메뉴 건너뛰기




Volumn 27, Issue 1, 2012, Pages 225-231

Association between LRRK2 and 4E-BP1 protein levels in normal and malignant cells

Author keywords

4E BP1; Kinases; LRRK2; MG132; Proteasome; Protein degradation

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; CYCLIC AMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA; CYCLIC AMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA; CYCLIN DEPENDENT KINASE 1; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 4E BINDING PROTEIN 1; LEUCINE RICH REPEAT KINASE 2; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 12; P21 ACTIVATED KINASE 2; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEASOME; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN TYROSINE KINASE; RAF PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84855271499     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1462     Document Type: Article
Times cited : (18)

References (34)
  • 2
    • 0345732640 scopus 로고    scopus 로고
    • mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E
    • DOI 10.1128/MCB.24.1.200-216.2004
    • Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C and Blenis J: mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 24: 200-216, 2004. (Pubitemid 38010048)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.1 , pp. 200-216
    • Fingar, D.C.1    Richardson, C.J.2    Tee, A.R.3    Cheatham, L.4    Tsou, C.5    Blenis, J.6
  • 3
    • 0036195727 scopus 로고    scopus 로고
    • Translational control of cell fate: Availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency
    • DOI 10.1128/MCB.22.8.2853-2861.2002
    • Li S, Sonenberg N, Gingras AC, et al.: Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency. Mol Cell Biol 22: 2853-2861, 2002. (Pubitemid 34263005)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.8 , pp. 2853-2861
    • Li, S.1    Sonenberg, N.2    Gingras, A.-C.3    Peterson, M.4    Avdulov, S.5    Polunovsky, V.A.6    Bitterman, P.B.7
  • 4
    • 0036181011 scopus 로고    scopus 로고
    • Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif
    • DOI 10.1128/MCB.22.6.1674-1683.2002
    • Tee AR and Proud CG: Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Mol Cell Biol 22: 1674-1683, 2002. (Pubitemid 34174985)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.6 , pp. 1674-1683
    • Tee, A.R.1    Proud, C.G.2
  • 7
    • 33750089285 scopus 로고    scopus 로고
    • Phosphorylated 4E binding protein 1: A hallmark of cell signaling that correlates with survival in ovarian cancer
    • DOI 10.1002/cncr.22195
    • Castellvi J, Garcia A, Rojo F, et al.: Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer. Cancer 107: 1801-1811, 2006. (Pubitemid 44582949)
    • (2006) Cancer , vol.107 , Issue.8 , pp. 1801-1811
    • Castellvi, J.1    Garcia, A.2    Rojo, F.3    Ruiz-Marcellan, C.4    Gil, A.5    Baselga, J.6    Ramon Y, C.S.7
  • 8
    • 69949156862 scopus 로고    scopus 로고
    • Cell signaling in endometrial carcinoma: Phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis
    • Castellvi J, Garcia A, Ruiz-Marcellan C, et al.: Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis. Hum Pathol 40: 1418-1426, 2009.
    • (2009) Hum Pathol , vol.40 , pp. 1418-1426
    • Castellvi, J.1    Garcia, A.2    Ruiz-Marcellan, C.3
  • 9
    • 65949111747 scopus 로고    scopus 로고
    • EIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival
    • Graff JR, Konicek BW, Lynch RL, et al.: eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival. Cancer Res 69: 3866-3873, 2009.
    • (2009) Cancer Res , vol.69 , pp. 3866-3873
    • Graff, J.R.1    Konicek, B.W.2    Lynch, R.L.3
  • 10
    • 65249119397 scopus 로고    scopus 로고
    • Phosphorylated 4E-BP1 is associated with poor survival in melanoma
    • O'Reilly KE, Warycha M, Davies MA, et al.: Phosphorylated 4E-BP1 is associated with poor survival in melanoma. Clin Cancer Res 15: 2872-2878, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 2872-2878
    • O'Reilly, K.E.1    Warycha, M.2    Davies, M.A.3
  • 11
    • 6044223545 scopus 로고    scopus 로고
    • Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers
    • DOI 10.1158/1078-0432.CCR-04-0112
    • Zhou X, Tan M, Stone Hawthorne V, et al.: Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clin Cancer Res 10: 6779-6788, 2004. (Pubitemid 39383026)
    • (2004) Clinical Cancer Research , vol.10 , Issue.20 , pp. 6779-6788
    • Zhou, X.1    Tan, M.2    Hawthorne, V.S.3    Klos, K.S.4    Lan, K.-H.5    Yang, Y.6    Yang, W.7    Smith, T.L.8    Shi, D.9    Yu, D.10
  • 13
    • 0032533173 scopus 로고    scopus 로고
    • Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111)
    • Heesom KJ, Avison MB, Diggle TA and Denton RM: Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111). Biochem J 336 (Pt 1): 39-48, 1998. (Pubitemid 28532558)
    • (1998) Biochemical Journal , vol.336 , Issue.1 , pp. 39-48
    • Heesom, K.J.1    Avison, M.B.2    Diggle, T.A.3    Denton, R.M.4
  • 14
    • 0347627139 scopus 로고    scopus 로고
    • MTOR-mediated regulation of translation factors by amino acids
    • Proud CG: mTOR-mediated regulation of translation factors by amino acids. Biochem Biophys Res Commun 313: 429-436, 2004.
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 429-436
    • Proud, C.G.1
  • 15
    • 31444434449 scopus 로고    scopus 로고
    • mTOR signaling: Implications for cancer and anticancer therapy
    • DOI 10.1038/sj.bjc.6602902, PII 6602902
    • Petroulakis E, Mamane Y, Le Bacquer O, Shahbazian D and Sonenberg N: mTOR signaling: implications for cancer and anticancer therapy. Br J Cancer 94: 195-199, 2006. (Pubitemid 43151534)
    • (2006) British Journal of Cancer , vol.94 , Issue.2 , pp. 195-199
    • Petroulakis, E.1    Mamane, Y.2    Le, B.O.3    Shahbazian, D.4    Sonenberg, N.5
  • 16
    • 0035806992 scopus 로고    scopus 로고
    • Cell cycle-dependent phosphorylation of the translational repressor elF-4E binding protein-1 (4E-BP1)
    • DOI 10.1016/S0960-9822(01)00422-5
    • Heesom KJ, Gampel A, Mellor H and Denton RM: Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1). Curr Biol 11: 1374-1379, 2001. (Pubitemid 32835880)
    • (2001) Current Biology , vol.11 , Issue.17 , pp. 1374-1379
    • Heesom, K.J.1    Gampel, A.2    Mellor, H.3    Denton, R.M.4
  • 17
    • 23044487721 scopus 로고    scopus 로고
    • Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism
    • DOI 10.1038/sj.onc.1208624
    • Greenberg VL and Zimmer SG: Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism. Oncogene 24: 4851-4860, 2005. (Pubitemid 41076303)
    • (2005) Oncogene , vol.24 , Issue.30 , pp. 4851-4860
    • Greenberg, V.L.1    Zimmer, S.G.2
  • 18
    • 0033662156 scopus 로고    scopus 로고
    • Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
    • Yang DQ and Kastan MB: Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nat Cell Biol 2: 893-898, 2000.
    • (2000) Nat Cell Biol , vol.2 , pp. 893-898
    • Yang, D.Q.1    Kastan, M.B.2
  • 19
    • 0032520009 scopus 로고    scopus 로고
    • 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
    • Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N and Hay N: 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev 12: 502-513, 1998. (Pubitemid 28101013)
    • (1998) Genes and Development , vol.12 , Issue.4 , pp. 502-513
    • Gingras, A.-C.1    Kennedy, S.G.2    O'Leary, M.A.3    Sonenberg, N.4    Hay, N.5
  • 21
    • 0037192868 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites
    • DOI 10.1074/jbc.M110367200
    • Herbert TP, Tee AR and Proud CG: The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites. J Biol Chem 277: 11591-11596, 2002. (Pubitemid 34952931)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.13 , pp. 11591-11596
    • Herbert, T.P.1    Tee, A.R.2    Proud, C.G.3
  • 22
    • 51949090816 scopus 로고    scopus 로고
    • Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    • Imai Y, Gehrke S, Wang HQ, et al.: Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J 27: 2432-2443, 2008.
    • (2008) EMBO J , vol.27 , pp. 2432-2443
    • Imai, Y.1    Gehrke, S.2    Wang, H.Q.3
  • 25
    • 15044340650 scopus 로고    scopus 로고
    • Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
    • DOI 10.1128/MCB.25.7.2558-2572.2005
    • Wang X, Beugnet A, Murakami M, Yamanaka S and Proud CG: Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol Cell Biol 25: 2558-2572, 2005. (Pubitemid 40381622)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.7 , pp. 2558-2572
    • Wang, X.1    Beugnet, A.2    Murakami, M.3    Yamanaka, S.4    Proud, C.G.5
  • 26
    • 33644927797 scopus 로고    scopus 로고
    • Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cells
    • Tilleray V, Constantinou C and Clemens MJ: Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cells. FEBS Lett 580: 1766-1770, 2006.
    • (2006) FEBS Lett , vol.580 , pp. 1766-1770
    • Tilleray, V.1    Constantinou, C.2    Clemens, M.J.3
  • 27
    • 1842831274 scopus 로고    scopus 로고
    • Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells
    • DOI 10.1101/gad.1185304
    • Walsh D and Mohr I: Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells. Genes Dev 18: 660-672, 2004. (Pubitemid 38489934)
    • (2004) Genes and Development , vol.18 , Issue.6 , pp. 660-672
    • Walsh, D.1    Mohr, I.2
  • 28
    • 20744448501 scopus 로고    scopus 로고
    • Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells
    • DOI 10.1128/JVI.79.13.8057-8064.2005
    • Walsh D, Perez C, Notary J and Mohr I: Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells. J Virol 79: 8057-8064, 2005. (Pubitemid 40853509)
    • (2005) Journal of Virology , vol.79 , Issue.13 , pp. 8057-8064
    • Walsh, D.1    Perez, C.2    Notary, J.3    Mohr, I.4
  • 29
    • 38749132980 scopus 로고    scopus 로고
    • Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1
    • DOI 10.1038/sj.onc.1210678, PII 1210678
    • Elia A, Constantinou C and Clemens MJ: Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1. Oncogene 27: 811-822, 2008. (Pubitemid 351186316)
    • (2008) Oncogene , vol.27 , Issue.6 , pp. 811-822
    • Elia, A.1    Constantinou, C.2    Clemens, M.J.3
  • 30
    • 20344387465 scopus 로고    scopus 로고
    • Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation
    • DOI 10.1128/MCB.25.12.5031-5039.2005
    • Karni R, Gus Y, Dor Y, Meyuhas O and Levitzki A: Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation. Mol Cell Biol 25: 5031-5039, 2005. (Pubitemid 40781103)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.12 , pp. 5031-5039
    • Karni, R.1    Gus, Y.2    Dor, Y.3    Meyuhas, O.4    Levitzki, A.5
  • 31
    • 77649328234 scopus 로고    scopus 로고
    • The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation
    • Kumar A, Greggio E, Beilina A, et al.: The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation. PLoS One 5: e8730, 2010.
    • (2010) PLoS One , vol.5
    • Kumar, A.1    Greggio, E.2    Beilina, A.3
  • 33
    • 0029912854 scopus 로고    scopus 로고
    • Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes
    • Lin TA and Lawrence JC Jr: Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes. J Biol Chem 271: 30199-30204, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 30199-30204
    • Lin, T.A.1    Lawrence Jr., J.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.