Efficient loading of primary alcohols onto a solid phase using a trityl bromide linker

Tetrahedron Letters

Volumn 49, Issue 41, 2008, Pages 5890-5893

  Crestey, François ^a   Ottesen, Lars K ^a   Jaroszewski, Jerzy W ^a   Franzyk, Henrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AZIRIDINE; POLYSTYRENE DERIVATIVE; REAGENT; RESIN; TRITYL BROMIDE; TRITYL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; HEAT; SOLID;

EID: 50049116914     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.07.130     Document Type: Article

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26. 3: C, 73.82; H, 7.12; N, 4.30. Found: C, 73.91; H, 6.98; N, 4.33.
27. 2. The resin was drained, washed with DMF, dioxane, MeOH, and DCM (each 3 × 5 mL for 5 min), and then cleaved with 2% TFA-DCM (2 × 2 mL for 30 min). The resin was further eluted with DCM (2 mL), and the resulting solutions were combined and co-evaporated with toluene in vacuo. The crude material was purified by preparative reversed-phase HPLC-DAD using a 21.2 × 250 mm Phenomenex C18 column (5 μm, 100 Å) in a system consisting of two preparative-scale pumps, an autosampler and a multiple-wavelength UV detector.
28. 3: C, 74.28; H, 6.55; N, 4.33. Found: C, 74.68; H, 6.79; N, 4.61.
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32. + 394.1437; found 394.1421; ΔM 4 ppm.
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