Maternal low-level lead exposure reduces the expression of PSA-NCAM and the activity of sialyltransferase in the hippocampi of neonatal rat pups

NeuroToxicology

Volumn 29, Issue 4, 2008, Pages 675-681

  Hu, Qiansheng ^a   Fu, Hongjun ^b   Ren, Tieling ^a   Wang, Shuyu ^a   Zhou, Wei ^a   Song, Hong ^a   Han, Yifan ^b   Dong, Shengzhang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Hippocampus; Lead; Neonatal rat pups; Polysialyltransferase; PSA NCAM

Indexed keywords

CELL ADHESION MOLECULE; LEAD CHLORIDE; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; PROTEIN PSA NCAM; SIALYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BRAIN TOXICITY; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; FEMALE; FLUORESCENCE ANALYSIS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; NONHUMAN; PERINATAL PERIOD; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HIPPOCAMPUS; LEAD; MALE; NEURAL CELL ADHESION MOLECULE L1; NEURAL CELL ADHESION MOLECULES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; SHIGA TOXIN; SIALIC ACIDS; SIALYLTRANSFERASES;

RATTUS; RATTUS NORVEGICUS;

EID: 46149106797     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2008.04.002     Document Type: Article

References (39)

1. Bellinger D., Leviton A., Waternaux C., Needleman H., and Rabinowitz M. Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development. N Engl J Med 316 (1987) 1037-1043
2. Breen K.C., Coughlan C.M., and Hayes F.D. The role of glycoproteins in neural development, function, and disease. Mol Neurobiol 16 (1998) 163-220
3. Breen K.C., Kelly P.G., and Regan C.M. Postnatal D2-CAM/N-CAM sialylation state is controlled by a developmentally regulated Golgi sialyltransferase. J Neurochem 48 (1987) 1486-1493
4. Breen K.C., and Regan C.M. Lead stimulates Golgi sialyltransferase at times coincident with the embryonic to adult conversion of the neural cell adhesion molecule. Toxicology 49 (1988) 71-76
5. Brocco M., Pollevick G.D., and Frasch A.C. Differential regulation of polysialyltransferase expression during hippocampus development: implications for neuronal survival. J Neurosci Res 74 (2003) 744-753
6. Bruses J.L., Oka S., and Rutishauser U. NCAM-associated polysialic acid on ciliary ganglion neurons is regulated by polysialytransferase levels and interaction with muscle. J Neurosci 15 (1995) 8310-8319
7. Chuong C.M., and Edelman G.M. Alterations in neural cell adhesion molecules during development of different regions of the nervous system. J Neurosci 4 (1984) 2354-2368
8. Cookman G.R., King W., and Regan C.K. Chronic low-level lead exposure impairs embryonic to adult conversion of the neural cell adhesion molecule. J Neurochem 49 (1987) 399-403
9. Cremer H., Lange R., Christoph A., Plomann M., Vopper G., Roes J., et al. Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature 367 (1994) 455-459
10. Crossin K.L., and Krushel L.A. Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily. Dev Dyn 218 (2000) 260-279
11. Dey P.M., Gochfeld M., and Reuhl K.R. Developmental methylmercury administration alters cerebellar PSA-NCAM expression and Golgi sialyltransferase activity. Brain Res 845 (1999) 139-151
12. Easton E.W., Schiphorst W.E., Koeleman C.A., Michalides R.J., and Van Den Eijinden D.H. CMP-NeuAc:(NeuAc alpha 2 → 8)n (colominic acid) sialyltransferase activity in rat brain and in tumour cells that express polysialic acid on neural cell adhesion molecules. Glycoconj J 12 (1995) 829-837
13. Eckhardt M., Muhlenhoff M., Bethe A., Koopman J., Frosch M., and Gerardy-Schahn R. Molecular characterization of eukaryotic polysialyltransferase-1. Nature 373 (1995) 715-718
14. Edelman G.M., and Crossin K.L. Cell adhesion molecules: implications for molecular histology. Annu Rev Biochem 60 (1991) 155-190
15. Edelman G.M. Cell adhesion molecules in the regulation of animal form and tissue pattern. Ann Rev Cell Biol 2 (1986) 81-116
16. Fox G.B., O'Connell A.W., Murphy K.J., and Regan C.M. Memory consolidation induces a transient and time-dependent increase in the frequency of neural cell adhesion molecule polysialylated cells in the adult rat hippocampus. J Neurochem 65 (1995) 2796-2799
17. Fujita Y., Terashima M., Hoshino Y., Ohtani S., Kashimura S., Kanzaki N., et al. Detection of cancer cells disseminated in bone marrow using real-time quantitative RT-PCR of CEA, CK19, and CK20 mRNA in patients with gastric cancer. Gastric Cancer 9 (2006) 308-314
18. Gardella C. Lead exposure in pregnancy: a review of the literature and argument for routine prenatal screening. Obstet Gynecol Surv 56 (2001) 231-238
19. Goyer R.A. Results of lead research: prenatal exposure and neurological consequences. Environ Health Perspect 104 (1996) 1050-1054
20. Gulson B.L., Mizon K.J., Korsch M.J., Palmer J.M., and Donnelly J.B. Mobilization of lead from human bone tissue during pregnancy and lactation-a summary of long-term research. Sci Total Environ 303 (2003) 79-104
21. Heidmets L.T., Zharkovsky T., Jurgenson M., Jaako-Movits K., and Zharkovsky A. Early post-natal, low-level lead exposure increases the number of PSA-NCAM expressing cells in the dentate gyrus of adult rat hippocampus. Neurotoxicology 27 (2006) 39-43
22. Horii A., Smith P.F., and Darlington C.L. Application of real-time quantitative polymerase chain reaction to quantification of glutamate receptor gene expression in the vestibular brainstem and cerebellum. Brain Res Brain Res Protoc 9 (2002) 77-83
23. Hu Q.S., Ren T.L., Fu H.J., Dong S.Z., and Chen X.M. Impact of low-level lead exposure on neural cell adhesion molecule expression of primarily cultured hippocampal neurons. Zhonghua Yu Fang Yi Xue Za Zhi 38 (2004) 379-382
24. Ibsen S., Berezin V., Nørgaard-Pedersen B., and Bock E. Quantification of the D2-glycoprotein in amniotic fluid and serum from pregnancies with fetal neural tube defects. J Neurochem 41 (1983) 363-366
25. Kojima N., Kono M., Yoshida Y., Tachida Y., Nakafuku M., and Tsuji S. Biosynthesis and expression of polysialic acid on the neural cell adhesion molecule is predominantly directed by ST8Sia II/STX during in vitro neuronal differentiation. J Biol Chem 271 (1996) 22058-22062
26. Lidsky T.I., and Schneider J.S. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 126 (2003) 5-19
27. Mackowiak M., Markowicz-Kula K., Fijal K., and Wedzony K. Acute and repeated administration of cocaine differentially regulates expression of PSA-NCAM-positive neurons in the rat hippocampus. Brain Res 1055 (2005) 149-155
28. Minana R., Climent E., Barettino D., Segui J.M., Renau-Piqueras J., and Guerri C. Alcohol exposure alters the expression pattern of neural cell adhesion molecules during brain development. J Neurochem 75 (2000) 954-964
29. Murphy K.J., and Regan C.M. Low-level lead exposure in the early postnatal period results in persisting neuroplastic deficits associated with memory consolidation. J Neurochem 72 (1999) 2099-2104
30. Nakayama J., Fukuda M.N., Fredette B., Ranscht B., and Fukuda M. Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain. Proc Natl Acad Sci USA 92 (1995) 7031-7035
31. Ono K., Tomasiewicz H., Magnuson T., and Rutishauser U. N-CAM mutation inhibits tangential neuronal migration and is phenocopied by enzymatic removal of polysialic acid. Neuron 13 (1994) 595-609
32. Plusquellec P., Muckle G., Dewailly E., Ayotte P., Jacobson S.W., and Jacobson J.L. The relation of low-level prenatal lead exposure to behavioral indicators of attention in Inuit infants in Arctic Quebec. Neurotoxicol Teratol 29 (2007) 527-537
33. Regan C.M., and Keegan K. Neuroteratological consequences of chronic low-level lead exposure. Dev Pharmacol Ther 15 (1990) 189-195
34. Rutishauser U. Polysialic acid and the regulation of cell interactions. Curr Opin Cell Biol 8 (1996) 679-684
35. Sadoul R., Hirn M., Deagostini-Bazin H., Rougon G., and Goridis C. Adult and embryonic mouse neural cell adhesion molecules have different binding properties. Nature 304 (1983) 347-349
36. Sanin L.H., Gonzalez-Cossio T., Romieu I., Peterson K.E., Ruiz S., Palazuelos E., et al. Effect of maternal lead burden on infant weight and weight gain at one month of age among breastfed infants. Pediatrics 107 (2001) 1016-1023
37. Scheidegger E.P., Sternberg L.R., Roth J., and Lowe J.B. A human STX cDNA confers polysialic acid expression in mammalian cells. J Biol Chem 270 (1995) 22685-22688
38. Shen X.M., Yan C.H., Guo D., Wu S.M., Li R.Q., Huang H., et al. Low-level prenatal lead exposure and neurobehavioral development of children in the first year of life: a prospective study in Shanghai. Environ Res 79 (1998) 1-8
39. Yun S.W., Gartner U., Arendt T., and Hoyer S. Increase in vulnerability of middle-aged rat brain to lead by cerebral energy depletion. Brain Res Bull 52 (2000) 371-378