Association between the IL7R T244I polymorphism and multiple sclerosis: A meta-analysis

Molecular Biology Reports

Volumn 38, Issue 8, 2011, Pages 5079-5084

  Zhang, Ruijie ^a   Duan, Lian ^a,b   Jiang, Yongshuai ^a   Zhang, Xuehong ^a   Sun, Peng ^a   Li, Jin ^a   Zhang, Mingming ^a   Tang, Guoping ^a   Wang, Xing ^a   Li, Xia ^a,c  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^c Biomedical Engineering Institute   (China)

Author keywords

IL7R; Meta analysis; Multiple sclerosis; Polymorphism

Indexed keywords

CYSTEINE; ISOLEUCINE; THREONINE;

ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INTERLEUKIN 7 RECEPTOR GENE; MAJOR CLINICAL STUDY; META ANALYSIS (TOPIC); MOLECULAR PATHOLOGY; MULTIPLE SCLEROSIS; RECEPTOR GENE; SYSTEMATIC REVIEW;

ALLELES; AMINO ACID SUBSTITUTION; CONFIDENCE INTERVALS; DATABASES, GENETIC; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MULTIPLE SCLEROSIS; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-7;

EID: 84855217291     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0654-5     Document Type: Article

References (31)

1. Mount HT (1973) Multiple sclerosis and other demyelinating diseases. Can Med Assoc J 108(11):1356
2. Hawkins SA, McDonnell GV (1999) Benign multiple sclerosis? Clinical course, long term follow up, and assessment of prognostic factors. J Neurol Neurosurg Psychiatry 67(2):148-152 (Pubitemid 29326942)
3. Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, Barkhof F, Radue EW, Lindberg RL, Uitdehaag BM, Johnson MR, Angelakopoulou A, Hall L, Richardson JC, Prinjha RK, Gass A, Geurts JJ, Kragt J, Sombekke M, Vrenken H, Qualley P, Lincoln RR, Gomez R, Caillier SJ, George MF, Mousavi H, Guerrero R, Okuda DT, Cree BA, Green AJ, Waubant E, Goodin DS, Pelletier D, Matthews PM, Hauser SL, Kappos L, Polman CH, Oksenberg JR (2009) Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet 18(4):767-778. doi:10.1093/hmg/ddn388
4. Weber F, Fontaine B, Cournu-Rebeix I, Kroner A, Knop M, Lutz S, Muller-Sarnowski F, Uhr M, Bettecken T, Kohli M, Ripke S, Ising M, Rieckmann P, Brassat D, Semana G, Babron MC, Mrejen S, Gout C, Lyon-Caen O, Yaouanq J, Edan G, Clanet M, Holsboer F, Clerget-Darpoux F, Muller-Myhsok B (2008) IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations. Genes Immun 9(3): 259-263. doi:10.1038/gene.2008.14 (Pubitemid 351584192)
5. Sadovnick AD, Ebers GC, Dyment DA, Risch NJ (1996) Evidence for genetic basis of multiple sclerosis. The Canadian collaborative study group. Lancet 347(9017):1728-1730 (Pubitemid 26187551)
6. Refining genetic associations in multiple sclerosis (2008) Lancet Neurol 7(7):567-569. doi:10.1016/S1474-4422(08)70122-4
7. Dyment DA, Willer CJ, Scott B, Armstrong H, Ligers A, Hillert J, Paty DW, Hashimoto S, Devonshire V, Hooge J, Kastrukoff L
8. Oger J, Metz L, Warren S, Hader W, Power C, Auty A, Nath A, Nelson R, Freedman M, Brunet D, Paulseth JE, Rice G, O'Connor P, Duquette P, Lapierre Y, Francis G, Bouchard JP, Murray TJ, Bhan V, Maxner C, Pryse-Phillips W, Stefanelli M, Sadovnick AD, Risch N, Ebers GC (2001) Genetic susceptibility to MS: a second stage analysis in Canadian MS families. Neur-ogenetics 3(3):145-151 (Pubitemid 33739053)
9. Hermanowski J, Bouzigon E, Forabosco P, Ng MY, Fisher SA, Lewis CM (2007) Meta-analysis of genome-wide linkage studies for multiple sclerosis, using an extended GSMA method. Eur J Hum Genet 15(6):703-710. doi:10.1038/sj.ejhg.5201818 (Pubitemid 46825059)
10. Baranzini SE, Galwey NW, Wang J, Khankhanian P, Lindberg R, Pelletier D, Wu W, Uitdehaag BM, Kappos L, Polman CH, Matthews PM, Hauser SL, Gibson RA, Oksenberg JR, Barnes MR (2009) Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet 18(11):2078-2090. doi:10.1093/hmg/ddp120
11. Barcellos LF, Sawcer S, Ramsay PP, Baranzini SE, Thomson G, Briggs F, Cree BC, Begovich AB, Villoslada P, Montalban X, Uccelli A, Savettieri G, Lincoln RR, DeLoa C, Haines JL, Peri-cak-Vance MA, Compston A, Hauser SL, Oksenberg JR (2006) Heterogeneity at the hla-drb1 locus and risk for multiple sclerosis. Hum Mol Genet 15(18):2813-2824. doi:10.1093/hmg/ddl223 (Pubitemid 44400408)
12. Stankovich J, Butzkueven H, Marriott M, Chapman C, Tubridy N, Tait BD, Varney MD, Taylor BV, Foote SJ, Kilpatrick TJ, Rubio JP (2009) Hla-drb1 associations with disease susceptibility and clinical course in Australians with multiple sclerosis. Tissue Antigens 74(1):17-21. doi:10.1111/j.1399-0039.2009. 01262.x
13. Dean G, Yeo TW, Goris A, Taylor CJ, Goodman RS, Elian M, Galea-Debono A, Aquilina A, Felice A, Vella M, Sawcer S, Compston DA (2008) Hla-drb1 and multiple sclerosis in malta. Neurology 70(2):101-105. doi:10.1212/01.wnl. 0000284598.985 25.d7
14. Alcina A, Fedetz M, Ndagire D, Fernandez O, Leyva L, Guerrero M, Arnal C, Delgado C, Matesanz F (2008) The T244I variant of the interleukin-7 receptor-alpha gene and multiple sclerosis. Tissue Antigens 72(2):158-161. doi:10.1111/j.1399-0039.2008. 01075.x (Pubitemid 352009810)
15. Teutsch SM, Booth DR, Bennetts BH, Heard RN, Stewart GJ (2003) Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosis. Eur J Hum Genet 11(7): 509-515. doi:10.1038/sj.ejhg.5200994 (Pubitemid 36896579)
16. Lundmark F, Duvefelt K, Iacobaeus E, Kockum I, Wallstrom E, Khademi M, Oturai A, Ryder LP, Saarela J, Harbo HF, Celius EG, Salter H, Olsson T, Hillert J (2007) Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet 39(9):1108-1113. doi:10.1038/ng2106 (Pubitemid 47340654)
17. Peltonen L (2007) Old suspects found guilty-the first genome profile of multiple sclerosis. N Engl J Med 357(9):927-929. doi: 10.1056/NEJMe078147 (Pubitemid 47347328)
18. Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science 262(5141):1877-1880 (Pubitemid 24041859)
19. Akkad DA, Hoffjan S, Petrasch-Parwez E, Beygo J, Gold R, Epplen JT (2009) Variation in the IL7RA and IL2RA genes in german multiple sclerosis patients. J Autoimmun 32(2):110-115. doi:10.1016/j.jaut.2009.01.002
20. Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL (2007) Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 39(9):1083-1091. doi: 10.1038/ng2103 (Pubitemid 47340652)
21. Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B, Oksenberg JR, Hauser SL (2007) Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 357(9):851-862. doi:10.1056/NEJMoa073493 (Pubitemid 47347319)
22. O'Doherty C, Kantarci O, Vandenbroeck K (2008) IL7RA polymorphisms and susceptibility to multiple sclerosis. N Engl J Med 358(7):753-754. doi:10.1056/NEJMc0707553 (Pubitemid 351240775)
23. Rubio JP, Stankovich J, Field J, Tubridy N, Marriott M, Chapman C, Bahlo M, Perera D, Johnson LJ, Tait BD, Varney MD, Speed TP, Taylor BV, Foote SJ, Butzkueven H, Kilpatrick TJ (2008) Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians. Genes Immun 9(7):624-630. doi:10.1038/gene.2008.59
24. 2 index? Psychol Methods 11(2):193-206. doi:10.1037/1082-989X. 11.2.193 (Pubitemid 44001277)
25. Lau J, Ioannidis JP, Schmid CH (1997) Quantitative synthesis in systematic reviews. Ann Intern Med 127(9):820-826 (Pubitemid 27465551)
26. Zintzaras E (2006) Methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: a meta-analysis. Clin Genet 69(4):327-336. doi:10.1111/j.1399-0004.2006.00605.x
27. Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttila T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, Lorentzen AR, De Jager PL, Daly MJ, Hafler DA, Palotie A, Peltonen L, Saarela J (2009) Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Hum Mol Genet 18(9):1670-1683. doi:10.1093/hmg/ddp073
28. Ramagopalan SV, Anderson C, Sadovnick AD, Ebers GC (2007) Genome wide study of multiple sclerosis. N Engl J Med 357(21): 2199-2200. author reply 2200-2191. doi:10.1056/NEJMc072836 (Pubitemid 350146121)
29. Svejgaard A (2008) The immunogenetics of multiple sclerosis. Immunogenetics 60(6):275-286. doi:10.1007/s00251-008-0295-1
30. Akkad DA (2009) Susceptibility genes for multiple sclerosis. Dissertation, Ruhr-University Bochum
31. Kallio SP (2009) Novel multiple sclerosis predisposing genetic variants outside the hla region. Dissertation, University of Helsinki