Neurocognitive performance in children and adolescents with bipolar disorder: A review

European Child and Adolescent Psychiatry

Volumn 20, Issue 9, 2011, Pages 433-450

  Horn, Karin ^a   Roessner, Veit ^a   Holtmann, Martin ^b  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Adolescence; Bipolar disorder; Childhood; Neurocognitive function; Neuropsychology

Indexed keywords

ANTICONVULSIVE AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; LITHIUM; MOOD STABILIZER; PSYCHOSTIMULANT AGENT; SEROTONIN UPTAKE INHIBITOR;

ADOLESCENT; BIPOLAR DISORDER; CHILD; COGNITIVE DEFECT; CONTROLLED STUDY; EXECUTIVE FUNCTION; FEMALE; HUMAN; INTELLIGENCE QUOTIENT; MALE; MEMORY DISORDER; MENTAL PERFORMANCE; ONSET AGE; PHENOMENOLOGY; REVIEW; SPEECH ANALYSIS; SYSTEMATIC REVIEW; VERBAL MEMORY; VISUAL MEMORY; WORKING MEMORY;

ADOLESCENT; ATTENTION; BIPOLAR DISORDER; CHILD; COGNITION; HUMANS; MEMORY; NEUROPSYCHOLOGICAL TESTS; VERBAL LEARNING;

EID: 84855199936     PISSN: 10188827     EISSN: 1435165X     Source Type: Journal    
DOI: 10.1007/s00787-011-0209-x     Document Type: Review

References (78)

1. Altshuler LL, Bearden CE, Green MF, van Gorp W, Mintz J (2008) A relationship between neurocognitive impairment and functional impairment in bipolar disorder: a pilot study. Psychiatry Res 157:289-293 (Pubitemid 350166539)
2. Arts B, Jabben N, Krabbendam L, van Os J (2008) Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychol Med 38:771-785 (Pubitemid 351684591)
3. Balanza-Martinez V, Rubio C, Selva-Vera G, Martinez-Aran A, Sanchez-Moreno J, Salazar-Fraile J, Vieta E, Tabares-Seisdedos R (2008) Neurocognitive endophenotypes (endophenocognitypes) from studies of relatives of bipolar disorder subjects: a systematic review. Neurosci Biobehav Rev 32:1426-1438
4. Balanza-Martinez V, Selva G, Martinez-Aran A, Prickaerts J, Salazar J, Gonzalez-Pinto A, Vieta E, Tabares-Seisdedos R (2010) Neurocognition in bipolar disorders-a closer look at comorbidities and medications. Eur J Pharmacol 626:87-96
5. Bearden CE, Glahn DC, Caetano S, Olvera RL, Fonseca M, Najt P, Hunter K, Pliszka SR, Soares JC (2007) Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. Bipolar Disord 9(Suppl 1):145-159 (Pubitemid 47399257)
6. Birmaher B, Axelson D, Goldstein B, Strober M, Gill MK, Hunt J, Houck P, Ha W, Iyengar S, Kim E, Yen S, Hower H, Esposito-Smythers C, Goldstein T, Ryan N, Keller M (2009) Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the Course and Outcome of Bipolar Youth (COBY) study. Am J Psychiatry 166:795-804
7. Birmaher B, Axelson D, Strober M, Gill MK, Valeri S, Chiappetta L, Ryan N, Leonard H, Hunt J, Iyengar S, Keller M (2006) Clinical course of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry 63:175-183 (Pubitemid 43213879)
8. Blumberg HP, Martin A, Kaufman J, Leung HC, Skudlarski P, Lacadie C, Fulbright RK, Gore JC, Charney DS, Krystal JH, Peterson BS (2003) Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI. Am J Psychiatry 160:1345-1347 (Pubitemid 41070956)
9. Brissos S,DiasVV, Kapczinski F (2008)Cognitive performance and quality of life in bipolar disorder. Can J Psychiatry 53:517-524
10. Brotman MA, Rooney MH, Skup M, Pine DS, Leibenluft E (2009) Increased intrasubject variability in response time in youths with bipolar disorder and at-risk family members. J Am Acad Child Adolesc Psychiatry 48:628-635
11. Brotman MA, Schmajuk M, Rich BA, Dickstein DP, Guyer AE, Costello EJ, Egger HL, Angold A, Pine DS, Leibenluft E (2006) Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Biol Psychiatry 60:991-997 (Pubitemid 44739929)
12. Burdick KE, Gunawardane N, Woodberry K, Malhotra AK (2009) The role of general intelligence as an intermediate phenotype for neuropsychiatric disorders. Cogn Neuropsychiatry 14:299-311
13. Cahill CM, Walter G, Malhi GS (2009) Neurocognition in bipolar disorder and juvenile bipolar disorder. J Can Acad Child Adolesc Psychiatry 18:221-230
14. Carrus D, Christodoulou T, Hadjulis M, Haldane M, Galea A, Koukopoulos A, Kumari V, Frangou S (2009) Gender differences in immediate memory in bipolar disorder. Psychol Med:1-7
15. Castillo M, Kwock L, Courvoisie H, Hooper SR (2000) Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations. AJNR Am J Neuroradiol 21:832-838 (Pubitemid 30262828)
16. Deckersbach T, Nierenberg AA, Kessler R, Lund HG, Ametrano RM, Sachs G, Rauch SL, Dougherty D (2009) Cognitive Rehabilitation for Bipolar Disorder: an Open Trial for Employed Patients with Residual Depressive Symptoms. CNS Neurosci Ther
17. DelBello MP, Adler CM, Amicone J, Mills NP, Shear PK, Warner J, Strakowski SM (2004) Parametric neurocognitive task design: a pilot study of sustained attention in adolescents with bipolar disorder. J Affect Disord 82(Suppl 1):S79-S88 (Pubitemid 39574986)
18. Dickstein DP, Nelson EE, McClure EB, Grimley ME, Knopf L, Brotman MA, Rich BA, Pine DS, Leibenluft E (2007) Cognitive flexibility in phenotypes of pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry 46:341-355
19. Dickstein DP, Rich BA, Roberson-Nay R, Berghorst L, Vinton D, Pine DS, Leibenluft E (2007) Neural activation during encoding of emotional faces in pediatric bipolar disorder. Bipolar Disord 9:679-692 (Pubitemid 350042402)
20. Dickstein DP, Treland JE, Snow J, McClure EB, Mehta MS, Towbin KE, Pine DS, Leibenluft E (2004) Neuropsychological performance in pediatric bipolar disorder. Biol Psychiatry 55:32-39 (Pubitemid 38045430)
21. Doyle AE, Wilens TE, Kwon A, Seidman LJ, Faraone SV, Fried R, Swezey A, Snyder L, Biederman J (2005) Neuropsychological functioning in youth with bipolar disorder. Biol Psychiatry 58:540-548 (Pubitemid 41457299)
22. Doyle AE, Wozniak J, Wilens TE, Henin A, Seidman LJ, Petty C, Fried R, Gross LM, Faraone SV, Biederman J (2009) Neurocognitive impairment in unaffected siblings of youth with bipolar disorder. Psychol Med 39:1253-1263
23. Duffy A, Alda M, Hajek T, Sherry SB, Grof P (2009) Early stages in the development of bipolar disorder. J Affect Disord
24. Ernst M, Dickstein DP, Munson S, Eshel N, Pradella A, Jazbec S, Pine DS, Leibenluft E (2004) Reward-related processes in pediatric bipolar disorder: a pilot study. J Affect Disord 82(Suppl 1):S89-S101 (Pubitemid 39574987)
25. Fisher M, Holland C, Subramaniam K, Vinogradov S (2009) Neuroplasticity-Based Cognitive Training in Schizophrenia: An Interim Report on the Effects 6 Months Later. Schizophr Bull
26. Geller B, Tillman R, Bolhofner K, Zimerman B (2008) Child bipolar I disorder: prospective continuity with adult bipolar I disorder; characteristics of second and third episodes; predictors of 8-year outcome. Arch Gen Psychiatry 65:1125-1133
27. Glahn DC, Bearden CE, Barguil M, Barrett J, Reichenberg A, Bowden CL, Soares JC, Velligan DI (2007) The neurocognitive signature of psychotic bipolar disorder. Biol Psychiatry 62:910-916 (Pubitemid 47488219)
28. Glahn DC, Bearden CE, Caetano S, Fonseca M, Najt P, Hunter K, Pliszka SR, Olvera RL, Soares JC (2005) Declarative memory impairment in pediatric bipolar disorder. Bipolar Disord 7:546-554 (Pubitemid 41830002)
29. Gorlyn M, Keilp JG, Grunebaum MF, Taylor BP, Oquendo MA, Bruder GE, Stewart JW, Zalsman G, Mann JJ (2008) Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects. J Neural Transm 115:1213-1219
30. Gorrindo T, Blair RJ, Budhani S, Dickstein DP, Pine DS, Leibenluft E (2005) Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder. Am J Psychiatry 162:1975-1977 (Pubitemid 41428633)
31. Guyer AE, McClure EB, Adler AD, Brotman MA, Rich BA, Kimes AS, Pine DS, Ernst M, Leibenluft E (2007) Specificity of facial expression labeling deficits in childhood psychopathology. J Child Psychol Psychiatry 48:863-871 (Pubitemid 47244899)
32. Harvey PD, Wingo AP, Burdick KE, Baldessarini RJ (2010) Cognition and disability in bipolar disorder: lessons from schizophrenia research. Bipolar Disord 12:364-375
33. Henin A, Mick E, Biederman J, Fried R, Hirshfeld-Becker DR, Micco JA, Miller KG, Rycyna CC, Wozniak J (2009) Is psychopharmacologic treatment associated with neuropsychological deficits in bipolar youth? J Clin Psychiatry 70:1178-1185
34. Henin A, Mick E, Biederman J, Fried R, Wozniak J, Faraone SV, Harrington K, Davis S, Doyle AE (2007) Can bipolar disorderspecific neuropsychological impairments in children be identified? J Consult Clin Psychol 75:210-220 (Pubitemid 47444726)
35. Hill SK, Harris MS, Herbener ES, Pavuluri M, Sweeney JA (2008) Neurocognitive allied phenotypes for schizophrenia and bipolar disorder. Schizophr Bull 34:743-759 (Pubitemid 351957555)
36. Holtmann M, Buchmann AF, Esser G, Schmidt MH, Banaschewski T, Laucht M (2011) The Child Behavior Checklist-Dysregulation Profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis. J Child Psychol Psychiatry 52:139-147
37. Holtmann M, Goth K, Wockel L, Poustka F, Bolte S (2008) CBCL-pediatric bipolar disorder phenotype: severe ADHD or bipolar disorder? J Neural Transm 115:155-161
38. Hsiao YL, Wu YS, Wu JY, Hsu MH, Chen HC, Lee SY, Lee IH, Yeh TL, Yang YK, Ko HC, Lu RB (2009) Neuropsychological functions in patients with bipolar I and bipolar II disorder. Bipolar Disord 11:547-554
39. Jaideep T, Reddy YC, Srinath S (2006) Comorbidity of attention deficit hyperactivity disorder in juvenile bipolar disorder. Bipolar Disord 8:182-187 (Pubitemid 44026771)
40. Joseph MF, Frazier TW, Youngstrom EA, Soares JC (2008) A quantitative and qualitative review of neurocognitive performance in pediatric bipolar disorder. J Child Adolesc Psychopharmacol 18:595-605
41. Klingberg T, Fernell E, Olesen PJ, Johnson M, Gustafsson P, Dahlstrom K, Gillberg CG, Forssberg H, Westerberg H (2005) Computerized training of working memory in children with ADHD-a randomized, controlled trial. J Am Acad Child Adolesc Psychiatry 44:177-186 (Pubitemid 40189829)
42. Kowatch RA, Youngstrom EA, Danielyan A, Findling RL (2005) Review and meta-analysis of the phenomenology and clinical characteristics of mania in children and adolescents. Bipolar Disord 7:483-496 (Pubitemid 41829996)
43. Kraepelin E (ed) (1915) Psychiatrie. Ein Lehrbuch für Studierende und Ärzte. Barth Verlag Leipzig
44. Kucyi A, Alsuwaidan MT, Liauw SS, McIntyre RS (2010) Aerobic physical exercise as a possible treatment for neurocognitive dysfunction in bipolar disorder. Postgrad Med 122:107-116
45. Kurtz MM, Gerraty RT (2009) A meta-analytic investigation of neurocognitive deficits in bipolar illness: profile and effects of clinical state. Neuropsychology 23:551-562
46. Kyte ZA, Carlson GA, Goodyer IM (2006) Clinical and neuropsychological characteristics of child and adolescent bipolar disorder. Psychol Med 36:1197-1211 (Pubitemid 44184696)
47. Leibenluft E, Charney DS, Towbin KE, Bhangoo RK, Pine DS (2003) Defining clinical phenotypes of juvenile mania. Am J Psychiatry 160:430-437 (Pubitemid 41094250)
48. Lish JD, Dime-Meenan S, Whybrow PC, Price RA, Hirschfeld RM (1994) The National Depressive and Manic-depressive Association (DMDA) survey of bipolar members. J Affect Disord 31:281-294 (Pubitemid 24254711)
49. MacCabe JH, Lambe MP, Cnattingius S, Sham PC, David AS, Reichenberg A, Murray RM, Hultman CM (2010) Excellent school performance at age 16 and risk of adult bipolar disorder: national cohort study. Br J Psychiatry 196:109-115
50. Maziade M, Rouleau N, Gingras N, Boutin P, Paradis ME, Jomphe V, Boutin J, Letourneau K, Gilbert E, Lefebvre AA, Dore MC, Marino C, Battaglia M, Merette C, Roy MA (2009) Shared neurocognitive dysfunctions in young offspring at extreme risk for schizophrenia or bipolar disorder in eastern quebec multigenerational families. Schizophr Bull 35:919-930
51. McCarthy J, Arrese D, McGlashan A, Rappaport B, Kraseski K, Conway F, Mule C, Tucker J (2004) Sustained attention and visual processing speed in children and adolescents with bipolar disorder and other psychiatric disorders. Psychol Rep 95:39-47 (Pubitemid 39453992)
52. McCarthy J, Kraseski K, Schvartz I, Mercado V, Daisy N, Tobing L, Ryan E (2005) Sustained attention, visual processing speed, and IQ in children and adolescents with Schizophrenia Spectrumdisorder and Psychosis Not Otherwise Specified. Percept Mot Skills 100:1097-1106 (Pubitemid 41328657)
53. McClure EB, Treland JE, Snow J, Dickstein DP, Towbin KE, Charney DS, Pine DS, Leibenluft E (2005) Memory and learning in pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry 44:461-469 (Pubitemid 40559694)
54. McClure EB, Treland JE, Snow J, Schmajuk M, Dickstein DP, Towbin KE, Charney DS, Pine DS, Leibenluft E (2005) Deficits in social cognition and response flexibility in pediatric bipolar disorder. Am J Psychiatry 162:1644-1651 (Pubitemid 41318233)
55. Meyer SE, Carlson GA, Wiggs EA, Martinez PE, Ronsaville DS, Klimes-Dougan B, Gold PW, Radke-Yarrow M (2004) A prospective study of the association among impaired executive functioning, childhood attentional problems, and the development of bipolar disorder. Dev Psychopathol 16:461-476 (Pubitemid 351480006)
56. Miklowitz DJ, Chang KD (2008) Prevention of bipolar disorder in at-risk children: theoretical assumptions and empirical foundations. Dev Psychopathol 20:881-897 (Pubitemid 352003602)
57. Moreno C, Laje G, Blanco C, Jiang H, Schmidt AB, Olfson M (2007) National trends in the outpatient diagnosis and treatment of bipolar disorder in youth. Arch Gen Psychiatry 64:1032-1039 (Pubitemid 47360848)
58. Olvera RL, Semrud-Clikeman M, Pliszka SR, O'Donnell L (2005) Neuropsychological deficits in adolescents with conduct disorder and comorbid bipolar disorder: a pilot study. Bipolar Disord 7:57-67 (Pubitemid 40227837)
59. Pavuluri MN, O'Connor MM, Harral EM, Moss M, Sweeney JA (2006) Impact of neurocognitive function on academic difficulties in pediatric bipolar disorder: a clinical translation. Biol Psychiatry 60:951-956 (Pubitemid 44584209)
60. Pavuluri MN, O'Connor MM, Harral EM, Sweeney JA (2008) An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder. Psychiatry Res 162:244-255
61. Pavuluri MN, Passarotti AM, Harral EM, Sweeney JA (2009) An fMRI study of the neural correlates of incidental versus directed emotion processing in pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry 48:308-319
62. Pavuluri MN, Schenkel LS, Aryal S, Harral EM, Hill SK, Herbener ES, Sweeney JA (2006) Neurocognitive function in unmedicated manic and medicated euthymic pediatric bipolar patients. Am J Psychiatry 163:286-293 (Pubitemid 44480849)
63. Pavuluri MN, West A, Hill SK, Jindal K, Sweeney JA (2009) Neurocognitive function in pediatric bipolar disorder: 3-year follow-up shows cognitive development lagging behind healthy youths. J Am Acad Child Adolesc Psychiatry 48:299-307
64. Perlis RH, Miyahara S, Marangell LB, Wisniewski SR, Ostacher M, DelBello MP, Bowden CL, Sachs GS, Nierenberg AA (2004) Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry 55:875-881 (Pubitemid 38526299)
65. Rau G, Blair KS, Berghorst L, Knopf L, Skup M, Luckenbaugh DA, Pine DS, Blair RJ, Leibenluft E (2008) Processing of differentially valued rewards and punishments in youths with bipolar disorder or severe mood dysregulation. J Child Adolesc Psychopharmacol 18:185-196 (Pubitemid 351591439)
66. Rich BA, Grimley ME, Schmajuk M, Blair KS, Blair RJ, Leibenluft E (2008) Face emotion labeling deficits in children with bipolar disorder and severe mood dysregulation. Dev Psychopathol 20:529-546 (Pubitemid 351584023)
67. Rich BA, Vinton DT, Roberson-Nay R, Hommer RE, Berghorst LH, McClure EB, Fromm SJ, Pine DS, Leibenluft E (2006) Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proc Natl Acad Sci USA 103:8900-8905 (Pubitemid 43878115)
68. Robinson LJ, Thompson JM, Gallagher P, Goswami U, Young AH, Ferrier IN, Moore PB (2006) A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord 93:105-115 (Pubitemid 43816055)
69. Rucklidge JJ (2006) Impact of ADHD on the neurocognitive functioning of adolescents with bipolar disorder. Biol Psychiatry 60:921-928 (Pubitemid 44584213)
70. Seidman LJ, Giuliano AJ, Smith CW, Stone WS, Glatt SJ, Meyer E, Faraone SV, Tsuang MT, Cornblatt B (2006) Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies. Schizophr Bull 32:507-524 (Pubitemid 43992325)
71. Shiratsuchi T, Takahashi N, Suzuki T, Abe K (2000) Depressive episodes of bipolar disorder in early teenage years: changes with increasing age and the significance of IQ. J Affect Disord 58:161-166 (Pubitemid 30227312)
72. Smith PJ, Blumenthal JA, Hoffman BM, Cooper H, Strauman TA, Welsh-Bohmer K, Browndyke JN, Sherwood A (2010) Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med 72:239-252
73. Tabares-Seisdedos R, Balanza-Martinez V, Sanchez-Moreno J, Martinez-Aran A, Salazar-Fraile J, Selva-Vera G, Rubio C, Mata I, Gomez-Beneyto M, Vieta E (2008) Neurocognitive and clinical predictors of functional outcome in patients with schizophrenia and bipolar I disorder at one-year follow-up. J Affect Disord 109:286-299
74. Twamley EW, Jeste DV, Bellack AS (2003) A review of cognitive training in schizophrenia. Schizophr Bull 29:359-382 (Pubitemid 37187698)
75. VoelbelGT, BatesME,Buckman JF, PandinaG,HendrenRL(2006) Caudate nucleus volume and cognitive performance: Are they related in childhood psychopathology? Biol Psychiatry 60:942-950
76. Wingo AP, Harvey PD, Baldessarini RJ (2009) Neurocognitive impairment in bipolar disorder patients: functional implications. Bipolar Disord 11:113-125
77. Wingo AP, Wingo TS, Harvey PD, Baldessarini RJ (2009) Effects of lithium on cognitive performance: a meta-analysis. J Clin Psychiatry 70:1588-1597
78. Youngstrom EA, Freeman AJ, Jenkins MM (2009) The assessment of children and adolescents with bipolar disorder. Child Adolesc Psychiatr Clin N Am 18:353-390, viii-ix