Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity

Nucleic Acids Research

Volumn 40, Issue 1, 2012, Pages 75-87

  Kim, Ji Young ^a   Lee, Kyu Sun ^b   Seol, Jin Ee ^a   Yu, Kweon ^b   Chakravarti, Debabrata ^c   Seo, Sang Beom ^a  

^a Chung Ang University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CHAPERONE; HISTONE ACETYLTRANSFERASE PCAF; INHAT PROTEIN; INHIBITOR OF HISTONE ACETYLTRANSFERASE; MULTIPROTEIN COMPLEX; PROTEIN; PROTEIN P53; SET TAF IBETA PROTEIN; UNCLASSIFIED DRUG;

ACETYLATION; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRESS; CONTROLLED STUDY; DROSOPHILA; EYE; FLUORESCENCE ACTIVATED CELL SORTING; GENE OVEREXPRESSION; GENE TRANSCRIPTION INHIBITION; GENETIC TRANSCRIPTION; NICK END LABELING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SUBUNIT; SIGNAL TRANSDUCTION; ULTRAVIOLET IRRADIATION;

ACETYLATION; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN SUBUNITS; REPRESSOR PROTEINS; STRESS, PHYSIOLOGICAL; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 84855270324     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkr614     Document Type: Article

References (36)

1. Prives, C. and Manley, J.L. (2001) Why is p53 acetylated? Cell, 107, 815-818. (Pubitemid 34084971)
2. Gu, W. and Roeder, R.G. (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell, 90, 595-606. (Pubitemid 27357952)
3. Gu, W., Shi, X.L. and Roeder, R.G. (1997) Synergistic activation of transcription by CBP and p53. Nature, 387, 819-823. (Pubitemid 27270909)
4. Sakaguchi, K., Herrera, J.E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C.W. and Appella, E. (1998) DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev., 12, 2831-2841. (Pubitemid 28440142)
5. Avantaggiati, M.L., Ogryzko, V., Gardner, K., Giordano, A., Levine, A.S. and Kelly, K. (1997) Recruitment of p300/CBP in p53-dependent signal pathways. Cell, 89, 1175-1184. (Pubitemid 127678750)
6. Liu, L., Scolnick, D.M., Trievel, R.C., Zhang, H.B., Marmorstein, R., Halazonetis, T.D. and Berger, S.L. (1999) p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol. Cell. Biol., 19, 1202-1209. (Pubitemid 29046862)
7. Sykes, S.M., Mellert, H.S., Holbert, M.A., Li, K., Marmorstein, R., Lane, W.S. and McMahon, S.B. (2006) Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol. Cell, 24, 841-851. (Pubitemid 44960096)
8. Toledo, F. and Wahl, G.M. (2006) Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Cancer, 6, 909-923. (Pubitemid 44862676)
9. Krummel, K.A., Lee, C.J., Toledo, F. and Wahl, G.M. (2005) The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc. Natl Acad. Sci. USA, 102, 10188-10193. (Pubitemid 41023347)
10. Feng, L., Lin, T., Uranishi, H., Gu, W. and Xu, Y. (2005) Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol. Cell. Biol., 25, 5389-5395. (Pubitemid 40853576)
11. Tang, Y., Zhao, W., Chen, Y., Zhao, Y. and Gu, W. (2008) Acetylation is indispensable for p53 activation. Cell, 133, 612-626. (Pubitemid 351636297)
12. Seo, S.B., McNamara, P., Heo, S., Turner, A., Lane, W.S. and Chakravarti, D. (2001) Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Cell, 104, 119-130. (Pubitemid 32144977)
13. Schneider, R., Bannister, A.J., Weise, C. and Kouzarides, T. (2004) Direct binding of INHAT to H3 tails disrupted by modifications. J. Biol. Chem., 279, 23859-23862. (Pubitemid 38725241)
14. Kutney, S.N., Hong, R., Macfarlan, T. and Chakravarti, D. (2004) A signaling role of histone-binding proteins and INHAT subunits pp32 and Set/TAF-Ibeta in integrating chromatin hypoacetylation and transcriptional repression. J. Biol. Chem., 279, 30850-30855. (Pubitemid 38938020)
15. Nagata, K., Kawase, H., Handa, H., Yano, K., Yamasaki, M., Ishimi, Y., Okuda, A., Kikuchi, A. and Matsumoto, K. (1995) Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis. Proc. Natl Acad. Sci. USA, 92, 4279-4283.
16. Brennan, C.M., Gallouzi, I.E. and Steitz, J.A. (2000) Protein ligands to HuR modulate its interaction with target mRNAs in vivo. J. Cell. Biol., 151, 1-14.
17. Chakravarti, D. and Hong, R. (2003) SET-ting the stage for life and death. Cell, 112, 589-591. (Pubitemid 36335801)
18. Fan, Z., Beresford, P.J., Oh, D.Y., Zhang, D. and Lieberman, J. (2003) Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell, 112, 659-672. (Pubitemid 36331778)
19. Jiang, X., Kim, H.E., Shu, H., Zhao, Y., Zhang, H., Kofron, J., Donnelly, J., Burns, D., Ng, S.C., Rosenberg, S. et al. (2003) Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science, 299, 223-226. (Pubitemid 36125203)
20. von Lindern, M., van Baal, S., Wiegant, J., Raap, A., Hagemeijer, A. and Grosveld, G. (1992) Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. Mol. Cell. Biol., 12, 3346-3355.
21. Adachi, Y., Pavlakis, G.N. and Copeland, T.D. (1994) Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia. J. Biol. Chem., 269, 2258-2262. (Pubitemid 24035441)
22. Hublitz, P., Kunowska, N., Mayer, U.P., Muller, J.M., Heyne, K., Yin, N., Fritzsche, C., Poli, C., Miguet, L., Schupp, I.W. et al. (2005) NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev., 19, 2912-2924. (Pubitemid 41739975)
23. Rubin, G.M. and Spradling, A.C. (1982) Genetic transformation of Drosophila with transposable element vectors. Science, 218, 348-353. (Pubitemid 12037603)
24. Brand, A.H. and Perrimon, N. (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development, 118, 401-415. (Pubitemid 23214028)
25. Luo, J., Li, M., Tang, Y., Laszkowska, M., Roeder, R.G. and Gu, W. (2004) Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc. Natl Acad. Sci. USA, 101, 2259-2264. (Pubitemid 38269299)
26. Shikama, N., Chan, H.M., Krstic-Demonacos, M., Smith, L., Lee, C.W., Cairns, W. and La Thangue, N.B. (2000) Functional interaction between nucleosome assembly proteins and p300/ CREB-binding protein family coactivators. Mol. Cell. Biol., 20, 8933-8943. (Pubitemid 32245924)
27. Asahara, H., Tartare-Deckert, S., Nakagawa, T., Ikehara, T., Hirose, F., Hunter, T., Ito, T. and Montminy, M. (2002) Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol. Cell. Biol., 22, 2974-2983. (Pubitemid 34437456)
28. Rehtanz, M., Schmidt, H.M., Warthorst, U. and Steger, G. (2004) Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription. Mol. Cell. Biol., 24, 2153-2168. (Pubitemid 38248953)
29. Ollmann, M., Young, L.M., Di Como, C.J., Karim, F., Belvin, M., Robertson, S., Whittaker, K., Demsky, M., Fisher, W.W., Buchman, A. et al. (2000) Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell, 101, 91-101.
30. Brodsky, M.H., Nordstrom, W., Tsang, G., Kwan, E., Rubin, G.M. and Abrams, J.M. (2000) Drosophila p53 binds a damage response element at the reaper locus. Cell, 101, 103-113.
31. Jin, S., Martinek, S., Joo, W.S., Wortman, J.R., Mirkovic, N., Sali, A., Yandell, M.D., Pavletich, N.P., Young, M.W. and Levine, A.J. (2000) Identification and characterization of a p53 homologue in Drosophila melanogaster. Proc. Natl Acad. Sci. USA, 97, 7301-7306. (Pubitemid 30431458)
32. Brodsky, M.H., Weinert, B.T., Tsang, G., Rong, Y.S., McGinnis, N.M., Golic, K.G., Rio, D.C. and Rubin, G.M. (2004) Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol. Cell. Biol., 24, 1219-1231. (Pubitemid 38112184)
33. Zhou, L. and Steller, H. (2003) Distinct pathways mediate UV-induced apoptosis in Drosophila embryos. Dev. Cell, 4, 599-605. (Pubitemid 36437565)
34. Jenuwein, T. and Allis, C.D. (2001) Translating the histone code. Science, 293, 1074-1080. (Pubitemid 32758077)
35. Strahl, B.D. and Allis, C.D. (2000) The language of covalent histone modifications. Nature, 403, 41-45. (Pubitemid 30038513)
36. Hay, B.A., Wolff, T. and Rubin, G.M. (1994) Expression of baculovirus P35 prevents cell death in Drosophila. Development, 120, 2121-2129. (Pubitemid 24232280)