Transcription factor GATA-4 is abundantly expressed in childhood but not in adult liver tumors

Journal of Pediatric Gastroenterology and Nutrition

Volumn 54, Issue 1, 2012, Pages 101-108

  Soini, Tea ^a   Haveri, Hanna ^a   Elo, Jenni M ^a   Kauppinen, Marjut ^a   Kyrönlahti, Antti ^a   Salo, Matti K ^b   Lohi, Jouko ^a   Andersson, Leif C ^a   Wilson, David B ^c   Heikinheimo, Markku ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

GATA 4; hepatoblastoma; hepatocellular carcinoma; transcription factor

Indexed keywords

ERYTHROPOIETIN; TRANSCRIPTION FACTOR GATA 4;

ADOLESCENT; ADULT; ADULT DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHILD; CHILDHOOD CANCER; CONTROLLED STUDY; FEMALE; FETUS; GROUPS BY AGE; HEPATOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; LIVER CELL CARCINOMA; LIVER TUMOR; MALE; MOUSE; NONHUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD;

EID: 84855340453     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0b013e31822d52cf     Document Type: Article

References (48)

1. Meyers RL. Tumors of the liver in children. Surg Oncol 2007;16:195-203. (Pubitemid 350086944)
2. Ross JA, Gurney JG. Hepatoblastoma incidence in the United States from 1973 to 1992. Med Pediatr Oncol 1998;30:141-2. (Pubitemid 28028516)
3. Litten JB, Tomlinson GE. Liver tumors in children. Oncologist 2008;13:812-20.
4. Ishak K, Goodman Z, Stocker T. Tumors of the Liver and Intrahepatic Bile Ducts. Washington, DC: American Registry of Pathology; 2001.
5. Ashorn M, Pitkanen S, Salo MK, et al. Current strategies for the treatment of hereditary tyrosinemia type I. Paediatr Drugs 2006;8: 47-54.
6. Deleted in proof.
7. Burch JB. Regulation of GATA gene expression during vertebrate development. Semin Cell Dev Biol 2005;16:71-81. (Pubitemid 40126878)
8. Brewer A, Pizzey J. GATA factors in vertebrate heart development and disease. Expert Rev Mol Med 2006;8:1-20. (Pubitemid 44404697)
9. Bossard P, Zaret KS. GATA transcription factors as potentiators of gut endoderm differentiation. Development 1998;125:4909-17. (Pubitemid 29026772)
10. Nemer G, Nemer M. Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6. Dev Biol 2003;254: 131-48. (Pubitemid 36259877)
11. Dame C, Sola MC, Lim KC, et al. Hepatic erythropoietin gene regulation by GATA-4. J Biol Chem 2004;279:2955-61. (Pubitemid 38114288)
12. Morrisey EE, Tang Z, Sigrist K, et al. GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev 1998;12:3579-90. (Pubitemid 28553248)
13. Zhao R, Watt AJ, Li J, et al. GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol 2005;25:2622-31. (Pubitemid 40381626)
14. Ribatti D, Marzullo A, Gentile A, et al. Erythropoietin/ erythropoietinreceptor system is involved in angiogenesis in human hepatocellular carcinoma. Histopathology 2007;50:591-6. (Pubitemid 46495824)
15. von Schweinitz D, Schmidt D, Fuchs J, et al. Extramedullary hematopoiesis and intratumoral production of cytokines in childhood hepatoblastoma. Pediatr Res 1995;38:555-63.
16. Liang SH, Hassett C, Omiecinski CJ. Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1). Mol Pharmacol 2005;67:220-30. (Pubitemid 40069982)
17. Ivanov GS, Kater JM, Jha SH, et al. Sp and GATA factors are critical for apolipoprotein AI downstream enhancer activity in human HepG2 cells. Gene 2003;323:31-42. (Pubitemid 37501083)
18. Viger RS, Guittot SM, Anttonen M, et al. Role of the GATA family of transcription factors in endocrine development, function, and disease. Mol Endocrinol 2008;22:781-98. (Pubitemid 351485626)
19. Ribatti D, Vacca A, Roccaro AM, et al. Erythropoietin as an angiogenic factor. Eur J Clin Invest 2003;33:891-6. (Pubitemid 37215045)
20. Westenfelder C, Baranowski RL. Erythropoietin stimulates proliferation of human renal carcinoma cells. Kidney Int 2000;58:647-57. (Pubitemid 30620014)
21. Arcasoy MO, Amin K, Karayal AF, et al. Functional significance of erythropoietin receptor expression in breast cancer. Lab Invest 2002; 82:911-8. (Pubitemid 34761666)
22. Kayser K, Gabius HJ. Analysis of expression of erythropoietin-binding sites in human lung carcinoma by the biotinylated ligand. Zentralbl Pathol 1992;138:266-70.
23. Haveri H,Westerholm-Ormio M, Lindfors K, et al. Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa. BMC Gastroenterol 2008;8:9.
24. Dzieran J, Beck JF, Sonnemann J. Differential responsiveness of human hepatoma cells versus normal hepatocytes to TRAIL in combination with either histone deacetylase inhibitors or conventional cytostatics. Cancer Sci 2008;99:1685-92.
25. Charron F, Tsimiklis G, Arcand M, et al. Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev 2001;15:2702-19. (Pubitemid 32988880)
26. Liang Q, DeWindt LJ, Witt SA, et al. The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo. J Biol Chem 2001;276:30245-53.
27. Kyronlahti A, Ramo M, Tamminen M, et al. GATA-4 regulates Bcl-2 expression in ovarian granulosa cell tumors. Endocrinology 2008;149: 5635-42.
28. Jaaskelainen M, Kyronlahti A, Anttonen M, et al. TRAIL pathway components and their putative role in granulosa cell apoptosis in the human ovary. Differentiation 2009;77:369-76.
29. Karafin MS, Cummings CT, Fu B, et al. The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinoma. Int J Clin Exp Pathol 2009;3:47-55.
30. Dame C, Fahnenstich H, Freitag P, et al. Erythropoietin mRNA expression in human fetal and neonatal tissue. Blood 1998;92:3218-25. (Pubitemid 28492329)
31. Kiiveri S, Siltanen S, Rahman N, et al. Reciprocal changes in the expression of transcription factors GATA-4 and GATA-6 accompany adrenocortical tumorigenesis in mice and humans. Mol Med 1999; 5:490-501. (Pubitemid 29399754)
32. Laitinen MP, Anttonen M, Ketola I, et al. Transcription factors GATA-4 and GATA-6 and a GATA family cofactor, FOG-2, are expressed in human ovary and sex cord-derived ovarian tumors. J Clin Endocrinol Metab 2000;85:3476-83.
33. Ketola I, Pentikainen V, Vaskivuo T, et al. Expression of transcription factor GATA-4 during human testicular development and disease. J Clin Endocrinol Metab 2000;85:3925-31.
34. Guo M, House MG, Akiyama Y, et al. Hypermethylation of the GATA gene family in esophageal cancer. Int J Cancer 2006;119:2078-83. (Pubitemid 44423664)
35. Hoene V, Fischer M, Ivanova A, et al. GATA factors in human neuroblastoma: distinctive expression patterns in clinical subtypes. Br J Cancer 2009;101:1481-9.
36. Cabibbo G, Craxi A. Epidemiology, risk factors and surveillance of hepatocellular carcinoma. Eur Rev Med Pharmacol Sci 2010;14:352-5.
37. Lieber J, Kirchner B, Eicher C, et al. Inhibition of Bcl-2 and Bcl-X enhances chemotherapy sensitivity in hepatoblastoma cells. Pediatr Blood Cancer 2010;55:1089-95.
38. Warmann SW, Frank H, Heitmann H, et al. Bcl-2 gene silencing in pediatric epithelial liver tumors. J Surg Res 2008;144:43-8. (Pubitemid 350234956)
39. Aries A, Paradis P, Lefebvre C, et al. Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity. Proc Natl Acad Sci U S A 2004;101:6975-80. (Pubitemid 38596428)
40. Kobayashi S, Lackey T, Huang Y, et al. Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo. FASEB J 2006;20:800-2. (Pubitemid 46671220)
41. Suzuki YJ, Nagase H,Wong CM, et al. Regulation of Bcl-xL expression in lung vascular smooth muscle. Am J Respir Cell Mol Biol 2007; 36:678-87. (Pubitemid 46871422)
42. Charlotte F, L'Hermine A, Martin N, et al. Immunohistochemical detection of bcl-2 protein in normal and pathological human liver. Am J Pathol 1994;144:460-5. (Pubitemid 24176749)
43. Divine JK, Staloch LJ, Haveri H, et al. GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha. Am J Physiol Gastrointest Liver Physiol 2004;287: G1086-99. (Pubitemid 39423702)
44. Cirillo LA, Lin FR, Cuesta I, et al. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol Cell 2002;9:279-89. (Pubitemid 34195554)
45. Xu L, Hui L, Wang S, et al. Expression profiling suggested a regulatory role of liver-enriched transcription factors in human hepatocellular carcinoma. Cancer Res 2001;61:3176-81. (Pubitemid 32691972)
46. Kalkuhl A, Kaestner K, Buchmann A, et al. Expression of hepatocyteenriched nuclear transcription factors in mouse liver tumours. Carcinogenesis 1996;17:609-12. (Pubitemid 26085347)
47. Flodby P, Liao DZ, Blanck A, et al. Expression of the liver-enriched transcription factors C/EBP alpha, C/EBP beta, HNF-1, and HNF-4 in preneoplastic nodules and hepatocellular carcinoma in rat liver. Mol Carcinog 1995;12:103-9.
48. Kyronlahti A, Kauppinen M, Lind E, et al. GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis. Endocr Relat Cancer 2010;17:709-17.