Up-regulation of TGF-β via the activation of extracellular signal-regulated kinase 1 and 2 induced by prorenin in human renal mesangial cells

Molecular Medicine Reports

Volumn 5, Issue 1, 2012, Pages 223-227

  Wei, Song ^a   Zhang, Ying ^a   Jia, Chen ^a   Ren, Lili ^a   Mi, Yumei ^a   Lu, Yan ^a   Jiang, Yinong ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

ERK1 2 signal transduction; Handle region peptide; Human renal mesangial cells; Prorenin; Prorenin receptor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PRORENIN RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; COCULTURE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; MESANGIUM CELL; PHARMACOLOGICAL BLOCKING; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

CELLS, CULTURED; ENZYME ACTIVATION; ENZYME ACTIVATORS; FLAVONOIDS; HUMANS; MESANGIAL CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OLIGOPEPTIDES; PHOSPHORYLATION; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; RENIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 84855209070     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.615     Document Type: Article

References (30)

1. Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T and Sraer JD: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 109: 1417-1427, 2002. (Pubitemid 34596167)
2. Saris JJ, Derkx FH, De Bruin RJ, et al.: High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin. Am J Physiol Heart Circ Physiol 280: H1706-H1715, 2001.
3. Van Kesteren CA, Danser AH, Derkx FH, Dekkers DH, Lamers JM, Saxena PR and Schalekamp MA: Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cells. Hypertension 30: 1389-1396, 1997. (Pubitemid 27528080)
4. Nguyen G, Burckle CA and Sraer JD: Renin/prorenin-receptor biochemistry and functional significance. Curr Hypertens Rep 6: 129-132, 2004. (Pubitemid 39359553)
5. Nguyen G: Renin/prorenin receptors. Kidney Int 69: 1503-1506, 2006.
6. Nguyen G: The (pro)renin receptor: a new kid in town. Semin Nephrol 27: 519-523, 2007.
7. Nguyen G: The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathology. Curr Opin Nephrol Hypertens 16: 129-133, 2007.
8. Inagami T and Ichihara A: Prorenin/renin receptor, signals, and therapeutic efficacy of receptor blocker in end-organ damage. Curr Hypertens Rep 9: 474-479, 2007.
9. Suzuki F, Hayakawa M, Nakagawa T, et al.: Human prorenin has 'gate and handle' regions for its non-proteolytic activation. J Biol Chem 278: 22217-22222, 2003. (Pubitemid 36830267)
10. Batenburg WW and Jan Danser AH: The (pro)renin receptor: a new addition to the renin-angiotensin system? Eur J Pharmacol 585: 320-324, 2008.
11. Takahashi H, Ichihara A, Kaneshiro Y, et al.: Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade. J Am Soc Nephrol 18: 2054-2061, 2007. (Pubitemid 47041071)
12. Ichihara A, Suzuki F, Nakagawa T, et al.: Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice. J Am Soc Nephrol 17: 1950-1961, 2006. (Pubitemid 44036179)
13. Ichihara A, Kaneshiro Y and Suzuki F: Prorenin receptor blockers: effects on cardiovascular complications of diabetes and hypertension. Expert Opin Investig Drugs 15: 1137-1139, 2006. (Pubitemid 44608253)
14. Ichihara A, Kaneshiro Y, Takemitsu T, et al.: Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol 17: 2495-2503, 2006. (Pubitemid 44300965)
15. Huang Y, Noble NA, Zhang J, Xu C and Border WA: Renin-stimulated TGF-β1 expression is regulated by a mitogen-activated protein kinase in mesangial cells. Kidney Int 72: 45-52, 2007. (Pubitemid 47014443)
16. Danser AH: Local renin-angiotensin systems: the unanswered questions. Int J Biochem Cell Biol 35: 759-768, 2003.
17. Campbell DJ: Critical review of prorenin and (pro)renin receptor research. Hypertension 51: 1259-1264, 2008.
18. Schefe JH, Menk M, Reinemund J, et al.: A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res 99: 1355-1366, 2006. (Pubitemid 44949671)
19. Border WA and Noble NA: Transforming growth factor β in tissue fibrosis. N Engl J Med 331: 1286-1292, 1994. (Pubitemid 24333194)
20. Muslin AJ: MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets. Clin Sci (Lond) 115: 203-218, 2008.
21. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M and Itoh H: The (pro)renin receptor and the kidney. Semin Nephrol 27: 524-528, 2007. (Pubitemid 47374903)
22. Ichihara A, Kaneshiro Y, Takemitsu T, et al.: Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension 47: 894-900, 2006. (Pubitemid 44297561)
23. Satofuka S, Ichihara A, Nagai N, et al.: Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization. Invest Ophthalmol Vis Sci 48: 422-429, 2007. (Pubitemid 47251433)
24. Novo S, Lunetta M, Evola S and Novo G: Role of ARBs in the blood hypertension therapy and prevention of cardiovascular events. Curr Drug Targets 10: 20-25, 2009.
25. Jensen C, Herold P and Brunner HR: Aliskiren: the first renin inhibitor for clinical treatment. Nat Rev Drug Discov 7: 399-410, 2008. (Pubitemid 351619112)
26. Ichihara A, Hayashi M, Kaneshiro Y, et al.: Inhibition of diabetic nephropathy by a decoy peptide corresponding to the 'handle' region for nonproteolytic activation of prorenin. J Clin Invest 114: 1128-1135, 2004. (Pubitemid 39578702)
27. Batenburg WW, Krop M, Garrelds IM, et al.: Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor. J Hypertens 25: 2441-2453, 2007. (Pubitemid 350060383)
28. Feldt S, Batenburg WW, Mazak I, et al.: Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension 51: 682-688, 2008. (Pubitemid 351301521)
29. Feldt S, Maschke U, Dechend R, Luft FC and Muller DN: The putative (pro)renin receptor blocker HRP fails to prevent (pro) renin signaling. J Am Soc Nephrol 19: 743-748, 2008.
30. Muller DN, Klanke B, Feldt S, et al.: (Pro)renin receptor peptide inhibitor 'handle-region' peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. Hypertension 51: 676-681, 2008. (Pubitemid 351301520)