Region specific increase in the antioxidant enzymes and lipid peroxidation products in the brain of rats exposed to lead

Free Radical Research

Volumn 41, Issue 3, 2007, Pages 267-273

  Bennet, Christopher ^a   Bettaiya, Rajanna ^a   Rajanna, Sharada ^a   Baker, Levenia ^a   Yallapragada, Prabhakara Rao ^b   Brice, Jon ^a   White, Samuel ^a   Bokara, Kiran Kumar ^b  

^a ALCORN STATE UNIVERSITY   (United States)

^b ANDHRA UNIVERSITY   (India)

Author keywords

Antioxidant enzymes; Lead toxicity; Lipid peroxidation products; Rat brain

Indexed keywords

CATALASE; LEAD ACETATE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; FRONTAL CORTEX; HIPPOCAMPUS; LEAD POISONING; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; TISSUE SPECIFICITY;

ANIMALS; ANTIOXIDANTS; BRAIN; CATALASE; LIPID PEROXIDATION; MALE; ORGANOMETALLIC COMPOUNDS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; UP-REGULATION;

ANIMALIA; RATTUS;

EID: 33947283929     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760600889855     Document Type: Article

References (75)

1. Bellinger, DC (2004) Lead. Pediatrics, 113, pp. 1016-1022.
2. Toscano, CD and Guilarte, TR (2005) Lead neurotoxicity: From exposure to molecular effects. Brain Res Rev, 49, pp. 529-554.
3. Papanikolaou, NC, Hatzidaki, EG, Belivanis, S., Tzanakakis, GN and Tsatsakis, AM (2005) Lead toxicity update: A brief review. Med Sci Monit, 11, pp. 329-336.
4. Bressler, J., Kim, KA, Chakraborti, T. and Goldstein, G. (1999) Mechanism of lead neurotoxicity. Neurochem Res, 24, pp. 595-600.
5. Marques, CC, Nunes, AC, Pinheiro, T., Lopes, PA, Santos, MC, Viegas-Crespo, AM, Ramalhinho, MG and Mathias, ML (2006) An assessment of time-dependent effects of lead exposure in Algerian mice (Mus spretus) using different methodological approaches. Biol Trace Elem Res, 109, pp. 75-90.
6. Minnema, DJ, Michaelson, IA and Cooper, GP (1988) Calcium efflux and neurotransmitter release from rat brain hippocampal synaptosomes exposed to lead. Toxicol Appl Pharmacol, 92, pp. 351-357.
7. Minnema, DJ and Michaelson, IA (1986) Differential effects of inorganic lead and delta aminolevulinic acid in vitro on synaptosomal gamma aminobutyric acid release. Toxicol Appl Pharmacol, 86, pp. 437-447.
8. Ghosh, S., Chatterjee, AK and Gupta, M. (1992) Impact of lead toxicity on brain metabolisms of nucleic acid and catecholamine in protein malnourished rats. J Nutr Sci Vitaminol, 38, pp. 451-462.
9. Shellenberger, MK (1994) Effects of early lead exposure on the neurotransmitter systems in the brain: A review with commentary. Neurotoxicology, 5, pp. 177-212.
10. Fitsanakis, VA and Aschner, M. (2005) The importance of glutamate, glycine, and gamma-aminobutyric acid transport and regulation in manganese, mercury and lead neurotoxicity. Toxicol Appl Pharmacol, 204, pp. 343-354.
11. Tsao, DA, Yu, HS, Cheng, JT, Ho, CK and Chang, HR (2000) Alterations in beta-adrenergic receptor density and adenylate cyclase activity in the rat brain treated chronically with lead. Toxicology, 146, pp. 93-99.
12. Suszkiw, JB (2004) Presynaptic disruption of transmitter release by lead. Neurotoxicology, 25, pp. 599-604.
13. 2+: Association with deficits of LTP and spatial learning. Neurotoxicology, 22, pp. 635-643.
14. Struzynska, L., Chalimoniuk, M. and Sulkowski, G. (2005) Changes in expression of neuronal and glial glutamate transporters in lead-exposed adult rat brain. Neurochem Int, 47, pp. 326-333.
15. Struzynska, L. and Sulkowski, G. (2004) Relationships between glutamine, glutamate, and GABA in nerve endings under Pb-toxicity conditions. J Inorg Biochem, 98, pp. 951-958.
16. Gidlow, DA (2004) Lead toxicity. Occup Med, 54, pp. 76-81.
17. Pounds, JG, Long, GJ and Rosen, JF (1991) Cellular and molecular toxicity of lead in bone. Environ Health Perspect, 91, pp. 17-32.
18. Bressler, JP and Goldstein, GW (1991) Mechanisms of lead neurotoxicity. Biochem Pharmacol, 41, pp. 479-484.
19. Simons, TJB (1993) Lead-calcium interactions in cellular lead toxicity. Neurotoxicology, 14, pp. 77-86.
20. Goldstein, GW (1993) Evidence that lead acts as a calcium substitute in a second messenger metabolism. Neurotoxicology, 14, pp. 97-101.
21. Vazquez, A. and Ortiz, SP (2004) Lead impairs long-term memory and blocks learning-induced increases in hippocampal protein kinase C activity. Toxicol Appl Pharmacol, 200, pp. 27-39.
22. Munoz, C., Garbe, K., Lileinthal, H. and Winneke, G. (1988) Significance of hippocampal dysfunction in low level lead exposure of rats. Neurotoxicol Teratol, 10, pp. 245-253.
23. Wang, L., Xiao, C., Guo, F. and Ruan, DY (2005) Effects of lead on voltage-gated sodium channels in rat hippocampal CA1 neurons. Neuroscience, 133, pp. 679-690.
24. Altmann, L., Weinberg, F., Sveinsson, K., Lilienthal, H., Wiegand, H. and Winneke, G. (1993) Impairment of long-term potentiation following chronic lead exposure. Toxicol Lett, 66, pp. 105-112.
25. 2+-ATPase in synaptic plasma membranes and microsomes of rat cerebral cortex and cerebellum. Ecotoxicol Environ Saf, 33, pp. 157-162.
26. Rajanna, B., Rajanna, S., Hall, E. and Yallapragada, PR (1997) In vitro metal inhibition of N-methyl--aspartate specific glutamate receptor binding in neonatal and adult rat brain. Drug Chem Toxicol, 20, pp. 21-29.
27. +-ATPase activity in different regions of adult rat brain. Drug Chem Toxicol, 26, pp. 117-124.
28. Chen, SM, Swilley, S., Bell, R., Rajanna, S., Reddy, SLN and Rajanna, B. (2000) Lead-induced alterations in nitrite and nitrate levels in different regions of the rat brain. Comp Biochem Physiol, 125, pp. 115-123.
29. Bredt, DS and Snyder, SH (1989) Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA, 86, pp. 9030-9033.
30. Sharifi, AM, Mousavi, SH, Bakhashayesh, M., Tehrani, FK, Mahmoudiean, M. and Oryan, S. (2005) Study of correlation between lead-induced cytotoxicity and nitric oxide production in PC-12 cells. Toxicol Lett, 160, pp. 43-48.
31. Chetty, CS, Vemuri, MC, Campbell, K. and Suresh, C. (2005) Lead-induced cell death of human neuroblastoma cells involves GSH depletion. Cell Mol Biol Lett, 10, pp. 413-423.
32. Kodavanti, PRS (1999) Reactive oxygen species and antioxidant homeostasis in neurotoxicology. Neurotoxicology, Taylor &Francis, USA
33. Sandhir, R., Julka, D. and Gill, KD (1994) Lipoperoxidative damage on lead treatment in rat brain and its implications on membrane bound enzymes. Pharmacol Toxicol, 74, pp. 66-71.
34. Adonaylo, VN and Oteiza, PI (1999) Lead intoxication: Antioxidant defenses and oxidative damage in rat brain. Toxicology, 135, pp. 77-85.
35. Patra, RC, Swarup, D. and Dwivedi, SK (2001) Antioxidant effects of alpha tocopherol, ascorbic acid and -methionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicology, 162, pp. 81-88.
36. Tandon, SK, Singh, S., Prasad, S., Srivastava, S. and Siddiqui, MKJ (2002) Reversal of lead-induced oxidative stress by chelating agent, antioxidant, or their combination in the rat. Environ Res, 90, pp. 61-66.
37. Flora, JSS, Pande, M. and Mehta, A. (2003) Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication. Chem Biol Interact, 145, pp. 267-280.
38. Hiroshi, O., Ohishi, N. and Yagi, K. (1979) Assay for lipid peroxides in animal tissues by TBA reaction. Anal Biochem, 95, pp. 351-358.
39. Aebi, H. and Packer, L. (1984) Catalase in vitro. Methods Enzymol, 105, pp. 121-126.
40. Beuchamp, PC and Fridovich, I. (1971) Superoxide dismutase: Improved assay and an assay applicable to PAGE. Anal Biochem, 44, pp. 276-287.
41. Snedecor, GW and Cochran, WG (1967) Statistical methods, The Iowa State University Press, Iowa
42. Adonaylo, VN and Oteiza, PI (1999) Lead promotes lipid oxidation and alterations in membrane physical properties. Toxicology, 132, pp. 19-32.
43. Gong, Z. and Evans, HL (1997) Effect of chelation with meso-dimercaptosuccinic acid (DMSA) before and after the appearance of lead-induced neurotoxicity in the rat. Toxicol Appl Pharmacol, 144, pp. 205-214.
44. Stark, M., Wolff, JE and Korbmacher, A. (1992) Modulation of glial cell differentiation by exposure to lead and cadmium. Neurotoxicol Teratol, 14, pp. 247-252.
45. Medina, L., Figueredo-Cardenas, G. and Reiner, A. (1996) Differential abundance of superoxide dismutase in interneurons versus projection neurons and in matrix versus striosome neurons in monkey striatum. Brain Res, 708, pp. 59-70.
46. Zawia, NH and Harry, GJ (1996) Developmental exposure to lead interferes with glial and neuronal differential gene expression in the rat cerebellum. Toxicol Appl Pharmacol, 138, pp. 43-47.
47. Jindal, V. and Gill, KD (1999) Ethanol potentiates lead-induced inhibition of rat brain antioxidant defense systems. Phamacol Toxicol, 85, pp. 16-21.
48. Jiun, YS and Hsien, LT (1994) Lipid peroxidation in workers exposed to lead. Arch Environ Health, 49, pp. 256-259.
49. West, WL, Knight, EM, Edwards, CH, Menning, M., Spurlock, B., James, H., Johnson, AA, Oyemade, UJ, Jackson, C. and Westney, LS (1994) Maternal low level lead and pregnancy outcomes. J Nutr, 124, pp. 9815-9986.
50. Bachara, EJH, Mediros, MHG, Monteiro, HP, Hermes-Lima, M., Pereira, B., Demasi, M., Costa, CA, Abdullah, DSP, Onuki, J., Wendel, CMA and Mascio, P Di (1993) A free radical hypothesis of lead poisoning and inborn porphyries associated with 5-aminolevulinic acid overload. Quim Nova, 16, pp. 385-392.
51. Oteiza, PI, Verstraeten, SV and Adonaylo, VN (1995) Oxidative damage induced by metals without redox capacity in biological systems. Cienc Cult, 47, pp. 330-335.
52. Hsu, P. and Guo, Y. (2002) Anitoxidant nutrients and lead toxicity. Toxicology, 180, pp. 33-44.
53. Nehru, B. and Kanwar, SS (2004) N-acetylcysteine exposure on lead-induced lipid peroxidative damage and oxidative defense system in brain regions of rats. Biol Trace Elem Res, 101, pp. 257-264.
54. Krall, J., Bagley, AC, Mulienbach, GT, Hallewell, RA and Lynch, RE (1988) Superoxide mediates the toxicity of paraquat for cultured mammalian cells. J Biol Chem, 263, pp. 1910-1914.
55. Alvarez, S. and Boveria, A. (1993) Induction of antioxidant enzymes and DT-diaphrorase in human blood mononuclear cells by light stress. Arch Biochem Biophys, 305, pp. 247-251.
56. Cavanagh, EM, Inserra, R., Feder, L., Romano, L., Ercole, L. and Fraga, CG (1995) Superoxide dismutase and glutathione peroxidase activities are incrased by enalapril and captopril in mouse liver. FEBS Lett, 361, pp. 22-24.
57. Monteiro, HP, Abdalla, DSP, Falijoni, AA and Bachera, EJH (1986) Generation of active oxygen species during coupled autooxidation of haemoglobin and delta aminolevulinic acid. Biochem Biophys Acta, 881, pp. 100-106.
58. Gurer, H., Ozgunes, H., Neal, R., Spitzand, DR and Ercal, N. (1998) Antioxidant effects of N-acetyl cysteine and succimer in red blood cells from lead exposed rats. Toxicology, 128, pp. 181-189.
59. Halliwell, B. (1994) Free radicals, antioxidants, and human disease: Curiosity, cause and consequence?. Lancet, 344, pp. 721-724.
60. Campbell, A., Hamai, D. and Bondy, SC (2001) Differential toxicity of aluminium salts in human cell lines of neural origin: Implications for neurodegeneration. Neurotoxicology, 22:1, pp. 63-71.
61. Pathak, N. and Khandelwal, S. (2006) Oxidative stress and apoptic changes in murine splenocytes exposed to cadmium. Toxicology, 220:1, pp. 26-36.
62. 2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria. Biochem Pharmacol, 45:10, pp. 2017-2024.
63. Galvan-Arzate, S., Pedraza-Chaverri, J., Medina-Campos, ON, Maldonado, PD, Vazquez-Roman, B., Rios, C. and Santamaria, A. (2005) Delayed effects of thallium in the rat brain: Regional changes in lipid peroxidation and behavioral markers but moderate alterations in antioxidants after a single administration. Food Chem Toxicol, 43:7, pp. 1037-7045.
64. Scheuhammer, AM and Cherian, MG (1982) The regional distribution of lead in normal rat brain. Neurotoxicology, 3:1, pp. 85-92.
65. Kishi, R., Ikeda, T., Miyake, H., Uchino, E., Tsuzuki, T. and Inoue, K. (1982) Regional distribution of lead, iron and copper in suckling and adult rat brains. Brain Res, 251:1, pp. 180-182.
66. Clark, DE, Nation, JR, Bourgeosis, AJ, Hare, MF, Baker, DE and Hinderberger, EJ (1985) The regional distribution of cadmium in the brains of orally exposed rats. Neurotoxicology, 6:3, pp. 109-114.
67. Hazell, AS, Noormandin, L., Norenberg, MD, Kennedy, G. and Yi, JH (2006) Alzheimer type II astrocytic changes following subacute exposure to manganese and its prevention by antioxidant treatment. Neurosci Lett, 396:3, pp. 167-171.
68. Gelman, BB, Michealson, IA and Bus, JS (1978) The effect of lead on oxidative haemolysis and erythrocyte defense mechanisms in the rat. Toxicol Appl Pharmacol, 45, pp. 119-129.
69. Othman, AI and El-Missiry, MA (1998) Role of selenium against lead toxicity in male rats. J Biochem Mol Toxicol, 12, pp. 345-349.
70. Daniel, S., Limson, JL, Dairam, A., Watkins, G. and Dava, S. (2004) Through metal binding, curcumin protects against lead-and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. J Inorg Biochem, 98, pp. 266-275.
71. 2+-induced increased in oxidative stress: An experimental model using dissociated rat brain neurons. Jpn J Pharmacol, 72, pp. 381-385.
72. Aykin-Burns, N., Franklin, EA and Ercal, N. (2005) Effects of N-acetylcysteine on lead-exposed PC-12 cells. Arch Environ Contam Toxicol, 49:1, pp. 119-123.
73. Oh, SH and Lim, SC (2006) A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation. Toxicol Appl Pharmacol, 212:3, pp. 212-223.
74. Johnson, VJ, Kim, SH and Sharma, RP (2005) Aluminum-maltolate induceds apoptosis and necrosis in neuro-2a cells: Potential role for p53 signalling. Toxicol Sci, 83:2, pp. 329-339.
75. Wang, CH, Monette, R., Lee, SC, Morely, P. and Wu, WG (2005) Cobra cardiotoxin kinduced cell death in fetal rat cardiomyocytes and cortical neurons: Different pathway but similar cell surface target. Toxicon, 46:4, pp. 430-440.