Identification of the common regulators for hepatocellular carcinoma induced by hepatitis B virus X antigen in a mouse model

Carcinogenesis

Volumn 33, Issue 1, 2012, Pages 209-219

  Lu, Jeng Wei ^a,b   Hsia, Yu ^a,b   Yang, Wan Yu ^a   Lin, Yu I ^a   Li, Chao Chin ^c   Tsai, Ting Fen ^a,c   Chang, Ko Wei ^d   Shieh, Grace S ^d   Tsai, Shih Feng ^a   Wang, Horng Dar ^e   Yuh, Chiou Hwa ^a,e,f  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL CENTRAL UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d INSTITUTE OF STATISTICAL SCIENCE   (Taiwan)

^e NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^f NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; ENDOTHELIN 1; HEPATITIS B VIRUS X PROTEIN; OSTEOGENIC PROTEIN 1; PROTEIN TYROSINE KINASE; SPIB PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT CARCINOMA; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CANCER TISSUE; CELL MIGRATION; CELL VIABILITY; COLONY FORMATION; COMPUTER PROGRAM; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENOME ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; REGULATOR GENE; TUMOR PROMOTION; UPREGULATION; VIRUS CARCINOGENESIS;

EID: 84855395049     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr224     Document Type: Article

References (56)

1. Farazi,P.A. et al. (2006) Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer, 6, 674-687.
2. El-Serag,H.B. et al. (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132, 2557-2576.
3. Anzola,M. (2004) Hepatocellular carcinoma: role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesis. J. Viral. Hepat., 11, 383-393.
4. Perz,J.F. et al. (2006) The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J. Hepatol., 45, 529-538.
5. Park,N.H. et al. (2007) Molecular pathogenesis of hepatitis-B-virusassociated hepatocellular carcinoma. Gut Liver, 1, 101-117.
6. Cougot,D. et al. (2005) HBV induced carcinogenesis. J. Clin. Virol., 34 (Suppl 1), S75-S78.
7. Tsai,W.L. et al. (2010) Viral hepatocarcinogenesis. Oncogene, 29, 2309-2324.
8. Lu,J.W. et al. (2011) Liver development and cancer formation in zebrafish. Birth Defects Res. C Embryo Today, 93, 157-172.
9. Koike,K. et al. (1989) Oncogenic potential of hepatitis B virus. Mol. Biol. Med., 6, 151-160.
10. Seifer,M. et al. (1991) In vitro tumorigenicity of hepatitis B virus DNA and HBx protein. J. Hepatol., 13 (Suppl. 4), S61-S65.
11. Zhang,W.Y. et al. (2009) Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacol. Sin., 30, 424-434.
12. Wang,H.D. et al. (1995) The hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes. Mol. Cell. Biol., 15, 6720-6728.
13. Wang,H.D. et al. (1997) Hepatitis B virus X protein induces RNA polymerase III-dependent gene transcription and increases cellular TATA-binding protein by activating the Ras signaling pathway. Mol. Cell. Biol., 17, 6838-6846.
14. Wang,H.D. et al. (1998) Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATAbinding protein. Mol. Cell. Biol., 18, 7086-7094.
15. Wu,B.K. et al. (2006) Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B virus X protein transgenic mice. Biochem. Biophys. Res. Commun., 340, 916-928.
16. Kim,C.M. et al. (1991) HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature, 351, 317-320.
17. Ullrich,S.J. et al. (1994) Transgenic mouse models of human gastric and hepatic carcinomas. Semin. Cancer Biol., 5, 61-68.
18. Wu,Y.F. et al. (2008) Chemopreventive effect of silymarin on liver pathology in HBV X protein transgenic mice. Cancer Res., 68, 2033-2042.
19. Yang,C.W. et al. (2005) Integrative genomics based identification of potential human hepatocarcinogenesis-associated cell cycle regulators: RHAMM as an example. Biochem. Biophys. Res. Commun., 330, 489-497.
20. Ng,R.K. et al. (2004) cDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesis. Biochem. Biophys. Res. Commun., 322, 827-835.
21. Chiba,T. et al. (2004) Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells. J. Hepatol., 41, 436-445.
22. Iizuka,N. et al. (2004) Molecular signature in three types of hepatocellular carcinoma with different viral origin by oligonucleotide microarray. Int. J. Oncol., 24, 565-574.
23. Chan,T.M. et al. (2009) Functional analysis of the evolutionarily conserved cis-regulatory elements on the sox17 gene in zebrafish. Dev. Biol., 326, 456-470.
24. Rozen,S. et al. (2000) Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol., 132, 365-386.
25. Oda,T. et al. (1992) p53 gene mutation spectrum in hepatocellular carcinoma. Cancer Res., 52, 6358-6364.
26. Murakami,S. (2001) Hepatitis B virus X protein: a multifunctional viral regulator. J. Gastroenterol., 36, 651-660.
27. Seo,J.H. et al. (1997) Lack of colocalization of HBxAg and insulin like growth factor II in the livers of patients with chronic hepatitis B, cirrhosis and hepatocellular carcinoma. J. Korean Med. Sci., 12, 523-531.
28. Pal,J. et al. (2001) Immunohistochemical assessment and prognostic value of hepatitis B virus X protein in chronic hepatitis and primary hepatocellular carcinomas using anti-HBxAg monoclonal antibody. Pathol. Oncol. Res., 7, 178-184.
29. Kobayashi,I. et al. (2010) Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells. Blood, 115, e1-e9.
30. Zare,H. et al. (2009) Reconstruction of Escherichia coli transcriptional regulatory networks via regulon-based associations. BMC Syst. Biol., 3, 39.
31. Ueda,H. et al. (1995) Functional inactivation but not structural mutation of p53 causes liver cancer. Nat. Genet., 9, 41-47.
32. Terradillos,O. et al. (1998) p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro. Oncogene, 17, 2115-2123.
33. Leenders,M.W. et al. (2008) Mouse models in liver cancer research: a review of current literature. World J. Gastroenterol., 14, 6915-6923.
34. Koike,K. (1993) [Transgenic mouse model for hepatocellular carcinoma in human hepatitis B virus infection]. Nippon Rinsho, 51, 536-541.
35. Yu,D.Y. et al. (1999) Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein. J. Hepatol., 31, 123-132.
36. Xu,X.B. et al. (2010) [Observation on experimental liver fibrosis and hepatic carcinogenesis of HBV gene knock-in transgenic mice induced by CCl4/ethanol]. Zhonghua Yi Xue Za Zhi, 90, 822-825.
37. Koike,K. (2002) Hepatocarcinogenesis in hepatitis viral infection: lessons from transgenic mouse studies. J. Gastroenterol., 37 (Suppl. 13), 55-64.
38. Terradillos,O. et al. (1997) The hepatitis B virus X gene potentiates c-mycinduced liver oncogenesis in transgenic mice. Oncogene, 14, 395-404.
39. Vitvitski-Trepo,L. et al. (1990) Early and frequent detection of HBxAg and/or anti-HBx in hepatitis B virus infection. Hepatology, 12, 1278-1283.
40. Zentgraf,H. et al. (1990) Mouse monoclonal antibody directed against hepatitis B virus X protein synthesized in Escherichia coli: detection of reactive antigen in liver cell carcinoma and chronic hepatitis. Oncology, 47, 143-148.
41. Su,Q. et al. (1998) Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinomas. Hepatology, 27, 1109-1120.
42. Wang,W.L. et al. (1991) HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis. Hepatology, 14, 29-37.
43. Doria,M. et al. (1995) The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. EMBO J., 14, 4747-4757.
44. Caselmann,W.H. (1995) Transactivation of cellular gene expression by hepatitis B viral proteins: a possible molecular mechanism of hepatocarcinogenesis. J. Hepatol., 22, 34-37.
45. Cougot,D. et al. (2007) The hepatitis B virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription. J. Biol. Chem., 282, 4277-4287.
46. Kekule,A.S. et al. (1993) Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature, 361, 742-745.
47. Benn,J. et al. (1994) Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc. Natl Acad. Sci. USA, 91, 10350-10354.
48. Lee,Y.H. et al. (1998) HBx protein of hepatitis B virus activates Jak1-STAT signaling. J. Biol. Chem., 273, 25510-25515.
49. Li,B. et al. (2007) Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response. Virus Res., 124, 44-49.
50. Deng,H. et al. (2007) Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells. Exp. Cell Res., 313, 1033-1044.
51. Motoyama,K. et al. (2008) Clinical significance of BMP7 in human colorectal cancer. Ann. Surg. Oncol., 15, 1530-1537.
52. Pfab,T. et al. (2004) The endothelin system in Morris hepatoma-7777: an endothelin receptor antagonist inhibits growth in vitro and in vivo. Br. J. Pharmacol., 141, 215-222.
53. Ray-Gallet,D. et al. (1995) DNA binding specificities of Spi-1/PU.1 and Spi-B transcription factors and identification of a Spi-1/Spi-B binding site in the c-fes/c-fps promoter. Oncogene, 11, 303-313.
54. Muller,S. et al. (1996) Cell specific expression of human Bruton's agammaglobulinemia tyrosine kinase gene (Btk) is regulated by Sp1- and Spi-1/PU.1-family members. Oncogene, 13, 1955-1964.
55. Lau,G.M. et al. (2009) Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro. Dig. Dis. Sci., 54, 1465-1474.
56. Klein,N.P. et al. (1997) Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Mol. Cell. Biol., 17, 6427-6436.