. (Pubitemid 27314595)
29. Orestes-Cardoso SM, et al. (2001) Postnatal Msx1 expression pattern in craniofacial, axial, and appendicular skeleton of transgenic mice from the first week until the second year. Dev Dyn 221:1-13.
30. Lopes M, et al. (2011) Msx genes define a population of mural cell precursors required for head blood vessel maturation. Development 138:3055-3066.
31. Gargioli C, Slack JM (2004) Cell lineage tracing during Xenopus tail regeneration. Development 131:2669-2679.
32. Rinkevich Y, Lindau P, Ueno H, Longaker MT, Weissman IL (2011) Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip. Nature 476:409-413.
33. Mohammad KS, Neufeld DA (2000) Denervation retards but does not prevent toetip regeneration. Wound Repair Regen 8:277-281.
34. Agrawal V, et al. (2010) Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci USA 107:3351-3355.
35. Feil R, et al. (1996) Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci USA 93:10887-10890. (Pubitemid 26333086)