Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling

International Journal of Radiation Oncology Biology Physics

Volumn 78, Issue 2, 2010, Pages 555-562

  Folkvord, Sigurd ^a   Flatmark, Kjersti ^a   Dueland, Svein ^a   De Wijn, Rik ^b   Grøholt, Krystyna Kotanska ^a   Hole, Knut H ^a   Nesland, Jahn M ^a,c   Ruijtenbeek, Rob ^b   Boender, Piet J ^b   Johansen, Marianne ^a   Giercksky, Karl Erik ^a,c   Ree, Anne Hansen ^c,d  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b PamGene International BV   (Netherlands)

^c UNIVERSITY OF OSLO   (Norway)

^d AKERSHUS UNIVERSITY HOSPITAL   (Norway)

Author keywords

Chemoradiotherapy response; Multiplex analysis; Prediction; Rectal cancer; Tumor kinase activity

Indexed keywords

CHEMORADIOTHERAPY; CLINICAL RADIOTHERAPY; CROSS VALIDATION; FLUOROURACIL; KINASE ACTIVITY; KINASE INHIBITORS; KINASE SUBSTRATES; LEAVE-ONE-OUT; MULTIPLEX ANALYSIS; OXALIPLATIN; PARTIAL LEAST SQUARES; PATIENT POPULATION; PRE-TREATMENT; PREDICTION; PREDICTION MODEL; PREDICTION PERFORMANCE; PREDICTIVE MODELS; RADIATION RESPONSE; RADIORESISTANCE; RECTAL CANCER; SIGNALING PATHWAYS; TEST SETS; TREATMENT OUTCOMES; TUMOR MODELS; TUMOR REGRESSION GRADES; TUMOR RESPONSE;

DISCRIMINANT ANALYSIS; DISEASES; FORECASTING; MATHEMATICAL MODELS; MULTIPLEXING; PHOSPHORYLATION; RADIOTHERAPY; SIGNALING; SUBSTRATES;

TUMORS;

CAPECITABINE; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN; PHOSPHOTRANSFERASE; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE; INDOLE DERIVATIVE; PLATINUM COMPLEX; PYRROLE DERIVATIVE; SUNITINIB; TUMOR PROTEIN;

ADULT; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER STAGING; ENZYME ACTIVITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; MULTIPLE CYCLE TREATMENT; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RECTUM BIOPSY; RECTUM CANCER; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR REGRESSION; ANALOGS AND DERIVATIVES; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROCEDURES; RADIATION DOSE; RECTAL NEOPLASMS; RECTUM; REGRESSION ANALYSIS; REMISSION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; DEOXYCYTIDINE; FEMALE; FLUOROURACIL; HUMANS; INDOLES; LEAST-SQUARES ANALYSIS; LEUCOVORIN; MALE; MIDDLE AGED; NEOPLASM PROTEINS; ORGANOPLATINUM COMPOUNDS; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PYRROLES; RADIATION TOLERANCE; RECTAL NEOPLASMS; RECTUM; REMISSION INDUCTION; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TREATMENT OUTCOME;

EID: 79953251110     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.04.036     Document Type: Article

References (46)

1. W.P. Ceelen, Y. Van Nieuwenhove, and K. Fierens Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer Cochrane Database Syst Rev 2009 Jan 21:CD006041
2. V. Valentini, R. Beets-Tan, and J.M. Borras Evidence and research in rectal cancer Radiother Oncol 87 2008 449 474
3. C. Rodel, P. Martus, and T. Papadoupolos Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer J Clin Oncol 23 2005 8688 8696
4. R.K. Wong, V. Tandan, and S. De Silva Pre-operative radiotherapy and curative surgery for the management of localized rectal carcinoma Cochrane Database Syst Rev 2007 Apr 18:CD002102
5. J.G. Kuremsky, J.E. Tepper, and H.L. McLeod Biomarkers for response to neoadjuvant chemoradiation for rectal cancer Int J Radiat Oncol Biol Phys 74 2009 673 688
6. B.D. O'Neill, G. Brown, and R.J. Heald Non-operative treatment after neoadjuvant chemoradiotherapy for rectal cancer Lancet Oncol 8 2007 625 633
7. C.J. Bakkenist, and M.B. Kastan DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Nature 421 2003 499 506
8. M.F. Lavin, and S. Kozlov ATM activation and DNA damage response Cell Cycle 6 2007 931 942
9. J. Bussink, A.J. van der Kogel, and J.H. Kaanders Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer Lancet Oncol 9 2008 288 296
10. M. Krause, and M. Baumann Clinical biomarkers of kinase activity: Examples from EGFR inhibition trials Cancer Metastasis Rev 27 2008 387 402
11. T.K. Pandita, and C. Richardson Chromatin remodeling finds its place in the DNA double-strand break response Nucleic Acids Res 37 2009 1363 1377
12. M. Toulany, M. Baumann, and H.P. Rodemann Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity Mol Cancer Res 5 2007 863 872
13. J.A. Bonner, P.M. Harari, and J. Giralt Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck N Engl J Med 354 2006 567 578
14. K. De Keersmaecker, M. Versele, and J. Cools Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases Leukemia 22 2008 2208 2216
15. R. Hilhorst, L. Houkes, and A. van den Berg Peptide microarrays for detailed, high-throughput substrate identification, kinetic characterization, and inhibition studies on protein kinase A Anal Biochem 387 2009 150 161
16. M. Jinnin, D. Medici, and L. Park Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma Nat Med 14 2008 1236 1246
17. S. Lemeer, C. Jopling, and F. Naji Protein-tyrosine kinase activity profiling in knock down zebrafish embryos PLoS One 2 2007 e581
18. S. Lemeer, R. Ruijtenbeek, and M.W. Pinkse Endogenous phosphotyrosine signaling in zebrafish embryos Mol Cell Proteomics 6 2007 2088 2099
19. W. Maat, M. el Filali, and A. Dirks-Mulder Episodic Src activation in uveal melanoma revealed by kinase activity profiling Br J Cancer 101 2009 312 319
20. A.J. Poot, J. van Ameijde, and M. Slijper Development of selective bisubstrate-based inhibitors against protein kinase C (PKC) isozymes by using dynamic peptide microarrays Chembiochem 10 2009 2042 2051
21. A.H. Sikkema, S.H. Diks, and W.F. den Dunnen Kinome profiling in pediatric brain tumors as a new approach for target discovery Cancer Res 69 2009 5987 5995
22. M. Versele, W. Talloen, and C. Rockx Response prediction to a multitargeted kinase inhibitor in cancer cell lines and xenograft tumors using high-content tyrosine peptide arrays with a kinetic readout Mol Cancer Ther 8 2009 1846 1855
23. H. Sorbye, B. Glimelius, and A. Berglund Multicenter phase II study of Nordic fluorouracil and folinic acid bolus schedule combined with oxaliplatin as first-line treatment of metastatic colorectal cancer J Clin Oncol 22 2004 31 38
24. M. Braendengen, K.M. Tveit, and A. Berglund Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer J Clin Oncol 26 2008 3687 3694
25. MERCURY Study Group Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: Prospective observational study BMJ 333 2006 779
26. MERCURY Study Group Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer: Results of the MERCURY study Radiology 243 2007 132 139
27. N.J. Smith, Y. Barbachano, and A.R. Norman Prognostic significance of magnetic resonance imaging-detected extramural vascular invasion in rectal cancer Br J Surg 95 2008 229 236
28. H. Bouzourene, F.T. Bosman, and W. Seelentag Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy Cancer 94 2002 1121 1130
29. M. Barker, and W. Rayens Partial least squares for discrimination J Chemometrics 17 2003 166 173
30. X. Huang, and W. Pan Linear regression and two-class classification with gene expression data Bioinformatics 19 2003 2072 2078
31. A.L. Boulesteix, and K. Strimmer Partial least squares: A versatile tool for the analysis of high-dimensional genomic data Brief Bioinform 8 2007 32 44
32. A.L. Boulesteix, C. Strobl, and T. Augustin Evaluating microarray-based classifiers: An overview Cancer Inform 6 2008 77 97
33. J.A. Westerhuis, C.J. Huub, and C.J. Hoefsloot Assessment of PLSDA cross validation Metabolomics 4 2008 81 89
34. Kyoto Encyclopedia of Genes and Genomes Pathway Database. http://www.genome.jp/kegg/pathway.html. Accessed on November 15, 2009.
35. C. Aschele, C. Pinto, and S. Cordio Preoperative fluorouracil (FU)-based chemoradiation with and without weekly oxaliplatin in locally advanced rectal cancer: Pathologic response analysis of the STAR-01 randomized phase III trial Proc Am Soc Clin Oncol 27 2009 804 [Abstract]
36. J.P. Gerard, D. Azria, and S. Gourgou-Bourgade Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: Results of the phase III trial ACCORD 12/0405-Prodige 2 J Clin Oncol 28 2010 1638 1644
37. S. Folkvord, K. Flatmark, and T. Seierstad Inhibitory effects of oxaliplatin in experimental radiation treatment of colorectal carcinoma: Does oxaliplatin improve 5-fluorouracil-dependent radiosensitivity? Radiother Oncol 86 2008 428 434
38. B.M. Ghadimi, M. Grade, and M.J. Difilippantonio Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy J Clin Oncol 23 2005 1826 1838
39. I.J. Kim, S.B. Lim, and H.C. Kang Microarray gene expression profiling for predicting complete response to preoperative chemoradiotherapy in patients with advanced rectal cancer Dis Colon Rectum 50 2007 1342 1353
40. C. Rimkus, J. Friederichs, and A.L. Boulesteix Microarray-based prediction of tumor response to neoadjuvant radiochemotherapy of patients with locally advanced rectal cancer Clin Gastroenterol Hepatol 6 2008 53 61
41. T. Watanabe, Y. Komuro, and T. Kiyomatsu Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles Cancer Res 66 2006 3370 3374
42. L.Q. Chow, and S.G. Eckhardt Sunitinib: From rational design to clinical efficacy J Clin Oncol 25 2007 884 896
43. I. Zlobec, T. Vuong, and C.C. Compton Combined analysis of VEGF and EGFR predicts complete tumour response in rectal cancer treated with preoperative radiotherapy Br J Cancer 98 2008 450 456
44. C. Bengala, S. Bettelli, and F. Bertolini Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer Ann Oncol 20 2009 469 474
45. Swiss Institute of Bioinformatics: ExPASy Proteomics Server Swiss-prot. http://au.expasy.org/sprot. Accessed on November 15, 2009.
46. ArrayExpress Experiments Archive. http://www.ebi.ac.uk/microarray-as/ae/. Accessed on February 26, 2010.