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Volumn 20, Issue 1, 2012, Pages 368-376

Structure-based redesign of an edema toxin inhibitor

(10) Chen, Deliang a Ma, Lili b Kanalas, John J c Gao, Jian c Pawlik, Jennifer a Jimenez, Maria Estrella b Walter, Mary A c Peterson, Johnny W a Gilbertson, Scott R b Schein, Catherine H a,d

a University of Texas Medical Branch School of Medicine (United States)

b University of Houston (United States)

c Mission Pharmacal Company (United States)

d UTMB (United States)

Author keywords

Adenylyl cyclase toxin inhibitor; Anthrax; Cell based assay; Computer aided design; ETEC (enterotoxigenic E. coli); Non nucleotide inhibitors; Toxicity profiling

Indexed keywords

2 AMINO 5 (9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDO)BENZOIC ACID; 2 CHLORO 3 (9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDO)BENZOIC ACID; 2 HYDROXY 3 (9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDO)BENZOIC ACID; 2 HYDROXY 5 (9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDO)BENZOIC ACID; 2 METHYL 3 (9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDO)BENZOIC ACID; 3 [(9 OXO 9H FLUORENE 1 CARBONYL) AMINO] BENZOIC ACID; 3 [(BIPHENYL 3 CARBONYL) AMINO] BENZOIC ACID; 3 AMINO 5 (9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDO)BENZOIC ACID; 3 BENZOYLAMINO BENZOIC ACID; 4 METHOXY 3 (9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDO)BENZOIC ACID; 5 AMINO 2 (9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDO)BENZOIC ACID; 9 OXO N [3 (TRIFLUOROMETHOXY)PHENYL] 9 OXO 9H FLUORENE 1 CARBOXAMIDE; 9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDE; BENZOIC ACID; EDEMA TOXIN INHIBITOR; LEAD; METHYL 2 HYDROXY 5 (9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDO)BENZOIC ACID; METHYL 2 METHYL 9 (9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDO)BENZOIC ACID; METHYL 3 (9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDO)BENZOIC ACID; METHYL 4 METHYL 3 (9 OXO N PHENYL 9H FLUORENE 1 CARBOXAMIDO)BENZOIC ACID; N (3 CARBAMIMIDOYLPHENYL) 9 OXO 9H FLUORENE 1 CARBOXAMIDE; N (3 CHLORO 4 FLUOROPHENYL) 9 OXO 9H FLUORENE 1 CARBOXAMIDE; N [3 (DIMETHYLAMINO)PHENYL] 9 OXO 9H FLUORENE 1 CARBOXAMIDE; N [3 (HYDROXYCARBOMYL)PHENYL] 9 OXO 9H FLUORENE 1 CARBOXAMIDE; N [3 (METHYLTHIO)PHENYL] 9 OXO 9H FLUORENE 1 CARBOXAMIDE; PROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; LIGAND BINDING; MUTAGEN TESTING; NONHUMAN; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

ADENYLATE CYCLASE; ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; BENZOIC ACIDS; BINDING SITES; CELL LINE; COMPUTER SIMULATION; CYCLIC AMP; DRUG DESIGN; FLUORENES; MICE; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

BACILLUS ANTHRACIS; ESCHERICHIA COLI; MAMMALIA; MURINAE;

EID: 84855196872 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.10.091 Document Type: Article

Times cited : (11)

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