Liquid chromatography-tandem mass spectrometry quantification of 6-thioguanine in DNA using endogenous guanine as internal standard

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 881-882, Issue , 2012, Pages 115-118

  Jacobsen, Jack H ^a   Schmiegelow, Kjeld ^a,b   Nersting, Jacob ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

6 Mercaptopurine; Acute lymphoblastic leukemia; DNA TGN; LC MSMS; Maintenance therapy; Thiopurines

Indexed keywords

6-MERCAPTOPURINE; ACUTE LYMPHOBLASTIC LEUKEMIA; DNA-TGN; LC-MSMS; THIOPURINES;

CHROMOSOMES; DISEASES; DRUG PRODUCTS; DRUG THERAPY; LIQUID CHROMATOGRAPHY; MAINTENANCE; MASS SPECTROMETRY; POSITIVE IONS; STANDARDS;

DNA;

DNA; GUANINE; MERCAPTOPURINE; METHOTREXATE; TIOGUANINE;

ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; HUMAN; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MAINTENANCE THERAPY; PRIORITY JOURNAL; STANDARD; TANDEM MASS SPECTROMETRY;

6-MERCAPTOPURINE; CALIBRATION; CHILD; CHROMATOGRAPHY, LIQUID; DNA; DNA, NEOPLASM; GUANINE; HUMANS; JURKAT CELLS; LEUKOCYTES; LIMIT OF DETECTION; LINEAR MODELS; METHOTREXATE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; THIOGUANINE;

EID: 84855348697     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.11.032     Document Type: Article

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