Disseminated tumour cells as a prognostic biomarker in colorectal cancer

British Journal of Cancer

Volumn 104, Issue 9, 2011, Pages 1434-1439

  Flatmark, K ^a   Borgen, E ^a   Nesland, J M ^a,b   Rasmussen, H ^a   Johannessen, H O ^a   Bukholm, I ^c   Rosales, R ^d   Harklau L ^a   Jacobsen, H J ^e   Sandstad, B ^a   Boye, K ^a   Fodstad, O ^a,b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^d VESTRE VIKEN HOSPITAL TRUST   (Norway)

^e DIAKONHJEMMET HOSPITAL   (Norway)

Author keywords

colorectal cancer; cytokeratin; disseminated tumour cells; EpCAM; prognostic biomarker

Indexed keywords

BIOLOGICAL MARKER; CYTOKERATIN ANTIBODY; EPITHELIAL CELL ADHESION MOLECULE;

ADULT; AGED; ARTICLE; CANCER CELL; COLORECTAL CANCER; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOMAGNETIC SEPARATION; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANTIGENS, NEOPLASM; BONE MARROW; CELL ADHESION MOLECULES; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOMAGNETIC SEPARATION; KAPLAN-MEIER ESTIMATE; KERATINS; MALE; MIDDLE AGED; NEOPLASM STAGING; NEOPLASTIC CELLS, CIRCULATING; NORWAY; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES;

EID: 79955466713     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.97     Document Type: Article

References (15)

1. Borgen E, Naume B, Nesland JM, Kvalheim G, Beiske K, Fodstad O, Diel I, Solomayer EF, Theocharous P, Coombes RC, Smith BM, Wunder E, Marolleau JP, Garcia J, Pantel K (1999) Standardization of the immunocytochemical detection of cancer cells in BM and blood: I. establishment of objective criteria for the evaluation of immunostained cells. Cytother 1: 377-388
2. Chambers AF, Groom AC, MacDonald IC (2002) Metastasis: dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2: 563-572 (Pubitemid 37328923)
3. Dukes CE (1932) The classification of cancer of the rectum. J Pathol Bacteriol 35: 323-332
4. Effenberger KE, Borgen E, Eulenburg CZ, Bartkowiak K, Grosser A, Synnestvedt M, Kaaresen R, Brandt B, Nesland JM, Pantel K, Naume B (2011) Detection and clinical relevance of early disseminated breast cancer cells depend on their cytokeratin expression pattern. Breast Cancer Res Treat 125: 729-738
5. Epstein RJ (2005) Maintenance therapy to suppress micrometastasis: the new challenge for adjuvant cancer treatment. Clin Cancer Res 11: 5337-5341 (Pubitemid 41060805)
6. Fehm T, Braun S, Muller V, Janni W, Gebauer G, Marth C, Schindlbeck C, Wallwiener D, Borgen E, Naume B, Pantel K, Solomayer E (2006) A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation. Cancer 107: 885-892 (Pubitemid 44291136)
7. Flatmark K, Bjornland K, Johannessen HO, Hegstad E, Rosales R, Harklau L, Solhaug JH, Faye RS, Soreide O, Fodstad O (2002) Immunomagnetic detection of micrometastatic cells in bone marrow of colorectal cancer patients. Clin Cancer Res 8: 444-449 (Pubitemid 34193963)
8. Gangnus R, Langer S, Breit E, Pantel K, Speicher MR (2004) Genomic profiling of viable and proliferative micrometastatic cells from early-stage breast cancer patients. Clin Cancer Res 10: 3457-3464 (Pubitemid 38685453)
9. Maetzel D, Denzel S, Mack B, Canis M, Went P, Benk M, Kieu C, Papior P, Baeuerle PA, Munz M, Gires O (2009) Nuclear signalling by tumour-associated antigen EpCAM. Nat Cell Biol 11: 162-171
10. McGowan PM, Kirstein JM, Chambers AF (2009) Micrometastatic disease and metastatic outgrowth: clinical issues and experimental approaches. Future Oncol 5: 1083-1098
11. Munz M, Baeuerle PA, Gires O (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res 69: 5627-5629
12. O'Connell JB, Maggard MA, Ko CY (2004) Colon cancer survival rates with the New American Joint Committee on cancer sixth edition staging. J Natl Cancer Inst 96: 1420-1425 (Pubitemid 39429665)
13. Pantel K, Alix-Panabieres C, Riethdorf S (2009) Cancer micrometastases. Nat Rev Clin Oncol 6: 339-351
14. Pfister DG, Benson III AB, Somerfield MR (2004) Surveillance strategies after curative treatment of colorectal cancer. N Engl J Med 350: 2375-2382
15. Rahbari NN, Aigner M, Thorlund K, Mollberg N, Motschall E, Jensen K, Diener MK, Buchler MW, Koch M, Weitz J (2010) Meta-analysis shows that detection of circulating tumor cells indicates poor prognosis in patients with colorectal cancer. Gastroenterol 138: 1714-1726