Tumor kinase activity in locally advanced rectal cancer: Angiogenic signaling and early systemic dissemination

Angiogenesis

Volumn 14, Issue 4, 2011, Pages 481-489

  Saelen, Marie Grøn ^a,d   Flatmark, Kjersti ^a   Folkvord, Sigurd ^a   De Wijn, Rik ^b   Rasmussen, Heidi ^a   Fodstad, O ^a,d   Ree, Anne Hansen ^c,d  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b PamGene International BV   (Netherlands)

^c AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

Angiogenesis; Disseminated tumor cells; Metastasis; Rectal cancer; Tyrosine kinase signaling

Indexed keywords

ERYTHROPOIETIN RECEPTOR; PHOSPHOPEPTIDE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; SUNITINIB; VASCULOTROPIN RECEPTOR;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BONE MARROW BIOPSY; CANCER RECURRENCE; CANCER RISK; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EX VIVO STUDY; FEMALE; HUMAN; IMMUNOMAGNETIC SEPARATION; INTRACELLULAR SIGNALING; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTEIN FUNCTION; RECTUM CANCER; RECURRENCE RISK; RISK ASSESSMENT; TUMOR BIOPSY; TUMOR VASCULARIZATION;

ADULT; AGED; ANALYSIS OF VARIANCE; BONE MARROW CELLS; CELL HYPOXIA; FEMALE; HUMANS; IMMUNOMAGNETIC SEPARATION; INDOLES; MALE; MIDDLE AGED; NEOPLASTIC CELLS, CIRCULATING; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHOPEPTIDES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PYRROLES; RECTAL NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 84855194345     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-011-9231-3     Document Type: Article

References (31)

1. JA Bertout SA Patel MC Simon 2008 The impact of O2 availability on human cancer Nat Rev Cancer 8 967 975 10.1038/nrc2540 18987634 10.1038/nrc2540 1:CAS:528:DC%2BD1cXhsVWhu7fO
2. P Ebbesen EO Pettersen TA Gorr G Jobst K Williams J Kieninger RH Wenger S Pastorekova L Dubois P Lambin BG Wouters T Van Den Beucken CT Supuran L Poellinger P Ratcliffe A Kanopka A Görlach M Gasmann AL Harris P Maxwell A Scozzafava 2009 Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies J Enzyme Inhib Med Chem 24 S1 S39 10.1080/14756360902784425 10.1080/14756360902784425
3. K Harrington P Jankowska M Hingorani 2007 Molecular biology for the radiation oncologist: the 5Rs of radiobiology meet the hallmarks of cancer Clin Oncol (R Coll Radiol) 19 561 571 10.1016/j.clon.2007.04.009 10.1016/j.clon.2007. 04.009 1:STN:280:DC%2BD2srhtlOktw%3D%3D (Pubitemid 47308644)
4. J Bussink AJ van der Kogel JH Kaanders 2008 Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer Lancet Oncol 9 288 296 10.1016/S1470-2045(08)70073-1 18308254 10.1016/S1470-2045(08)70073-1 1:CAS:528:DC%2BD1cXivVaqtb0%3D (Pubitemid 351722948)
5. X Lu Y Kang 2010 Hypoxia and hypoxia-inducible factors: master regulators of metastasis Clin Cancer Res 16 5928 5935 10.1158/1078-0432.CCR-10-1360 20962028 10.1158/1078-0432.CCR-10-1360 1:CAS:528:DC%2BC3cXhsFOjsbfJ
6. AL Harris 2002 Hypoxia-a key regulatory factor in tumour growth Nat Rev Cancer 2 38 47 10.1038/nrc704 11902584 10.1038/nrc704 1:CAS:528: DC%2BD38XhvF2jtL4%3D (Pubitemid 37328806)
7. R Sauer H Becker W Hohenberger C Rödel C Wittekind R Fietkau P Martus J Tschmelitsch E Hager CF Hess JH Karstens T Liersch H Schmidberger R Raab 2004 Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 351 1731 1740 15496622 10.1056/NEJMoa040694 1:CAS:528: DC%2BD2cXovFSksbo%3D (Pubitemid 39383208)
8. S Folkvord K Flatmark S Dueland R de Wijn KK Grøholt KH Hole JM Nesland R Ruijtenbeek PJ Boender M Johansen KE Giercksky AH Ree 2010 Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling Int J Radiat Oncol Biol Phys 78 555 562 10.1016/j.ijrobp.2010.04.036 20675069 10.1016/j.ijrobp.2010.04.036 1:CAS:528:DC%2BC3cXhtFCmtLbE
9. K Flatmark E Borgen JM Nesland H Rasmussen HO Johannessen I Bukholm R Rosales L Hårklau HJ Jacobsen B Sandstad K Boye Ø Fodstad 2011 Disseminated tumour cells as a prognostic biomarker in colorectal cancer Br J Cancer 104 1434 1439 10.1038/bjc.2011.97 21448171 10.1038/bjc.2011.97 1:STN:280:DC%2BC3MvmslKrsw%3D%3D
10. H Bouzourene FT Bosman W Seelentag M Matter P Coucke 2002 Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy Cancer 94 1121 1130 10.1002/cncr.10327 11920483 10.1002/cncr.10327 (Pubitemid 34150868)
11. K Flatmark K Bjornland HO Johannessen E Hegstad R Rosales L Hårklau JH Solhaug RS Faye O Søreide Ø Fodstad 2002 Immunomagnetic detection of micrometastatic cells in bone marrow of colorectal cancer patients Clin Cancer Res 8 444 449 11839662 (Pubitemid 34193963)
12. European Bioinformatics Institute: ArrayExpress Experiments Archive. http://www.ebi.ac.uk/microarray-as/ae/. Accessed 26 February 2010
13. European Bioinformatics Institute/Swiss Institute of Bioinformatics/ Protein Information Resource: Universal Protein Knowledgebase, UniProtKB/Swiss-Prot. http://au.expasy.org/sprot. Accessed 11 August 2010
14. K Pantel C Alix-Panabieres 2010 Circulating tumour cells in cancer patients: challenges and perspectives Trends Mol Med 16 398 406 10.1016/j.molmed.2010.07.001 20667783 10.1016/j.molmed.2010.07.001
15. Å Bratland PJ Boender HK Høifødt IHG Østensen R Ruijtenbeek M Wang JP Berg W Lilleby Ø Fodstad AH Ree 2009 Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells characterized by multiplex kinase activity profiling Clin Exp Metastasis 26 485 496 10.1007/s10585-009-9248-9 19294521 10.1007/s10585-009-9248-9 1:CAS:528:DC%2BD1MXmtVKgsLc%3D
16. LQ Chow SG Eckhardt 2007 Sunitinib: from rational design to clinical efficacy J Clin Oncol 25 884 896 10.1200/JCO.2006.06.3602 17327610 10.1200/JCO.2006.06.3602 1:CAS:528:DC%2BD2sXjvVKmtLY%3D (Pubitemid 350002890)
17. R Bicknell AL Harris 2004 Novel angiogenic signaling pathways and vascular targets Annu Rev Pharmacol Toxicol 44 219 238 10.1146/annurev.pharmtox. 44.101802.121650 14744245 10.1146/annurev.pharmtox.44.101802.121650 1:CAS:528:DC%2BD2cXhvVCktL4%3D (Pubitemid 38263840)
18. J Andrae R Gallini C Betsholtz 2008 Role of platelet-derived growth factors in physiology and medicine Genes Dev 22 1276 1312 10.1101/gad.165370 18483217 10.1101/gad.1653708 1:CAS:528:DC%2BD1cXmsVWmsbs%3D (Pubitemid 351717519)
19. JM Ebos RS Kerbel 2011 Antiangiogenic therapy: impact on invasion, disease progression, and metastasis Nat Rev Clin Oncol 8 210 221 10.1038/nrclinonc.2011.21 21364524 10.1038/nrclinonc.2011.21 1:CAS:528:DC%2BC3MXjvFKlsLg%3D
20. CJ Allegra G Yothers MJ O'Connell S Sharif NJ Petrelli LH Colangelo JN Atkins TE Seay L Fehrenbacher RM Goldberg S O'Reilly L Chu CA Azar S Lopa N Wolmark 2011 Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08 J Clin Oncol 29 1 16 10.1200/JCO.2010.30.0855 10.1200/JCO.2010.30.0855
21. De Gramont A, Van Cutsem E, Tabernero J, Moore MJ, Cunningham D, Rivera F, Im SA, Makrutzki M, Shang A, Hoff PM (2011) AVANT: results from a randomized, three-arm multinational phase III study to investigate Bevacizumab with either XELOX or FOLFOX4 versus FOLFOX4 alone as adjuvant treatment for colon cancer. In: Proceedings of 2011 Gastrointestinal Cancers Symposium, San Francisco, CA, January 20-22, 2011
22. I Helfrich I Scheffrahn S Bartling J Weis V von Felbert M Middleton M Kato S Ergün D Schadendorf 2010 Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma J Exp Med 207 491 503 10.1084/jem.20091846 20194633 10.1084/jem.20091846 1:CAS:528:DC%2BC3cXjvVOhsL0%3D
23. R Hlushchuk O Baum G Gruber J Wood V Djonov 2007 The synergistic action of a VEGF-receptor tyrosine-kinase inhibitor and a sensitizing PDGF-receptor blocker depends upon the stage of vascular maturation Microcirculation 14 813 825 10.1080/10739680701370021 17907017 10.1080/10739680701370021 1:CAS:528:DC%2BD2sXht12jtrnO (Pubitemid 350131389)
24. Z Zhou KS Stewart L Yu ES Kleinerman 2011 Bone marrow cells participate in tumor vessel formation that supports the growth of Ewing's sarcoma in the lung Angiogenesis 14 125 133 10.1007/s10456-010-9196-7 21184173 10.1007/s10456-010-9196-7
25. AM Chabowska M Sulkowska A Chabowski A Wincewicz M Koda S Sulkowski 2008 Erythropoietin and erythropoietin receptor in colorectal cancer Int J Surg Pathol 16 269 276 10.1177/1066896908315796 18487221 10.1177/1066896908315796 (Pubitemid 351873720)
26. ME Hardee Y Cao P Fu X Jiang Y Zhao ZN Rabbani Z Vujaskovic MW Dewhirst MO Arcasoy 2007 Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression PLoS One 2 e549 10.1371/journal.pone.0000549 17579721 10.1371/journal.pone.0000549 (Pubitemid 351193995)
27. G Cao ML Fehrenbach JT Williams JM Finklestein JX Zhu HM Delisser 2009 Angiogenesis in platelet endothelial cell adhesion molecule-1-null mice Am J Pathol 175 903 915 10.2353/ajpath.2009.090206 19574426 10.2353/ajpath.2009. 090206 1:CAS:528:DC%2BD1MXhtVGqt73O
28. BG Wouters M Koritzinsky 2008 Hypoxia signalling through mTOR and the unfolded protein response in cancer Nat Rev Cancer 8 851 864 10.1038/nrc2501 18846101 10.1038/nrc2501 1:CAS:528:DC%2BD1cXht1yjtbnI
29. T Winder HJ Lenz 2010 Vascular endothelial growth factor and epidermal growth factor signaling pathways as therapeutic targets for colorectal cancer Gastroenterology 138 2163 2176 10.1053/j.gastro.2010.02.005 20420953 10.1053/j.gastro.2010.02.005 1:CAS:528:DC%2BC3cXms1yiur4%3D
30. B Mosch B Reissenweber C Neuber J Pietzsch 2010 Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesis J Oncol 2010 135285 10.1155/2010/135285 20224755
31. NN Rahbari M Aigner K Thorlund N Mollberg E Motschall K Jensen MK Diener MW Büchler M Koch J Weitz 2010 Meta-analysis shows that detection of circulating tumor cells indicates poor prognosis in patients with colorectal cancer Gastroenterology 138 1714 1726 10.1053/j.gastro.2010.01.008 20100481 10.1053/j.gastro.2010.01.008