6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5630-5633

  Kato, Atsushi ^a   Kobayashi, Kaori ^a   Narukawa, Kayo ^b   Minoshima, Yuka ^a   Adachi, Isao ^a   Hirono, Shuichi ^b   Nash, Robert J ^c  

^a UNIVERSITY OF TOYAMA   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c Phytoquest Limited   (United Kingdom)

Author keywords

6,7 Dihydroxy 4 phenylcoumarin; Aldose reductase 2; ALR2 inhibitor; Galactitol accumulation; Molecular docking study; Structure activity relationships

Indexed keywords

6,7 DIHYDROXY 4 PHENYLCOUMARIN; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE 2; ALDOSE REDUCTASE INHIBITOR; COUMARIN DERIVATIVE; EPALRESTAT; GALACTITOL; HYDROXIDE; IDITOL DEHYDROGENASE; PHENYL GROUP; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; LENS; MOLECULAR DOCKING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ALDEHYDE REDUCTASE; ANIMALS; BINDING SITES; COMPUTER SIMULATION; COUMARINS; GALACTITOL; L-IDITOL 2-DEHYDROGENASE; LENS, CRYSTALLINE; PROTEIN STRUCTURE, TERTIARY; RATS; RHODANINE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

RATTUS;

EID: 77957608632     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.038     Document Type: Article

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