Bacterial vaginosis, HIV serostatus and T-cell subset distribution in a cohort of East African commercial sex workers: Retrospective analysis

AIDS

Volumn 26, Issue 3, 2012, Pages 387-393

  Schellenberg, John J ^a   Card, Catherine M ^a   Ball, T Blake ^a,b,c   Mungai, Jane Njeri ^b   Irungu, Erastus ^b   Kimani, Joshua ^b   Jaoko, Walter ^b   Wachihi, Charles ^b   Fowke, Keith R ^a,c   Plummer, Francis A ^a,b,c  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

bacterial vaginosis; commercial sex workers; HIV resistance; HIV AIDS; multiparameter flow cytometry; T helper cell subsets; Treg

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; FLOW CYTOMETRY; GRAM STAINING; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROSTITUTION; REGULATORY T LYMPHOCYTE; RETROSPECTIVE STUDY; T LYMPHOCYTE SUBPOPULATION; VAGINITIS;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; CROSS-SECTIONAL STUDIES; FEMALE; HIV SERONEGATIVITY; HUMANS; INCIDENCE; KENYA; RETROSPECTIVE STUDIES; RISK FACTORS; SEX WORKERS; T-LYMPHOCYTE SUBSETS; VAGINA; VAGINOSIS, BACTERIAL;

EID: 84855346184     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32834ed7f0     Document Type: Article

References (27)

1. Fowke KR, Nagelkerke NJ, Kimani J, Simonsen JN, Anzala AO, Bwayo JJ, et al. Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya. Lancet 1996; 348:1347-1351. (Pubitemid 26383775)
2. Miyazawa M, Lopalco L, Mazzotta F, Lo Caputo S, Veas F, Clerici M. The 'immunologic advantage' of HIV-exposed seronegative individuals. AIDS 2009; 23:161-175.
3. Burgener A, Boutilier J, Wachihi C, Kimani J, Carpenter M, Westmacott G, et al. Identification of differentially expressed proteins in the cervical mucosa of HIV-1-resistant sex workers. J Proteome Res 2008; 7:4446-4454.
4. Iqbal SM, Ball TB, Levinson P, Maranan L, Jaoko W, Wachihi C, et al. Elevated elafin/trappin-2 in the female genital tract is associated with protection against HIV acquisition. AIDS 2009; 23:1669-1677.
5. Card CM, McLaren PJ, Wachihi C, Kimani J, Plummer FA, Fowke KR. Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(R)CD25(R)FOXP3(R) regulatory T cells. J Infect Dis 2009; 199:1318-1322.
6. McLaren PJ, Ball TB, Wachihi C, Jaoko W, Kelvin DJ, Danesh A, et al. HIV-exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors. J Infect Dis 2010; 202 (Suppl 3):S339-S344.
7. Lo Caputo S, Trabattoni D, Vichi F, Piconi S, Lopalco L, Villa ML, et al. Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual men. AIDS 2003; 17:531-539. (Pubitemid 36293106)
8. Restrepo C, Rallon NI, del Romero J, Rodriguez C, Hernando V, Lopez M, et al. Low-level exposure to HIV induces virusspecific T cell responses and immune activation in exposed HIV-seronegative individuals. J Immunol 2010; 185:982-989.
9. Haase AT. Perils at mucosal front lines for HIV and SIV and their hosts. Nat Rev Immunol 2005; 5:783-792. (Pubitemid 41400852)
10. Hummelen R, Fernandes AD, Macklaim JM, Dickson RJ, Changalucha J, Gloor GB, et al. Deep Sequencing of the Vaginal Microbiota of Women with HIV. PLoS One 2010; 5.
11. Larsson PG, Bergstrom M, Forsum U, Jacobsson B, Strand A, Wolner-Hanssen P. Bacterial vaginosis. Transmission, role in genital tract infection and pregnancy outcome: an enigma. Apmis 2005; 113:233-245. (Pubitemid 40676804)
12. Westrom L, Evaldson G, Holmes KK. Taxonomy of vaginosis: bacterial vaginosis: a definition. Scand J Urol Nephrol Suppl 1984; 86:259-264.
13. Atashili J, Poole C, Ndumbe PM, Adimora AA, Smith JS. Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies. AIDS 2008; 22:1493-1501.
14. Hay P. Life in the littoral zone: lactobacilli losing the plot. Sex Transm Infect 2005; 81:100-102. (Pubitemid 40523817)
15. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol 1991; 29:297-301.
16. Martin HL, Richardson BA, Nyange PM, Lavreys L, Hillier SL, Chohan B, et al. Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition. J Infect Dis 1999; 180:1863-1868.
17. Myer L, Denny L, Telerant R, Souza M, Wright TC Jr, Kuhn L. Bacterial vaginosis and susceptibility to HIV infection in South African women: a nested case-control study. J Infect Dis 2005; 192:1372-1380. (Pubitemid 41401150)
18. Ross SA, Novak Z, Ashrith G, Rivera LB, Britt WJ, Hedges S, et al. Association between genital tract cytomegalovirus infection and bacterial vaginosis. J Infect Dis 2005; 192:1727-1730. (Pubitemid 41587822)
19. Schellenberg J, Blake Ball T, Lane M, Cheang M, Plummer F. Flow cytometric quantification of bacteria in vaginal swab samples self-collected by adolescents attending a gynecology clinic. J Microbiol Methods 2008; 73:216-226.
20. Mardh PA, Novikova N, Niklasson O, Bekassy Z, Skude L. Leukocyte esterase activity in vaginal fluid of pregnant and nonpregnant women with vaginitis/vaginosis and in controls. Infect Dis Obstet Gynecol 2003; 11:19-26. (Pubitemid 36604818)
21. Horton RE, McLaren PJ, Fowke K, Kimani J, Ball TB. Cohorts for the study of HIV-1-exposed but uninfected individuals: benefits and limitations. J Infect Dis 2010; 202 (Suppl 3):S377-S381.
22. Burgener A, Rahman S, Ahmad R, Lajoie J, Ramdahin S, Mesa C, et al. Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers. J Proteome Res 2011; 10:5139-5149.
23. Schellenberg JJ, Links MG, Hill JE, Dumonceaux TJ, Kimani J, Jaoko W, et al. Molecular definition of vaginal microbiota in East African commercial sex workers. Appl Environ Microbiol 2011; 77:4066-4074.
24. Taha TE, Hoover DR, Dallabetta GA, Kumwenda NI, Mtimavalye LA, Yang LP, et al. Bacterial vaginosis and disturbances of vaginal flora: association with increased acquisition of HIV. AIDS 1998; 12:1699-1706. (Pubitemid 28418342)
25. van de Wijgert JH, Morrison CS, Brown J, Kwok C, Van Der Pol B, Chipato T, et al. Disentangling contributions of reproductive tract infections to HIV acquisition in African women. Sex Transm Dis 2009; 36:357-364.
26. Kimani J, Kaul R, Nagelkerke NJ, Luo M, MacDonald KS, Ngugi E, et al. Reduced rates of HIV acquisition during unprotected sex by Kenyan female sex workers predating population declines in HIV prevalence. AIDS 2008; 22:131-137. (Pubitemid 350294887)
27. McClelland RS, Richardson BA, Hassan WM, Chohan V, Lavreys L, Mandaliya K, et al. Improvement of vaginal health for Kenyan women at risk for acquisition of human immunodeficiency virus type 1: results of a randomized trial. J Infect Dis 2008; 197:1361-1368. (Pubitemid 351706458)