Stereochemical diversity of AI-2 analogs modulates quorum sensing in Vibrio harveyi and Escherichia coli

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 249-256

  Rui, Fabio ^a,b   Marques, João C ^a,b,c   Miller, Stephen T ^d   Maycock, Christopher D ^a,e   Xavier, Karina B ^a,b   Ventura, M Rita ^a  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b Instituto Gulbenkian de Ciência ^*  (Portugal)

^c CHAMPALIMAUD CENTRE FOR THE UNKNOWN   (Portugal)

^d SWARTHMORE COLLEGE   (United States)

^e UNIVERSITY OF LISBON   (Portugal)

Author keywords

AI 2; DPD; DPD agonist; DPD analogs; Quorum sensing

Indexed keywords

1 (3 METHYLQUINOXALIN 2 YL)PROPANE 1,2 DIOL; 2 TERT BUTYLDIPHENYLSILOXYHEX 2 YN 3 ONE; 2 TERT BUTYLDIPHENYLSILYLOXYPROPANOIC ACID METHYL ESTER; 2,3 (CYCLOHEXYLIDENEDIOXY) HEX 4 YNE; 2,3 (CYCLOHEXYLIDENEDIOXY)HEX 4 YNE; 4,5 (CYCLOHEXYLIDENEDIOXY)HEXAN 2,3 DIONE; 4,5 DIHYDROXYPENTANEDIONE DERIVATIVE; 4,5 DIHYROXYHEXANEDIONE; AUTOINDUCER 2 RECEPTOR DERIVATIVE; BACTERIAL PROTEIN; HEX 4 YN 2,3 DIOL; N METHOXY N METHYL 2 (TERT BUTYLDIPHENYLSILYLOXY)PROPANAMIDE; NATURAL PRODUCT; RECEPTOR LSRB; RECEPTOR LUXP; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENANTIOMER; ESCHERICHIA COLI; IC 50; IN VIVO STUDY; LIGAND BINDING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PURIFICATION; QUORUM SENSING; SPECIES DIFFERENCE; STEREOCHEMISTRY; SUBSTITUTION REACTION; VIBRIO HARVEYI;

BACTERIAL PROTEINS; CYCLIZATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HEXANES; HOMOSERINE; LACTONES; PENTANES; QUORUM SENSING; REPRESSOR PROTEINS; STEREOISOMERISM; VIBRIO;

ESCHERICHIA COLI; VIBRIO HARVEYI;

EID: 84855192035     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.007     Document Type: Article

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