Hepatitis B virus X protein induces RNA polymerase III-dependent gene transcription and increases cellular TATA-binding protein by activating the Ras signaling pathway

Molecular and Cellular Biology

Volumn 17, Issue 12, 1997, Pages 6838-6846

  Wang, Horng Dar ^a   Trivedi, Alpa ^a   Johnson, Deborah L ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED RNA POLYMERASE III; RAF PROTEIN; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR; VIRUS PROTEIN;

ARTICLE; GENE ACTIVITY; GENE INDUCTION; GENETIC TRANSCRIPTION; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

HEPATITIS B VIRUS;

EID: 0030712869     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.12.6838     Document Type: Article

References (69)

1. Albagli, O., A. Klaes, E. Ferreira, D. Leprince, and C. Klambt. 1996. Function of ets genes is conserved between vertebrates and Drosophila. Mech. Dev. 59:29-40.
2. Avruch, J., X. F. Zhang, and J. M. Kyriakis. 1994. Raf meets Ras: completing the framework of a signal transduction pathway. Trends Biochem. Sci. 19:279-283.
3. Aufiero, B., and R. J. Schneider. 1990. The hepatitis B virus X gene product transactivates both RNA polymerase II and III promoters. EMBO J. 9:497-504.
4. Benn, J., and R. J. Schneider. 1994. Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc. Natl. Acad. Sci. USA 91:10350-10354.
5. Benn, J., and R. J. Schneider. 1995. Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls. Proc. Natl. Acad. Sci. USA 92:11215-11219.
6. Benn, J., F. Su, M. Doria, and R. J. Schneider. 1996. Hepatitis B virus Hbx protein induces transcription factor AP-1 by activation of extracellular signal-related and c-Jun N-terminal mitogen-activated protein kinases. J. Virol. 70:4978-4985.
7. Chen, H. S., S. Kaneko, R. Girone, R. W. Anderson, W. E. Hornbuckle, B. C. Tennant, P. J. Cote, J. L. Gerin, R. H. Purcell, and R. H. Miller. 1993. The woodchuck hepatitis B virus X gene is important for the establishment of virus infection in woodchucks. J. Virol. 67:1218-1226.
8. Cheong, J. H., M. Yi, Y. Lin, and S. Murakami. 1995. Human RPB5, a subunit shared by eucaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation. EMBO J. 14:142-150.
9. Chirillo, P., M. Falco, P. L. Puri, M. Artini, C. Balsano, M. Levrero, and G. Natoli. 1996. Hepatitis B virus pX activates NF-κB-dependent transcription through a Raf-independent pathway. J. Virol. 70:641-646.
10. Colgan, J., and J. L. Manley. 1992. TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA pol II promoters. Genes Dev. 6:304-315.
11. Cox, A. D., A. M. Garcia, J. K. Westwick, J. J. Kowalczyk, M. D. Lewis, D. A. Brenner, and C. J. Der. 1995. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylated or myristylated, oncogenic Ras signaling and transformation. J. Biol. Chem. 269:19203-19206.
12. Cross, J. C., P. Wen, and W. J. Rutter. 1993. Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases. Proc. Natl. Acad. Sci. USA 90:8078-8082.
13. Dingermann, T. S., S. Sharp, B. Appel, D. DeFranco, S. Mount, R. Heiermann, O. Pongs, and D. Soll. 1981. Transcription of cloned tRNA and 5S RNA genes in Drosophila cell free extract. Nucleic Acids Res. 9:3907-3918.
14. Doria, M., N. Klein, R. Lucito, and R. J. Schneider. 1995. The hepatitis B virus Hbx protein is a dual specificity cytoplasmic activator of ras and nuclear activator of transcription factors. EMBO J. 14:4747-4757.
15. Feitelson, M. A., M. Zhu, L. X. Duan, and W. T. London. 1993. Hepatitis B x antigen and p53 are associated in vitro and in liver tissue from patients with primary hepatocellular carcinoma. Oncogene 8:1109-1117.
16. Fisher, M., L. Runkel, and H. Schaller. 1995. HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteosome alpha subunit. Virus Genes 10:99-102.
17. Foulds, C. E., and D. K. Hawley. 1997. Analysis of the human TATA binding protein promoter and identification of an Ets site critical for activity. Nucleic Acids Res. 25:2485-2495.
18. Garber, M., S. Panchanathan, R. S. Fan, and D. L. Johnson. 1991. The phorbol ester, TPA induces specific transcription by RNA polymerase III in Drosophila Schneider cells. J. Biol. Chem. 266:20598-20601.
19. Garber, M. E., A. Vilalta, and D. L. Johnson. 1994. Induction of Drosophila RNA polymerase III gene expression by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is mediated by transcription factor IIIB. Mol. Cell. Biol. 14:339-347.
20. Gottesfeld, J. M., V. J. Wolf, T. Dang, D. J. Forbes, and P. Hartl. 1994. Mitotic repression of RNA polymerase III transcription in vitro mediated by phosphorylation of a TFIIIB component. Science 263:81-84.
21. Han, K., M. S. Levine, and J. L. Manley. 1989. Synergistic activation and repression of transcription by Drosophila homeobox protein. Cell 56:573-583.
22. Haviv, I., D. Vaizel, and Y. Shaul. 1995. The X protein of hepatitis B virus coactivates potent activation domains. Mol. Cell. Biol. 15:1079-1085.
23. Haviv, I., D. Vaizel, and Y. Shaul. 1996. pX, the HBV-encoded coactivator, interacts with components of the transcription machinery and stimulates transcription in a TAF-independent manner. EMBO J. 15:3413-3420.
24. Hernandez, N. 1993. TBP, a universal eukaryotic transcription factor? Genes Dev. 7:1291-1308.
25. Hoeffler, W. K., R. Kovelman, and R. G. Roeder. 1988. Activation of transcription factor IIIC by the adenovirus E1A protein. Cell 53:907-920.
26. Hohne, M., S. Schaefer, M. Seifer, M. A. Feitelson, D. Paul, and W. H. Gerlich. 1990. Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA. EMBO J. 9:1137-1145.
27. Huang, J., J. Kwong, E. C. Y. Sun, and T. J. Liang. 1996. Proteasome complex as a potential cellular target of hepatitis B virus X protein. J. Virol. 70:5582-5591.
28. Kekule, A. S., U. Lauer, L. Weiss, B. Luber, and P. H. Hofschneider. 1993. Hepatitis B virus transactivator uses a tumor promoter signalling pathway. Science 361:742-745.
29. Kim, C. M., K. Koike, I. Saito, T. Miyamura, and G. Jay. 1991. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351:317-320.
30. Kohl, N. E., S. D. Mosser, J. Desolms, E. A. Giuliani, D. L. Pompliano, S. L. Graham, R. L. Smith, E. M. Scolnick, A. Oliff, and J. B. Gibbs. 1993. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science 260:1934-1937.
31. Koike, K., K. Moriya, H. Yotsuyanagi, S. Iino, and K. Kurokawa. 1994. Induction of cell cycle progression by hepatitis B virus HBx gene expression in quiescent mouse fibroblasts. J. Clin. Invest. 94:44-49.
32. Lee, T. H., S. J. Elledge, and J. S. Butel. 1995. Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. J. Virol. 69:1107-1114.
33. Lin, Y., T. Nomura, J. Cheong, D. Dorjsuren, K. Iida, and S. Murakami. 1997. Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5. J. Biol. Chem. 272:7132-7139.
34. Lowy, D. R., and B. M. Willumsen. 1993. Function and regulation of Ras. Annu. Rev. Biochem. 62:851-891.
35. Luber, B., U. Lauer, L. Weiss, M. Hohne, P. H. Hofschneider, and A. S. Kekule. 1993. The hepatitis B virus transactivator HBx causes elevation of diacylglycerol and activation of protein kinase C. Res. Virol. 144:311-321.
36. Lucito, R., and R. J. Schneider. 1992. Hepatitis B virus X protein activates transcription factor NF-κB without a requirement for protein kinase C. J. Virol. 66:983-991.
37. Maguire, H. F., J. P. Hoeffler, and A. Siddiqui. 1991. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 252:842-844.
38. Natoli, G., M. L. Avantaggiati, P. Chirillo, P. L. Puri, A. Ianni, C. Balsano, and M. Levrero. 1994. Ras- and Raf-dependent activation of c-Jun transcriptional activity by the hepatitis B virus transactivator pX. Oncogene 9:2837-2843.
39. Powers, S., K. O'Neill, and M. Wigler. 1989. Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae. Mol. Cell. Biol. 9:390-395.
40. Qadri, I., H. F. Maguire, and A. Siddiqui. 1995. Hepatitis B virus transactivator protein X interacts with the TATA-binding protein. Proc. Natl. Acad. Sci. USA 92:1003-1007.
41. Qadri, I., J. W. Conaway, R. C. Conaway, J. Schaack, and A. Siddiqui. 1996. Hepatitis B virus transactivator protein. Hbx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH. Proc. Natl. Acad. Sci. USA 93:10578-10583.
42. Rapp, U. R., G. Heidecker, M. Huleihel, J. L. Cleveland, W. C. Choi, T. Pawson, J. N. Ihle, and W. B. Anderson. 1988. raf family serine/threonine protein kinase in mitogen signal transduction. Cold Spring Harbor Symp. Quant. Biol. 53:173-184.
43. Rossner, M. T. 1992. Hepatitis B virus X gene product: a promiscuous transcriptional activator. J. Med. Virol. 36:101-117.
44. Sadovsky, Y., P. Webb, G. Lopez, J. D. Baxter, P. M. Fitzpatrick, E. Gizang-Ginsberg, V. Cavailles, M. Parker, P. J. Kushner. 1995. Transcriptional activators differ in their responses to overexpression of TATA-box-binding protein. Mol. Cell. Biol. 15:1554-1563.
45. Seto, E., P. J. Mitchell, and T. S. Yen. 1990. Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature 344:72-74.
46. Shirakata, Y., M. Kawada, Y. Fujiki, H. Sano, M. Oda, K. Yaginuma, M. Kobayashi, and K. Koike. 1989. The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells. Jpn. J. Cancer Res. 80:617-621.
47. Su, F., and R. J. Schneider. 1996. Hepatitis B virus Hbx protein activates transcription factor NF-κB by acting on multiple cytoplasmic inhibitors of rel-related proteins. J. Virol. 70:4558-4566.
48. Tower, J., and B. Sollner-Webb. 1988. Polymerase III transcription factor B activity is reduced in extracts of growth-restricted cells. Mol. Cell. Biol. 8:1001-1005.
49. Treisman, R. 1994. Ternary complex factors: growth factor regulated transcriptional activators. Curr. Opin. Genet. Dev. 4:96-101.
50. Trivedi, A., A. Vilalta, S. Gopalan, and D. L. Johnson. 1996. TATA-binding protein is limiting for both TATA-containing and TATA-lacking RNA polymerase III promoters in Drosophila cells. Mol. Cell. Biol. 16:6909-6916.
51. Trivedi, A., H.-D. Wang, and D. L. Johnson. Unpublished data.
52. Ueda, H., S. J. Ullrich, J. D. Gangemi, C. A. Kappel, L. Ngo, M. A. Feitelson, and G. Jay. 1995. Functional inactivation hut not structural mutation of p53 causes liver cancer. Nat. Genet. 9:41-17.
53. Unger, T., and Y. Shaul. 1990. The X protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive element. EMBO J.
54. Vilalta, A., A. Trivedi, Z. Wang, R. G. Roeder, and D. L. Johnson. 1997. An RNA polymerase III-defective mutation in TATA-binding protein disrupts its interaction with a transcription factor IIIB subunit in Drosophila cells. J. Biol. Chem. 272:18087-18092.
55. Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214.
56. Wada, C., K. Kasai, T. Kameya, and H. Ohtani. 1992. A general transcription factor, human transcription factor IID, overexpressed in human lung and breast carcinoma and rapidly induced with serum stimulation. Cancer Res. 52:307-313.
57. Wang, H.-D., A. Trivedi, and D. L. Johnson. Unpublished data.
58. Wang, H.-D., C.-H. Yuh, C. V. Dang, and D. L. Johnson. 1995. The hepatitis B virus increases the cellular level of TATA-binding protein which mediates transactivation of RNA polymerase III genes. Mol. Cell. Biol. 15:6720-6728.
59. Wang, X. W., K. Forrester, H. Yeh, M. A. Feitelson, J. R. Gu, and C. C. Harris. 1994. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding transcriptional activity, and associalion with transcription factor ERCC3. Proc. Natl. Acad. Sci. USA 91:2230-2234.
60. Weber, H. W., S. Vallett, L. Neilson, M. Grotke, Y. Chao, M. Brudnak, A. S. Juan, and M. Pellegrini. 1993. Serum, insulin and phorbol esters stimulate rRNA and tRNA gene expression in both dividing and non-dividing Drosophila cells. Mol. Cell. Biochem. 104:201-207.
61. White, R. J., C. E. Khoo, J. A. Inostroza, D. Reinberg, S. P. Jackson. 1994. Differential regulation of RNA polymerases I, II, and III by the TBP-binding repressor Dr1. Science. 266:448-450.
62. White, R. J., T. M. Gottlieb, C. S. Downes, and S. P. Jackson. 1995. Cell cycle regulation of RNA polymerase III transcription. Mol. Cell. Biol. 15:6653-6662.
63. White, R. J., D. Stott, and P. W. J. Rigby. 1989. Regulation of RNA polymerase III transcription in response to F9 embryonal carcinoma stem cell differentiation. Cell 59:1081-1092.
64. White, R. J., D. Stott, and P. W. J. Rigby. 1990. Regulation of RNA polymcrase III transcription in response to simian virus 40 transformation. EMBO J. 9:3713-3721.
65. White, R. J., D. Trouche, K. Martin, S. P. Jackson, and T. Kouzarides. 1996. Repression of RNA polymerase III transcription by retinoblastoma protein. Nature 382:88-90.
66. Williams, J. S., and O. M. Andrisani. 1995. The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB. Proc. Natl. Acad. Sci. USA 92:3819-3823.
67. Willis, I. 1993. RNA polymerase III: genes, factors and transcriptional specificity. Eur. J. Biochem. 212:1-11.
68. Yen, T. S. B. 1996. Hepadnaviral X protein: review of recent progress. J. Biomed. Sci. 3:20-30.
69. Zoulim, F., J. Saputelli, and C. Seeger. 1994. Woodchuck hepatitis B virus X protein is required for viral infection in vivo. J. Virol. 68:2026-2030.