Molecular-weight-dependent, Anionic-substrate-preferential transport of β-lactam antibiotics via multidrug resistance-associated protein 4

Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 6, 2011, Pages 602-611

  Akanuma, Shin Ichi ^a,b   Uchida, Yasuo ^a   Ohtsuki, Sumio ^a,c   Kamiie, Jun Ichi ^a,c,d   Tachikawa, Masanori ^b   Terasaki, Tetsuya ^a,c   Hosoya, Ken Ichi ^b  

^a TOHOKU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d AZABU UNIVERSITY   (Japan)

Author keywords

ABC transporters; Antibiotics; Blood brain barrier; Cephalosporins; HPLC; Membrane permeability; MRP; MRP4; Transporters

Indexed keywords

AMPHOLYTE; AZTREONAM; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CEFACLOR; CEFADROXIL; CEFALEXIN; CEFALOTIN; CEFDINIR; CEFEPIME; CEFIXIME; CEFMINOX; CEFOPERAZONE; CEFOTIAM; CEFSULODIN; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; IMIPENEM; MEROPENEM; METHOTREXATE; MONOBACTAM DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN 4; PANIPENEM; PENAM DERIVATIVE; PENEM DERIVATIVE; TAZOBACTAM;

ARTICLE; CONTROLLED STUDY; DRUG TRANSPORT; MEMBRANE VESICLE; MOLECULAR WEIGHT; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

EID: 84855210153     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-11-RG-063     Document Type: Article

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