Notch-induced mammary tumorigenesis does not involve the lobule-limited epithelial progenitor

Oncogene

Volumn 31, Issue 1, 2012, Pages 60-67

  Bruno, R D ^a   Boulanger, C A ^a   Smith, G H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Int3; lobular progenitor; mammary development; Notch4; PI MEC

Indexed keywords

BETA GALACTOSIDASE; ESTROGEN RECEPTOR ALPHA; NOTCH RECEPTOR; NOTCH4 RECEPTOR; PROGESTERONE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST DEVELOPMENT; BREAST EPITHELIUM; BREAST TUMOR; CELL TRANSPLANTATION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; MAMMARY GLAND; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; MULTIPOTENT STEM CELL; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; TISSUE TRANSPLANTATION; TRANSGENIC MOUSE;

ANIMALS; EPITHELIAL CELLS; FEMALE; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MILK PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTORS, NOTCH; STEM CELLS;

MOUSE MAMMARY TUMOR VIRUS; MUS; MUS MUSCULUS;

EID: 84855360178     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.215     Document Type: Article

References (23)

1. Booth BW, Boulanger C, Anderson L, Smith G. (2011). The mammary microenvironment restricts the tumorigenic phenotype of MMTV-neu-transformed tumor cells. Oncogene 30: 679-689.
2. Booth BW, Mack DL, Androutsellis-Theotokis A, McKay RD, Boulanger CA, Smith GH. (2008). The mammary microenviron-ment alters the differentiation repertoire of neural stem cells. Proc Natl Acad Sci USA 105: 14891-14896.
3. Boulanger CA, Mack DL, Booth BW, Smith GH. (2007). Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivo. Proc Natl Acad Sci USA 104: 3871-3876. (Pubitemid 47181546)
4. Boulanger CA, Smith GH. (2001). Reducing mammary cancer risk through premature stem cell senescence. Oncogene 20: 2264-2272. (Pubitemid 32531284)
5. Boulanger CA, Wagner KU, Smith GH. (2005). Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression. Oncogene 24: 552-560. (Pubitemid 40188560)
6. Brisken C, Park S, Vass T, Lydon JP, O'Malley BW, Weinberg RA. (1998). A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci USA 95: 5076-5081. (Pubitemid 28208553)
7. Bruno RD, Smith GH. (2010). Functional characterization of stem cell activity in the mouse mammary gland. Stem Cell Rev 7: 238-247.
8. Bussard KM, Boulanger CA, Booth BW, Bruno RD, Smith GH. (2010). Reprogramming human cancer cells in the mouse mammary gland. Cancer Res 70: 6336-6343.
9. Callahan R, Egan SE. (2004). Notch signaling in mammary development and oncogenesis. J Mammary Gland Biol Neoplasia 9: 145-163. (Pubitemid 39177500)
10. Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA et al. (2000). The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell 103: 41-50.
11. Gallahan D, Callahan R. (1987). Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors. J Virol 61: 66-74. (Pubitemid 17212445)
12. Gallahan D, Jhappan C, Robinson G, Hennighausen L, Sharp R, Kordon E et al. (1996). Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis. Cancer Res 56: 1775-1785. (Pubitemid 26118213)
13. Gallahan D, Kozak C, Callahan R. (1987). A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17. J Virol 61: 218-220. (Pubitemid 17212466)
14. Henry MD, Triplett AA, Oh KB, Smith GH, Wagner KU. (2004). Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice. Oncogene 23: 6980-6985. (Pubitemid 39279998)
15. Jeselsohn R, Brown NE, Arendt L, Klebba I, Hu MG, Kuperwasser C et al. (2010). Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. Cancer Cell 17: 65-76.
16. Jhappan C, Gallahan D, Stahle C, Chu E, Smith GH, Merlino G et al. (1992). Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev 6: 345-355.
17. Matulka LA, Triplett AA, Wagner KU. (2007). Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells. Dev Biol 303: 29-44. (Pubitemid 46241114)
18. Mukherjee A, Soyal SM, Li J, Ying Y, He B, DeMayo FJ et al. (2010). Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression. FASEB J 24: 4408-4419.
19. Raafat A, Lawson S, Bargo S, Klauzinska M, Strizzi L, Goldhar AS et al. (2009). Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis. Oncogene 28: 219-230.
20. Smith GH, Medina D. (2008). Re-evaluation of mammary stem cell biology based on in vivo transplantation. Breast Cancer Res 10: 203.
21. Soriano P. (1999). Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21: 70-71. (Pubitemid 29036285)
22. Wagner KU, Boulanger CA, Henry MD, Sgagias M, Hennighausen L, Smith GH. (2002). An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal. Development 129: 1377-1386. (Pubitemid 34874159)
23. Wagner KU, Wall RJ, St-Onge L, Gruss P, Wynshaw-Boris A, Garrett L et al. (1997). Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res 25: 4323-4330. (Pubitemid 27485212)