Activation of PDE10 and PDE11 phosphodiesterases

Journal of Biological Chemistry

Volumn 287, Issue 2, 2012, Pages 1210-1219

  Jäger, Ronald ^a   Russwurm, Corina ^a   Schwede, Frank ^b   Genieser, Hans Gottfried ^b   Koesling, Doris ^a   Russwurm, Michael ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b BIOLOG Life Science Institute   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC REACTIONS; COMPETITIVE INHIBITION; CYCLASES; CYCLIC NUCLEOTIDE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES; N-TERMINALS; PHOSPHODIESTERASES; REGULATORY REGIONS; SYNTHETIC LIGANDS;

BIOLOGICAL MEMBRANES; CATALYSIS; ESTERS; NUCLEOTIDES;

LIGANDS;

CYCLIC AMP; GAF DOMAIN PROTEIN; HOLOENZYME; HOMEODOMAIN PROTEIN; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10; PHOSPHODIESTERASE 11; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN METABOLISM;

CYCLIC AMP; CYCLIC GMP; ENZYME ACTIVATION; HEK293 CELLS; HOLOENZYMES; HUMANS; PHOSPHORIC DIESTER HYDROLASES; PROTEIN STRUCTURE, TERTIARY;

EID: 84855507015     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.263806     Document Type: Article

References (39)

1. Bender, A. T., and Beavo, J. A. (2006) Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol. Rev. 58, 488-520
2. Conti, M., and Beavo, J. (2007) Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu. Rev. Biochem. 76, 481-511
3. Francis, S. H., Corbin, J. D., and Bischoff, E. (2009) Cyclic GMP-hydrolyzing phosphodiesterases. Handb. Exp. Pharmacol. 191, 367-408
4. Fujishige, K., Kotera, J., Michibata, H., Yuasa, K., Takebayashi, S., Okumura, K., and Omori, K. (1999) Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J. Biol. Chem. 274, 18438-18445
5. Loughney, K., Snyder, P. B., Uher, L., Rosman, G. J., Ferguson, K., and Florio, V. A. (1999) Isolation and characterization of PDE10A, a novel human 3′,5′-cyclic nucleotide phosphodiesterase. Gene 234, 109-117
6. Soderling, S. H., Bayuga, S. J., and Beavo, J. A. (1999) Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. Proc. Natl. Acad. Sci. U.S.A. 96, 7071-7076
7. Fawcett, L., Baxendale, R., Stacey, P., McGrouther, C., Harrow, I., Soderling, S., Hetman, J., Beavo, J. A., and Phillips, S. C. (2000) Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc. Natl. Acad. Sci. U.S.A. 97, 3702-3707
8. Hetman, J. M., Robas, N., Baxendale, R., Fidock, M., Phillips, S. C., Soderling, S. H., and Beavo, J. A. (2000) Cloning and characterization of two splice variants of human phosphodiesterase 11A. Proc. Natl. Acad. Sci. U.S.A. 97, 12891-12895
9. Yuasa, K., Kotera, J., Fujishige, K., Michibata, H., Sasaki, T., and Omori, K. (2000) Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression. J. Biol. Chem. 275, 31469-31479
10. O'Connor, V., Genin, A., Davis, S., Karishma, K. K., Doyère, V., De Zeeuw, C. I., Sanger, G., Hunt, S. P., Richter-Levin, G., Mallet, J., Laroche, S., Bliss, T. V., and French, P. J. (2004) Differential amplification of intron-containing transcripts reveals long term potentiation-associated up-regulation of specific Pde10A phosphodiesterase splice variants. J. Biol. Chem. 279, 15841-15849
11. Kotera, J., Sasaki, T., Kobayashi, T., Fujishige, K., Yamashita, Y., and Omori, K. (2004) Subcellular localization of cyclic nucleotide phosphodiesterase type 10A variants, and alteration of the localization by cAMP-dependent protein kinase-dependent phosphorylation. J. Biol. Chem. 279, 4366-4375
12. Yuasa, K., Ohgaru, T., Asahina, M., and Omori, K. (2001) Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants. Eur. J. Biochem. 268, 4440-4448
13. Seeger, T. F., Bartlett, B., Coskran, T. M., Culp, J. S., James, L. C., Krull, D. L., Lanfear, J., Ryan, A. M., Schmidt, C. J., Strick, C. A., Varghese, A. H., Williams, R. D., Wylie, P. G., and Menniti, F. S. (2003) Immunohistochemical localization of PDE10A in the rat brain. Brain Res. 985, 113-126
14. Yuasa, K., Kanoh, Y., Okumura, K., and Omori, K. (2001) Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains. Eur. J. Biochem. 268, 168-178
15. Loughney, K., Taylor, J., and Florio, V. A. (2005) 3′,5′- Cyclic nucleotide phosphodiesterase 11A: localization in human tissues. Int. J. Impot. Res. 17, 320-325
16. D'Andrea, M. R., Qiu, Y., Haynes-Johnson, D., Bhattacharjee, S., Kraft, P., and Lundeen, S. (2005) Expression of PDE11A in normal and malignant human tissues. J. Histochem. Cytochem. 53, 895-903
17. Kelly, M. P., Logue, S. F., Brennan, J., Day, J. P., Lakkaraju, S., Jiang, L., Zhong, X., Tam, M., Sukoff Rizzo, S. J., Platt, B. J., Dwyer, J. M., Neal, S., Pulito, V. L., Agostino, M. J., Grauer, S. M., Navarra, R. L., Kelley, C., Comery, T. A., Murrills, R. J., Houslay, M. D., and Brandon, N. J. (2010) Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proc. Natl. Acad. Sci. U.S.A. 107, 8457-8462
18. Aravind, L., and Ponting, C. P. (1997) The GAF domain: an evolutionary link between diverse phototransducing proteins. Trends Biochem. Sci. 22, 458-459
19. Martinez, S. E., Beavo, J. A., and Hol, W. G. (2002) GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides. Mol. Interv. 2, 317-323
20. Hurley, J. H. (2003) GAF domains: cyclic nucleotides come full circle. Sci. STKE 2003, PE1
21. Zoraghi, R., Corbin, J. D., and Francis, S. H. (2004) Properties and functions of GAF domains in cyclic nucleotide phosphodiesterases and other proteins. Mol. Pharmacol. 65, 267-278
22. Schultz, J. E. (2009) Structural and biochemical aspects of tandem GAF domains. Handb. Exp. Pharmacol. 191, 93-109
23. Beavo, J. A., Hardman, J. G., and Sutherland, E. W. (1971) Stimulation of adenosine 3′,5′-monophosphate hydrolysis by guanosine 3′,5′-monophosphate. J. Biol. Chem. 246, 3841-3846
24. Rybalkin, S. D., Rybalkina, I. G., Shimizu-Albergine, M., Tang, X. B., and Beavo, J. A. (2003) PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. EMBO J. 22, 469-478
25. Mullershausen, F., Friebe, A., Feil, R., Thompson, W. J., Hofmann, F., and Koesling, D. (2003) Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling. J. Cell Biol. 160, 719-727
26. 3H]Sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP. Mol. Pharmacol. 63, 1364-1372
27. Matthiesen, K., and Nielsen, J. (2009) Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity. Biochem. J. 423, 401-409
28. Gross-Langenhoff, M., Hofbauer, K., Weber, J., Schultz, A., and Schultz, J. E. (2006) cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11. J. Biol. Chem. 281, 2841-2846
29. Russwurm, M., Mullershausen, F., Friebe, A., Jäger, R., Russwurm, C., and Koesling, D. (2007) Design of fluorescence resonance energy transfer (FRET)-based cGMP indicators: a systematic approach. Biochem. J. 407, 69-77
30. Russwurm, C., Zoidl, G., Koesling, D., and Russwurm, M. (2009) Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes. J. Biol. Chem. 284, 25782-25790
31. Jäger, R., Schwede, F., Genieser, H. G., Koesling, D., and Russwurm, M. (2010) Activation of PDE2 and PDE5 by specific GAF ligands: delayed activation of PDE5. Br. J. Pharmacol. 161, 1645-1660
32. Habert, R., Lejeune, H., and Saez, J. M. (2001) Origin, differentiation and regulation of fetal and adult Leydig cells. Mol. Cell. Endocrinol. 179, 47-74
33. Schmidt, C. J., Chapin, D. S., Cianfrogna, J., Corman, M. L., Hajos, M., Harms, J. F., Hoffman, W. E., Lebel, L. A., McCarthy, S. A., Nelson, F. R., Proulx-LaFrance, C., Majchrzak, M. J., Ramirez, A. D., Schmidt, K., Seymour, P. A., Siuciak, J. A., Tingley, F. D., 3rd, Williams, R. D., Verhoest, P. R., and Menniti, F. S. (2008) Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia. J. Pharmacol. Exp. Ther. 325, 681-690
34. Pandit, J., Forman, M. D., Fennell, K. F., Dillman, K. S., and Menniti, F. S. (2009) Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the x-ray structure of a near full-length construct. Proc. Natl. Acad. Sci. U.S.A. 106, 18225-18230
35. Wang, H., Liu, Y., Hou, J., Zheng, M., Robinson, H., and Ke, H. (2007) Structural insight into substrate specificity of phosphodiesterase 10. Proc. Natl. Acad. Sci. U.S.A. 104, 5782-5787
36. Handa, N., Mizohata, E., Kishishita, S., Toyama, M., Morita, S., Uchikubo-Kamo, T., Akasaka, R., Omori, K., Kotera, J., Terada, T., Shirouzu, M., and Yokoyama, S. (2008) Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP. J. Biol. Chem. 283, 19657-19664
37. Vasta, V., Shimizu-Albergine, M., and Beavo, J. A. (2006) Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A. Proc. Natl. Acad. Sci. U.S.A. 103, 19925-19930
38. Gillespie, P. G., and Beavo, J. A. (1989) Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948. Mol. Pharmacol. 36, 773-781
39. Gross-Langenhoff, M., Stenzl, A., Altenberend, F., Schultz, A., and Schultz, J. E. (2008) The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain. FEBS J. 275, 1643-1650