Human ScFv that block sodium ion channel activity of tetrodotoxin

Toxicon

Volumn 59, Issue 2, 2012, Pages 272-282

  Chulanetra, Monrat ^a   Bangphoomi, Kunan ^b   Sookrung, Nitat ^a   Thanongsaksrikul, Jeeraphong ^a   Srimanote, Potjanee ^c   Sakolvarvaree, Yuwaporn ^a   Choowongkomon, Kiattawee ^b   Chaicumpa, Wanpen ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b KASETSART UNIVERSITY   (Thailand)

^c THAMMASAT UNIVERSITY   (Thailand)

Author keywords

Human single chain antibody (HuScFv); Mouse bioassay; Phage display; Puffer fish; Sodium channel; Tetrodotoxin (TTX)

Indexed keywords

ASPARTIC ACID; HYDROXYL GROUP; SERINE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SODIUM CHANNEL; TETRODOTOXIN; TYROSINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FOOD POISONING; LETHALITY; MALE; MOLECULAR CLONING; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR LIBRARY; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PUFFER FISH; SEQUENCE HOMOLOGY; TOXIC FISH;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BIOLOGICAL ASSAY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MALE; MICE; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SEQUENCE ANALYSIS, DNA; SINGLE-CHAIN ANTIBODIES; SODIUM CHANNELS; TANDEM MASS SPECTROMETRY; TETRAODONTIFORMES; TETRODOTOXIN;

ESCHERICHIA COLI; MAMMALIA; MUS; TETRAODONTIDAE;

EID: 84855218458     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2011.11.012     Document Type: Article

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