Renin/prorenin-receptor biochemistry and functional significance

Current Hypertension Reports

Volumn 6, Issue 2, 2004, Pages 129-132

  Nguyen, Geneviève ^a   Burcklé, Céline A ^a   Sraer, Jean Daniel ^a  

^a l'alimentation et l'Environnement   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSINOGEN; BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PRORENIN; RENIN; ATP6AP2 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; PRORENIN RECEPTOR; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

BIOCHEMISTRY; CATALYSIS; CELL SURFACE; CELLULAR DISTRIBUTION; HEART MUSCLE CELL; IMMUNOFLUORESCENCE; KIDNEY CELL; MESANGIUM CELL; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR BINDING; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; AMINO ACID SEQUENCE; ANIMAL; HUMAN; MESANGIUM; MOLECULAR GENETICS; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; GLOMERULAR MESANGIUM; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; MUSCLE, SMOOTH, VASCULAR; RECEPTORS, CELL SURFACE; RENIN; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 4644220247     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-004-0088-3     Document Type: Review

References (19)

1. Nguyen G, Delarue F, Burckle C, et al.: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002, 109:1417-1427.
2. Albitson AL, McDowall SG, Matsacos D, et al.: Evidence that the angiotensin IV (AT4) receptor is the enzyme insulin-regulated aminopeptidase. J Biol Chem 2001, 276: 8623-48626.
3. Dzau VJ, Bernstein K, Celemajer D, et al.: The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data. Am J Cardiol 2001, 88(Suppl : L-20L.
4. Schuijt MP, de Vries R, Saxena PR, et al.: Vasoconstriction is determined by interstitial rather than circulating angiotensin II. Br J Pharmacol 2002, 135:275-283.
5. Dell'Italia LJ, Meng QC, Balcells E, et al.: Compartimentalisation of angiotensin II generation in the dog heart: evidence for independent mechanisms in intravascular and interstitial space. J Clin Invest 1997, 100:253-258.
6. Nguyen G, Delarue F, Berrou J, et al.: Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney Int 1996, 50:1897-1903.
7. Saris JJ, Derkx FHM, de Bruin RJA, et al.: High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin. Am J Physiol Heart Circ Physiol 2001, H1706-H1715.
8. Admiraal PJ, van Kesteren CA, Danser AHJ, et al.: Uptake and proteolytic activation of prorenin by cultured human endothelial cells. J Hypertens 1999, 17:621-629.
9. Saris JJ, van den Eijnden MMED, Lamers JMJ, et al.: Prorenin-induced myocyte proliferation: no role for intracellular angiotensin II. Hypertension 2002, 39:573-577.
10. Mullins JJ, Peters J, Ganten D: Fulminant hypertension in transgenic rats harbouring the mouse ren-2d gene. Nature 1990, 344:541-544.
11. Peters J, Farrenkopf R, Clausmeyer S, et al.: Functional significance of prorenin internalization in the rat heart. Circ Res 2002, 90:1135-1141.
12. Re RN: Implications of intracrine hormone action for physiology and medicine. Am J Physiol Heart Circ Physiol 2003, 284:H751-H757.
13. Bader M, Ganten D: It's renin in the brain: transgenic animals elucidate the brain renin-angiotensin system. Circ Res 2002, 90:8-10.
14. Deinum J, Derkx FH, Danser AH, Schalekamp MA: Identification and quantification of renin and prorenin in the bovine eye. Endocrinology 1990, 126:1673-1682.
15. Methot D, Silversides DW, Reudelhuber TL: In vivo enzymatic assay reveals catalytic activity of the human renin precursor in tissues. Circ Res 1999, 84:1067-1072.
16. Prescott G, Silverside DW, Reudelhuber TL: Tissue activity of circulating prorenin. Am J Hypertens 2002, 13:280-285.
17. Moravski CJ, Kelly DJ, Cooper ME, et al.: Retinal neovascularization is prevented by blockade of the renin-angiotensin system. Hypertension 2000, 36:1099-1044.
18. Véniant M, Ménard J, Bruneval P, et al.: Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver. J Clin Invest 1996, 98: 966-1970.
19. Hollenberg NK, Fischer NDL: Renal circulation and blockade of the renin-angiotensin system: Is angiotensin-converting enzyme inhibition the last word? Hypertension 1995, 26:602-609.