Buy one, get one free: Additional functions of GM-CSF in DC maturation

European Journal of Immunology

Volumn 42, Issue 1, 2012, Pages 35-38

  Lutz, Manfred B ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Cell differentiation; Cellular activation; Cytokines; DCs; Monocytes

Indexed keywords

FLT3 LIGAND; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; JANUS KINASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; STAT PROTEIN; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING;

ANTIGEN PRESENTATION; CELL MATURATION; CELL PROLIFERATION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; GENETIC POLYMORPHISM; HUMAN; IMMUNE RESPONSE; INFECTION; MONOCYTE; MYELOID PROGENITOR CELL; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SINGLE NUCLEOTIDE POLYMORPHISM; TH1 CELL;

ANIMALS; DENDRITIC CELLS; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84855234591     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201142271     Document Type: Note

References (39)

1. Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245-252.
2. Merad, M. and Manz, M. G., Dendritic cell homeostasis. Blood 2009. 113: 3418-3427.
3. Shortman, K. and Naik, S. H., Steady-state and inflammatory dendritic-cell development. Nat. Rev. Immunol. 2007. 7: 19-30.
4. Reis e Sousa, C., Dendritic cells in a mature age. Nat. Rev. Immunol. 2006. 6: 476-483.
5. Turley, S. J., Dendritic cells: inciting and inhibiting autoimmunity. Curr. Opin. Immunol. 2002. 14: 765-770.
6. Lutz, M. B. and Schuler, G., Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 2002. 23: 445-449.
7. Auffray, C., Sieweke, M. H. and Geissmann, F., Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu. Rev. Immunol. 2009. 27: 669-692.
8. Cheong, C., Matos, I., Choi, J. H., Dandamudi, D. B., Shrestha, E., Longhi, M. P., Jeffrey, K. L. et al., Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell 2010. 143: 416-429.
9. Peters, J. H., Ruhl, S. and Friedrichs, D., Veiled accessory cells deduced from monocytes. Immunobiology 1987. 176: 154-166.
10. Caux, C., Dezutter-Dambuyant, C., Schmitt, D. and Banchereau, J., GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 1992. 360: 258-261.
11. Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S. et al., Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 1992. 176: 1693-1702.
12. Scheicher, C., Mehlig, M., Zecher, R. and Reske, K., Dendritic cells from mouse bone marrow: in vitro differentiation using low doses of recombinant granulocyte-macrophage colony-stimulating factor. J. Immunol. Methods 1992. 154: 253-264.
13. Xu, H., Friedrichs, U., Gieseler, R. K., Ruppert, J., Ocklind, G. and Peters, J. H., Human blood dendritic cells exhibit a distinct T-cell-stimulating mechanism and differentiation pattern. Scand. J. Immunol. 1992. 36: 689-696.
14. Rossi, G., Heveker, N., Thiele, B., Gelderblom, H. and Steinbach, F., Development of a Langerhans cell phenotype from peripheral blood monocytes. Immunol. Lett. 1992. 31: 189-197.
15. Lutz, M. B., Kukutsch, N., Ogilvie, A. L., Rossner, S., Koch, F., Romani, N. and Schuler, G., An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 1999. 223: 77-92.
16. Naik, S. H., Demystifying the development of dendritic cell subtypes, a little. Immunol. Cell. Biol. 2008. 86: 439-452.
17. Hamilton, J. A., Colony-stimulating factors in inflammation and autoimmunity. Nat. Rev. Immunol. 2008. 8: 533-544.
18. Welte, T., Koch, F., Schuler, G., Lechner, J., Doppler, W. and Heufler, C., Granulocyte-macrophage colony-stimulating factor induces a unique set of STAT factors in murine dendritic cells. Eur. J. Immunol. 1997. 27: 2737-2740.
19. Laouar, Y., Welte, T., Fu, X. Y. and Flavell, R. A., STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity 2003. 19: 903-912.
20. Gilliet, M., Boonstra, A., Paturel, C., Antonenko, S., Xu, X. L., Trinchieri, G., O'Garra, A. et al., The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 2002. 195: 953-958.
21. Esashi, E., Wang, Y. H., Perng, O., Qin, X. F., Liu, Y. J. and Watowich, S. S., The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity 2008. 28: 509-520.
22. Watowich, S. S. and Liu, Y. J., Mechanisms regulating dendritic cell specification and development. Immunol. Rev. 2010. 238: 76-92.
23. Lutz, M. B., Kukutsch, N. A., Menges, M., Rossner, S. and Schuler, G., Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro. Eur. J. Immunol. 2000. 30: 1048-1052.
24. Rotta, G., Edwards, E. W., Sangaletti, S., Bennett, C., Ronzoni, S., Colombo, M. P., Steinman, R. M. et al., Lipopolysaccharide or whole bacteria block the conversion of inflammatory monocytes into dendritic cells in vivo. J. Exp. Med. 2003. 198: 1253-1263.
25. Greifenberg, V., Ribechini, E., Rossner, S. and Lutz, M. B., Myeloid-derived suppressor cell activation by combined LPS and IFN-γ treatment impairs DC development. Eur. J. Immunol. 2009. 39: 2865-2876.
26. Lutz, M. B., Suri, R. M., Niimi, M., Ogilvie, A. L., Kukutsch, N. A., Rossner, S., Schuler, G. et al., Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur. J. Immunol. 2000. 30: 1813-1822.
27. Rößner, S., Voigtländer, C., Wiethe, C., Hänig, J., Seifarth, C. and Lutz, M. B., Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro. Eur. J. Immunol. 2005. 35: 3533-3544.
28. Miah, M. A., Yoon, C.-H., Kim, J., Jang, J., Seong, Y.-R. and Bae, Y.-S., A cytokine inducible SH2-domain protein (CISH), significantly induced during DC development, plays an important role in DC-mediated CTL activation. Eur. J. Immunol. 2012. 42: 58-68.
29. Imada, K. and Leonard, W. J., The Jak-STAT pathway. Mol. Immunol. 2000. 37: 1-11.
30. Yasukawa, H., Sasaki, A. and Yoshimura, A., Negative regulation of cytokine signaling pathways. Annu. Rev. Immunol. 2000. 18: 143-164.
31. Anderson, P., Sundstedt, A., Li, L., O'Neill, E. J., Li, S., Wraith, D. C. and Wang, P., Differential activation of signal transducer and activator of transcription (STAT)3 and STAT5 and induction of suppressors of cytokine signalling in T(h)1 and T(h)2 cells. Int. Immunol. 2003. 15: 1309-1317.
32. Anderson, S. T., Barclay, J. L., Fanning, K. J., Kusters, D. H., Waters, M. J. and Curlewis, J. D., Mechanisms underlying the diminished sensitivity to prolactin negative feedback during lactation: reduced STAT5 signaling and up-regulation of cytokine-inducible SH2 domain-containing protein (CIS) expression in tuberoinfundibular dopaminergic neurons. Endocrinology 2006. 147: 1195-1202.
33. Lavens, D., Montoye, T., Piessevaux, J., Zabeau, L., Vandekerckhove, J., Gevaert, K., Becker, W. et al., A complex interaction pattern of CIS and SOCS2 with the leptin receptor. J. Cell. Sci. 2006. 119: 2214-2224.
34. Miquet, J. G., Sotelo, A. I., Bartke, A. and Turyn, D., Desensitization of the JAK2/STAT5 GH signaling pathway associated with increased CIS protein content in liver of pregnant mice. Am. J. Physiol. Endocrinol. Metab. 2005. 289: E600-E607.
35. Nosaka, T., Kawashima, T., Misawa, K., Ikuta, K., Mui, A. L. and Kitamura, T., STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J. 1999. 18: 4754-4765.
36. van de Geijn, G. J., Gits, J. and Touw, I. P., Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling. J. Leukoc. Biol. 2004. 76: 237-244.
37. Khor, C. C., Vannberg, F. O., Chapman, S. J., Guo, H., Wong, S. H., Walley, A. J., Vukcevic, D. et al., CISH and susceptibility to infectious diseases. N. Engl. J. Med. 2010. 362: 2092-2101.
38. Okamoto, H., CISH and susceptibility to infectious diseases. N. Engl. J. Med. 2010. 363: 1675-1676; author reply 1676-1677.
39. Vani, J., Kaveri, S. V. and Bayry, J., CISH and susceptibility to infectious diseases. N. Engl. J. Med. 2010. 363: 1676; author reply 1676-1677.